GREMLIN Database
Q9HS59 - Uncharacterized protein
UniProt: Q9HS59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (331)
Sequences: 218 (163)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V71_A5.3461.00
38_G51_L4.5230.99
10_R82_D4.2290.99
27_W58_R3.9740.98
52_E129_V3.7790.97
12_G15_S3.6570.97
11_A46_S3.4320.95
22_T73_S3.1010.92
78_G81_A2.8620.88
17_Q37_M2.7880.87
37_M41_D2.6820.84
13_D74_A2.6560.84
6_V70_A2.5940.82
123_V279_L2.5870.82
56_V104_V2.4740.79
72_V89_F2.3510.75
223_V256_A2.3110.74
27_W31_Q2.2950.73
53_A69_V2.2740.73
167_V196_K2.2090.70
43_E150_D2.0620.65
6_V192_F2.0500.64
14_I73_S2.0310.64
75_T80_T2.0230.63
25_A90_D1.9440.60
145_K149_A1.8970.58
50_L71_A1.8950.58
111_E128_R1.8860.58
17_Q41_D1.8030.54
27_W54_L1.7930.54
24_I224_T1.7730.53
104_V176_G1.7700.53
229_G234_V1.7700.53
69_V127_D1.7570.52
157_V196_K1.7420.51
34_V107_S1.7290.51
12_G17_Q1.7290.51
7_C53_A1.7200.50
13_D17_Q1.7060.50
180_V234_V1.7050.50
13_D46_S1.6970.49
199_G284_I1.6810.49
128_R162_G1.6470.47
239_G263_S1.6370.47
263_S271_A1.6370.47
27_W37_M1.6230.46
123_V177_S1.6170.46
82_D125_A1.6100.46
120_R124_D1.5920.45
105_V121_I1.5670.44
8_V70_A1.5490.43
39_V104_V1.5400.43
88_Q117_V1.5330.42
45_A119_S1.5290.42
116_I129_V1.5170.42
52_E104_V1.5060.41
64_A173_M1.5050.41
123_V189_I1.5050.41
174_V204_V1.4870.40
22_T137_L1.4760.40
6_V196_K1.4690.40
58_R107_S1.4660.40
65_D102_V1.4620.39
74_A106_D1.4530.39
102_V163_I1.4460.39
31_Q187_T1.4410.39
5_V79_V1.4400.38
280_F293_F1.4380.38
37_M107_S1.4350.38
34_V37_M1.4130.37
215_L271_A1.3960.37
89_F202_E1.3940.37
204_V249_G1.3910.36
256_A259_F1.3790.36
109_A164_V1.3760.36
46_S107_S1.3740.36
20_L50_L1.3730.36
29_A231_L1.3690.36
33_L123_V1.3620.35
72_V229_G1.3620.35
69_V148_L1.3600.35
31_Q54_L1.3500.35
85_V152_E1.3470.35
18_T41_D1.3460.35
17_Q74_A1.3430.35
27_W107_S1.3270.34
234_V320_I1.3260.34
53_A137_L1.3220.34
8_V269_L1.3160.34
154_R198_L1.3130.33
32_S36_D1.3040.33
128_R215_L1.3010.33
310_F331_L1.2990.33
102_V115_P1.2990.33
108_A197_G1.2980.33
41_D150_D1.2880.32
269_L276_G1.2870.32
83_R197_G1.2760.32
130_V224_T1.2760.32
119_S131_V1.2740.32
128_R145_K1.2740.32
59_D305_L1.2720.32
259_F309_G1.2690.32
69_V113_V1.2670.32
59_D89_F1.2630.32
22_T79_V1.2520.31
281_D298_F1.2460.31
6_V327_P1.2440.31
37_M108_A1.2430.31
218_G298_F1.2370.31
17_Q33_L1.2370.31
4_L43_E1.2340.30
217_S229_G1.2310.30
23_P110_D1.2240.30
158_L306_V1.2150.30
112_R196_K1.2020.29
22_T93_V1.1940.29
5_V20_L1.1930.29
214_A256_A1.1900.29
324_L331_L1.1870.29
129_V268_T1.1820.29
56_V59_D1.1800.28
242_G294_V1.1730.28
9_D13_D1.1670.28
