GREMLIN Database
TRPE2 - Anthranilate synthase component 1 2
UniProt: Q9HS66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (435)
Sequences: 5598 (3766)
Seq/√Len: 180.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
338_S366_G4.5431.00
86_Q373_S4.1351.00
339_E367_R4.1071.00
387_I411_T4.0431.00
210_R214_E3.6771.00
339_E370_D3.4151.00
297_R312_A3.3131.00
287_E365_T3.2461.00
239_D438_T3.0221.00
296_T357_V3.0191.00
452_T455_A2.9701.00
346_P365_T2.9611.00
223_A228_D2.8111.00
214_E454_A2.7271.00
223_A401_T2.6901.00
347_D350_R2.6901.00
210_R454_A2.5861.00
213_F445_A2.5771.00
209_G212_A2.5681.00
394_R397_A2.5351.00
415_A425_L2.4351.00
80_G83_D2.4301.00
299_R306_D2.3991.00
52_F67_G2.3911.00
372_C376_D2.3891.00
307_D311_A2.3801.00
222_D226_D2.3781.00
344_A365_T2.3761.00
311_A315_A2.3711.00
369_R372_C2.3121.00
310_R353_A2.3111.00
80_G379_A2.2731.00
239_D440_H2.2441.00
246_P271_D2.2291.00
241_P438_T2.2281.00
208_A216_R2.2231.00
286_R367_R2.1851.00
229_T232_A2.1691.00
112_Y396_M2.1621.00
272_L409_P2.1221.00
384_G427_I2.0701.00
215_S218_R2.0621.00
220_I232_A2.0611.00
263_G414_L2.0591.00
42_Y51_S2.0121.00
62_G146_R1.9981.00
351_V360_L1.9931.00
287_E367_R1.9861.00
300_G305_E1.9471.00
263_G274_S1.9281.00
307_D310_R1.9211.00
353_A358_L1.9051.00
316_D319_E1.9011.00
65_Y144_A1.8951.00
314_R360_L1.8861.00
52_F107_F1.8831.00
218_R221_Q1.8381.00
337_V380_A1.8321.00
43_R251_E1.8321.00
303_P307_D1.8171.00
334_L338_S1.8101.00
273_V434_R1.7951.00
290_T330_E1.7821.00
434_R439_Y1.7811.00
245_H248_A1.7781.00
207_V405_T1.7551.00
149_F154_D1.7291.00
305_E308_A1.7281.00
301_A305_E1.7161.00
218_R453_P1.7061.00
398_L402_V1.7011.00
231_Q446_G1.6961.00
222_D225_R1.6941.00
279_L424_T1.6691.00
41_A145_W1.6601.00
300_G309_A1.6591.00
220_I234_V1.6541.00
454_A458_D1.6531.00
293_I361_V1.6391.00
310_R351_V1.6211.00
339_E369_R1.6161.00
291_E352_D1.6021.00
210_R457_Y1.6011.00
352_D361_V1.5951.00
106_L138_V1.5901.00
266_E271_D1.5831.00
110_L114_I1.5741.00
309_A312_A1.5601.00
458_D462_A1.5251.00
236_H460_T1.5131.00
308_A312_A1.5121.00
172_F176_R1.5001.00
378_I417_I1.4731.00
242_A434_R1.4711.00
432_L439_Y1.4571.00
284_R422_D1.4541.00
141_T178_R1.4521.00
302_T305_E1.4511.00
409_P428_T1.4451.00
234_V445_A1.4241.00
217_V453_P1.4171.00
214_E218_R1.4001.00
55_E254_R1.3881.00
219_R401_T1.3801.00
223_A394_R1.3741.00
210_R458_D1.3721.00
204_F240_A1.3721.00
237_R440_H1.3611.00
113_D400_D1.3561.00
335_G341_G1.3521.00
223_A398_L1.3481.00
41_A186_I1.3481.00
219_R222_D1.3461.00
81_A134_L1.3451.00
229_T395_T1.3341.00
86_Q90_G1.3331.00
378_I425_L1.3261.00
64_G147_E1.3161.00
212_A215_S1.3141.00
334_L366_G1.3131.00
288_L338_S1.3101.00
235_S442_R1.3071.00
124_T400_D1.3051.00
264_I271_D1.3021.00
274_S426_S1.3011.00
