GREMLIN Database
Q9HS61 - Glucose-1-phosphate thymidylyltransferase
UniProt: Q9HS61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (310)
Sequences: 9497 (6392)
Seq/√Len: 363.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
306_V309_S3.6651.00
308_N324_G3.4151.00
307_R323_S3.2481.00
154_D187_T3.1471.00
291_S307_R2.9481.00
140_F149_A2.9331.00
322_F325_A2.8871.00
298_D314_D2.7831.00
44_S52_A2.6691.00
180_K184_P2.6541.00
302_R318_D2.6521.00
170_H173_E2.5641.00
309_S322_F2.4901.00
154_D234_T2.4821.00
168_E186_S2.4161.00
111_V205_D2.3181.00
138_D142_A2.3181.00
311_I317_L2.3181.00
206_T227_R2.2391.00
297_P313_E2.2341.00
16_A60_I2.2331.00
300_T316_V2.2321.00
303_D319_S2.1791.00
314_D330_H2.1721.00
168_E176_N2.1591.00
280_L297_P2.1471.00
286_T302_R2.1401.00
119_D141_A2.1301.00
281_P297_P2.0731.00
176_N183_D2.0451.00
16_A54_L2.0211.00
146_D231_R2.0141.00
48_D78_H1.9781.00
139_F143_D1.9161.00
34_R40_P1.8941.00
327_I331_T1.8941.00
296_F313_E1.8911.00
290_V293_S1.8631.00
174_V232_A1.8531.00
315_T331_T1.8361.00
170_H175_I1.8241.00
287_N303_D1.8111.00
119_D197_P1.8051.00
283_A299_A1.7971.00
120_L198_E1.7731.00
284_E300_T1.7511.00
147_N197_P1.7471.00
152_A232_A1.7291.00
318_D335_N1.7231.00
51_F63_V1.7071.00
162_Q180_K1.7021.00
289_T305_D1.6681.00
292_N308_N1.6661.00
305_D321_D1.6491.00
295_I301_L1.6491.00
101_F105_G1.6361.00
311_I315_T1.6231.00
202_E206_T1.6111.00
119_D195_A1.6051.00
313_E329_A1.5961.00
312_D329_A1.5961.00
276_N292_N1.5881.00
143_D231_R1.5781.00
327_I333_I1.5751.00
136_F151_A1.5731.00
72_A76_R1.5661.00
134_S138_D1.5571.00
316_V332_T1.5361.00
274_G291_S1.5351.00
242_I251_A1.5301.00
136_F195_A1.5211.00
173_E231_R1.5211.00
304_C320_I1.4881.00
310_I326_L1.4811.00
173_E229_S1.4681.00
64_Y95_T1.4501.00
295_I299_A1.4411.00
319_S336_G1.4151.00
33_D298_D1.4131.00
267_T284_E1.4051.00
47_I79_L1.3921.00
54_L123_I1.3881.00
15_K62_T1.3831.00
277_V290_V1.3801.00
272_T289_T1.3761.00
276_N293_S1.3761.00
202_E227_R1.3701.00
139_F233_F1.3581.00
62_T90_S1.3471.00
203_D223_W1.3451.00
244_T263_A1.3271.00
48_D52_A1.3211.00
147_N228_Q1.3121.00
121_V195_A1.3121.00
315_T327_I1.3061.00
67_T72_A1.2991.00
122_V196_Y1.2921.00
286_T300_T1.2861.00
283_A295_I1.2851.00
136_F149_A1.2851.00
321_D338_D1.2791.00
306_V311_I1.2771.00
203_D227_R1.2771.00
200_V228_Q1.2761.00
169_L188_L1.2761.00
263_A266_A1.2701.00
273_I277_V1.2701.00
105_G108_A1.2681.00
299_A315_T1.2511.00
46_V242_I1.2441.00
320_I335_N1.2441.00
262_V265_D1.2391.00
72_A96_D1.2301.00
