GREMLIN Database
Q9HS56 - Endonuclease III
UniProt: Q9HS56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (203)
Sequences: 6884 (4185)
Seq/√Len: 293.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_A147_A3.9611.00
81_A89_A3.5561.00
232_A239_A3.2401.00
121_R125_E3.1271.00
142_D169_A2.8331.00
78_R97_V2.7621.00
227_T232_A2.7251.00
37_G210_A2.5871.00
121_R152_T2.5771.00
126_Y150_D2.4741.00
98_L116_I2.4471.00
116_I120_D2.2721.00
100_D103_S2.2511.00
196_E200_A2.2241.00
78_R101_T2.1981.00
114_T117_R2.0761.00
58_V118_I2.0401.00
243_A249_V2.0271.00
49_A52_E2.0091.00
234_L239_A1.9541.00
88_A123_C1.9171.00
80_G89_A1.9011.00
117_R152_T1.8591.00
35_R244_E1.8131.00
37_G213_F1.8121.00
55_V115_I1.7791.00
95_Q99_A1.7791.00
120_D124_E1.7661.00
88_A92_D1.7651.00
125_E150_D1.7271.00
94_D97_V1.7201.00
95_Q116_I1.7011.00
199_R203_E1.6331.00
188_I247_D1.6201.00
73_D77_Q1.6071.00
143_A146_A1.6051.00
147_A150_D1.6021.00
79_Y101_T1.5891.00
110_Q114_T1.5671.00
31_L245_H1.5581.00
48_R52_E1.5491.00
198_V202_L1.5241.00
180_H198_V1.4911.00
74_A77_Q1.4871.00
189_A201_A1.4731.00
63_T67_A1.4501.00
247_D251_V1.4401.00
31_L34_D1.4191.00
121_R150_D1.4111.00
210_A213_F1.4021.00
74_A101_T1.3941.00
186_M242_L1.3881.00
51_F82_A1.3821.00
123_C128_G1.3711.00
156_P199_R1.3681.00
51_F119_A1.3491.00
186_M245_H1.3471.00
52_E76_M1.3431.00
79_Y93_A1.3141.00
129_A142_D1.3011.00
199_R202_L1.2861.00
142_D167_G1.2831.00
110_Q113_A1.2771.00
55_V76_M1.2751.00
225_Y241_P1.2661.00
63_T105_A1.2631.00
54_L58_V1.2511.00
149_L156_P1.2451.00
93_A98_L1.2411.00
70_P73_D1.2351.00
60_S65_D1.2341.00
117_R120_D1.2321.00
121_R126_Y1.2311.00
220_Q224_E1.2281.00
206_V214_G1.2221.00
36_L40_Y1.2161.00
81_A88_A1.2151.00
163_L169_A1.1921.00
96_D99_A1.1911.00
148_L163_L1.1891.00
169_A172_V1.1761.00
67_A70_P1.1631.00
163_L172_V1.1601.00
33_V37_G1.1341.00
35_R39_L1.1301.00
54_L162_V1.1291.00
118_I151_M1.1161.00
99_A108_Y1.0981.00
126_Y147_A1.0881.00
90_L98_L1.0731.00
233_C246_C1.0671.00
226_C233_C1.0641.00
188_I253_A1.0591.00
196_E199_R1.0541.00
40_Y220_Q1.0471.00
188_I251_V1.0461.00
64_S67_A1.0341.00
95_Q120_D1.0331.00
50_A166_A1.0181.00
117_R121_R1.0141.00
52_E72_H1.0101.00
125_E147_A1.0101.00
90_L119_A1.0051.00
213_F217_A1.0051.00
122_V130_D1.0021.00
32_V242_L0.9991.00
164_L215_H0.9991.00
118_I121_R0.9791.00
214_G218_M0.9751.00
46_G73_D0.9661.00
118_I122_V0.9641.00
194_D197_A0.9641.00
193_A198_V0.9641.00
51_F90_L0.9621.00
191_A198_V0.9501.00
94_D116_I0.9451.00
39_L241_P0.9431.00
95_Q113_A0.9381.00
42_Q46_G0.9331.00
34_D38_E0.9211.00
72_H76_M0.9101.00
66_K70_P0.9051.00
31_L35_R0.8991.00
69_Q73_D0.8971.00
221_F225_Y0.8931.00
242_L245_H0.8881.00
113_A117_R0.8871.00
28_Q242_L0.8871.00
193_A202_L0.8851.00
183_A218_M0.8771.00
164_L174_P0.8761.00
91_A119_A0.8731.00
146_A149_L0.8691.00
47_G52_E0.8681.00
208_D211_C0.8671.00
164_L212_G0.8571.00
36_L216_T0.8521.00
160_D173_F0.8501.00
183_A202_L0.8481.00
54_L118_I0.8451.00
173_F203_E0.8451.00
197_A201_A0.8441.00
184_R198_V0.8441.00
226_C246_C0.8401.00
33_V213_F0.8351.00
53_C166_A0.8341.00
163_L167_G0.8341.00
225_Y239_A0.8331.00
66_K69_Q0.8321.00
130_D148_L0.8311.00
74_A78_R0.8281.00
173_F211_C0.8241.00
249_V253_A0.8241.00
184_R189_A0.8211.00
168_G212_G0.8211.00
191_A197_A0.8201.00
95_Q112_S0.8201.00
30_A34_D0.8141.00
195_H198_V0.8121.00
156_P160_D0.8101.00
