Q9HS61 - HALSA - GREMLIN Contacts

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Q9HS61 - Glucose-1-phosphate thymidylyltransferase

UniProt:	Q9HS61	Sequences: MKKDLPDRVDLVGMKAVVLAGGYATRLWPITKDRPKMFLPVGDSTVIDRIFADLESDDRIDTVYVSTNERFADEFRSHLAERSFEKPQLSVEDTTDENEKFGVMGALAQLVDRESITDDLVVIAGDNLISFDVSAFVDFFAADDADNPAIAAYDVGSYERAQSYGLVELHGDEVINFQEKPDDPNSTLVSIACYAYPESVVEDIDTYLAADGNPDEPGWFVEWLQDRQSVRAFTFEGAWFDIGTPESYLDAVAWTLDGDSIVADDATVSNTTIGENVHVLPGAELTNSTVSNSVIFPDATLRDCDVRNSIIDEDTVLDSIDFSGALIGAHTTIENGHDADGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	342 (310)
Sequences:	9497 (6392)
Seq/√Len:	363.1

ECOLI - GLGC GLMU RMLA1 RMLA2 GALF GALU
BACSU - GLGC GLMU GLGD YNGB RMLA GTAB RFBF YTDA
HALSA - Q9HS61 Q9HSZ9 Q9HSZ8 Q9HQQ4 Q9HSV0
SULSO - Q980H9 Q97ZD1 Q97XG0 Q7LXE7 Q7LXK9 Q980D4 Q97U06 Q97VX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
306_V	309_S	3.665	1.00
308_N	324_G	3.415	1.00
307_R	323_S	3.248	1.00
154_D	187_T	3.147	1.00
291_S	307_R	2.948	1.00
140_F	149_A	2.933	1.00
322_F	325_A	2.887	1.00
298_D	314_D	2.783	1.00
44_S	52_A	2.669	1.00
180_K	184_P	2.654	1.00
302_R	318_D	2.652	1.00
170_H	173_E	2.564	1.00
309_S	322_F	2.490	1.00
154_D	234_T	2.482	1.00
168_E	186_S	2.416	1.00
111_V	205_D	2.318	1.00
138_D	142_A	2.318	1.00
311_I	317_L	2.318	1.00
206_T	227_R	2.239	1.00
297_P	313_E	2.234	1.00
16_A	60_I	2.233	1.00
300_T	316_V	2.232	1.00
303_D	319_S	2.179	1.00
314_D	330_H	2.172	1.00
168_E	176_N	2.159	1.00
280_L	297_P	2.147	1.00
286_T	302_R	2.140	1.00
119_D	141_A	2.130	1.00
281_P	297_P	2.073	1.00
176_N	183_D	2.045	1.00
16_A	54_L	2.021	1.00
146_D	231_R	2.014	1.00
48_D	78_H	1.978	1.00
139_F	143_D	1.916	1.00
34_R	40_P	1.894	1.00
327_I	331_T	1.894	1.00
296_F	313_E	1.891	1.00
290_V	293_S	1.863	1.00
174_V	232_A	1.853	1.00
315_T	331_T	1.836	1.00
170_H	175_I	1.824	1.00
287_N	303_D	1.811	1.00
119_D	197_P	1.805	1.00
283_A	299_A	1.797	1.00
120_L	198_E	1.773	1.00
284_E	300_T	1.751	1.00
147_N	197_P	1.747	1.00
152_A	232_A	1.729	1.00
318_D	335_N	1.723	1.00
51_F	63_V	1.707	1.00
162_Q	180_K	1.702	1.00
289_T	305_D	1.668	1.00
292_N	308_N	1.666	1.00
305_D	321_D	1.649	1.00
295_I	301_L	1.649	1.00
101_F	105_G	1.636	1.00
311_I	315_T	1.623	1.00
202_E	206_T	1.611	1.00
119_D	195_A	1.605	1.00
313_E	329_A	1.596	1.00
312_D	329_A	1.596	1.00
276_N	292_N	1.588	1.00
143_D	231_R	1.578	1.00
327_I	333_I	1.575	1.00
136_F	151_A	1.573	1.00
72_A	76_R	1.566	1.00