64_A186_T1.1640.28
85_V220_V1.1570.28
195_Y201_D1.1510.27
59_D64_A1.1490.27
5_V216_Y1.1480.27
50_L66_D1.1480.27
100_S124_D1.1470.27
136_D197_G1.1410.27
8_V123_V1.1400.27
90_D120_R1.1320.27
91_S166_L1.1290.27
139_S266_W1.1280.27
233_L237_F1.1210.26
322_A328_S1.1210.26
145_K156_T1.1110.26
41_D142_Y1.1080.26
160_P304_G1.1080.26
45_A117_V1.1050.26
14_I30_V1.0930.26
116_I189_I1.0920.25
13_D44_D1.0860.25
219_R258_T1.0850.25
108_A150_D1.0790.25
44_D106_D1.0780.25
236_V267_V1.0770.25
123_V183_A1.0760.25
322_A325_T1.0720.25
114_V272_L1.0660.25
34_V51_L1.0530.24
53_A82_D1.0530.24
98_P140_T1.0490.24
8_V78_G1.0470.24
4_L70_A1.0370.24
11_A107_S1.0360.24
168_F192_F1.0350.24
137_L169_P1.0340.24
5_V280_F1.0310.24
98_P185_I1.0290.23
160_P309_G1.0270.23
10_R53_A1.0230.23
37_M192_F1.0170.23
253_L257_M1.0170.23
87_Q102_V1.0150.23
117_V205_A1.0120.23
45_A81_A1.0120.23
96_H126_V1.0110.23
108_A160_P1.0060.23
270_G315_M1.0060.23
41_D108_A1.0060.23
11_A53_A1.0040.23
139_S159_V1.0000.23
50_L214_A0.9870.22
160_P266_W0.9870.22
6_V101_C0.9800.22
81_A134_A0.9800.22
12_G33_L0.9780.22
104_V229_G0.9750.22
110_D115_P0.9730.22
72_V226_V0.9720.22
4_L69_V0.9720.22
300_V303_V0.9710.22
34_V58_R0.9690.22
144_L180_V0.9690.22
116_I285_R0.9680.22
237_F240_A0.9660.22
150_D259_F0.9640.22
59_D233_L0.9560.21
24_I272_L0.9540.21
232_G240_A0.9540.21
199_G298_F0.9450.21
17_Q40_A0.9440.21
228_A277_G0.9410.21
204_V253_L0.9380.21
34_V151_E0.9320.21
220_V260_T0.9270.20
146_Q198_L0.9270.20
46_S74_A0.9250.20
52_E69_V0.9220.20
24_I253_L0.9210.20
28_E252_R0.9180.20
293_F298_F0.9180.20
13_D106_D0.9160.20
101_C150_D0.9120.20
73_S235_G0.9120.20
73_S200_V0.9110.20
144_L187_T0.9070.20
56_V317_R0.9060.20
61_R123_V0.9030.20
22_T78_G0.9010.20
58_R151_E0.8980.20
154_R294_V0.8960.20
182_A316_E0.8930.20
87_Q91_S0.8930.20
146_Q193_L0.8920.19
273_T301_L0.8910.19
22_T88_Q0.8890.19
85_V189_I0.8880.19
37_M58_R0.8880.19
12_G74_A0.8830.19
8_V22_T0.8800.19
53_A267_V0.8720.19
11_A57_T0.8710.19
12_G16_R0.8690.19
134_A154_R0.8680.19
105_V284_I0.8660.19
36_D61_R0.8600.19
5_V226_V0.8600.19
116_I157_V0.8590.19
39_V95_R0.8580.19
34_V47_V0.8560.19
325_T329_A0.8550.18
51_L107_S0.8550.18
88_Q109_A0.8540.18
166_L313_Y0.8530.18
12_G61_R0.8530.18
57_T73_S0.8530.18
79_V125_A0.8510.18
110_D117_V0.8500.18
83_R297_P0.8470.18
45_A131_V0.8450.18
3_T124_D0.8410.18
51_L147_F0.8360.18
24_I326_A0.8350.18
104_V333_A0.8350.18
99_D233_L0.8340.18
162_G197_G0.8320.18
45_A142_Y0.8300.18
30_V72_V0.8260.18
155_Q199_G0.8210.18
8_V300_V0.8180.18
182_A189_I0.8170.18
54_L77_D0.8170.18
115_P125_A0.8160.17
