GREMLIN Database
Q9HS63 - Uncharacterized protein
UniProt: Q9HS63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (127)
Sequences: 131 (97)
Seq/√Len: 8.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_L32_D3.1210.91
52_V115_V3.0630.90
81_V139_D2.6240.82
21_Q125_S2.5130.79
116_D123_T2.4170.76
93_A107_C2.3370.73
50_I58_S2.2740.71
60_T86_L2.2360.70
23_A34_F2.1510.67
43_S106_P2.1130.65
81_V90_K2.0790.64
143_P146_L1.9890.60
62_W128_D1.9530.59
82_R137_G1.8030.52
93_A106_P1.7840.52
37_T73_T1.7140.49
23_A27_D1.7050.48
44_G130_D1.7000.48
51_L62_W1.6220.45
86_L106_P1.6050.44
49_A132_E1.5510.42
61_G115_V1.5420.41
29_Q109_G1.5040.40
56_D143_P1.4900.39
61_G142_D1.4840.39
26_T139_D1.4790.39
35_R133_F1.4670.38
87_V127_T1.4450.37
48_E137_G1.4320.37
97_P139_D1.4250.37
103_T117_V1.4140.36
32_D67_M1.3890.35
26_T127_T1.3590.34
89_R96_D1.3590.34
83_D101_V1.3550.34
26_T31_G1.3320.33
55_S59_I1.2880.31
81_V97_P1.2880.31
37_T71_D1.2410.30
37_T90_K1.2330.29
93_A110_A1.2250.29
27_D34_F1.2140.29
55_S62_W1.1640.27
38_V99_S1.1630.27
111_T114_A1.1480.27
101_V109_G1.1480.27
25_V124_V1.1470.27
69_W94_T1.1440.26
40_D113_T1.1310.26
69_W148_T1.1160.26
19_G120_Q1.0840.25
21_Q123_T1.0810.24
76_S90_K1.0680.24
42_D140_P1.0660.24
37_T69_W1.0640.24
27_D31_G1.0600.24
54_L60_T1.0560.24
51_L117_V1.0470.23
73_T83_D1.0450.23
98_T107_C1.0400.23
22_I42_D1.0270.23
36_F123_T1.0230.23
50_I75_D1.0100.22
39_R116_D0.9940.22
34_F131_Y0.9890.22
38_V115_V0.9840.21
82_R128_D0.9830.21
50_I97_P0.9820.21
25_V61_G0.9800.21
18_D149_S0.9780.21
38_V133_F0.9730.21
118_T127_T0.9690.21
94_T139_D0.9560.21
39_R45_D0.9530.21
75_D78_S0.9520.21
93_A98_T0.9510.21
38_V52_V0.9420.20
42_D46_E0.9400.20
37_T94_T0.9380.20
71_D110_A0.9380.20
38_V49_A0.9370.20
93_A103_T0.9340.20
118_T134_V0.9330.20
52_V116_D0.9310.20
38_V61_G0.9250.20
24_S52_V0.9160.20
18_D51_L0.9080.19
83_D89_R0.9060.19
94_T115_V0.8930.19
48_E82_R0.8920.19
43_S56_D0.8680.18
77_G126_L0.8660.18
33_S107_C0.8580.18
56_D114_A0.8540.18
104_H148_T0.8510.18
25_V30_A0.8470.18
129_P132_E0.8460.18
51_L118_T0.8250.17
93_A104_H0.8180.17
37_T137_G0.8180.17
103_T110_A0.8130.17
38_V125_S0.8120.17
74_L117_V0.8090.17
70_T74_L0.8080.17
33_S111_T0.8050.17
117_V123_T0.7950.17
89_R111_T0.7890.16
109_G131_Y0.7810.16
29_Q53_A0.7790.16
28_L96_D0.7670.16
61_G92_A0.7640.16
115_V129_P0.7630.16
22_I78_S0.7600.16
25_V116_D0.7590.16
129_P141_G0.7490.16
47_Q127_T0.7430.15
20_A23_A0.7430.15
143_P147_S0.7320.15
24_S122_G0.7300.15
82_R85_E0.7270.15
26_T140_P0.7250.15
91_H100_G0.7240.15
64_N105_G0.7240.15
66_C88_C0.7240.15
66_C91_H0.7240.15
66_C100_G0.7240.15
66_C105_G0.7240.15
68_H88_C0.7240.15
68_H91_H0.7240.15
68_H105_G0.7240.15
100_G105_G0.7240.15
91_H105_G0.7240.15
68_H100_G0.7240.15
64_N100_G0.7240.15
64_N91_H0.7240.15
64_N88_C0.7240.15
88_C91_H0.7240.15
88_C100_G0.7240.15
88_C105_G0.7240.15
64_N68_H0.7240.15
45_D130_D0.7190.15
71_D90_K0.7180.15
107_C148_T0.7170.15
42_D56_D0.7170.15
23_A38_V0.7110.15
25_V127_T0.7070.15
86_L101_V0.6880.14
65_Y110_A0.6840.14
80_A128_D0.6790.14
61_G99_S0.6730.14
93_A146_L0.6670.14
22_I36_F0.6650.14
46_E50_I0.6620.14
104_H107_C0.6570.14
39_R131_Y0.6460.13
95_F119_V0.6440.13
104_H108_E0.6320.13
21_Q117_V0.6300.13
22_I107_C0.6160.13
23_A31_G0.6110.13
89_R107_C0.6100.13
63_L73_T0.6070.13
90_K143_P0.6000.12
28_L31_G0.5970.12
42_D130_D0.5970.12
142_D148_T0.5910.12
89_R104_H0.5890.12
27_D44_G0.5770.12
56_D122_G0.5750.12
78_S140_P0.5700.12
31_G109_G0.5660.12
36_F63_L0.5600.12
103_T107_C0.5490.12
29_Q46_E0.5470.12
55_S58_S0.5470.12
70_T133_F0.5440.11
63_L113_T0.5400.11
62_W87_V0.5400.11
27_D130_D0.5360.11
65_Y70_T0.5330.11
86_L94_T0.5240.11
77_G119_V0.5190.11
54_L67_M0.5170.11
69_W108_E0.5150.11
43_S74_L0.5150.11
49_A134_V0.5100.11
63_L110_A0.5040.11
38_V149_S0.5010.11
69_W90_K0.5010.11
89_R148_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gceA 1 0.6667 99.7 0.71 Contact Map
2jo6A 1 0.6667 99.7 0.713 Contact Map
3c0dA 1 0.6667 99.7 0.715 Contact Map
1rieA 1 0.6474 99.7 0.72 Contact Map
2i7fA 1 0.6538 99.7 0.721 Contact Map
2de6D 1 0.6603 99.7 0.723 Contact Map
2qpzA 1 0.6603 99.7 0.723 Contact Map
1fqtA 2 0.6987 99.7 0.723 Contact Map
3dqyA 1 0.6795 99.6 0.723 Contact Map
1vm9A 1 0.6987 99.6 0.727 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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