GREMLIN Database
AROE - Shikimate dehydrogenase (NADP(+))
UniProt: Q9HS68 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (256)
Sequences: 6307 (4639)
Seq/√Len: 289.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_E224_A4.5991.00
9_N37_E4.1161.00
75_D97_Y3.1191.00
246_E252_D2.8611.00
102_A243_E2.8101.00
84_V96_G2.8081.00
207_V219_L2.5921.00
119_Q142_T2.5911.00
243_E246_E2.5771.00
66_Q130_R2.5451.00
89_F94_P2.3791.00
72_V96_G2.2591.00
121_V177_A2.2201.00
132_A210_A2.1441.00
72_V87_I2.1341.00
218_R222_D2.1101.00
216_E221_R2.1021.00
19_L241_G2.0601.00
104_V208_L2.0471.00
78_A84_V2.0441.00
88_D247_R2.0021.00
59_N244_A1.9961.00
90_S95_R1.9841.00
109_A139_A1.9681.00
122_V133_A1.9381.00
67_S70_S1.9361.00
106_R109_A1.8761.00
150_R154_D1.8621.00
207_V223_A1.8511.00
8_G61_T1.8351.00
58_L87_I1.8251.00
3_V34_V1.8031.00
130_R159_D1.7961.00
120_A141_A1.7811.00
68_A72_V1.7731.00
220_L230_T1.7721.00
9_N40_P1.7661.00
104_V132_A1.7621.00
76_S79_A1.7341.00
5_G36_F1.7071.00
69_A74_T1.6991.00
45_A48_R1.6831.00
119_Q178_T1.6461.00
24_Y31_A1.6331.00
154_D158_A1.6271.00
64_F67_S1.6271.00
97_Y247_R1.6251.00
68_A87_I1.6171.00
42_D45_A1.6081.00
202_H205_L1.5971.00
4_Y31_A1.5831.00
75_D95_R1.5701.00
7_I58_L1.5571.00
106_R239_Y1.5351.00
86_T99_T1.5221.00
87_I94_P1.5131.00
4_Y24_Y1.5051.00
90_S93_A1.5021.00
128_A210_A1.4971.00
33_Y59_N1.4921.00
72_V84_V1.4841.00
125_A147_N1.4841.00
74_T79_A1.4811.00
121_V146_A1.4741.00
44_A48_R1.4641.00
119_Q144_R1.4601.00
107_A208_L1.4431.00
73_A93_A1.4421.00
81_V101_V1.4401.00
4_Y56_A1.4191.00
149_T152_A1.4131.00
144_R177_A1.4121.00
49_G52_A1.4031.00
10_P13_H1.3971.00
50_A55_V1.3891.00
77_M97_Y1.3671.00
6_L35_T1.3621.00
9_N64_F1.3541.00
62_A185_T1.3511.00
77_M138_D1.3421.00
80_R138_D1.3391.00
6_L11_V1.3311.00
221_R225_A1.3201.00
107_A235_W1.3171.00
38_P46_A1.3101.00
39_A42_D1.3101.00
9_N39_A1.3021.00
142_T163_T1.2931.00
22_A26_E1.2901.00
12_G37_E1.2551.00
205_L228_A1.2381.00
147_N185_T1.2381.00
129_G183_A1.2291.00
118_A178_T1.2291.00
133_A160_V1.2231.00
5_G58_L1.2201.00
224_A230_T1.2141.00
51_G89_F1.2091.00
101_V135_A1.2011.00
134_F138_D1.1981.00
51_G94_P1.1941.00
3_V32_R1.1721.00
253_A258_M1.1711.00
74_T96_G1.1701.00
245_F249_T1.1671.00
120_A136_L1.1641.00
206_A231_I1.1621.00
113_V206_A1.1591.00
88_D97_Y1.1521.00
110_H239_Y1.1491.00
50_A58_L1.1441.00
187_G211_V1.1371.00
239_Y255_V1.1361.00
7_I60_V1.1291.00
223_A228_A1.1191.00
136_L181_V1.1191.00
74_T78_A1.1111.00
18_P22_A1.1021.00
43_A68_A1.0851.00
29_L249_T1.0841.00
24_Y245_F1.0831.00
80_R134_F1.0711.00
222_D226_A1.0531.00
222_D225_A1.0531.00
22_A25_D1.0481.00
26_E257_A1.0471.00
51_G73_A1.0461.00
102_A106_R1.0331.00
11_V37_E1.0271.00
21_A32_R1.0171.00
41_D67_S1.0161.00
