GREMLIN Database
SYP - Proline--tRNA ligase
UniProt: Q9HS52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 501 (382)
Sequences: 3484 (1556)
Seq/√Len: 79.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_D257_R5.9201.00
30_G44_R3.4171.00
312_Y315_E3.3431.00
61_W64_D3.3321.00
253_D257_R3.2901.00
382_A385_D3.1331.00
75_F145_V3.0641.00
315_E319_E3.0221.00
295_V325_V2.9721.00
317_A321_E2.6421.00
239_Q260_Y2.5981.00
192_E199_V2.5721.00
61_W189_R2.5191.00
297_I317_A2.4881.00
75_F112_V2.4791.00
178_A182_L2.4711.00
364_E379_D2.4171.00
307_D311_Q2.4111.00
171_A252_E2.3751.00
15_E281_D2.3561.00
68_E328_H2.3241.00
189_R193_D2.3221.00
319_E384_A2.3181.00
386_R389_D2.3091.00
332_R343_E2.3021.00
171_A249_F2.2861.00
56_D60_G2.2771.00
364_E377_V2.2381.00
248_T256_E2.2321.00
170_H175_A2.2201.00
309_V357_P2.2191.00
177_W236_H2.2121.00
296_V344_W2.2011.00
294_Q326_R2.1941.00
337_P341_F2.1911.00
314_A318_A2.1851.00
188_H192_E2.1591.00
239_Q243_D2.1471.00
317_A329_F2.1171.00
78_E109_R2.1041.00
52_E55_Q2.0901.00
67_V179_E2.0261.00
382_A386_R2.0161.00
376_T386_R2.0131.00
379_D382_A1.9991.00
312_Y360_V1.9961.00
216_T219_V1.9831.00
275_V284_L1.9021.00
170_H179_E1.8921.00
53_A326_R1.8751.00
236_H260_Y1.8401.00
274_L290_V1.8371.00
78_E83_R1.8221.00
175_A178_A1.8181.00
172_T175_A1.8121.00
84_E125_S1.8051.00
64_D321_E1.7961.00
318_A322_A1.7531.00
389_D393_E1.7461.00
185_D189_R1.7271.00
185_D188_H1.7191.00
297_I313_G1.7181.00
251_D255_A1.7121.00
59_D69_N1.7101.00
210_F223_M1.7081.00
344_W349_V1.6881.00
60_G64_D1.6861.00
325_V388_H1.6701.00
63_K139_N1.6401.00
112_V145_V1.6321.00
50_L271_I1.6321.00
385_D389_D1.6281.00
57_N61_W1.6261.00
311_Q315_E1.6221.00
363_D381_A1.6151.00
351_V387_V1.6121.00
323_Q388_H1.6001.00
17_S20_D1.5971.00
282_Q342_N1.5931.00
46_R347_N1.5861.00
52_E63_K1.5841.00
366_T377_V1.5831.00
70_A120_I1.5781.00
169_A259_A1.5701.00
317_A327_V1.5450.99
388_H392_D1.5440.99
78_E82_E1.5290.99
308_D361_E1.5210.99
177_W181_T1.5180.99
67_V137_R1.5110.99
314_A329_F1.5030.99
314_A331_D1.4860.99
313_G329_F1.4750.99
121_A247_I1.4670.99
188_H201_R1.4640.99
311_Q314_A1.4550.99
191_Y219_V1.4460.99
35_A40_F1.4420.99
358_N362_D1.4310.99
293_K328_H1.4250.99
26_V155_F1.4140.99
357_P361_E1.3910.99
319_E380_R1.3890.99
358_N361_E1.3760.99
319_E381_A1.3720.99
121_A261_T1.3680.99
351_V367_V1.3630.99
52_E69_N1.3630.99
188_H199_V1.3600.99
383_I387_V1.3530.99
314_A317_A1.3250.98
