Q9HS64 - HALSA - GREMLIN Contacts

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Q9HS64 - Branched-chain amino acid aminotransferase

UniProt:	Q9HS64	Sequences: MRYHVNGALVDAADATVSVRDRGFQYGDAAFETMRAYGGQTFAWTAHYRRLQATCDSLGIDHGLSEAALRGRVHETLAANDLADAYVRLSITRGVQDGRLTPRDTTDPTVVVVVDALPRGGVDGDPVWSMPATVETTTVTQHRDTTIPSTAKTHNYLPGVLARRDIAADADEALFVTPDGHLTEGAASNLFFVADGTLYTPSGDLDVLPGITRWAVAELAAEHGLTVHTGAYTPSRLYDADEAFLTNTTWEVRPIARVDDATYDTCRIGAALASAYNAEIERRHY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	285 (265)
Sequences:	8857 (5877)
Seq/√Len:	361.0

ECOLI - ILVE PABC
BACSU - ILVE1 PABC ILVE2 DAAA
HALSA - Q9HS64 Q9HNF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
197_T	228_H	4.272	1.00
133_T	257_R	4.246	1.00
197_T	226_T	3.071	1.00
230_G	236_R	3.049	1.00
49_R	66_E	3.017	1.00
52_Q	66_E	3.015	1.00
198_L	220_A	3.015	1.00
9_L	79_A	2.564	1.00
209_P	214_W	2.505	1.00
199_Y	230_G	2.352	1.00
181_H	231_A	2.326	1.00
75_E	79_A	2.269	1.00
65_S	68_A	2.220	1.00
46_A	214_W	2.201	1.00
59_G	167_A	2.143	1.00
135_E	170_A	2.085	1.00
71_G	75_E	2.027	1.00
185_G	188_S	2.025	1.00
135_E	168_A	2.006	1.00
217_A	227_V	2.005	1.00
30_A	54_T	1.973	1.00
243_A	255_I	1.962	1.00
223_H	278_A	1.954	1.00
189_N	210_G	1.903	1.00
136_T	259_D	1.855	1.00
194_A	241_D	1.855	1.00
75_E	78_A	1.845	1.00
214_W	218_E	1.817	1.00
136_T	234_P	1.812	1.00
28_D	93_R	1.803	1.00
273_A	277_N	1.781	1.00
45_T	70_R	1.756	1.00
56_D	63_G	1.753	1.00
43_A	215_A	1.742	1.00
51_L	91_I	1.739	1.00
274_S	278_A	1.668	1.00
37_Y	251_E	1.664	1.00
12_A	18_S	1.662	1.00
134_V	185_G	1.633	1.00
192_F	232_Y	1.625	1.00
223_H	274_S	1.619	1.00
134_V	255_I	1.597	1.00
257_R	260_D	1.585	1.00
216_V	246_T	1.573	1.00
165_D	168_A	1.570	1.00
126_P	130_M	1.562	1.00
134_V	174_L	1.556	1.00
72_R	110_V	1.553	1.00
55_C	91_I	1.551	1.00
243_A	258_V	1.526	1.00
30_A	55_C	1.517	1.00
11_D	14_D	1.512	1.00
191_F	246_T	1.508	1.00
44_W	48_Y	1.504	1.00
190_L	243_A	1.499	1.00
177_T	181_H	1.481	1.00
49_R	53_A	1.479	1.00
60_I	91_I	1.465	1.00
133_T	171_D	1.464	1.00
6_N	109_T	1.460	1.00
132_A	171_D	1.459	1.00
202_S	231_A	1.455	1.00
133_T	256_A	1.450	1.00
70_R	74_H	1.446	1.00
198_L	225_L	1.438	1.00
185_G	245_L	1.433	1.00
181_H	233_T	1.430	1.00
60_I	108_P	1.415	1.00
44_W	70_R	1.414	1.00
192_F	240_A	1.397	1.00
53_A	56_D	1.394	1.00
34_M	41_T	1.391	1.00
45_T	49_R	1.391	1.00
192_F	199_Y	1.373	1.00
205_L	231_A	1.362	1.00
257_R	262_T	1.361	1.00
220_A	225_L	1.355	1.00
193_V	271_A	1.338	1.00
191_F	244_F	1.333	1.00
46_A	218_E	1.325	1.00
36_A	77_L	1.322	1.00
238_Y	261_A	1.321	1.00