134_S	138_D	1.557	1.00
316_V	332_T	1.536	1.00
274_G	291_S	1.535	1.00
242_I	251_A	1.530	1.00
136_F	195_A	1.521	1.00
173_E	231_R	1.521	1.00
304_C	320_I	1.488	1.00
310_I	326_L	1.481	1.00
173_E	229_S	1.468	1.00
64_Y	95_T	1.450	1.00
295_I	299_A	1.441	1.00
319_S	336_G	1.415	1.00
33_D	298_D	1.413	1.00
267_T	284_E	1.405	1.00
47_I	79_L	1.392	1.00
54_L	123_I	1.388	1.00
15_K	62_T	1.383	1.00
277_V	290_V	1.380	1.00
272_T	289_T	1.376	1.00
276_N	293_S	1.376	1.00
202_E	227_R	1.370	1.00
139_F	233_F	1.358	1.00
62_T	90_S	1.347	1.00
203_D	223_W	1.345	1.00
244_T	263_A	1.327	1.00
48_D	52_A	1.321	1.00
147_N	228_Q	1.312	1.00
121_V	195_A	1.312	1.00
315_T	327_I	1.306	1.00
67_T	72_A	1.299	1.00
122_V	196_Y	1.292	1.00
286_T	300_T	1.286	1.00
283_A	295_I	1.285	1.00
136_F	149_A	1.285	1.00
321_D	338_D	1.279	1.00
306_V	311_I	1.277	1.00
203_D	227_R	1.277	1.00
200_V	228_Q	1.276	1.00
169_L	188_L	1.276	1.00
263_A	266_A	1.270	1.00
273_I	277_V	1.270	1.00
105_G	108_A	1.268	1.00
299_A	315_T	1.251	1.00
46_V	242_I	1.244	1.00
320_I	335_N	1.244	1.00
262_V	265_D	1.239	1.00
72_A	96_D	1.230	1.00
137_V	195_A	1.213	1.00
222_E	226_D	1.186	1.00
105_G	109_Q	1.183	1.00
48_D	82_R	1.180	1.00
147_N	229_S	1.168	1.00
223_W	227_R	1.163	1.00
206_T	223_W	1.158	1.00
38_F	78_H	1.158	1.00
163_S	180_K	1.155	1.00
262_V	266_A	1.155	1.00
34_R	74_E	1.148	1.00
288_S	302_R	1.140	1.00
238_A	254_W	1.135	1.00
148_P	224_L	1.135	1.00
312_D	326_L	1.126	1.00
74_E	77_S	1.121	1.00
124_A	127_N	1.119	1.00
73_D	77_S	1.118	1.00
165_G	179_E	1.113	1.00
178_Q	185_N	1.100	1.00
168_E	178_Q	1.096	1.00
169_L	232_A	1.094	1.00
280_L	283_A	1.092	1.00
274_G	277_V	1.092	1.00
108_A	111_V	1.078	1.00
35_P	74_E	1.077	1.00
117_T	199_S	1.074	1.00
296_F	299_A	1.070	1.00
293_S	306_V	1.070	1.00
123_I	133_V	1.067	1.00
282_G	298_D	1.067	1.00
42_G	255_T	1.066	1.00
315_T	328_G	1.060	1.00
285_L	288_S	1.059	1.00
279_V	283_A	1.057	1.00
240_F	250_D	1.055	1.00
291_S	305_D	1.052	1.00
132_D	135_A	1.050	1.00
240_F	254_W	1.049	1.00
143_D	146_D	1.048	1.00
271_T	274_G	1.047	1.00
160_R	163_S	1.047	1.00
246_E	250_D	1.039	1.00
80_A	94_T	1.038	1.00
174_V	230_V	1.033	1.00
68_N	100_K	1.030	1.00
168_E	175_I	1.019	1.00
244_T	247_S	1.012	1.00
270_N	287_N	1.010	1.00
160_R	180_K	1.009	1.00
37_M	125_G	1.006	1.00
107_L	122_V	1.006	1.00
152_A	167_V	1.002	1.00
135_A	138_D	1.001	1.00
40_P	45_T	0.982	1.00
275_E	291_S	0.981	1.00
41_V	252_V	0.979	1.00
199_S	202_E	0.973	1.00