137_V195_A1.2131.00
222_E226_D1.1861.00
105_G109_Q1.1831.00
48_D82_R1.1801.00
147_N229_S1.1681.00
223_W227_R1.1631.00
206_T223_W1.1581.00
38_F78_H1.1581.00
163_S180_K1.1551.00
262_V266_A1.1551.00
34_R74_E1.1481.00
288_S302_R1.1401.00
238_A254_W1.1351.00
148_P224_L1.1351.00
312_D326_L1.1261.00
74_E77_S1.1211.00
124_A127_N1.1191.00
73_D77_S1.1181.00
165_G179_E1.1131.00
178_Q185_N1.1001.00
168_E178_Q1.0961.00
169_L232_A1.0941.00
280_L283_A1.0921.00
274_G277_V1.0921.00
108_A111_V1.0781.00
35_P74_E1.0771.00
117_T199_S1.0741.00
296_F299_A1.0701.00
293_S306_V1.0701.00
123_I133_V1.0671.00
282_G298_D1.0671.00
42_G255_T1.0661.00
315_T328_G1.0601.00
285_L288_S1.0591.00
279_V283_A1.0571.00
240_F250_D1.0551.00
291_S305_D1.0521.00
132_D135_A1.0501.00
240_F254_W1.0491.00
143_D146_D1.0481.00
271_T274_G1.0471.00
160_R163_S1.0471.00
246_E250_D1.0391.00
80_A94_T1.0381.00
174_V230_V1.0331.00
68_N100_K1.0301.00
168_E175_I1.0191.00
244_T247_S1.0121.00
270_N287_N1.0101.00
160_R180_K1.0091.00
37_M125_G1.0061.00
107_L122_V1.0061.00
152_A167_V1.0021.00
135_A138_D1.0011.00
40_P45_T0.9821.00
275_E291_S0.9811.00
41_V252_V0.9791.00
199_S202_E0.9731.00
152_A188_L0.9721.00
181_P211_D0.9721.00
283_A313_E0.9681.00
159_E187_T0.9661.00
49_R255_T0.9651.00
264_D281_P0.9581.00
45_T48_D0.9531.00
315_T329_A0.9511.00
322_F327_I0.9481.00
272_T275_E0.9451.00
24_A36_K0.9371.00
76_R96_D0.9251.00
62_T92_E0.9241.00
45_T78_H0.9221.00
263_A281_P0.9221.00
167_V174_V0.9211.00
202_E205_D0.9161.00
121_V137_V0.9161.00
305_D318_D0.9151.00
213_N219_W0.9091.00
130_S238_A0.9091.00
311_I327_I0.9071.00
320_I333_I0.9031.00
299_A313_E0.9011.00
279_V285_L0.9001.00
91_V94_T0.8981.00
265_D268_V0.8961.00
270_N274_G0.8961.00
166_L189_V0.8951.00
65_V79_L0.8911.00
100_K105_G0.8901.00
266_A283_A0.8891.00
265_D282_G0.8871.00
190_S194_Y0.8851.00
118_D198_E0.8851.00
139_F231_R0.8801.00
15_K116_I0.8761.00
47_I75_F0.8751.00
269_S272_T0.8751.00
246_E263_A0.8741.00
148_P196_Y0.8671.00
298_D313_E0.8611.00
321_D336_G0.8601.00
155_V189_V0.8561.00
108_A205_D0.8511.00
265_D281_P0.8491.00
139_F142_A0.8421.00
17_V120_L0.8401.00
118_D197_P0.8391.00
203_D224_L0.8391.00
135_A139_F0.8371.00
299_A312_D0.8351.00
299_A311_I0.8331.00
45_T49_R0.8301.00
26_R36_K0.8261.00
197_P200_V0.8261.00
268_V271_T0.8251.00
282_G297_P0.8241.00
55_E83_S0.8201.00
246_E261_I0.8181.00
188_L234_T0.8151.00
17_V64_Y0.8111.00
303_D318_D0.8101.00
224_L228_Q0.8071.00
133_V136_F0.8021.00
253_A256_L0.8011.00
320_I337_H0.8001.00