104_V181_V1.0041.00
44_A71_A1.0031.00
11_V14_S0.9961.00
36_F55_V0.9951.00
254_P257_A0.9901.00
74_T84_V0.9781.00
157_A161_G0.9741.00
68_A84_V0.9721.00
105_K109_A0.9721.00
40_P67_S0.9671.00
69_A72_V0.9611.00
183_A210_A0.9561.00
155_E159_D0.9531.00
49_G53_L0.9511.00
51_G54_G0.9481.00
122_V129_G0.9471.00
15_L18_P0.9441.00
106_R243_E0.9431.00
218_R221_R0.9431.00
127_G131_A0.9421.00
133_A143_V0.9381.00
235_W239_Y0.9341.00
242_A255_V0.9331.00
38_P64_F0.9321.00
238_L242_A0.9311.00
111_H231_I0.9301.00
88_D95_R0.9231.00
166_G169_D0.9181.00
125_A145_I0.9131.00
27_C251_L0.9051.00
44_A67_S0.8991.00
43_A71_A0.8991.00
184_T187_G0.8961.00
21_A25_D0.8911.00
89_F92_A0.8871.00
23_A27_C0.8871.00
60_V64_F0.8791.00
8_G11_V0.8761.00
128_A183_A0.8731.00
211_V217_T0.8651.00
66_Q152_A0.8641.00
105_K135_A0.8571.00
105_K138_D0.8561.00
180_L205_L0.8551.00
27_C245_F0.8481.00
146_A165_V0.8471.00
103_G236_M0.8421.00
47_I71_A0.8351.00
190_D218_R0.8351.00
107_A239_Y0.8341.00
147_N153_A0.8341.00
19_L237_L0.8281.00
106_R110_H0.8261.00
12_G35_T0.8231.00
167_L170_L0.8191.00
4_Y249_T0.8141.00
113_V179_V0.8131.00
150_R166_G0.8101.00
194_S222_D0.8091.00
76_S80_R0.8081.00
46_A53_L0.8030.99
119_Q176_D0.8010.99
216_E220_L0.7960.99
58_L68_A0.7910.99
22_A257_A0.7890.99
147_N152_A0.7860.99
83_A98_N0.7840.99
7_I46_A0.7820.99
169_D172_R0.7780.99
136_L141_A0.7720.99
29_L245_F0.7700.99
46_A49_G0.7700.99
129_G133_A0.7690.99
198_A222_D0.7690.99
151_A155_E0.7640.99
23_A245_F0.7610.99
62_A188_M0.7580.99
47_I68_A0.7580.99
3_V53_L0.7500.99
23_A258_M0.7470.99
20_H241_G0.7430.99
137_A160_V0.7420.99
243_E247_R0.7380.99
198_A226_A0.7370.99
15_L213_S0.7350.99
66_Q70_S0.7300.99
210_A236_M0.7290.99
7_I38_P0.7240.99
133_A145_I0.7230.99
179_V206_A0.7220.99
206_A229_T0.7210.99
72_V94_P0.7200.99
43_A67_S0.7170.99
81_V134_F0.7170.99
47_I51_G0.7160.99
26_E254_P0.7130.99
36_F46_A0.7120.99
216_E230_T0.7120.99
198_A225_A0.7120.99
152_A155_E0.7110.99
192_D195_P0.7110.99
110_H235_W0.7110.99
58_L89_F0.7100.99
13_H62_A0.7100.99
201_L207_V0.7080.99
73_A94_P0.7080.99
123_V184_T0.7060.99
231_I235_W0.7060.99
121_V180_L0.7000.99
20_H86_T0.6980.99
107_A111_H0.6960.99
43_A64_F0.6960.99
101_V134_F0.6940.98
204_D228_A0.6920.98
137_A143_V0.6890.98
201_L222_D0.6880.98
81_V131_A0.6870.98
155_E158_A0.6850.98
207_V220_L0.6820.98
215_V232_D0.6810.98
48_R51_G0.6790.98
3_V36_F0.6790.98
101_V138_D0.6770.98
146_A167_L0.6760.98
182_H219_L0.6760.98
153_A157_A0.6750.98
199_D226_A0.6710.98
211_V232_D0.6700.98
83_A131_A0.6700.98
235_W259_R0.6680.98
115_L141_A0.6660.98
81_V98_N0.6660.98
5_G35_T0.6660.98
75_D247_R0.6640.98
243_E252_D0.6630.98
121_V174_L0.6630.98
20_H24_Y0.6620.98
22_A258_M0.6620.98
144_R165_V0.6600.98
188_M211_V0.6600.98
