GREMLIN Database
Q9HS60 - Uncharacterized protein
UniProt: Q9HS60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (206)
Sequences: 1142 (829)
Seq/√Len: 57.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_Q29_D3.4091.00
23_A110_I3.3861.00
156_E175_R3.3521.00
52_L205_L3.2901.00
174_R183_A2.9071.00
22_R141_Q2.8601.00
197_G202_F2.8331.00
54_E66_N2.7741.00
159_I180_A2.7061.00
146_L150_M2.6771.00
6_W30_V2.6711.00
117_D121_S2.5711.00
34_V94_A2.5701.00
21_Y155_F2.4601.00
120_T124_E2.4221.00
141_Q149_A2.2551.00
147_A176_L2.1631.00
156_E215_P2.1011.00
150_M155_F2.0321.00
92_E129_R2.0141.00
144_R148_D2.0031.00
162_V167_L1.8511.00
97_D101_T1.8100.99
61_G213_D1.8050.99
108_G135_Y1.7990.99
141_Q145_E1.7910.99
6_W110_I1.7750.99
18_W150_M1.7670.99
156_E208_D1.7650.99
111_A134_L1.7470.99
144_R185_A1.7310.99
10_F17_S1.7290.99
7_V34_V1.7030.99
6_W108_G1.6950.99
67_V97_D1.6700.99
60_I211_H1.6400.99
8_G20_L1.5980.99
96_T100_D1.5790.98
205_L216_I1.5690.98
55_L216_I1.5580.98
22_R149_A1.5380.98
95_V132_C1.4970.98
152_T178_R1.4930.98
111_A136_A1.4920.98
124_E136_A1.4850.98
59_S214_R1.4700.98
24_L211_H1.4700.98
117_D140_Q1.4590.97
28_L135_Y1.4580.97
180_A184_L1.4560.97
177_D180_A1.4450.97
221_E226_G1.4400.97
10_F56_A1.4250.97
184_L193_V1.4240.97
115_E143_P1.4200.97
208_D215_P1.4020.97
18_W153_A1.3800.96
7_V98_V1.3790.96
95_V109_V1.3760.96
36_V69_P1.3710.96
109_V127_C1.3300.96
222_T225_A1.3290.95
20_L30_V1.3230.95
148_D178_R1.2960.95
115_E140_Q1.2800.94
168_D171_W1.2780.94
58_E214_R1.2740.94
121_S125_G1.2670.94
57_A62_I1.2370.93
50_T66_N1.2330.93
163_A166_G1.2310.93
174_R177_D1.2290.93
155_F211_H1.2090.93
175_R207_T1.1910.92
148_D181_L1.1870.92
119_Q122_R1.1760.92
176_L202_F1.1740.91
156_E207_T1.1710.91
44_M71_A1.1510.91
67_V93_D1.1420.90
57_A64_V1.1410.90
55_L58_E1.1380.90
92_E130_L1.1350.90
67_V94_A1.1160.89
171_W183_A1.1160.89
124_E134_L1.1150.89
17_S56_A1.1090.89
222_T226_G1.1040.89
150_M153_A1.0960.88
30_V62_I1.0910.88
198_E201_E1.0840.88
221_E225_A1.0610.87
6_W23_A1.0570.86
21_Y25_E1.0520.86
65_V97_D1.0500.86
147_A202_F1.0470.86
113_A122_R1.0440.86
118_F122_R1.0390.86
60_I209_A1.0370.85
143_P194_H1.0320.85
19_A110_I1.0300.85
116_S119_Q1.0140.84
113_A203_E1.0110.84
21_Y24_L1.0100.84
19_A23_A1.0060.84
162_V168_D1.0040.83
9_L119_Q1.0030.83
18_W149_A0.9950.83
6_W20_L0.9620.81
221_E224_W0.9600.81
36_V67_V0.9590.81
23_A30_V0.9550.80
98_V106_L0.9480.80
7_V32_R0.9470.80
5_Q105_G0.9350.79
10_F33_L0.9250.78
167_L171_W0.9170.78
34_V98_V0.9120.77
4_G107_A0.9110.77
151_L176_L0.9100.77
42_S49_A0.9090.77
20_L62_I0.9080.77
5_Q107_A0.9040.76
65_V98_V0.9040.76
127_C134_L0.8990.76
55_L59_S0.8980.76
151_L181_L0.8870.75
20_L24_L0.8850.75
169_K222_T0.8830.75
113_A118_F0.8820.75
42_S47_V0.8820.75
6_W28_L0.8810.75
39_E68_T0.8800.75
7_V106_L0.8770.74
56_A212_M0.8750.74
146_L197_G0.8710.74
18_W22_R0.8630.73
123_M136_A0.8600.73
39_E106_L0.8600.73
21_Y153_A0.8560.72
91_L122_R0.8540.72
199_G203_E0.8530.72
176_L180_A0.8520.72
158_R207_T0.8500.72
111_A123_M0.8500.72
109_V132_C0.8490.72
148_D152_T0.8480.72
44_M123_M0.8430.71
11_S14_K0.8390.71
22_R25_E0.8350.71
178_R182_A0.8350.71
122_R127_C0.8340.70
38_P69_P0.8340.70
113_A116_S0.8260.70
150_M157_I0.8240.70
155_F210_P0.8230.69
8_G16_S0.8060.68
113_A123_M0.8040.68
18_W155_F0.7970.67
116_S203_E0.7970.67
115_E122_R0.7910.66
18_W146_L0.7890.66