138_D141_A0.8001.00
36_K126_D0.7991.00
104_M207_Y0.7981.00
144_D197_P0.7961.00
290_V295_I0.7951.00
304_C335_N0.7931.00
140_F197_P0.7921.00
207_Y220_F0.7901.00
73_D76_R0.7881.00
196_Y220_F0.7811.00
296_F312_D0.7811.00
38_F74_E0.7771.00
70_R74_E0.7771.00
283_A296_F0.7761.00
203_D220_F0.7741.00
178_Q183_D0.7741.00
254_W257_D0.7711.00
223_W226_D0.7681.00
214_P219_W0.7671.00
150_I167_V0.7651.00
264_D267_T0.7651.00
101_F215_D0.7621.00
55_E63_V0.7611.00
285_L290_V0.7591.00
47_I65_V0.7561.00
67_T76_R0.7501.00
283_A297_P0.7481.00
51_F79_L0.7471.00
308_N323_S0.7461.00
323_S338_D0.7451.00
92_E95_T0.7431.00
152_A155_V0.7361.00
304_C319_S0.7361.00
314_D329_A0.7311.00
200_V224_L0.7301.00
280_L296_F0.7291.00
55_E82_R0.7281.00
54_L60_I0.7271.00
68_N105_G0.7251.00
319_S335_N0.7251.00
76_R80_A0.7241.00
307_R321_D0.7231.00
274_G289_T0.7170.99
317_L320_I0.7150.99
315_T333_I0.7140.99
18_V54_L0.7100.99
150_I174_V0.7050.99
163_S247_S0.6990.99
299_A329_A0.6980.99
299_A317_L0.6980.99
207_Y223_W0.6960.99
306_V322_F0.6960.99
19_L124_A0.6930.99
147_N200_V0.6920.99
304_C317_L0.6870.99
42_G49_R0.6800.99
22_G36_K0.6800.99
277_V293_S0.6780.99
153_Y239_W0.6760.99
20_A65_V0.6750.99
266_A279_V0.6740.99
140_F195_A0.6720.99
126_D241_D0.6720.99
263_A267_T0.6710.99
146_D149_A0.6690.99
62_T84_F0.6670.99
50_I123_I0.6660.99
18_V51_F0.6640.99
262_V268_V0.6620.99
257_D261_I0.6620.99
52_A56_S0.6620.99
260_S268_V0.6610.99
318_D321_D0.6590.99
183_D186_S0.6580.99
35_P70_R0.6570.99
52_A55_E0.6550.99
250_D253_A0.6540.99
176_N222_E0.6520.99
203_D206_T0.6510.99
76_R94_T0.6510.99
146_D229_S0.6510.99
207_Y218_G0.6430.99
305_D319_S0.6420.99
274_G292_N0.6420.99
151_A193_C0.6420.99
270_N273_I0.6390.99
41_V46_V0.6380.99
334_E337_H0.6370.99
62_T115_S0.6350.99
52_A82_R0.6350.99
137_V141_A0.6340.99
49_R52_A0.6330.99
207_Y212_G0.6320.99
48_D79_L0.6310.99
77_S80_A0.6300.99
113_R116_I0.6280.99
240_F251_A0.6280.99
318_D336_G0.6280.99
46_V50_I0.6240.99
188_L232_A0.6220.99
203_D207_Y0.6220.99
42_G252_V0.6200.99
58_D133_V0.6200.99
262_V267_T0.6190.99
153_Y189_V0.6190.99
67_T75_F0.6180.98
153_Y191_I0.6170.98
22_G26_R0.6160.98
80_A83_S0.6160.98
33_D281_P0.6150.98
317_L322_F0.6130.98
148_P230_V0.6120.98
162_Q182_D0.6110.98
288_S304_C0.6100.98
67_T94_T0.6100.98
191_I239_W0.6090.98
124_A192_A0.6080.98
114_E118_D0.6080.98
19_L66_S0.6020.98
290_V294_V0.6020.98
286_T304_C0.6000.98
151_A154_D0.5990.98
99_E105_G0.5980.98
121_V133_V0.5970.98
15_K120_L0.5950.98
173_E225_Q0.5950.98
272_T277_V0.5940.98