152_A	188_L	0.972	1.00
181_P	211_D	0.972	1.00
283_A	313_E	0.968	1.00
159_E	187_T	0.966	1.00
49_R	255_T	0.965	1.00
264_D	281_P	0.958	1.00
45_T	48_D	0.953	1.00
315_T	329_A	0.951	1.00
322_F	327_I	0.948	1.00
272_T	275_E	0.945	1.00
24_A	36_K	0.937	1.00
76_R	96_D	0.925	1.00
62_T	92_E	0.924	1.00
45_T	78_H	0.922	1.00
263_A	281_P	0.922	1.00
167_V	174_V	0.921	1.00
202_E	205_D	0.916	1.00
121_V	137_V	0.916	1.00
305_D	318_D	0.915	1.00
213_N	219_W	0.909	1.00
130_S	238_A	0.909	1.00
311_I	327_I	0.907	1.00
320_I	333_I	0.903	1.00
299_A	313_E	0.901	1.00
279_V	285_L	0.900	1.00
91_V	94_T	0.898	1.00
265_D	268_V	0.896	1.00
270_N	274_G	0.896	1.00
166_L	189_V	0.895	1.00
65_V	79_L	0.891	1.00
100_K	105_G	0.890	1.00
266_A	283_A	0.889	1.00
265_D	282_G	0.887	1.00
190_S	194_Y	0.885	1.00
118_D	198_E	0.885	1.00
139_F	231_R	0.880	1.00
15_K	116_I	0.876	1.00
47_I	75_F	0.875	1.00
269_S	272_T	0.875	1.00
246_E	263_A	0.874	1.00
148_P	196_Y	0.867	1.00
298_D	313_E	0.861	1.00
321_D	336_G	0.860	1.00
155_V	189_V	0.856	1.00
108_A	205_D	0.851	1.00
265_D	281_P	0.849	1.00
139_F	142_A	0.842	1.00
17_V	120_L	0.840	1.00
118_D	197_P	0.839	1.00
203_D	224_L	0.839	1.00
135_A	139_F	0.837	1.00
299_A	312_D	0.835	1.00
299_A	311_I	0.833	1.00
45_T	49_R	0.830	1.00
26_R	36_K	0.826	1.00
197_P	200_V	0.826	1.00
268_V	271_T	0.825	1.00
282_G	297_P	0.824	1.00
55_E	83_S	0.820	1.00
246_E	261_I	0.818	1.00
188_L	234_T	0.815	1.00
17_V	64_Y	0.811	1.00
303_D	318_D	0.810	1.00
224_L	228_Q	0.807	1.00
133_V	136_F	0.802	1.00
253_A	256_L	0.801	1.00
320_I	337_H	0.800	1.00
138_D	141_A	0.800	1.00
36_K	126_D	0.799	1.00
104_M	207_Y	0.798	1.00
144_D	197_P	0.796	1.00
290_V	295_I	0.795	1.00
304_C	335_N	0.793	1.00
140_F	197_P	0.792	1.00
207_Y	220_F	0.790	1.00
73_D	76_R	0.788	1.00
196_Y	220_F	0.781	1.00
296_F	312_D	0.781	1.00
38_F	74_E	0.777	1.00
70_R	74_E	0.777	1.00
283_A	296_F	0.776	1.00
203_D	220_F	0.774	1.00
178_Q	183_D	0.774	1.00
254_W	257_D	0.771	1.00
223_W	226_D	0.768	1.00
214_P	219_W	0.767	1.00
150_I	167_V	0.765	1.00
264_D	267_T	0.765	1.00
101_F	215_D	0.762	1.00
55_E	63_V	0.761	1.00
285_L	290_V	0.759	1.00
47_I	65_V	0.756	1.00
67_T	76_R	0.750	1.00
283_A	297_P	0.748	1.00
51_F	79_L	0.747	1.00
308_N	323_S	0.746	1.00
323_S	338_D	0.745	1.00
92_E	95_T	0.743	1.00
152_A	155_V	0.736	1.00
304_C	319_S	0.736	1.00
314_D	329_A	0.731	1.00
200_V	224_L	0.730	1.00
280_L	296_F	0.729	1.00
55_E	82_R	0.728	1.00
54_L	60_I	0.727	1.00
