GREMLIN Database
Q9HS64 - Branched-chain amino acid aminotransferase
UniProt: Q9HS64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (265)
Sequences: 8857 (5877)
Seq/√Len: 361.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_T228_H4.2721.00
133_T257_R4.2461.00
197_T226_T3.0711.00
230_G236_R3.0491.00
49_R66_E3.0171.00
52_Q66_E3.0151.00
198_L220_A3.0151.00
9_L79_A2.5641.00
209_P214_W2.5051.00
199_Y230_G2.3521.00
181_H231_A2.3261.00
75_E79_A2.2691.00
65_S68_A2.2201.00
46_A214_W2.2011.00
59_G167_A2.1431.00
135_E170_A2.0851.00
71_G75_E2.0271.00
185_G188_S2.0251.00
135_E168_A2.0061.00
217_A227_V2.0051.00
30_A54_T1.9731.00
243_A255_I1.9621.00
223_H278_A1.9541.00
189_N210_G1.9031.00
136_T259_D1.8551.00
194_A241_D1.8551.00
75_E78_A1.8451.00
214_W218_E1.8171.00
136_T234_P1.8121.00
28_D93_R1.8031.00
273_A277_N1.7811.00
45_T70_R1.7561.00
56_D63_G1.7531.00
43_A215_A1.7421.00
51_L91_I1.7391.00
274_S278_A1.6681.00
37_Y251_E1.6641.00
12_A18_S1.6621.00
134_V185_G1.6331.00
192_F232_Y1.6251.00
223_H274_S1.6191.00
134_V255_I1.5971.00
257_R260_D1.5851.00
216_V246_T1.5731.00
165_D168_A1.5701.00
126_P130_M1.5621.00
134_V174_L1.5561.00
72_R110_V1.5531.00
55_C91_I1.5511.00
243_A258_V1.5261.00
30_A55_C1.5171.00
11_D14_D1.5121.00
191_F246_T1.5081.00
44_W48_Y1.5041.00
190_L243_A1.4991.00
177_T181_H1.4811.00
49_R53_A1.4791.00
60_I91_I1.4651.00
133_T171_D1.4641.00
6_N109_T1.4601.00
132_A171_D1.4591.00
202_S231_A1.4551.00
133_T256_A1.4501.00
70_R74_H1.4461.00
198_L225_L1.4381.00
185_G245_L1.4331.00
181_H233_T1.4301.00
60_I108_P1.4151.00
44_W70_R1.4141.00
192_F240_A1.3971.00
53_A56_D1.3941.00
34_M41_T1.3911.00
45_T49_R1.3911.00
192_F199_Y1.3731.00
205_L231_A1.3621.00
257_R262_T1.3611.00
220_A225_L1.3551.00
193_V271_A1.3381.00
191_F244_F1.3331.00
46_A218_E1.3251.00
36_A77_L1.3221.00
238_Y261_A1.3211.00
218_E222_E1.2901.00
213_R229_T1.2851.00
192_F243_A1.2851.00
43_A46_A1.2731.00
23_G29_A1.2691.00
41_T44_W1.2621.00
174_L190_L1.2581.00
71_G74_H1.2571.00
53_A209_P1.2541.00
82_L85_A1.2481.00
54_T151_A1.2461.00
193_V198_L1.2351.00
25_Q88_R1.2281.00
247_N250_W1.2121.00
194_A239_D1.2101.00
23_G92_T1.2061.00
76_T112_V1.2021.00
274_S277_N1.1971.00
233_T236_R1.1951.00
46_A49_R1.1891.00
21_D92_T1.1861.00
164_R167_A1.1851.00
139_V165_D1.1821.00
41_T73_V1.1811.00
269_G272_L1.1811.00
74_H78_A1.1761.00
199_Y228_H1.1751.00
29_A154_H1.1721.00
36_A85_A1.1611.00
200_T213_R1.1581.00
68_A71_G1.1571.00
72_R112_V1.1151.00
73_V87_V1.1091.00
202_S230_G1.1081.00
57_S151_A1.1021.00
9_L76_T1.1021.00
4_H72_R1.0871.00
162_A175_F1.0851.00
203_G213_R1.0811.00
73_V112_V1.0691.00
232_Y236_R1.0631.00
30_A51_L1.0581.00
4_H64_L1.0571.00
191_F213_R1.0551.00
235_S239_D1.0541.00
4_H9_L1.0531.00
52_Q63_G1.0411.00
67_A71_G1.0331.00
213_R217_A1.0311.00
134_V245_L1.0251.00
202_S229_T1.0201.00
66_E70_R1.0161.00