165_F212_G0.8101.00
52_E80_G0.8071.00
97_V101_T0.8061.00
55_V118_I0.7960.99
47_G53_C0.7930.99
226_C240_C0.7890.99
247_D250_G0.7730.99
59_L68_S0.7680.99
49_A53_C0.7680.99
174_P215_H0.7670.99
123_C126_Y0.7650.99
93_A97_V0.7640.99
201_A204_A0.7640.99
57_T165_F0.7620.99
35_R241_P0.7600.99
35_R245_H0.7590.99
231_P246_C0.7510.99
221_F241_P0.7460.99
82_A123_C0.7430.99
67_A104_M0.7380.99
112_S115_I0.7360.99
221_F224_E0.7330.99
115_I119_A0.7290.99
32_V217_A0.7160.99
35_R38_E0.7140.99
170_P208_D0.7130.99
197_A200_A0.7100.99
233_C240_C0.7080.99
182_I221_F0.7080.99
79_Y98_L0.7040.99
200_A203_E0.6990.99
210_A217_A0.6890.98
29_A205_A0.6830.98
154_V162_V0.6760.98
150_D163_L0.6740.98
195_H199_R0.6720.98
190_P253_A0.6710.98
200_A204_A0.6710.98
74_A104_M0.6680.98
97_V100_D0.6680.98
29_A207_P0.6680.98
67_A105_A0.6660.98
70_P74_A0.6660.98
30_A209_A0.6660.98
88_A128_G0.6660.98
49_A80_G0.6640.98
82_A130_D0.6620.98
71_A74_A0.6620.98
91_A123_C0.6610.98
34_D37_G0.6590.98
149_L159_A0.6530.98
173_F206_V0.6490.98
173_F214_G0.6460.98
33_V210_A0.6420.98
160_D174_P0.6420.98
180_H184_R0.6420.98
37_G217_A0.6340.97
227_T230_D0.6320.97
91_A116_I0.6280.97
187_G205_A0.6280.97
82_A88_A0.6260.97
172_V203_E0.6250.97
55_V58_V0.6230.97
203_E211_C0.6200.97
170_P212_G0.6190.97
40_Y221_F0.6190.97
58_V154_V0.6190.97
194_D198_V0.6180.97
193_A197_A0.6130.97
112_S116_I0.6120.97
57_T158_T0.6100.97
43_K220_Q0.6090.97
41_W223_R0.6060.97
240_C246_C0.6060.97
245_H249_V0.6040.97
185_R226_C0.6030.97
185_R231_P0.6000.96
177_T228_A0.5990.96
57_T162_V0.5990.96
158_T162_V0.5980.96
160_D199_R0.5980.96
79_Y97_V0.5940.96
122_V128_G0.5940.96
91_A94_D0.5910.96
68_S105_A0.5890.96
206_V211_C0.5890.96
120_D123_C0.5880.96
129_A167_G0.5870.96
148_L172_V0.5870.96
121_R151_M0.5860.96
185_R233_C0.5860.96
148_L162_V0.5850.96
143_A169_A0.5840.96
101_T104_M0.5800.96
193_A199_R0.5790.96
154_V158_T0.5790.96
65_D68_S0.5760.96
52_E90_L0.5740.95
99_A112_S0.5710.95
89_A92_D0.5710.95
142_D147_A0.5710.95
32_V36_L0.5710.95
185_R227_T0.5700.95
34_D210_A0.5690.95
165_F216_T0.5690.95
50_A167_G0.5690.95
61_Q158_T0.5670.95
36_L217_A0.5650.95
175_V179_V0.5620.95
30_A210_A0.5610.95
162_V166_A0.5600.95
157_K175_V0.5590.95
211_C215_H0.5590.95
98_L102_I0.5560.95
207_P211_C0.5560.95
93_A116_I0.5540.94
80_G93_A0.5520.94
91_A120_D0.5500.94
143_A163_L0.5490.94
170_P211_C0.5470.94
60_S219_I0.5460.94
45_Y48_R0.5460.94
80_G90_L0.5450.94
32_V218_M0.5430.94
148_L154_V0.5430.94
186_M247_D0.5390.94
33_V36_L0.5370.94
121_R124_E0.5350.93
82_A119_A0.5310.93
40_Y213_F0.5310.93
56_R76_M0.5280.93
164_L172_V0.5280.93
54_L122_V0.5230.93
149_L160_D0.5200.92
98_L101_T0.5200.92
28_Q186_M0.5200.92
172_V211_C0.5170.92
92_D123_C0.5130.92
54_L130_D0.5120.92
55_V119_A0.5070.91
33_V206_V0.5070.91
32_V186_M0.5040.91
175_V198_V0.5020.91
65_D69_Q0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kg2A 1 0.8226 100 0.287 Contact Map
3fspA 1 0.834 100 0.291 Contact Map
4uobA 1 0.8642 100 0.293 Contact Map
4unfA 1 0.8717 100 0.296 Contact Map
3n5nX 1 0.8604 100 0.299 Contact Map
2abkA 1 0.7887 100 0.309 Contact Map
1ornA 1 0.8 100 0.313 Contact Map
1keaA 2 0.8038 100 0.318 Contact Map
1pu6A 1 0.7321 100 0.415 Contact Map
3s6iA 1 0.7358 100 0.5 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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