218_E	222_E	1.290	1.00
213_R	229_T	1.285	1.00
192_F	243_A	1.285	1.00
43_A	46_A	1.273	1.00
23_G	29_A	1.269	1.00
41_T	44_W	1.262	1.00
174_L	190_L	1.258	1.00
71_G	74_H	1.257	1.00
53_A	209_P	1.254	1.00
82_L	85_A	1.248	1.00
54_T	151_A	1.246	1.00
193_V	198_L	1.235	1.00
25_Q	88_R	1.228	1.00
247_N	250_W	1.212	1.00
194_A	239_D	1.210	1.00
23_G	92_T	1.206	1.00
76_T	112_V	1.202	1.00
274_S	277_N	1.197	1.00
233_T	236_R	1.195	1.00
46_A	49_R	1.189	1.00
21_D	92_T	1.186	1.00
164_R	167_A	1.185	1.00
139_V	165_D	1.182	1.00
41_T	73_V	1.181	1.00
269_G	272_L	1.181	1.00
74_H	78_A	1.176	1.00
199_Y	228_H	1.175	1.00
29_A	154_H	1.172	1.00
36_A	85_A	1.161	1.00
200_T	213_R	1.158	1.00
68_A	71_G	1.157	1.00
72_R	112_V	1.115	1.00
73_V	87_V	1.109	1.00
202_S	230_G	1.108	1.00
57_S	151_A	1.102	1.00
9_L	76_T	1.102	1.00
4_H	72_R	1.087	1.00
162_A	175_F	1.085	1.00
203_G	213_R	1.081	1.00
73_V	112_V	1.069	1.00
232_Y	236_R	1.063	1.00
30_A	51_L	1.058	1.00
4_H	64_L	1.057	1.00
191_F	213_R	1.055	1.00
235_S	239_D	1.054	1.00
4_H	9_L	1.053	1.00
52_Q	63_G	1.041	1.00
67_A	71_G	1.033	1.00
213_R	217_A	1.031	1.00
134_V	245_L	1.025	1.00
202_S	229_T	1.020	1.00
66_E	70_R	1.016	1.00
194_A	236_R	1.015	1.00
48_Y	70_R	1.014	1.00
191_F	217_A	1.010	1.00
245_L	255_I	1.009	1.00
199_Y	232_Y	0.998	1.00
31_F	156_Y	0.992	1.00
137_T	173_A	0.989	1.00
24_F	92_T	0.984	1.00
94_G	109_T	0.981	1.00
182_L	190_L	0.976	1.00
45_T	66_E	0.974	1.00
180_G	235_S	0.971	1.00
77_L	85_A	0.970	1.00
172_E	186_A	0.968	1.00
30_A	91_I	0.967	1.00
76_T	114_V	0.965	1.00
225_L	271_A	0.959	1.00
52_Q	56_D	0.959	1.00
201_P	232_Y	0.957	1.00
131_P	256_A	0.955	1.00
273_A	276_Y	0.954	1.00
57_S	150_T	0.953	1.00
46_A	215_A	0.952	1.00
220_A	275_A	0.951	1.00
271_A	274_S	0.947	1.00
53_A	150_T	0.947	1.00
203_G	209_P	0.940	1.00
101_T	104_D	0.933	1.00
172_E	185_G	0.927	1.00
264_D	269_G	0.926	1.00
138_T	165_D	0.923	1.00
242_E	272_L	0.917	1.00
242_E	269_G	0.917	1.00
193_V	242_E	0.907	1.00
5_V	15_A	0.903	1.00
210_G	246_T	0.902	1.00
196_G	241_D	0.897	1.00
132_A	253_R	0.895	1.00
174_L	237_L	0.893	1.00
194_A	199_Y	0.890	1.00
91_I	110_V	0.890	1.00
90_S	111_V	0.888	1.00
220_A	227_V	0.888	1.00
176_V	234_P	0.886	1.00
49_R	52_Q	0.877	1.00
270_A	274_S	0.875	1.00
221_A	226_T	0.871	1.00
221_A	229_T	0.869	1.00
25_Q	113_V	0.869	1.00
35_R	84_D	0.865	1.00
265_T	269_G	0.864	1.00
270_A	273_A	0.864	1.00
53_A	57_S	0.862	1.00
189_N	246_T	0.861	1.00
21_D	94_G	0.860	1.00
85_A	114_V	0.857	1.00
19_V	111_V	0.857	1.00
256_A	266_C	0.854	1.00
48_Y	66_E	0.852	1.00
48_Y	73_V	0.849	1.00
59_G	164_R	0.847	1.00