68_N	105_G	0.725	1.00
319_S	335_N	0.725	1.00
76_R	80_A	0.724	1.00
307_R	321_D	0.723	1.00
274_G	289_T	0.717	0.99
317_L	320_I	0.715	0.99
315_T	333_I	0.714	0.99
18_V	54_L	0.710	0.99
150_I	174_V	0.705	0.99
163_S	247_S	0.699	0.99
299_A	329_A	0.698	0.99
299_A	317_L	0.698	0.99
207_Y	223_W	0.696	0.99
306_V	322_F	0.696	0.99
19_L	124_A	0.693	0.99
147_N	200_V	0.692	0.99
304_C	317_L	0.687	0.99
42_G	49_R	0.680	0.99
22_G	36_K	0.680	0.99
277_V	293_S	0.678	0.99
153_Y	239_W	0.676	0.99
20_A	65_V	0.675	0.99
266_A	279_V	0.674	0.99
140_F	195_A	0.672	0.99
126_D	241_D	0.672	0.99
263_A	267_T	0.671	0.99
146_D	149_A	0.669	0.99
62_T	84_F	0.667	0.99
50_I	123_I	0.666	0.99
18_V	51_F	0.664	0.99
262_V	268_V	0.662	0.99
257_D	261_I	0.662	0.99
52_A	56_S	0.662	0.99
260_S	268_V	0.661	0.99
318_D	321_D	0.659	0.99
183_D	186_S	0.658	0.99
35_P	70_R	0.657	0.99
52_A	55_E	0.655	0.99
250_D	253_A	0.654	0.99
176_N	222_E	0.652	0.99
203_D	206_T	0.651	0.99
76_R	94_T	0.651	0.99
146_D	229_S	0.651	0.99
207_Y	218_G	0.643	0.99
305_D	319_S	0.642	0.99
274_G	292_N	0.642	0.99
151_A	193_C	0.642	0.99
270_N	273_I	0.639	0.99
41_V	46_V	0.638	0.99
334_E	337_H	0.637	0.99
62_T	115_S	0.635	0.99
52_A	82_R	0.635	0.99
137_V	141_A	0.634	0.99
49_R	52_A	0.633	0.99
207_Y	212_G	0.632	0.99
48_D	79_L	0.631	0.99
77_S	80_A	0.630	0.99
113_R	116_I	0.628	0.99
240_F	251_A	0.628	0.99
318_D	336_G	0.628	0.99
46_V	50_I	0.624	0.99
188_L	232_A	0.622	0.99
203_D	207_Y	0.622	0.99
42_G	252_V	0.620	0.99
58_D	133_V	0.620	0.99
262_V	267_T	0.619	0.99
153_Y	189_V	0.619	0.99
67_T	75_F	0.618	0.98
153_Y	191_I	0.617	0.98
22_G	26_R	0.616	0.98
80_A	83_S	0.616	0.98
33_D	281_P	0.615	0.98
317_L	322_F	0.613	0.98
148_P	230_V	0.612	0.98
162_Q	182_D	0.611	0.98
288_S	304_C	0.610	0.98
67_T	94_T	0.610	0.98
191_I	239_W	0.609	0.98
124_A	192_A	0.608	0.98
114_E	118_D	0.608	0.98
19_L	66_S	0.602	0.98
290_V	294_V	0.602	0.98
286_T	304_C	0.600	0.98
151_A	154_D	0.599	0.98
99_E	105_G	0.598	0.98
121_V	133_V	0.597	0.98
15_K	120_L	0.595	0.98
173_E	225_Q	0.595	0.98
272_T	277_V	0.594	0.98
79_L	91_V	0.594	0.98
28_W	32_K	0.593	0.98
15_K	64_Y	0.593	0.98
332_T	335_N	0.592	0.98
312_D	328_G	0.590	0.98
43_D	278_H	0.589	0.98
141_A	195_A	0.589	0.98
217_P	220_F	0.585	0.98
135_A	236_E	0.585	0.98
44_S	49_R	0.578	0.98
84_F	91_V	0.577	0.98
53_D	133_V	0.572	0.98
14_M	118_D	0.572	0.98
280_L	313_E	0.571	0.97
60_I	137_V	0.571	0.97
270_N	275_E	0.570	0.97
66_S	106_A	0.570	0.97