214_E453_P1.2941.00
217_V447_I1.2931.00
246_P434_R1.2871.00
457_Y461_L1.2851.00
249_V434_R1.2801.00
127_D130_G1.2801.00
416_A424_T1.2781.00
443_V464_A1.2751.00
455_A458_D1.2731.00
113_D406_R1.2721.00
289_T365_T1.2651.00
212_A404_A1.2601.00
84_T87_A1.2561.00
234_V447_I1.2521.00
304_A308_A1.2391.00
211_A215_S1.2371.00
38_P145_W1.2361.00
205_E241_P1.2351.00
418_G422_D1.2341.00
291_E347_D1.2211.00
263_G272_L1.2201.00
241_P437_A1.2191.00
414_L428_T1.2141.00
458_D461_L1.2121.00
394_R401_T1.2121.00
368_L377_A1.2051.00
346_P363_E1.1991.00
36_T44_R1.1971.00
432_L467_L1.1851.00
288_L334_L1.1851.00
233_N444_G1.1831.00
46_R266_E1.1731.00
283_R377_A1.1731.00
240_A439_Y1.1701.00
169_D173_E1.1691.00
324_A348_Y1.1671.00
249_V432_L1.1661.00
232_A399_I1.1641.00
144_A158_I1.1611.00
283_R288_L1.1611.00
219_R223_A1.1581.00
375_R417_I1.1571.00
86_Q376_D1.1561.00
252_A473_D1.1541.00
127_D406_R1.1521.00
236_H461_L1.1511.00
206_S236_H1.1511.00
212_A216_R1.1491.00
136_L425_L1.1471.00
215_S219_R1.1461.00
324_A349_R1.1461.00
83_D86_Q1.1421.00
445_A460_T1.1351.00
283_R368_L1.1351.00
286_R370_D1.1331.00
225_R449_H1.1321.00
261_Y279_L1.1311.00
409_P433_V1.1301.00
249_V273_V1.1271.00
310_R358_L1.1251.00
102_H105_G1.1221.00
320_R349_R1.1211.00
289_T363_E1.1161.00
311_A314_R1.1111.00
143_A155_L1.1091.00
157_L183_A1.1011.00
110_L417_I1.1011.00
81_A117_E1.0941.00
218_R222_D1.0891.00
247_V264_I1.0861.00
274_S414_L1.0841.00
257_N275_A1.0831.00
131_L433_V1.0811.00
135_Q267_F1.0811.00
246_P264_I1.0791.00
308_A311_A1.0751.00
71_A140_P1.0621.00
157_L179_V1.0541.00
242_A249_V1.0511.00
145_W155_L1.0511.00
441_L468_V1.0431.00
294_A386_T1.0421.00
75_R135_Q1.0391.00
138_V419_F1.0361.00
441_L464_A1.0341.00
291_E363_E1.0311.00
280_L381_V1.0281.00
334_L381_V1.0271.00
269_G435_R1.0260.99
314_R351_V1.0200.99
297_R309_A1.0110.99
327_V348_Y1.0090.99
232_A398_L1.0040.99
250_F254_R1.0030.99
294_A323_H1.0020.99
71_A138_V0.9990.99
257_N356_E0.9980.99
179_V183_A0.9940.99
157_L182_L0.9930.99
205_E239_D0.9930.99
70_P139_Y0.9890.99
242_A439_Y0.9850.99
305_E309_A0.9840.99
221_Q449_H0.9820.99
387_I429_I0.9800.99
178_R181_S0.9770.99
55_E250_F0.9770.99
83_D87_A0.9750.99
80_G117_E0.9750.99
86_Q379_A0.9740.99
326_L386_T0.9740.99
228_D394_R0.9730.99
280_L290_T0.9700.99
236_H457_Y0.9650.99
465_R469_T0.9620.99
65_Y142_I0.9590.99
204_F468_V0.9560.99
141_T159_A0.9530.99
339_E342_S0.9530.99
116_R400_D0.9480.99
413_S425_L0.9470.99
90_G373_S0.9460.99
67_G107_F0.9450.99
288_L377_A0.9440.99
316_D455_A0.9400.99
121_I397_A0.9400.99
129_R440_H0.9340.99
37_D40_A0.9340.99
221_Q225_R0.9330.99
69_D141_T0.9320.99
298_P462_A0.9310.99
294_A326_L0.9300.99
220_I402_V0.9260.99
298_P309_A0.9250.99
119_E393_P0.9250.99
208_A404_A0.9200.99
101_P284_R0.9180.99
220_I447_I0.9150.99