126_M129_R0.7840.66
207_T218_L0.7810.65
150_M209_A0.7780.65
25_E153_A0.7760.65
93_D96_T0.7710.64
158_R175_R0.7590.63
32_R65_V0.7580.63
194_H203_E0.7550.63
115_E194_H0.7530.63
23_A135_Y0.7520.62
158_R218_L0.7510.62
45_Y119_Q0.7390.61
141_Q146_L0.7380.61
44_M116_S0.7380.61
114_V146_L0.7360.61
177_D183_A0.7340.61
157_I161_Q0.7330.60
9_L84_G0.7320.60
224_W227_D0.7300.60
222_T227_D0.7290.60
31_G106_L0.7220.59
5_Q31_G0.7200.59
84_G159_I0.7200.59
119_Q203_E0.7170.59
22_R26_A0.7130.58
208_D212_M0.6990.57
25_E204_T0.6970.57
56_A61_G0.6960.57
7_V12_G0.6950.56
50_T53_A0.6940.56
157_I206_V0.6940.56
122_R203_E0.6910.56
19_A111_A0.6900.56
155_F209_A0.6850.55
113_A163_A0.6800.55
17_S212_M0.6760.54
116_S122_R0.6730.54
19_A137_P0.6730.54
21_Y211_H0.6720.54
120_T139_W0.6720.54
37_H68_T0.6710.54
11_S36_V0.6700.54
6_W33_L0.6700.54
146_L149_A0.6690.54
118_F203_E0.6660.53
119_Q163_A0.6640.53
35_T66_N0.6590.52
167_L193_V0.6540.52
213_D219_D0.6500.52
100_D128_D0.6490.51
65_V214_R0.6490.51
23_A137_P0.6470.51
148_D159_I0.6410.51
9_L87_E0.6320.50
7_V109_V0.6320.50
220_Y224_W0.6320.50
121_S124_E0.6310.49
53_A64_V0.6310.49
87_E113_A0.6300.49
42_S116_S0.6280.49
101_T128_D0.6280.49
11_S15_D0.6270.49
127_C143_P0.6200.48
92_E96_T0.6200.48
87_E203_E0.6150.48
45_Y88_L0.6130.47
164_A193_V0.6110.47
44_M118_F0.6100.47
118_F199_G0.6100.47
30_V219_D0.6090.47
124_E128_D0.6070.47
86_T90_P0.6070.47
177_D181_L0.6060.47
171_W180_A0.6060.47
119_Q166_G0.6040.46
98_V159_I0.6000.46
41_D50_T0.5980.46
17_S155_F0.5970.46
21_Y209_A0.5970.46
4_G28_L0.5960.46
69_P90_P0.5940.45
87_E122_R0.5930.45
33_L56_A0.5930.45
42_S118_F0.5930.45
208_D211_H0.5870.45
8_G23_A0.5870.45
52_L64_V0.5830.44
223_V226_G0.5810.44
25_E155_F0.5800.44
31_G62_I0.5800.44
113_A119_Q0.5790.44
150_M207_T0.5750.43
162_V172_L0.5730.43
26_A179_D0.5700.43
32_R62_I0.5700.43
46_H115_E0.5610.42
43_Y122_R0.5590.42
36_V123_M0.5560.41
157_I175_R0.5560.41
84_G88_L0.5540.41
22_R153_A0.5540.41
171_W174_R0.5530.41
109_V119_Q0.5530.41
35_T56_A0.5520.41
71_A88_L0.5500.41
87_E116_S0.5500.41
155_F206_V0.5500.41
22_R140_Q0.5490.40
45_Y118_F0.5490.40
109_V172_L0.5490.40
195_M204_T0.5480.40
215_P218_L0.5470.40
61_G101_T0.5460.40
140_Q176_L0.5450.40
119_Q199_G0.5420.40
206_V212_M0.5420.40
9_L44_M0.5420.40
71_A90_P0.5400.40
12_G114_V0.5380.39
12_G15_D0.5370.39
155_F212_M0.5370.39
163_A203_E0.5360.39
17_S211_H0.5340.39
105_G209_A0.5330.39
177_D184_L0.5320.39
174_R178_R0.5290.38
131_G227_D0.5240.38
42_S203_E0.5230.38
38_P44_M0.5230.38
100_D169_K0.5230.38
127_C209_A0.5230.38
146_L196_L0.5200.37
7_V48_P0.5170.37
136_A203_E0.5160.37
175_R179_D0.5160.37
116_S199_G0.5150.37
107_A132_C0.5130.37
92_E125_G0.5110.37
9_L109_V0.5100.36
93_D186_A0.5090.36
93_D215_P0.5070.36
9_L163_A0.5050.36
42_S119_Q0.5050.36
65_V101_T0.5030.36
94_A166_G0.5030.36
6_W135_Y0.5010.36
174_R180_A0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rjzA 2 0.8458 100 0.413 Contact Map
2nz2A 4 0.95 99.7 0.784 Contact Map
2ywbA 4 0.8833 99.6 0.796 Contact Map
1korA 4 0.9167 99.6 0.797 Contact Map
4xfjA 4 0.9458 99.6 0.804 Contact Map
4kr6A 2 0.8375 99.6 0.806 Contact Map
2c5sA 2 0.8083 99.6 0.809 Contact Map
4nzpA 4 0.8917 99.5 0.81 Contact Map
2dplA 2 0.8792 99.5 0.812 Contact Map
1k92A 4 0.95 99.5 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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