39_V196_K0.8150.17
5_V204_V0.8140.17
24_I116_I0.8140.17
159_V198_L0.8140.17
56_V305_L0.8130.17
114_V253_L0.8130.17
15_S46_S0.8130.17
8_V255_A0.8120.17
151_E292_S0.8090.17
169_P281_D0.8000.17
129_V162_G0.8000.17
46_S80_T0.7980.17
67_A204_V0.7960.17
136_D159_V0.7930.17
14_I27_W0.7900.17
225_Y281_D0.7880.17
121_I243_L0.7850.17
67_A113_V0.7850.17
38_G47_V0.7810.17
326_A329_A0.7790.17
203_Y284_I0.7770.17
54_L203_Y0.7750.16
145_K195_Y0.7740.16
28_E73_S0.7710.16
126_V154_R0.7690.16
159_V195_Y0.7660.16
12_G173_M0.7640.16
25_A245_N0.7630.16
307_V310_F0.7560.16
156_T270_G0.7550.16
282_E293_F0.7530.16
235_G275_S0.7500.16
86_A266_W0.7490.16
117_V169_P0.7490.16
148_L332_G0.7480.16
186_T200_V0.7470.16
14_I233_L0.7470.16
33_L46_S0.7470.16
62_D278_R0.7450.16
194_L224_T0.7440.16
196_K205_A0.7420.16
194_L277_G0.7420.16
276_G280_F0.7380.16
256_A264_I0.7380.16
27_W262_Y0.7370.16
124_D160_P0.7330.16
279_L321_V0.7300.15
115_P119_S0.7290.15
59_D265_P0.7290.15
233_L254_V0.7240.15
136_D266_W0.7230.15
81_A257_M0.7220.15
191_L206_A0.7210.15
46_S106_D0.7210.15
53_A269_L0.7180.15
11_A33_L0.7150.15
14_I85_V0.7130.15
223_V228_A0.7130.15
84_S294_V0.7130.15
261_Y312_V0.7110.15
194_L229_G0.7100.15
10_R43_E0.7080.15
39_V87_Q0.7070.15
128_R133_Q0.7040.15
66_D260_T0.7030.15
228_A270_G0.7030.15
47_V215_L0.7030.15
57_T66_D0.7020.15
125_A128_R0.6980.15
6_V13_D0.6980.15
81_A88_Q0.6960.15
85_V99_D0.6960.15
45_A74_A0.6950.15
5_V181_A0.6940.15
270_G280_F0.6930.15
178_L320_I0.6930.15
39_V52_E0.6910.15
189_I249_G0.6910.15
45_A168_F0.6900.15
171_L256_A0.6900.15
9_D26_G0.6890.15
73_S197_G0.6870.14
73_S92_L0.6870.14
105_V152_E0.6870.14
226_V269_L0.6810.14
6_V49_C0.6810.14
269_L280_F0.6800.14
10_R125_A0.6800.14
53_A93_V0.6780.14
223_V313_Y0.6770.14
83_R263_S0.6750.14
25_A171_L0.6740.14
65_D105_V0.6720.14
232_G270_G0.6710.14
103_V198_L0.6710.14
147_F272_L0.6690.14
284_I289_V0.6670.14
14_I176_G0.6670.14
132_R159_V0.6660.14
325_T328_S0.6620.14
159_V270_G0.6600.14
144_L192_F0.6590.14
88_Q139_S0.6580.14
264_I293_F0.6570.14
36_D132_R0.6540.14
139_S160_P0.6520.14
90_D331_L0.6490.14
258_T262_Y0.6440.14
55_R58_R0.6440.14
109_A138_E0.6440.14
174_V245_N0.6440.14
159_V266_W0.6420.14
67_A181_A0.6400.14
125_A159_V0.6380.13
116_I150_D0.6380.13
84_S87_Q0.6380.13
46_S57_T0.6370.13
13_D138_E0.6360.13
2_R151_E0.6350.13
30_V37_M0.6340.13
22_T96_H0.6320.13
35_T50_L0.6320.13
219_R298_F0.6320.13
43_E160_P0.6320.13
75_T123_V0.6310.13
93_V121_I0.6270.13
51_L292_S0.6260.13
67_A144_L0.6260.13
70_A113_V0.6250.13
88_Q262_Y0.6230.13
224_T231_L0.6220.13
189_I333_A0.6210.13
13_D37_M0.6200.13
