GREMLIN Database
Q9HS57 - Uncharacterized protein
UniProt: Q9HS57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (131)
Sequences: 186 (129)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_G106_F3.8390.99
93_V103_R3.4690.98
29_L33_G3.1910.96
91_S101_D3.1040.96
28_F39_I2.7760.92
91_S103_R2.6240.90
21_L67_L2.4220.86
67_L130_L2.2170.80
74_D111_K2.1980.79
116_V120_L2.1270.77
112_A115_D2.1230.77
69_T120_L2.0610.75
7_A26_D2.0300.73
45_P48_F1.9340.70
45_P105_V1.9340.70
93_V101_D1.8560.66
30_T33_G1.8540.66
5_V41_A1.7730.63
25_T44_S1.7530.62
68_D71_Q1.6810.58
65_L132_A1.6750.58
88_N91_S1.6630.57
85_T100_V1.6490.57
76_I110_D1.6470.57
8_T40_D1.6400.56
81_H107_V1.6380.56
65_L78_G1.5660.53
94_G116_V1.5500.52
88_N101_D1.5470.52
26_D90_R1.5350.51
53_V86_F1.5320.51
23_L102_D1.5010.50
120_L132_A1.4790.48
68_D73_R1.4290.46
37_L116_V1.3680.43
7_A38_G1.3460.42
88_N102_D1.3300.41
91_S99_Y1.3300.41
90_R101_D1.2930.40
23_L87_T1.2680.38
13_V27_D1.2610.38
59_A110_D1.2570.38
5_V42_D1.2370.37
74_D117_D1.2090.36
42_D134_L1.1990.35
25_T111_K1.1970.35
85_T102_D1.1880.35
44_S88_N1.1820.35
5_V51_A1.1730.34
11_D98_T1.1720.34
28_F99_Y1.1490.33
43_C49_S1.1110.31
25_T92_M1.1030.31
78_G127_G1.0940.31
57_Q76_I1.0840.30
64_T93_V1.0770.30
5_V71_Q1.0740.30
52_F134_L1.0720.30
26_D56_C1.0670.30
26_D94_G1.0420.29
42_D52_F1.0340.28
65_L111_K1.0270.28
19_S91_S1.0180.28
69_T116_V1.0120.27
67_L116_V1.0090.27
21_L39_I0.9860.26
12_N78_G0.9700.26
100_V107_V0.9670.26
111_K115_D0.9630.26
63_I86_F0.9560.25
5_V134_L0.9510.25
34_D112_A0.9400.25
56_C63_I0.9370.25
25_T47_A0.9340.25
54_A98_T0.9320.24
66_V73_R0.9310.24
17_H39_I0.9240.24
56_C86_F0.9220.24
94_G105_V0.9210.24
55_A109_A0.9150.24
80_G84_L0.9140.24
37_L76_I0.9120.24
105_V134_L0.9010.23
109_A113_A0.8980.23
62_T93_V0.8920.23
38_G67_L0.8820.23
78_G110_D0.8810.23
26_D63_I0.8660.22
48_F133_T0.8650.22
57_Q85_T0.8570.22
111_K116_V0.8500.22
15_A121_V0.8440.21
19_S52_F0.8400.21
21_L94_G0.8250.21
69_T89_D0.8190.21
71_Q76_I0.8140.20
94_G106_F0.8110.20
77_T110_D0.7900.20
17_H84_L0.7890.20
68_D131_T0.7850.20
37_L40_D0.7800.19
122_A128_A0.7790.19
47_A85_T0.7670.19
86_F100_V0.7660.19
23_L58_D0.7650.19
34_D115_D0.7530.19
44_S48_F0.7490.18
69_T72_H0.7420.18
17_H80_G0.7380.18
122_A125_A0.7370.18
39_I73_R0.7330.18
105_V126_D0.7330.18
76_I133_T0.7300.18
127_G130_L0.7260.18
65_L106_F0.7190.18
71_Q89_D0.7130.17
56_C106_F0.7030.17
42_D49_S0.6980.17
62_T126_D0.6960.17
26_D102_D0.6930.17
50_D116_V0.6900.17
50_D105_V0.6890.17
19_S67_L0.6740.16
5_V84_L0.6710.16
55_A112_A0.6690.16
31_P113_A0.6680.16
106_F117_D0.6680.16
21_L86_F0.6660.16
42_D123_A0.6640.16
26_D40_D0.6620.16
74_D120_L0.6600.16
50_D54_A0.6600.16
38_G130_L0.6550.16
46_A61_A0.6540.16
107_V121_V0.6530.16
19_S89_D0.6510.16
70_P100_V0.6480.16
45_P109_A0.6410.16
110_D114_A0.6390.15
87_T102_D0.6380.15
48_F128_A0.6360.15
13_V51_A0.6340.15
38_G115_D0.6330.15
28_F91_S0.6330.15
18_D46_A0.6320.15
21_L88_N0.6250.15
63_I108_D0.6220.15
69_T76_I0.6210.15
63_I134_L0.6190.15
23_L45_P0.6180.15
70_P82_P0.6150.15
18_D76_I0.6130.15
62_T108_D0.6100.15
62_T103_R0.6040.15
54_A94_G0.6030.15
28_F33_G0.6030.15
11_D19_S0.6010.15
66_V74_D0.5920.14
69_T105_V0.5850.14
6_S42_D0.5840.14
32_A125_A0.5840.14
18_D111_K0.5810.14
62_T73_R0.5760.14
65_L134_L0.5730.14
4_S131_T0.5720.14
28_F88_N0.5720.14
23_L39_I0.5700.14
8_T70_P0.5680.14
56_C107_V0.5600.14
59_A79_S0.5590.14
47_A98_T0.5570.13
15_A110_D0.5550.13
46_A88_N0.5550.13
60_A74_D0.5530.13
18_D48_F0.5520.13
12_N31_P0.5500.13
78_G94_G0.5470.13
4_S77_T0.5470.13
7_A48_F0.5440.13
61_A112_A0.5390.13
14_T127_G0.5390.13
44_S65_L0.5380.13
74_D100_V0.5380.13
68_D121_V0.5350.13
18_D44_S0.5340.13
30_T39_I0.5330.13
15_A45_P0.5320.13
26_D61_A0.5310.13
86_F89_D0.5280.13
63_I103_R0.5270.13
66_V93_V0.5240.13
106_F127_G0.5140.13
32_A57_Q0.5130.13
117_D122_A0.5010.12
65_L92_M0.5010.12
59_A82_P0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cbnA 1 0.9927 100 0.045 Contact Map
2rodB 1 0.1971 13.9 0.953 Contact Map
3k7pA 4 0.2701 12.6 0.954 Contact Map
3pl5A 1 0.219 12.4 0.954 Contact Map
2pt5A 2 0.8905 11.8 0.954 Contact Map
4cnkA 2 0.4599 7.6 0.958 Contact Map
3fysA 1 0.2336 6.2 0.96 Contact Map
2odfA 2 0.8394 6 0.96 Contact Map
3akoA 1 0.4088 5.7 0.961 Contact Map
1xgwA 1 0.4599 5.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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