206_D209_K1.3230.98
312_Y355_I1.3200.98
195_L290_V1.3180.98
282_Q373_G1.3000.98
58_L62_F1.2990.98
297_I316_I1.2970.98
58_L190_L1.2730.98
248_T258_T1.2580.98
173_D177_W1.2560.98
369_H372_D1.2550.98
59_D63_K1.2490.98
70_A138_V1.2490.98
75_F98_V1.2450.98
219_V231_G1.2440.97
249_F257_R1.2430.97
82_E86_D1.2370.97
297_I355_I1.2320.97
61_W65_T1.2260.97
99_T109_R1.2230.97
353_F367_V1.2220.97
392_D396_D1.2030.97
60_G193_D1.1980.97
183_R186_Q1.1870.97
64_D189_R1.1820.97
49_A53_A1.1800.97
330_D340_K1.1790.97
312_Y380_R1.1740.96
14_K224_P1.1730.96
26_V31_L1.1720.96
232_G266_L1.1710.96
90_G240_S1.1680.96
65_T182_L1.1660.96
363_D379_D1.1650.96
84_E245_F1.1630.96
367_V378_E1.1610.96
249_F259_A1.1590.96
113_R116_S1.1540.96
315_E363_D1.1530.96
176_A236_H1.1500.96
365_V380_R1.1480.96
367_V387_V1.1470.96
191_Y270_A1.1370.96
65_T186_Q1.1330.96
158_T268_W1.1330.96
124_L138_V1.1320.96
266_L270_A1.1260.95
300_I337_P1.1200.95
351_V390_H1.1160.95
97_W111_A1.1130.95
321_E327_V1.1120.95
250_A256_E1.1070.95
316_I383_I1.1040.95
197_I273_A1.0990.95
30_G127_W1.0990.95
43_T271_I1.0970.95
128_V169_A1.0880.95
53_A56_D1.0830.94
83_R89_E1.0830.94
184_L234_S1.0740.94
64_D322_A1.0700.94
122_P125_S1.0650.94
94_E97_W1.0630.94
214_D260_Y1.0600.94
31_L155_F1.0580.94
63_K69_N1.0580.94
242_A259_A1.0570.94
386_R390_H1.0540.94
128_V136_L1.0490.93
216_T220_E1.0480.93
296_V328_H1.0460.93
369_H390_H1.0360.93
74_M145_V1.0290.93
11_T24_E1.0220.92
309_V360_V1.0190.92
14_K24_E1.0180.92
42_V123_Y1.0170.92
175_A179_E1.0150.92
385_D388_H1.0130.92
214_D236_H1.0110.92
173_D260_Y1.0090.92
298_V352_R1.0080.92
48_Y52_E1.0060.92
33_D126_Q0.9960.92
308_D311_Q0.9960.92
189_R192_E0.9940.91
372_D390_H0.9930.91
33_D127_W0.9890.91
250_A255_A0.9830.91
24_E28_K0.9800.91
279_S285_V0.9800.91
37_M110_L0.9770.91
71_Y162_L0.9760.91
179_E182_L0.9740.91
177_W215_T0.9730.91
70_A123_Y0.9730.91
54_I271_I0.9720.90
58_L266_L0.9700.90
325_V387_V0.9700.90
345_E348_G0.9680.90
302_Q314_A0.9610.90
43_T268_W0.9610.90
345_E352_R0.9600.90
197_I277_S0.9590.90
88_V111_A0.9590.90
367_V383_I0.9560.90
384_A388_H0.9540.90
46_R293_K0.9500.89
323_Q384_A0.9500.89
79_D83_R0.9500.89
367_V386_R0.9490.89
54_I270_A0.9490.89
242_A258_T0.9480.89
315_E380_R0.9450.89
50_L286_L0.9440.89
51_W162_L0.9420.89
297_I329_F0.9400.89
185_D201_R0.9400.89
102_G108_Q0.9390.89
137_R179_E0.9350.89
182_L186_Q0.9310.88
33_D44_R0.9310.88
328_H349_V0.9300.88