136_F	140_F	0.569	0.97
255_T	259_D	0.566	0.97
53_D	130_S	0.566	0.97
148_P	221_V	0.564	0.97
304_C	318_D	0.562	0.97
155_V	187_T	0.562	0.97
320_I	334_E	0.560	0.97
37_M	75_F	0.559	0.97
64_Y	110_L	0.559	0.97
271_T	290_V	0.558	0.97
43_D	49_R	0.558	0.97
237_G	258_G	0.558	0.97
67_T	96_D	0.556	0.97
33_D	297_P	0.554	0.97
279_V	295_I	0.554	0.97
123_I	193_C	0.553	0.97
19_L	106_A	0.551	0.97
196_Y	200_V	0.551	0.97
254_W	258_G	0.548	0.97
97_E	105_G	0.548	0.97
17_V	107_L	0.548	0.97
213_N	218_G	0.547	0.97
177_F	190_S	0.546	0.97
325_A	337_H	0.546	0.97
16_A	63_V	0.544	0.97
116_I	119_D	0.541	0.97
181_P	212_G	0.540	0.96
107_L	201_V	0.540	0.96
217_P	222_E	0.539	0.96
95_T	109_Q	0.539	0.96
165_G	192_A	0.538	0.96
328_G	331_T	0.537	0.96
253_A	269_S	0.537	0.96
283_A	298_D	0.536	0.96
167_V	188_L	0.534	0.96
108_A	204_I	0.534	0.96
107_L	216_E	0.532	0.96
204_I	207_Y	0.532	0.96
117_T	198_E	0.532	0.96
116_I	199_S	0.532	0.96
288_S	301_L	0.531	0.96
151_A	191_I	0.531	0.96
119_D	140_F	0.530	0.96
152_A	174_V	0.530	0.96
235_F	239_W	0.529	0.96
318_D	323_S	0.529	0.96
252_V	256_L	0.528	0.96
103_V	126_D	0.527	0.96
149_A	195_A	0.527	0.96
276_N	279_V	0.527	0.96
269_S	274_G	0.526	0.96
257_D	260_S	0.525	0.96
118_D	199_S	0.524	0.96
21_G	66_S	0.524	0.96
18_V	50_I	0.524	0.96
50_I	53_D	0.524	0.96
271_T	288_S	0.523	0.96
56_S	134_S	0.522	0.96
122_V	217_P	0.520	0.96
288_S	303_D	0.519	0.96
247_S	250_D	0.518	0.96
225_Q	230_V	0.518	0.96
53_D	58_D	0.516	0.95
220_F	223_W	0.515	0.95
135_A	233_F	0.513	0.95
94_T	97_E	0.512	0.95
250_D	261_I	0.512	0.95
42_G	259_D	0.512	0.95
275_E	289_T	0.511	0.95
24_A	241_D	0.511	0.95
276_N	291_S	0.510	0.95
79_L	94_T	0.510	0.95
38_F	47_I	0.510	0.95
80_A	84_F	0.509	0.95
23_Y	100_K	0.508	0.95
286_T	291_S	0.507	0.95
167_V	177_F	0.505	0.95
150_I	194_Y	0.504	0.95
26_R	37_M	0.503	0.95
280_L	299_A	0.502	0.95
268_V	285_L	0.502	0.95
133_V	140_F	0.501	0.95
270_N	288_S	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3brkX	2	0.9298	100	0.372	Contact Map
1yp2A	4	0.9591	100	0.387	Contact Map
2ggoA	3	0.8918	100	0.403	Contact Map
4g3qA	3	0.9327	100	0.439	Contact Map
1hm9A	3	0.9123	100	0.448	Contact Map
2v0hA	3	0.9123	100	0.473	Contact Map
4fceA	3	0.8977	100	0.479	Contact Map
2icyA	1	0.9152	100	0.513	Contact Map
3jukA	3	0.6988	100	0.517	Contact Map
2i5kA	5	0.9152	100	0.519	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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