122_P397_A0.9130.99
400_D406_R0.9120.99
110_L136_L0.9120.99
128_A405_T0.9080.99
88_A91_A0.9070.99
109_W409_P0.9060.99
233_N387_I0.9060.99
211_A214_E0.9050.99
457_Y460_T0.9030.99
63_W144_A0.9020.99
72_S88_A0.8960.99
297_R319_E0.8940.99
262_S275_A0.8910.99
347_D363_E0.8880.99
323_H326_L0.8870.99
272_L414_L0.8860.99
102_H107_F0.8860.99
184_A188_D0.8830.98
271_D434_R0.8820.98
238_L468_V0.8810.98
469_T472_G0.8800.98
220_I229_T0.8780.98
113_D116_R0.8770.98
118_L382_F0.8770.98
233_N388_T0.8770.98
354_Y361_V0.8720.98
176_R180_Q0.8710.98
233_N411_T0.8690.98
183_A187_R0.8650.98
238_L461_L0.8650.98
52_F139_Y0.8640.98
62_G148_P0.8640.98
73_M135_Q0.8630.98
173_E177_D0.8590.98
82_L114_I0.8560.98
468_V472_G0.8560.98
110_L378_I0.8550.98
114_I117_E0.8540.98
131_L270_V0.8520.98
445_A455_A0.8520.98
279_L289_T0.8520.98
250_F273_V0.8480.98
171_A174_A0.8480.98
114_I134_L0.8480.98
283_R374_L0.8460.98
149_F153_D0.8410.98
263_G426_S0.8360.98
229_T398_L0.8310.98
202_A241_P0.8290.98
384_G426_S0.8200.98
130_G435_R0.8200.98
394_R398_L0.8190.98
34_P37_D0.8140.97
312_A315_A0.8120.97
180_Q183_A0.8080.97
111_S133_R0.8070.97
297_R462_A0.8040.97
207_V239_D0.8000.97
290_T381_V0.8000.97
374_L423_A0.7990.97
286_R339_E0.7970.97
283_R286_R0.7960.97
116_R123_D0.7930.97
107_F265_V0.7920.97
259_A262_S0.7920.97
85_V136_L0.7910.97
214_E217_V0.7870.97
51_S266_E0.7860.97
217_V221_Q0.7850.97
72_S138_V0.7790.97
330_E384_G0.7790.97
68_V141_T0.7780.97
272_L431_T0.7760.97
76_A134_L0.7760.97
323_H386_T0.7680.96
319_E455_A0.7660.96
110_L425_L0.7650.96
432_L441_L0.7640.96
285_G422_D0.7640.96
57_T60_S0.7610.96
142_I158_I0.7600.96
125_T400_D0.7590.96
181_S185_A0.7590.96
118_L379_A0.7580.96
270_V435_R0.7580.96
232_A395_T0.7550.96
42_Y264_I0.7540.96
335_G340_Y0.7540.96
283_R423_A0.7490.96
129_R406_R0.7480.96
117_E133_R0.7470.96
115_A396_M0.7470.96
123_D400_D0.7450.96
216_R220_I0.7450.96
218_R225_R0.7440.96
81_A85_V0.7440.96
116_R122_P0.7440.96
280_L330_E0.7420.96
344_A367_R0.7410.96
280_L294_A0.7400.96
127_D237_R0.7380.95
320_R348_Y0.7370.95
265_V414_L0.7370.95
282_A289_T0.7360.95
110_L134_L0.7340.95
214_E452_T0.7330.95
417_I423_A0.7330.95
398_L401_T0.7300.95
34_P39_F0.7260.95
256_T469_T0.7240.95
177_D180_Q0.7240.95
290_T334_L0.7230.95
393_P396_M0.7230.95
183_A186_I0.7210.95
314_R320_R0.7210.95
216_R234_V0.7190.95
116_R133_R0.7180.95
69_D178_R0.7170.95
323_H411_T0.7160.95
350_R363_E0.7150.95
280_L323_H0.7130.95
123_D406_R0.7110.94
329_L385_G0.7020.94
279_L291_E0.7000.94
355_S466_A0.7000.94
298_P301_A0.6980.94
243_A437_A0.6950.94
216_R404_A0.6940.94
63_W101_P0.6940.94
175_G186_I0.6930.94
298_P458_D0.6930.94
207_V236_H0.6930.94
223_A397_A0.6920.94
337_V377_A0.6910.94
237_R405_T0.6900.94
281_L377_A0.6900.94
235_S460_T0.6890.93