14_K281_D0.9200.88
365_V383_I0.9190.88
298_V337_P0.9150.88
229_V273_A0.9130.88
96_A147_W0.9120.87
82_E85_K0.9110.87
319_E322_A0.9110.87
181_T185_D0.9060.87
49_A63_K0.9060.87
313_G355_I0.9060.87
316_I319_E0.9060.87
243_D258_T0.9030.87
155_F158_T0.9000.87
310_E314_A0.8990.87
137_R182_L0.8950.86
43_T47_G0.8900.86
44_R123_Y0.8870.86
54_I190_L0.8860.86
339_F344_W0.8800.86
336_N339_F0.8780.85
30_G347_N0.8770.85
158_T161_F0.8750.85
371_P390_H0.8730.85
310_E331_D0.8700.85
319_E323_Q0.8700.85
13_S16_H0.8680.85
296_V349_V0.8650.85
298_V340_K0.8620.84
299_P329_F0.8600.84
203_R209_K0.8600.84
288_P351_V0.8590.84
26_V275_V0.8560.84
28_K346_L0.8540.84
49_A326_R0.8530.84
285_V348_G0.8490.83
345_E368_V0.8480.83
57_N193_D0.8420.83
125_S246_D0.8390.83
79_D108_Q0.8390.83
288_P391_L0.8360.82
51_W268_W0.8360.82
162_L268_W0.8340.82
33_D123_Y0.8300.82
93_P102_G0.8300.82
81_L95_V0.8300.82
144_V264_W0.8240.82
280_D283_G0.8190.81
359_E362_D0.8140.81
57_N189_R0.8080.80
48_Y162_L0.8040.80
367_V390_H0.8020.80
351_V369_H0.8020.80
56_D64_D0.7990.80
184_L201_R0.7970.79
85_K91_F0.7970.79
212_G225_D0.7920.79
48_Y71_Y0.7910.79
170_H262_T0.7900.79
171_A175_A0.7880.79
43_T158_T0.7780.78
352_R375_S0.7760.78
378_E386_R0.7750.77
76_I119_I0.7700.77
72_F123_Y0.7690.77
58_L268_W0.7620.76
380_R384_A0.7580.76
288_P294_Q0.7570.76
319_E363_D0.7570.76
325_V391_L0.7560.76
21_W278_H0.7540.75
327_V331_D0.7500.75
74_M112_V0.7500.75
54_I290_V0.7500.75
55_Q59_D0.7490.75
75_F96_A0.7460.75
35_A42_V0.7430.74
203_R215_T0.7430.74
31_L50_L0.7390.74
362_D377_V0.7350.74
96_A112_V0.7340.74
65_T137_R0.7340.74
339_F346_L0.7320.73
20_D24_E0.7320.73
122_P126_Q0.7310.73
390_H394_V0.7280.73
173_D214_D0.7270.73
333_D340_K0.7270.73
37_M40_F0.7270.73
247_I261_T0.7260.73
288_P394_V0.7230.72
223_M229_V0.7210.72
315_E318_A0.7170.72
48_Y55_Q0.7170.72
196_G395_Y0.7150.72
124_L136_L0.7140.71
6_Q9_G0.7120.71
174_E178_A0.7110.71
19_G23_A0.7110.71
40_F75_F0.7100.71
308_D312_Y0.7090.71
21_W279_S0.7060.71
174_E177_W0.7030.70
62_F186_Q0.7020.70
191_Y266_L0.7000.70
382_A388_H0.6990.70
173_D236_H0.6950.69
288_P390_H0.6940.69
247_I259_A0.6940.69
164_Q187_Y0.6920.69
144_V161_F0.6910.69
289_T392_D0.6900.69
120_I138_V0.6880.69
231_G270_A0.6870.69
30_G343_E0.6870.69
337_P344_W0.6840.68
355_I365_V0.6820.68
156_F229_V0.6810.68
56_D59_D0.6810.68
18_P276_M0.6790.68
339_F342_N0.6780.68
36_P123_Y0.6770.67
351_V391_L0.6770.67