79_L91_V0.5940.98
28_W32_K0.5930.98
15_K64_Y0.5930.98
332_T335_N0.5920.98
312_D328_G0.5900.98
43_D278_H0.5890.98
141_A195_A0.5890.98
217_P220_F0.5850.98
135_A236_E0.5850.98
44_S49_R0.5780.98
84_F91_V0.5770.98
53_D133_V0.5720.98
14_M118_D0.5720.98
280_L313_E0.5710.97
60_I137_V0.5710.97
270_N275_E0.5700.97
66_S106_A0.5700.97
136_F140_F0.5690.97
255_T259_D0.5660.97
53_D130_S0.5660.97
148_P221_V0.5640.97
304_C318_D0.5620.97
155_V187_T0.5620.97
320_I334_E0.5600.97
37_M75_F0.5590.97
64_Y110_L0.5590.97
271_T290_V0.5580.97
43_D49_R0.5580.97
237_G258_G0.5580.97
67_T96_D0.5560.97
33_D297_P0.5540.97
279_V295_I0.5540.97
123_I193_C0.5530.97
19_L106_A0.5510.97
196_Y200_V0.5510.97
254_W258_G0.5480.97
97_E105_G0.5480.97
17_V107_L0.5480.97
213_N218_G0.5470.97
177_F190_S0.5460.97
325_A337_H0.5460.97
16_A63_V0.5440.97
116_I119_D0.5410.97
181_P212_G0.5400.96
107_L201_V0.5400.96
217_P222_E0.5390.96
95_T109_Q0.5390.96
165_G192_A0.5380.96
328_G331_T0.5370.96
253_A269_S0.5370.96
283_A298_D0.5360.96
167_V188_L0.5340.96
108_A204_I0.5340.96
107_L216_E0.5320.96
204_I207_Y0.5320.96
117_T198_E0.5320.96
116_I199_S0.5320.96
288_S301_L0.5310.96
151_A191_I0.5310.96
119_D140_F0.5300.96
152_A174_V0.5300.96
235_F239_W0.5290.96
318_D323_S0.5290.96
252_V256_L0.5280.96
103_V126_D0.5270.96
149_A195_A0.5270.96
276_N279_V0.5270.96
269_S274_G0.5260.96
257_D260_S0.5250.96
118_D199_S0.5240.96
21_G66_S0.5240.96
18_V50_I0.5240.96
50_I53_D0.5240.96
271_T288_S0.5230.96
56_S134_S0.5220.96
122_V217_P0.5200.96
288_S303_D0.5190.96
247_S250_D0.5180.96
225_Q230_V0.5180.96
53_D58_D0.5160.95
220_F223_W0.5150.95
135_A233_F0.5130.95
94_T97_E0.5120.95
250_D261_I0.5120.95
42_G259_D0.5120.95
275_E289_T0.5110.95
24_A241_D0.5110.95
276_N291_S0.5100.95
79_L94_T0.5100.95
38_F47_I0.5100.95
80_A84_F0.5090.95
23_Y100_K0.5080.95
286_T291_S0.5070.95
167_V177_F0.5050.95
150_I194_Y0.5040.95
26_R37_M0.5030.95
280_L299_A0.5020.95
268_V285_L0.5020.95
133_V140_F0.5010.95
270_N288_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3brkX 2 0.9298 100 0.372 Contact Map
1yp2A 4 0.9591 100 0.387 Contact Map
2ggoA 3 0.8918 100 0.403 Contact Map
4g3qA 3 0.9327 100 0.439 Contact Map
1hm9A 3 0.9123 100 0.448 Contact Map
2v0hA 3 0.9123 100 0.473 Contact Map
4fceA 3 0.8977 100 0.479 Contact Map
2icyA 1 0.9152 100 0.513 Contact Map
3jukA 3 0.6988 100 0.517 Contact Map
2i5kA 5 0.9152 100 0.519 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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