17_V	24_F	0.842	1.00
25_Q	90_S	0.841	1.00
8_A	16_T	0.835	1.00
52_Q	69_L	0.835	1.00
143_R	178_P	0.835	1.00
199_Y	236_R	0.830	1.00
172_E	188_S	0.829	1.00
44_W	73_V	0.828	1.00
55_C	60_I	0.825	1.00
196_G	226_T	0.821	1.00
64_L	68_A	0.820	1.00
134_V	172_E	0.819	1.00
179_D	231_A	0.817	1.00
16_T	19_V	0.807	1.00
64_L	72_R	0.795	1.00
14_D	18_S	0.792	1.00
36_A	41_T	0.791	1.00
182_L	192_F	0.786	1.00
218_E	221_A	0.785	1.00
48_Y	52_Q	0.783	1.00
220_A	223_H	0.783	1.00
46_A	211_I	0.783	1.00
5_V	111_V	0.782	1.00
217_A	229_T	0.779	1.00
195_D	241_D	0.776	1.00
76_T	80_N	0.776	1.00
177_T	206_D	0.774	1.00
135_E	259_D	0.774	1.00
37_Y	42_F	0.772	1.00
215_A	218_E	0.770	1.00
35_R	248_T	0.770	1.00
129_S	273_A	0.768	1.00
240_A	243_A	0.762	1.00
219_L	223_H	0.761	1.00
193_V	244_F	0.756	1.00
42_F	215_A	0.753	1.00
173_A	186_A	0.751	1.00
198_L	244_F	0.750	1.00
204_D	231_A	0.749	1.00
90_S	154_H	0.748	1.00
21_D	96_Q	0.747	1.00
262_T	265_T	0.742	1.00
9_L	72_R	0.741	1.00
58_L	157_L	0.741	1.00
184_E	208_L	0.740	1.00
235_S	238_Y	0.737	1.00
68_A	72_R	0.733	1.00
162_A	186_A	0.733	1.00
86_Y	249_T	0.732	1.00
166_I	169_D	0.730	1.00
263_Y	266_C	0.729	1.00
34_M	73_V	0.729	1.00
140_T	145_T	0.727	1.00
48_Y	69_L	0.722	1.00
163_R	172_E	0.721	0.99
38_G	83_A	0.718	0.99
67_A	70_R	0.716	0.99
222_E	278_A	0.715	0.99
22_R	28_D	0.712	0.99
27_G	155_N	0.711	0.99
180_G	234_P	0.710	0.99
69_L	110_V	0.710	0.99
236_R	239_D	0.710	0.99
34_M	89_L	0.709	0.99
142_H	145_T	0.709	0.99
32_E	54_T	0.709	0.99
162_A	173_A	0.708	0.99
12_A	20_R	0.708	0.99
102_P	164_R	0.708	0.99
141_Q	144_D	0.703	0.99
36_A	87_V	0.702	0.99
242_E	266_C	0.701	0.99
95_V	109_T	0.700	0.99
163_R	187_A	0.700	0.99
137_T	162_A	0.698	0.99
200_T	229_T	0.697	0.99
191_F	200_T	0.697	0.99
133_T	170_A	0.694	0.99
37_Y	84_D	0.692	0.99
58_L	153_T	0.689	0.99
190_L	201_P	0.689	0.99
35_R	251_E	0.685	0.99
33_T	86_Y	0.683	0.99
267_R	270_A	0.681	0.99
250_W	253_R	0.680	0.99
28_D	160_V	0.680	0.99
152_K	208_L	0.673	0.99
217_A	221_A	0.669	0.99
92_T	109_T	0.667	0.99
136_T	176_V	0.665	0.99
137_T	165_D	0.664	0.99
182_L	232_Y	0.662	0.99
33_T	247_N	0.660	0.99
130_M	171_D	0.659	0.99
215_A	219_L	0.658	0.99
15_A	111_V	0.656	0.99
33_T	249_T	0.656	0.99
15_A	19_V	0.653	0.99
86_Y	115_D	0.651	0.99
100_L	159_G	0.649	0.99
72_R	75_E	0.649	0.99
237_L	258_V	0.647	0.99
5_V	10_V	0.645	0.99
139_V	142_H	0.644	0.99
188_S	245_L	0.642	0.99
22_R	93_R	0.639	0.99
132_A	245_L	0.637	0.99
196_G	225_L	0.636	0.99
9_L	75_E	0.635	0.99
131_P	253_R	0.633	0.99
203_G	229_T	0.632	0.99
176_V	182_L	0.632	0.99
272_L	276_Y	0.628	0.99