44_A70_S0.6550.98
68_A71_A0.6520.98
194_S198_A0.6490.98
123_V146_A0.6480.98
122_V145_I0.6470.98
86_T244_A0.6470.98
201_L228_A0.6430.98
76_S138_D0.6410.97
234_A238_L0.6380.97
105_K139_A0.6360.97
220_L232_D0.6270.97
80_R159_D0.6260.97
101_V105_K0.6220.97
45_A49_G0.6220.97
33_Y86_T0.6210.97
177_A180_L0.6180.97
115_L118_A0.6180.97
164_A167_L0.6140.97
168_G171_P0.6130.97
111_H229_T0.6130.97
29_L251_L0.6120.97
201_L226_A0.6100.97
174_L177_A0.6070.97
106_R246_E0.6000.96
110_H259_R0.5980.96
150_R164_A0.5980.96
103_G107_A0.5980.96
111_H235_W0.5960.96
6_L59_N0.5950.96
119_Q177_A0.5950.96
120_A181_V0.5930.96
9_N41_D0.5910.96
123_V180_L0.5910.96
123_V167_L0.5890.96
108_F231_I0.5860.96
144_R173_S0.5840.96
107_A231_I0.5830.96
193_T218_R0.5830.96
9_N13_H0.5810.96
244_A248_W0.5790.95
192_D218_R0.5770.95
113_V229_T0.5770.95
7_I64_F0.5730.95
151_A154_D0.5690.95
135_A139_A0.5690.95
181_V210_A0.5690.95
120_A179_V0.5680.95
80_R137_A0.5650.95
149_T185_T0.5630.95
254_P258_M0.5620.95
213_S237_L0.5610.95
87_I96_G0.5610.95
69_A78_A0.5610.95
7_I43_A0.5600.95
56_A90_S0.5570.94
242_A258_M0.5570.94
77_M134_F0.5560.94
54_G89_F0.5560.94
134_F160_V0.5550.94
182_H211_V0.5540.94
11_V213_S0.5540.94
10_P64_F0.5530.94
5_G55_V0.5530.94
153_A164_A0.5530.94
18_P35_T0.5530.94
146_A170_L0.5520.94
101_V132_A0.5480.94
122_V183_A0.5460.94
32_R35_T0.5450.94
116_S140_G0.5450.94
128_A131_A0.5450.94
114_S118_A0.5450.94
245_F253_A0.5450.94
180_L207_V0.5440.94
89_F93_A0.5440.94
21_A30_D0.5440.94
11_V61_T0.5440.94
16_S237_L0.5430.94
189_D213_S0.5420.94
55_V58_L0.5410.94
62_A211_V0.5400.93
255_V259_R0.5350.93
77_M101_V0.5340.93
215_V234_A0.5330.93
163_T166_G0.5320.93
216_E232_D0.5320.93
189_D192_D0.5320.93
59_N86_T0.5310.93
125_A149_T0.5310.93
186_V211_V0.5300.93
3_V54_G0.5290.93
21_A34_V0.5290.93
132_A181_V0.5280.93
111_H208_L0.5270.93
108_F136_L0.5270.93
202_H228_A0.5260.93
125_A152_A0.5240.92
24_Y248_W0.5210.92
122_V136_L0.5190.92
125_A129_G0.5190.92
165_V169_D0.5190.92
129_G147_N0.5180.92
184_T188_M0.5170.92
39_A64_F0.5130.92
246_E253_A0.5080.91
109_A114_S0.5060.91
220_L224_A0.5060.91
23_A253_A0.5040.91
197_S200_A0.5030.91
215_V220_L0.5030.91
83_A128_A0.5030.91
38_P49_G0.5010.91
145_I156_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1npyA 1 0.9662 100 0.209 Contact Map
3t4eA 2 1 100 0.211 Contact Map
4xijA 1 0.9474 100 0.219 Contact Map
2o7sA 2 0.9511 100 0.243 Contact Map
3phhA 1 0.9361 100 0.245 Contact Map
3tnlA 2 0.9887 100 0.251 Contact Map
3pwzA 1 0.9887 100 0.26 Contact Map
3jyoA 2 0.9962 100 0.261 Contact Map
2d5cA 2 0.9774 100 0.271 Contact Map
3fbtA 2 0.985 100 0.272 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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