180_Q184_A0.6870.93
206_S460_T0.6860.93
387_I427_I0.6850.93
173_E219_R0.6820.93
208_A212_A0.6810.93
119_E336_K0.6810.93
267_F270_V0.6800.93
42_Y66_F0.6780.93
373_S376_D0.6770.93
41_A143_A0.6770.93
286_R368_L0.6750.93
86_Q375_R0.6740.93
135_Q270_V0.6740.93
351_V358_L0.6730.93
321_A450_D0.6730.93
115_A118_L0.6730.93
143_A157_L0.6710.93
49_A266_E0.6710.93
298_P455_A0.6700.92
378_I423_A0.6690.92
310_R314_R0.6680.92
244_V249_V0.6660.92
42_Y46_R0.6660.92
435_R438_T0.6650.92
393_P397_A0.6650.92
39_F251_E0.6650.92
323_H358_L0.6630.92
259_A356_E0.6600.92
208_A236_H0.6590.92
281_L381_V0.6590.92
110_L415_A0.6570.92
328_D331_R0.6550.92
50_P73_M0.6550.92
33_L37_D0.6540.92
249_V439_Y0.6510.91
320_R324_A0.6510.91
40_A43_R0.6450.91
291_E350_R0.6440.91
203_P472_G0.6440.91
34_P251_E0.6440.91
234_V402_V0.6430.91
323_H330_E0.6410.91
434_R437_A0.6400.91
40_A44_R0.6390.91
397_A401_T0.6380.91
55_E262_S0.6370.91
328_D333_D0.6370.91
115_A400_D0.6350.90
313_L351_V0.6350.90
178_R182_L0.6330.90
268_P271_D0.6300.90
325_M333_D0.6300.90
287_E346_P0.6290.90
221_Q453_P0.6290.90
272_L428_T0.6280.90
71_A419_F0.6270.90
125_T128_A0.6250.90
235_S444_G0.6240.90
131_L409_P0.6230.90
323_H327_V0.6230.90
224_I449_H0.6230.90
127_D435_R0.6220.89
258_P355_S0.6210.89
36_T40_A0.6190.89
182_L186_I0.6190.89
103_P420_D0.6180.89
103_P418_G0.6170.89
233_N274_S0.6160.89
247_V251_E0.6160.89
43_R247_V0.6150.89
386_T445_A0.6150.89
469_T473_D0.6120.89
342_S367_R0.6120.89
92_R95_R0.6110.89
347_D352_D0.6110.89
233_N426_S0.6100.89
321_A325_M0.6100.89
461_L465_R0.6080.88
405_T442_R0.6080.88
345_V348_Y0.6070.88
349_R360_L0.6070.88
171_A175_G0.6070.88
238_L464_A0.6060.88
230_F332_N0.6050.88
74_L84_T0.6040.88
216_R402_V0.6040.88
411_T426_S0.6040.88
280_L326_L0.6010.88
359_H446_G0.6010.88
326_L445_A0.6000.88
132_P270_V0.6000.88
330_E386_T0.5990.88
306_D358_L0.5990.88
298_P305_E0.5990.88
237_R442_R0.5990.88
77_D81_A0.5980.88
300_G303_P0.5980.88
294_A445_A0.5970.87
82_L379_A0.5970.87
323_H362_S0.5960.87
173_E176_R0.5950.87
87_A90_G0.5950.87
46_R245_H0.5940.87
177_D181_S0.5920.87
384_G387_I0.5910.87
433_V440_H0.5890.87
314_R317_D0.5880.87
238_L443_V0.5880.87
233_N263_G0.5870.87
275_A416_A0.5870.87
315_A320_R0.5850.86
109_W382_F0.5840.86
44_R189_G0.5840.86
73_M137_G0.5840.86
71_A106_L0.5840.86
330_E411_T0.5810.86
290_T364_V0.5810.86
248_A251_E0.5800.86
112_Y388_T0.5800.86
172_F175_G0.5800.86
46_R49_A0.5780.86
42_Y247_V0.5760.86
233_N359_H0.5730.85
274_S384_G0.5720.85
77_D84_T0.5720.85
317_D320_R0.5720.85
56_T61_D0.5720.85
274_S428_T0.5720.85
160_A419_F0.5710.85
35_V43_R0.5710.85
263_G431_T0.5700.85
170_G174_A0.5700.85
36_T41_A0.5700.85
387_I467_L0.5690.85
45_A66_F0.5680.85
217_V445_A0.5680.85
174_A177_D0.5680.85
241_P436_A0.5670.85
