GREMLIN Database
Q9HS58 - Uncharacterized protein
UniProt: Q9HS58 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (250)
Sequences: 36450 (32212)
Seq/√Len: 2037.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_A188_H2.2671.00
240_F243_V2.2091.00
37_F41_R2.2091.00
34_A37_F2.1201.00
90_R93_L2.0941.00
27_K30_L2.0691.00
76_R80_N2.0571.00
226_F229_A2.0041.00
184_A187_H1.9741.00
177_A180_V1.9511.00
97_A100_L1.9431.00
90_R94_N1.9351.00
219_A222_M1.9311.00
119_L123_K1.9121.00
198_A201_H1.9071.00
41_R45_N1.9031.00
55_R59_N1.8571.00
212_A215_I1.8421.00
41_R44_L1.8301.00
212_A216_R1.7941.00
62_T65_K1.7661.00
76_R79_L1.7531.00
55_R58_L1.7371.00
126_I130_E1.7331.00
48_A51_R1.7191.00
72_H76_R1.7151.00
104_V107_R1.7001.00
69_A72_H1.6931.00
247_L250_L1.6901.00
180_V184_A1.6841.00
191_V194_L1.6821.00
233_A236_H1.6811.00
104_V108_K1.6691.00
236_H240_F1.6591.00
170_L173_L1.6531.00
19_D22_L1.6401.00
83_V86_H1.6331.00
215_I219_A1.6281.00
240_F244_Q1.6191.00
229_A233_A1.6001.00
198_A202_H1.5651.00
97_A101_F1.5361.00
48_A52_A1.5321.00
205_M208_A1.5261.00
86_H90_R1.4901.00
106_Q110_D1.4811.00
126_I129_L1.4751.00
254_E257_E1.4711.00
194_L198_A1.4591.00
176_E181_R1.4571.00
27_K31_I1.4471.00
29_Q33_N1.4471.00
172_G176_E1.4461.00
152_G156_E1.4391.00
186_K190_K1.4391.00
261_K265_E1.4361.00
243_V247_L1.4331.00
177_A181_R1.4151.00
247_L251_D1.4121.00
93_L97_A1.4101.00
170_L174_V1.4001.00
92_D96_D1.3961.00
219_A223_H1.3941.00
99_E103_E1.3791.00
128_E132_K1.3681.00
62_T66_V1.3551.00
254_E258_E1.3441.00
100_L104_V1.3421.00
214_D218_E1.3231.00
242_E246_R1.3201.00
149_K154_R1.3181.00
246_R251_D1.3181.00
103_E108_K1.3171.00
118_D123_K1.3131.00
19_D23_Q1.3111.00
235_A239_A1.3091.00
15_E19_D1.3061.00
249_E253_Q1.2971.00
187_H191_V1.2971.00
119_L122_L1.2961.00
78_E82_R1.2881.00
30_L34_A1.2781.00
261_K264_Q1.2701.00
111_L115_E1.2591.00
121_Q125_E1.2481.00
43_E47_L1.2471.00
228_E232_A1.2471.00
226_F230_Q1.2441.00
36_Q40_R1.2411.00
257_E261_K1.2411.00
150_I154_R1.2391.00
208_A212_A1.2281.00
96_D99_E1.1941.00
125_E130_E1.1931.00
33_N38_R1.1881.00
245_K249_E1.1851.00
233_A237_H1.1791.00
207_E211_E1.1701.00
96_D101_F1.1701.00
146_L150_I1.1651.00
193_E197_K1.1571.00
183_E186_K1.1511.00
221_E225_D1.1421.00
58_L62_T1.1381.00
175_E179_S1.1351.00
205_M209_Y1.1331.00
150_I153_K1.1261.00
155_E159_D1.1251.00
201_H205_M1.1211.00
191_V195_A1.1191.00
34_A38_R1.1171.00
133_Q137_V1.1131.00
117_K121_Q1.1081.00
44_L48_A1.1031.00
83_V87_K1.1011.00
200_E204_Q1.0991.00
211_E216_R1.0941.00
166_Q170_L1.0881.00
64_E68_E1.0831.00
238_E242_E1.0811.00
40_R45_N1.0811.00
241_V244_Q1.0771.00
17_I21_E1.0741.00
115_E119_L1.0741.00
61_K66_V1.0701.00
239_A244_Q1.0621.00