100_Q109_R0.6770.67
344_W352_R0.6730.67
144_V267_S0.6710.67
44_R127_W0.6690.66
295_V327_V0.6660.66
208_D211_P0.6660.66
87_I240_S0.6660.66
170_H176_A0.6620.66
129_R250_A0.6610.66
137_R166_G0.6600.65
205_P208_D0.6570.65
31_L275_V0.6550.65
58_L141_W0.6540.65
95_V111_A0.6540.65
78_E111_A0.6520.64
344_W347_N0.6520.64
23_A34_Y0.6510.64
190_L266_L0.6500.64
392_D395_Y0.6500.64
210_F213_A0.6490.64
68_E136_L0.6490.64
129_R136_L0.6480.64
26_V123_Y0.6470.64
355_I360_V0.6470.64
299_P302_Q0.6470.64
19_G108_Q0.6460.64
295_V353_F0.6460.64
74_M143_S0.6410.63
158_T162_L0.6400.63
234_S263_S0.6380.63
310_E329_F0.6370.63
62_F190_L0.6360.63
376_T382_A0.6350.62
124_L128_V0.6350.62
345_E375_S0.6340.62
32_A43_T0.6330.62
176_A237_L0.6300.62
358_N377_V0.6290.62
301_W309_V0.6280.62
163_W262_T0.6280.62
385_D396_D0.6270.61
383_I388_H0.6250.61
358_N364_E0.6240.61
365_V378_E0.6240.61
12_E24_E0.6240.61
322_A389_D0.6230.61
47_G271_I0.6220.61
212_G224_P0.6220.61
65_T183_R0.6210.61
318_A321_E0.6210.61
10_I14_K0.6210.61
60_G324_G0.6210.61
279_S284_L0.6190.60
223_M273_A0.6190.60
337_P340_K0.6180.60
75_F110_L0.6180.60
121_A258_T0.6170.60
376_T390_H0.6150.60
91_F114_P0.6140.60
15_E18_P0.6120.60
87_I118_S0.6110.59
216_T222_L0.6090.59
386_R393_E0.6090.59
384_A393_E0.6090.59
36_P40_F0.6080.59
12_E19_G0.6080.59
317_A331_D0.6070.59
324_G327_V0.6060.59
316_I380_R0.6060.59
89_E244_A0.6030.58
390_H393_E0.6030.58
378_E382_A0.6030.58
320_L384_A0.6010.58
92_D95_V0.6010.58
295_V387_V0.6010.58
46_R328_H0.5980.58
43_T51_W0.5980.58
339_F343_E0.5970.58
391_L395_Y0.5960.58
62_F183_R0.5960.58
153_K156_F0.5910.57
175_A236_H0.5910.57
325_V384_A0.5910.57
31_L284_L0.5910.57
318_A323_Q0.5890.57
324_G329_F0.5890.57
363_D382_A0.5890.57
358_N375_S0.5880.57
298_V344_W0.5880.57
278_H285_V0.5870.56
387_V391_L0.5870.56
240_S244_A0.5860.56
187_Y264_W0.5860.56
302_Q310_E0.5860.56
56_D63_K0.5840.56
84_E241_F0.5830.56
354_E366_T0.5830.56
285_V371_P0.5820.56
308_D385_D0.5820.56
275_V278_H0.5800.56
178_A181_T0.5800.56
101_G147_W0.5790.55
372_D394_V0.5780.55
177_W366_T0.5770.55
11_T346_L0.5770.55
337_P345_E0.5760.55
6_Q68_E0.5750.55
252_E381_A0.5740.55
214_D238_G0.5730.55
38_G159_K0.5730.55
239_Q258_T0.5720.55
355_I380_R0.5720.55
215_T236_H0.5710.54
72_F127_W0.5710.54
34_Y154_P0.5700.54
9_G358_N0.5690.54
319_E383_I0.5690.54
96_A145_V0.5680.54
123_Y127_W0.5670.54
289_T395_Y0.5670.54
23_A154_P0.5660.54
324_G388_H0.5660.54