194_A236_R1.0151.00
48_Y70_R1.0141.00
191_F217_A1.0101.00
245_L255_I1.0091.00
199_Y232_Y0.9981.00
31_F156_Y0.9921.00
137_T173_A0.9891.00
24_F92_T0.9841.00
94_G109_T0.9811.00
182_L190_L0.9761.00
45_T66_E0.9741.00
180_G235_S0.9711.00
77_L85_A0.9701.00
172_E186_A0.9681.00
30_A91_I0.9671.00
76_T114_V0.9651.00
225_L271_A0.9591.00
52_Q56_D0.9591.00
201_P232_Y0.9571.00
131_P256_A0.9551.00
273_A276_Y0.9541.00
57_S150_T0.9531.00
46_A215_A0.9521.00
220_A275_A0.9511.00
271_A274_S0.9471.00
53_A150_T0.9471.00
203_G209_P0.9401.00
101_T104_D0.9331.00
172_E185_G0.9271.00
264_D269_G0.9261.00
138_T165_D0.9231.00
242_E272_L0.9171.00
242_E269_G0.9171.00
193_V242_E0.9071.00
5_V15_A0.9031.00
210_G246_T0.9021.00
196_G241_D0.8971.00
132_A253_R0.8951.00
174_L237_L0.8931.00
194_A199_Y0.8901.00
91_I110_V0.8901.00
90_S111_V0.8881.00
220_A227_V0.8881.00
176_V234_P0.8861.00
49_R52_Q0.8771.00
270_A274_S0.8751.00
221_A226_T0.8711.00
221_A229_T0.8691.00
25_Q113_V0.8691.00
35_R84_D0.8651.00
265_T269_G0.8641.00
270_A273_A0.8641.00
53_A57_S0.8621.00
189_N246_T0.8611.00
21_D94_G0.8601.00
85_A114_V0.8571.00
19_V111_V0.8571.00
256_A266_C0.8541.00
48_Y66_E0.8521.00
48_Y73_V0.8491.00
59_G164_R0.8471.00
17_V24_F0.8421.00
25_Q90_S0.8411.00
8_A16_T0.8351.00
52_Q69_L0.8351.00
143_R178_P0.8351.00
199_Y236_R0.8301.00
172_E188_S0.8291.00
44_W73_V0.8281.00
55_C60_I0.8251.00
196_G226_T0.8211.00
64_L68_A0.8201.00
134_V172_E0.8191.00
179_D231_A0.8171.00
16_T19_V0.8071.00
64_L72_R0.7951.00
14_D18_S0.7921.00
36_A41_T0.7911.00
182_L192_F0.7861.00
218_E221_A0.7851.00
48_Y52_Q0.7831.00
220_A223_H0.7831.00
46_A211_I0.7831.00
5_V111_V0.7821.00
217_A229_T0.7791.00
195_D241_D0.7761.00
76_T80_N0.7761.00
177_T206_D0.7741.00
135_E259_D0.7741.00
37_Y42_F0.7721.00
215_A218_E0.7701.00
35_R248_T0.7701.00
129_S273_A0.7681.00
240_A243_A0.7621.00
219_L223_H0.7611.00
193_V244_F0.7561.00
42_F215_A0.7531.00
173_A186_A0.7511.00
198_L244_F0.7501.00
204_D231_A0.7491.00
90_S154_H0.7481.00
21_D96_Q0.7471.00
262_T265_T0.7421.00
9_L72_R0.7411.00
58_L157_L0.7411.00
184_E208_L0.7401.00
235_S238_Y0.7371.00
68_A72_R0.7331.00
162_A186_A0.7331.00
86_Y249_T0.7321.00
166_I169_D0.7301.00
263_Y266_C0.7291.00
34_M73_V0.7291.00
140_T145_T0.7271.00
48_Y69_L0.7221.00
163_R172_E0.7210.99
38_G83_A0.7180.99
67_A70_R0.7160.99
222_E278_A0.7150.99
22_R28_D0.7120.99
27_G155_N0.7110.99
180_G234_P0.7100.99
69_L110_V0.7100.99
236_R239_D0.7100.99
34_M89_L0.7090.99
142_H145_T0.7090.99
32_E54_T0.7090.99
162_A173_A0.7080.99
12_A20_R0.7080.99
102_P164_R0.7080.99
141_Q144_D0.7030.99
36_A87_V0.7020.99
242_E266_C0.7010.99
95_V109_T0.7000.99
163_R187_A0.7000.99
137_T162_A0.6980.99
200_T229_T0.6970.99
191_F200_T0.6970.99
133_T170_A0.6940.99
37_Y84_D0.6920.99
58_L153_T0.6890.99
190_L201_P0.6890.99
35_R251_E0.6850.99
33_T86_Y0.6830.99
267_R270_A0.6810.99