222_M226_F1.0551.00
57_D61_K1.0551.00
67_D71_E1.0491.00
118_D121_Q1.0471.00
157_Y161_E1.0471.00
178_E181_R1.0451.00
241_V245_K1.0391.00
169_D174_V1.0331.00
71_E75_K1.0281.00
89_I92_D1.0271.00
68_E73_R1.0231.00
51_R55_R1.0231.00
157_Y160_R1.0231.00
225_D230_Q1.0161.00
183_E188_H1.0121.00
133_Q136_E1.0111.00
22_L27_K1.0051.00
179_S183_E1.0041.00
197_K202_H0.9991.00
82_R85_E0.9961.00
156_E161_E0.9941.00
149_K152_G0.9871.00
85_E89_I0.9871.00
145_E149_K0.9771.00
176_E179_S0.9761.00
125_E128_E0.9751.00
122_L126_I0.9751.00
169_D172_G0.9731.00
54_E59_N0.9711.00
50_S54_E0.9701.00
167_S171_E0.9681.00
135_T139_S0.9681.00
127_E131_F0.9641.00
69_A73_R0.9641.00
37_F40_R0.9631.00
33_N36_Q0.9611.00
82_R87_K0.9601.00
182_A186_K0.9591.00
98_N101_F0.9561.00
40_R43_E0.9511.00
65_K69_A0.9471.00
256_E260_D0.9471.00
239_A242_E0.9471.00
124_E128_E0.9441.00
13_A17_I0.9431.00
232_A237_H0.9431.00
63_R66_V0.9431.00
185_S188_H0.9351.00
42_N45_N0.9351.00
120_E123_K0.9341.00
173_L177_A0.9331.00
220_D223_H0.9321.00
59_N63_R0.9321.00
248_R251_D0.9281.00
136_E139_S0.9261.00
196_D200_E0.9251.00
160_R164_L0.9251.00
61_K64_E0.9231.00
253_Q258_E0.9171.00
127_E130_E0.9161.00
180_V183_E0.9161.00
70_Q74_E0.9141.00
102_D106_Q0.9131.00
72_H75_K0.9111.00
103_E106_Q0.9091.00
262_R265_E0.9071.00
28_G31_I0.8991.00
77_D80_N0.8901.00
171_E174_V0.8901.00
202_H206_I0.8881.00
231_E235_A0.8821.00
178_E182_A0.8791.00
60_A64_E0.8771.00
229_A232_A0.8741.00
18_T23_Q0.8731.00
197_K200_E0.8711.00
88_E92_D0.8701.00
156_E159_D0.8681.00
89_I94_N0.8671.00
218_E223_H0.8641.00
91_N94_N0.8551.00
66_V70_Q0.8541.00
81_E85_E0.8521.00
213_D216_R0.8501.00
204_Q209_Y0.8481.00
181_R184_A0.8451.00
98_N102_D0.8401.00
137_V141_E0.8381.00
174_V178_E0.8341.00
227_V230_Q0.8331.00
199_Q202_H0.8301.00
246_R249_E0.8281.00
91_N95_A0.8271.00
126_I133_Q0.8261.00
47_L52_A0.8221.00
225_D228_E0.8171.00
171_E175_E0.8161.00
47_L50_S0.8161.00
73_R76_R0.8151.00
94_N98_N0.8131.00
129_L132_K0.8131.00
144_R147_I0.8121.00
86_H89_I0.8121.00
243_V246_R0.8121.00
75_K78_E0.8021.00
49_S53_S0.8011.00
225_D229_A0.8011.00
204_Q207_E0.8001.00
120_E124_E0.7991.00
195_A199_Q0.7961.00
148_E152_G0.7951.00
151_E155_E0.7941.00
79_L83_V0.7931.00
220_D224_E0.7921.00
244_Q248_R0.7901.00
46_Q50_S0.7891.00
24_N29_Q0.7891.00
105_E108_K0.7851.00
39_D43_E0.7841.00
68_E71_E0.7841.00
168_G172_G0.7831.00
234_D237_H0.7811.00
227_V231_E0.7801.00
240_F247_L0.7781.00
20_D23_Q0.7781.00
210_R214_D0.7771.00
49_S52_A0.7731.00
147_I151_E0.7681.00
38_R42_N0.7661.00
56_D59_N0.7641.00
190_K193_E0.7631.00
203_N207_E0.7631.00
234_D238_E0.7631.00
105_E109_E0.7621.00
123_K127_E0.7621.00
217_D221_E0.7561.00
23_Q28_G0.7561.00