179_E215_T0.5640.54
322_A385_D0.5640.54
320_L325_V0.5630.53
32_A41_I0.5630.53
13_S281_D0.5630.53
388_H391_L0.5620.53
141_W164_Q0.5600.53
66_G321_E0.5590.53
195_L270_A0.5590.53
298_V328_H0.5590.53
38_G119_I0.5580.53
301_W337_P0.5580.53
354_E375_S0.5580.53
255_A308_D0.5580.53
193_D289_T0.5560.52
299_P337_P0.5550.52
61_W193_D0.5550.52
323_Q385_D0.5540.52
295_V319_E0.5540.52
360_V365_V0.5530.52
303_E308_D0.5510.52
232_G270_A0.5500.52
319_E377_V0.5490.52
368_V373_G0.5480.51
295_V320_L0.5460.51
308_D357_P0.5450.51
210_F278_H0.5450.51
246_D258_T0.5430.51
59_D141_W0.5430.51
52_E56_D0.5410.51
302_Q329_F0.5400.50
296_V299_P0.5400.50
25_V28_K0.5390.50
179_E262_T0.5390.50
66_G393_E0.5380.50
128_V143_S0.5360.50
42_V210_F0.5360.50
285_V370_R0.5350.50
76_I94_E0.5330.50
302_Q307_D0.5330.50
286_L291_A0.5330.50
53_A294_Q0.5330.50
330_D337_P0.5330.50
52_E59_D0.5320.49
165_E262_T0.5310.49
312_Y359_E0.5290.49
338_G352_R0.5290.49
76_I120_I0.5260.49
372_D376_T0.5260.49
116_S140_Q0.5260.49
12_E339_F0.5250.48
388_H393_E0.5240.48
11_T20_D0.5230.48
71_Y142_N0.5230.48
312_Y316_I0.5210.48
128_V259_A0.5200.48
212_G220_E0.5200.48
62_F164_Q0.5190.48
186_Q189_R0.5190.48
42_V128_V0.5180.48
351_V384_A0.5170.47
71_Y74_M0.5170.47
316_I353_F0.5170.47
17_S27_Q0.5170.47
191_Y231_G0.5160.47
36_P159_K0.5160.47
323_Q393_E0.5150.47
297_I327_V0.5150.47
62_F237_L0.5150.47
312_Y383_I0.5150.47
35_A122_P0.5140.47
301_W336_N0.5140.47
83_R109_R0.5140.47
56_D185_D0.5140.47
322_A384_A0.5130.47
57_N290_V0.5130.47
314_A389_D0.5110.47
303_E309_V0.5110.47
25_V29_A0.5100.47
112_V272_G0.5100.47
8_L12_E0.5100.47
273_A277_S0.5090.46
242_A260_Y0.5080.46
72_F76_I0.5080.46
282_Q345_E0.5070.46
12_E20_D0.5070.46
294_Q325_V0.5060.46
26_V32_A0.5050.46
173_D181_T0.5030.46
42_V73_P0.5030.46
131_H250_A0.5030.46
280_D370_R0.5030.46
197_I231_G0.5020.46
48_Y51_W0.5010.45
359_E377_V0.5000.45
180_T219_V0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ncxA 2 0.9022 100 0.27 Contact Map
3ialA 2 0.9481 100 0.279 Contact Map
1hc7A 2 0.9202 100 0.287 Contact Map
4hvcA 2 0.9541 100 0.29 Contact Map
1nj1A 2 0.9202 100 0.297 Contact Map
1nj8A 2 0.9022 100 0.303 Contact Map
1qf6A 1 0.7625 100 0.526 Contact Map
2i4lA 2 0.7545 100 0.531 Contact Map
1nyrA 2 0.7605 100 0.536 Contact Map
2j3lA 2 0.7685 100 0.55 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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