250_W253_R0.6800.99
28_D160_V0.6800.99
152_K208_L0.6730.99
217_A221_A0.6690.99
92_T109_T0.6670.99
136_T176_V0.6650.99
137_T165_D0.6640.99
182_L232_Y0.6620.99
33_T247_N0.6600.99
130_M171_D0.6590.99
215_A219_L0.6580.99
15_A111_V0.6560.99
33_T249_T0.6560.99
15_A19_V0.6530.99
86_Y115_D0.6510.99
100_L159_G0.6490.99
72_R75_E0.6490.99
237_L258_V0.6470.99
5_V10_V0.6450.99
139_V142_H0.6440.99
188_S245_L0.6420.99
22_R93_R0.6390.99
132_A245_L0.6370.99
196_G225_L0.6360.99
9_L75_E0.6350.99
131_P253_R0.6330.99
203_G229_T0.6320.99
176_V182_L0.6320.99
272_L276_Y0.6280.99
52_Q65_S0.6280.99
267_R273_A0.6260.99
49_R214_W0.6250.99
178_P181_H0.6210.99
156_Y159_G0.6200.98
41_T74_H0.6190.98
221_A227_V0.6180.98
92_T111_V0.6160.98
238_Y259_D0.6160.98
30_A58_L0.6150.98
152_K184_E0.6150.98
24_F111_V0.6150.98
153_T157_L0.6110.98
111_V115_D0.6090.98
17_V21_D0.6070.98
237_L243_A0.6060.98
177_T205_L0.6020.98
73_V89_L0.5960.98
183_T207_V0.5920.98
174_L243_A0.5910.98
60_I93_R0.5900.98
56_D61_D0.5900.98
41_T87_V0.5890.98
34_M44_W0.5850.98
202_S205_L0.5850.98
269_G273_A0.5840.98
51_L89_L0.5830.98
8_A14_D0.5820.98
42_F248_T0.5810.98
135_E165_D0.5800.98
170_A260_D0.5800.98
24_F90_S0.5800.98
12_A80_N0.5800.98
192_F237_L0.5790.98
109_T115_D0.5790.98
162_A165_D0.5790.98
134_V258_V0.5780.98
212_T248_T0.5700.97
80_N114_V0.5680.97
168_A260_D0.5680.97
88_R154_H0.5660.97
200_T203_G0.5660.97
101_T105_T0.5610.97
34_M48_Y0.5590.97
10_V13_A0.5590.97
272_L275_A0.5570.97
189_N209_P0.5550.97
232_Y240_A0.5550.97
234_P238_Y0.5540.97
43_A211_I0.5540.97
136_T258_V0.5530.97
216_V275_A0.5520.97
211_I214_W0.5460.97
31_F152_K0.5440.97
26_Y155_N0.5420.97
191_F198_L0.5410.96
35_R117_L0.5400.96
192_F230_G0.5400.96
176_V183_T0.5400.96
142_H158_P0.5390.96
73_V76_T0.5370.96
126_P129_S0.5370.96
127_V130_M0.5370.96
211_I215_A0.5280.96
44_W74_H0.5280.96
140_T143_R0.5260.96
32_E51_L0.5250.96
64_L110_V0.5220.96
244_F252_V0.5220.96
76_T79_A0.5220.96
243_A263_Y0.5190.96
190_L237_L0.5190.96
200_T207_V0.5160.95
50_R208_L0.5160.95
20_R25_Q0.5120.95
30_A153_T0.5080.95
5_V16_T0.5080.95
45_T67_A0.5070.95
219_L222_E0.5060.95
87_V114_V0.5060.95
132_A188_S0.5050.95
166_I173_A0.5050.95
10_V15_A0.5030.95
140_T176_V0.5030.95
100_L156_Y0.5020.95
30_A151_A0.5010.95
200_T217_A0.5010.95
22_R98_G0.5000.95
130_M267_R0.5000.95
156_Y208_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iyeA 5 0.993 100 0.133 Contact Map
2eiyA 5 0.9895 100 0.145 Contact Map
4chiA 2 0.986 100 0.146 Contact Map
3u0gA 5 0.986 100 0.148 Contact Map
4tm5A 2 0.9719 100 0.157 Contact Map
3daaA 2 0.9649 100 0.158 Contact Map
4cmfA 4 0.9895 100 0.17 Contact Map
2y4rA 2 0.9439 100 0.174 Contact Map
4jxuA 2 0.9509 100 0.18 Contact Map
1i2kA 2 0.9404 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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