52_Q	65_S	0.628	0.99
267_R	273_A	0.626	0.99
49_R	214_W	0.625	0.99
178_P	181_H	0.621	0.99
156_Y	159_G	0.620	0.98
41_T	74_H	0.619	0.98
221_A	227_V	0.618	0.98
92_T	111_V	0.616	0.98
238_Y	259_D	0.616	0.98
30_A	58_L	0.615	0.98
152_K	184_E	0.615	0.98
24_F	111_V	0.615	0.98
153_T	157_L	0.611	0.98
111_V	115_D	0.609	0.98
17_V	21_D	0.607	0.98
237_L	243_A	0.606	0.98
177_T	205_L	0.602	0.98
73_V	89_L	0.596	0.98
183_T	207_V	0.592	0.98
174_L	243_A	0.591	0.98
60_I	93_R	0.590	0.98
56_D	61_D	0.590	0.98
41_T	87_V	0.589	0.98
34_M	44_W	0.585	0.98
202_S	205_L	0.585	0.98
269_G	273_A	0.584	0.98
51_L	89_L	0.583	0.98
8_A	14_D	0.582	0.98
42_F	248_T	0.581	0.98
135_E	165_D	0.580	0.98
170_A	260_D	0.580	0.98
24_F	90_S	0.580	0.98
12_A	80_N	0.580	0.98
192_F	237_L	0.579	0.98
109_T	115_D	0.579	0.98
162_A	165_D	0.579	0.98
134_V	258_V	0.578	0.98
212_T	248_T	0.570	0.97
80_N	114_V	0.568	0.97
168_A	260_D	0.568	0.97
88_R	154_H	0.566	0.97
200_T	203_G	0.566	0.97
101_T	105_T	0.561	0.97
34_M	48_Y	0.559	0.97
10_V	13_A	0.559	0.97
272_L	275_A	0.557	0.97
189_N	209_P	0.555	0.97
232_Y	240_A	0.555	0.97
234_P	238_Y	0.554	0.97
43_A	211_I	0.554	0.97
136_T	258_V	0.553	0.97
216_V	275_A	0.552	0.97
211_I	214_W	0.546	0.97
31_F	152_K	0.544	0.97
26_Y	155_N	0.542	0.97
191_F	198_L	0.541	0.96
35_R	117_L	0.540	0.96
192_F	230_G	0.540	0.96
176_V	183_T	0.540	0.96
142_H	158_P	0.539	0.96
73_V	76_T	0.537	0.96
126_P	129_S	0.537	0.96
127_V	130_M	0.537	0.96
211_I	215_A	0.528	0.96
44_W	74_H	0.528	0.96
140_T	143_R	0.526	0.96
32_E	51_L	0.525	0.96
64_L	110_V	0.522	0.96
244_F	252_V	0.522	0.96
76_T	79_A	0.522	0.96
243_A	263_Y	0.519	0.96
190_L	237_L	0.519	0.96
200_T	207_V	0.516	0.95
50_R	208_L	0.516	0.95
20_R	25_Q	0.512	0.95
30_A	153_T	0.508	0.95
5_V	16_T	0.508	0.95
45_T	67_A	0.507	0.95
219_L	222_E	0.506	0.95
87_V	114_V	0.506	0.95
132_A	188_S	0.505	0.95
166_I	173_A	0.505	0.95
10_V	15_A	0.503	0.95
140_T	176_V	0.503	0.95
100_L	156_Y	0.502	0.95
30_A	151_A	0.501	0.95
200_T	217_A	0.501	0.95
22_R	98_G	0.500	0.95
130_M	267_R	0.500	0.95
156_Y	208_L	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1iyeA	5	0.993	100	0.133	Contact Map
2eiyA	5	0.9895	100	0.145	Contact Map
4chiA	2	0.986	100	0.146	Contact Map
3u0gA	5	0.986	100	0.148	Contact Map
4tm5A	2	0.9719	100	0.157	Contact Map
3daaA	2	0.9649	100	0.158	Contact Map
4cmfA	4	0.9895	100	0.17	Contact Map
2y4rA	2	0.9439	100	0.174	Contact Map
4jxuA	2	0.9509	100	0.18	Contact Map
1i2kA	2	0.9404	100	0.181	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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