84_Q87_K0.7541.00
77_D81_E0.7541.00
84_Q88_E0.7501.00
93_L96_D0.7501.00
230_Q234_D0.7491.00
159_D163_K0.7461.00
51_R54_E0.7431.00
239_A243_V0.7421.00
61_K65_K0.7421.00
32_K36_Q0.7411.00
129_L133_Q0.7401.00
35_G38_R0.7391.00
237_H241_V0.7361.00
35_G39_D0.7351.00
33_N37_F0.7331.00
185_S189_E0.7321.00
140_T144_R0.7321.00
211_E214_D0.7291.00
65_K68_E0.7291.00
74_E78_E0.7291.00
223_H227_V0.7241.00
154_R158_Q0.7161.00
112_E116_G0.7141.00
38_R41_R0.7111.00
215_I218_E0.7091.00
70_Q73_R0.6981.00
131_F135_T0.6951.00
161_E165_D0.6921.00
166_Q169_D0.6901.00
95_A99_E0.6881.00
80_N84_Q0.6851.00
14_D18_T0.6841.00
31_I35_G0.6841.00
218_E221_E0.6811.00
107_R110_D0.6801.00
45_N49_S0.6791.00
54_E57_D0.6781.00
13_A16_L0.6771.00
58_L61_K0.6771.00
28_G32_K0.6761.00
248_R252_K0.6731.00
63_R67_D0.6731.00
224_E228_E0.6701.00
32_K35_G0.6541.00
100_L103_E0.6501.00
257_E260_D0.6501.00
130_E134_Q0.6491.00
87_K91_N0.6491.00
253_Q257_E0.6451.00
190_K195_A0.6441.00
209_Y213_D0.6351.00
216_R219_A0.6301.00
199_Q203_N0.6271.00
52_A55_R0.6251.00
87_K90_R0.6241.00
18_T21_E0.6151.00
252_K256_E0.6151.00
192_T195_A0.6141.00
56_D60_A0.6121.00
151_E154_R0.6091.00
260_D263_A0.6081.00
255_E259_K0.6051.00
250_L254_E0.6051.00
187_H190_K0.6021.00
158_Q161_E0.6011.00
255_E258_E0.5991.00
20_D24_N0.5991.00
67_D70_Q0.5981.00
175_E178_E0.5981.00
206_I209_Y0.5971.00
222_M225_D0.5951.00
158_Q162_E0.5941.00
213_D217_D0.5921.00
232_A235_A0.5891.00
16_L20_D0.5881.00
119_L126_I0.5861.00
216_R220_D0.5851.00
251_D255_E0.5751.00
146_L149_K0.5741.00
259_K263_A0.5731.00
47_L51_R0.5681.00
201_H204_Q0.5681.00
192_T196_D0.5641.00
88_E91_N0.5631.00
194_L197_K0.5511.00
75_K80_N0.5501.00
96_D100_L0.5481.00
170_L177_A0.5421.00
236_H239_A0.5421.00
60_A63_R0.5391.00
15_E18_T0.5361.00
138_L142_D0.5321.00
189_E193_E0.5301.00
68_E72_H0.5281.00
161_E164_L0.5271.00
52_A56_D0.5271.00
188_H192_T0.5271.00
260_D265_E0.5261.00
101_F105_E0.5241.00
198_A205_M0.5221.00
44_L47_L0.5211.00
53_S57_D0.5191.00
131_F134_Q0.5191.00
124_E127_E0.5181.00
117_K120_E0.5171.00
30_L33_N0.5161.00
258_E261_K0.5091.00
19_D27_K0.5081.00
94_N97_A0.5071.00
42_N46_Q0.5031.00
253_Q256_E0.5011.00
97_A104_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.27 99.3 0.323 Contact Map
1c1gA 2 0.9333 99.1 0.391 Contact Map
2dfsA 2 0.4267 96.6 0.66 Contact Map
4linA 5 0.7333 96.1 0.675 Contact Map
2v71A 3 0.4833 95.5 0.69 Contact Map
4cgkA 3 0.7533 95.4 0.692 Contact Map
4uxvA 1 0.9233 94.4 0.709 Contact Map
3ojaB 1 0.43 93.6 0.718 Contact Map
4iloA 3 0.6367 92.8 0.727 Contact Map
3o0zA 2 0.51 92.7 0.728 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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