266_W315_M0.6200.13
184_S209_G0.6180.13
8_V13_D0.6160.13
19_G121_I0.6150.13
207_L313_Y0.6150.13
101_C113_V0.6130.13
139_S150_D0.6120.13
15_S33_L0.6090.13
237_F303_V0.6090.13
33_L71_A0.6080.13
65_D235_G0.6080.13
102_V174_V0.6080.13
272_L307_V0.6070.13
117_V229_G0.6070.13
188_V192_F0.6070.13
20_L61_R0.6000.13
24_I77_D0.5960.13
192_F196_K0.5960.13
161_V288_D0.5950.13
144_L314_F0.5940.13
14_I25_A0.5930.13
159_V216_Y0.5910.13
122_Q222_I0.5910.13
30_V81_A0.5900.13
3_T67_A0.5880.12
156_T160_P0.5860.12
66_D262_Y0.5860.12
135_R290_R0.5840.12
28_E93_V0.5830.12
53_A182_A0.5820.12
14_I67_A0.5820.12
55_R105_V0.5810.12
27_W111_E0.5790.12
165_L218_G0.5790.12
133_Q143_L0.5780.12
55_R59_D0.5770.12
14_I61_R0.5770.12
328_S332_G0.5760.12
126_V260_T0.5750.12
8_V53_A0.5750.12
54_L332_G0.5750.12
15_S68_V0.5740.12
7_C139_S0.5740.12
5_V301_L0.5730.12
95_R104_V0.5700.12
21_R249_G0.5670.12
104_V319_G0.5650.12
141_Y266_W0.5630.12
8_V287_D0.5610.12
129_V176_G0.5590.12
97_D294_V0.5580.12
167_V232_G0.5570.12
114_V192_F0.5570.12
157_V193_L0.5570.12
146_Q165_L0.5550.12
24_I91_S0.5540.12
12_G333_A0.5530.12
81_A161_V0.5520.12
76_G226_V0.5510.12
54_L98_P0.5500.12
6_V16_R0.5490.12
67_A92_L0.5490.12
72_V117_V0.5480.12
17_Q58_R0.5450.12
36_D315_M0.5440.12
117_V135_R0.5440.12
129_V260_T0.5430.12
184_S202_E0.5420.12
53_A115_P0.5410.12
98_P276_G0.5410.12
38_G143_L0.5390.12
243_L259_F0.5390.12
5_V67_A0.5390.12
40_A58_R0.5370.12
29_A233_L0.5370.12
162_G168_F0.5370.12
220_V296_L0.5330.11
39_V322_A0.5330.11
127_D168_F0.5320.11
162_G188_V0.5300.11
67_A226_V0.5300.11
141_Y194_L0.5260.11
320_I330_A0.5250.11
17_Q192_F0.5240.11
86_A120_R0.5230.11
205_A285_R0.5230.11
7_C277_G0.5220.11
42_P57_T0.5210.11
117_V303_V0.5180.11
109_A153_L0.5180.11
123_V174_V0.5170.11
157_V265_P0.5160.11
223_V309_G0.5140.11
227_V248_A0.5130.11
220_V249_G0.5110.11
2_R118_E0.5100.11
64_A148_L0.5100.11
98_P125_A0.5090.11
43_E108_A0.5080.11
28_E69_V0.5040.11
101_C196_K0.5030.11
251_S279_L0.5020.11
327_P331_L0.5020.11
165_L260_T0.5010.11
41_D277_G0.5010.11
223_V259_F0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j29A 2 0.1361 51.8 0.971 Contact Map
2aifA 1 0.1283 49.2 0.971 Contact Map
1e2bA 1 0.233 44.3 0.972 Contact Map
3ar4A 1 0.8482 34.4 0.973 Contact Map
4nutA 1 0.1335 29.3 0.974 Contact Map
4bbjA 1 0.4817 28.6 0.975 Contact Map
4ezeA 1 0.3743 23.5 0.976 Contact Map
2l2qA 1 0.233 20.7 0.976 Contact Map
2yxbA 1 0.3141 20.5 0.976 Contact Map
2gmwA 1 0.3063 19.5 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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