320_R360_L0.5670.85
326_L330_E0.5660.85
376_D380_A0.5660.85
312_A316_D0.5650.84
331_R390_A0.5650.84
332_N336_K0.5640.84
35_V153_D0.5620.84
70_P73_M0.5620.84
115_A386_T0.5620.84
199_D243_A0.5610.84
62_G149_F0.5600.84
105_G419_F0.5600.84
281_L423_A0.5590.84
42_Y53_H0.5590.84
274_S411_T0.5580.84
231_Q448_V0.5580.84
76_A133_R0.5580.84
288_L366_G0.5570.84
288_L368_L0.5560.84
316_D387_I0.5560.84
220_I399_I0.5550.83
274_S387_I0.5550.83
139_Y142_I0.5550.83
297_R358_L0.5540.83
404_A442_R0.5540.83
161_V175_G0.5530.83
381_V425_L0.5510.83
461_L468_V0.5510.83
240_A471_L0.5510.83
294_A448_V0.5510.83
462_A465_R0.5500.83
249_V471_L0.5500.83
215_S222_D0.5500.83
330_E426_S0.5490.83
386_T442_R0.5480.83
227_G331_R0.5480.83
338_S343_V0.5480.83
220_I398_L0.5470.83
328_D390_A0.5470.83
213_F460_T0.5470.83
209_G214_E0.5460.82
304_A307_D0.5460.82
130_G196_P0.5450.82
258_P275_A0.5440.82
228_D332_N0.5430.82
384_G411_T0.5420.82
302_T308_A0.5410.82
319_E386_T0.5390.82
291_E354_Y0.5390.82
356_E466_A0.5380.82
321_A331_R0.5380.82
330_E364_V0.5370.81
186_I190_D0.5360.81
233_N395_T0.5360.81
177_D195_P0.5340.81
233_N384_G0.5340.81
304_A370_D0.5340.81
231_Q326_L0.5340.81
125_T404_A0.5320.81
170_G173_E0.5320.81
136_L415_A0.5310.81
309_A358_L0.5310.81
65_Y107_F0.5300.81
39_F247_V0.5300.81
129_R408_G0.5290.80
181_S184_A0.5290.80
468_V471_L0.5280.80
206_S443_V0.5270.80
39_F53_H0.5260.80
176_R179_V0.5250.80
263_G384_G0.5250.80
280_L386_T0.5250.80
275_A467_L0.5240.80
359_H387_I0.5240.80
46_R51_S0.5230.80
230_F325_M0.5230.80
325_M328_D0.5220.80
323_H349_R0.5220.80
325_M331_R0.5210.79
66_F143_A0.5190.79
79_A83_D0.5190.79
120_A400_D0.5180.79
257_N466_A0.5180.79
325_M390_A0.5170.79
230_F331_R0.5160.79
384_G395_T0.5160.79
332_N335_G0.5160.79
210_R236_H0.5150.79
256_T356_E0.5150.79
293_I429_I0.5140.79
190_D194_G0.5140.79
214_E457_Y0.5130.78
110_L382_F0.5130.78
292_P329_L0.5120.78
233_N330_E0.5110.78
76_A117_E0.5090.78
31_A34_P0.5090.78
196_P243_A0.5080.78
120_A397_A0.5060.77
82_L118_L0.5060.77
230_F333_D0.5060.77
76_A81_A0.5060.77
221_Q448_V0.5060.77
456_E459_E0.5050.77
464_A468_V0.5050.77
231_Q359_H0.5040.77
133_R406_R0.5040.77
284_R287_E0.5040.77
367_R370_D0.5030.77
104_G418_G0.5030.77
115_A326_L0.5030.77
234_V444_G0.5020.77
78_G86_Q0.5020.77
317_D450_D0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k0eA 1 0.8586 100 0.183 Contact Map
1qdlA 1 0.8463 100 0.191 Contact Map
1i1qA 2 0.9098 100 0.191 Contact Map
4grhA 1 0.8627 100 0.2 Contact Map
3logA 1 0.8811 100 0.231 Contact Map
3h9mA 1 0.7951 100 0.235 Contact Map
2fn0A 2 0.8053 100 0.274 Contact Map
3gseA 1 0.8463 100 0.301 Contact Map
3bzmA 1 0.8627 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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