Q9HS50 - HALSA - GREMLIN Contacts

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Q9HS50 - Uncharacterized protein

UniProt:	Q9HS50	Sequences: MDTALVIGGTRFIGRHLVAELLAHDYDVTTFNRGTHDNPFADDDRVARVEGDRTERRALLDAKRTVDPDAVFDCVAYKPRDVESATDIFGDVDAYVYVSSGAAYAAEEVPKREGETRLESCSAEEATDDSSATYGARKAAGDRIVFEAAARGVPAMAVRPPVVYGPHDYTERLAYWVERVAERDEIVVPGDGTNLWQRVYVEDVARGLRLVAEDGEPGEAYNVGDRNAVTLDGMLDLIADALDTSVERSYTSPRELSIVDLGPGEFPLYRDAPHVLDTTKIAELGYESTPPAEAMQRTVDAHREHGRTGDDNGPDRETEDRLLDVLDTV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	329 (275)
Sequences:	53110 (38146)
Seq/√Len:	2300.3

ECOLI - RMLB2 GM4D RMLB1 YBJS GALE HLDD FCL YFCH YEEZ RMLD QOR2 YBJT YRAR
BACSU - RMLB YFNG GALE YTCB SPSK YFHF YESF YTBQ YWNB YHFK YHEG
HALSA - Q9HS50 Q9HSU9 Q9HSV1 Q9HRD1 Q9HML4 Q9HSE7 Q9HNV3 Q9HPF1 Q9HSQ3 Q9HR86
SULSO - Q97VN5 Q97XJ9 Q980W1 Q7LXE8 Q97XG1 Q7LXG5 Q97UM3 Q7LX44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_G	30_T	3.321	1.00
3_T	27_D	3.033	1.00
207_G	223_V	2.831	1.00
237_L	292_A	2.827	1.00
219_E	280_K	2.679	1.00
20_E	206_R	2.660	1.00
221_Y	283_E	2.489	1.00
60_L	90_G	2.388	1.00
76_A	80_R	2.387	1.00
70_A	212_A	2.308	1.00
240_D	292_A	2.238	1.00
98_V	208_L	2.225	1.00
31_F	51_G	2.181	1.00
94_A	154_P	2.117	1.00
7_I	73_D	2.110	1.00
55_E	58_A	2.109	1.00
206_R	289_T	2.108	1.00
20_E	24_H	2.094	1.00
164_Y	294_A	2.084	1.00
73_D	97_Y	2.048	1.00
51_G	58_A	2.006	1.00
20_E	209_R	1.994	1.00
72_F	212_A	1.985	1.00
24_H	213_E	1.935	1.00
6_V	18_V	1.927	1.00
5_L	68_P	1.907	1.00
112_R	115_E	1.893	1.00
241_A	296_Q	1.889	1.00
206_R	210_L	1.881	1.00
160_P	208_L	1.876	1.00
29_T	47_A	1.875	1.00
232_D	236_D	1.859	1.00
29_T	68_P	1.859	1.00
202_E	297_R	1.855	1.00
3_T	29_T	1.820	1.00
158_V	211_V	1.801	1.00
279_T	282_A	1.799	1.00
237_L	240_D	1.736	1.00
17_L	205_A	1.724	1.00
145_V	155_A	1.716	1.00
54_T	76_A	1.680	1.00
27_D	47_A	1.673	1.00
230_T	233_G	1.669	1.00
99_S	103_A	1.668	1.00
29_T	49_V	1.665	1.00
17_L	72_F	1.627	1.00
178_E	182_E	1.613	1.00
200_Y	297_R	1.602	1.00
104_Y	222_N	1.592	1.00
34_G	48_R	1.589	1.00
20_E	23_A	1.551	1.00
60_L	88_I	1.531	1.00
56_R	87_D	1.521	1.00
17_L	74_C	1.520	1.00
83_E	144_I	1.517	1.00
296_Q	300_D	1.511	1.00
161_P	276_L	1.479	1.00
24_H	209_R	1.471	1.00
233_G	236_D	1.470	1.00
19_A	167_H	1.462	1.00
158_V	208_L	1.462	1.00
179_R	184_D	1.452	1.00
209_R	213_E	1.440	1.00
200_Y	294_A	1.431	1.00
61_D	65_T	1.430	1.00
237_L	241_A	1.428	1.00
13_I	163_V	1.428	1.00
83_E	87_D	1.424	1.00
80_R	83_E	1.421	1.00
281_I	284_L	1.408	1.00
65_T	68_P	1.407	1.00
160_P	204_V	1.406	1.00
4_A	26_Y	1.403	1.00
60_L	91_D	1.402	1.00
18_V	30_T	1.391	1.00
20_E	205_A	1.385	1.00
139_A	143_R	1.381	1.00
72_F	208_L	1.378	1.00
69_D	93_D	1.376	1.00
134_Y	138_K	1.371	1.00
128_D	139_A	1.368	1.00
78_K	137_R	1.335	1.00
73_D	82_V	1.332	1.00
201_V	205_A	1.327	1.00
26_Y	213_E	1.326	1.00
82_V	141_G	1.314	1.00
94_A	156_M	1.296	1.00
74_C	98_V	1.279	1.00
293_E	296_Q	1.270	1.00
199_V	204_V	1.261	1.00
71_V	89_F	1.258	1.00
56_R	84_S	1.251	1.00
61_D	64_R	1.246	1.00
197_Q	226_R	1.245	1.00
86_T	148_A	1.238	1.00
85_A	95_Y	1.234	1.00
98_V	160_P	1.234	1.00
87_D	90_G	1.227	1.00
187_V	249_S	1.224	1.00
143_R	146_F	1.211	1.00
12_F	165_G	1.204	1.00
58_A	61_D	1.201	1.00
278_T	288_S	1.189	1.00
293_E	297_R	1.188	1.00
232_D	250_Y	1.187	1.00
159_R	220_A	1.168	1.00
63_K	68_P	1.158	1.00
63_K	71_V	1.157	1.00
10_T	32_N	1.155	1.00
9_G	18_V	1.152	1.00
113_E	280_K	1.151	1.00
219_E	283_E	1.149	1.00
21_L	209_R	1.148	1.00
195_L	228_A	1.145	1.00
97_Y	141_G	1.141	1.00
146_F	157_A	1.136	1.00
4_A	21_L	1.132	1.00
22_L	46_V	1.127	1.00
53_R	81_D	1.126	1.00
206_R	286_Y	1.122	1.00
290_P	297_R	1.112	1.00
15_R	167_H	1.112	1.00
111_K	115_E	1.106	1.00
207_G	281_I	1.105	1.00
89_F	95_Y	1.105	1.00
56_R	60_L	1.105	1.00
112_R	277_D	1.105	1.00
114_G	280_K	1.101	1.00
16_H	202_E	1.097	1.00
203_D	225_D	1.094	1.00
77_Y	81_D	1.090	1.00
142_D	159_R	1.087	1.00
154_P	217_P	1.086	1.00
200_Y	290_P	1.085	1.00
53_R	75_V	1.085	1.00
193_T	232_D	1.079	1.00
146_F	220_A	1.075	1.00
108_E	115_E	1.072	1.00
30_T	46_V	1.062	1.00
20_E	202_E	1.061	1.00
5_L	31_F	1.059	1.00
74_C	208_L	1.056	1.00
210_L	284_L	1.053	1.00
159_R	222_N	1.047	1.00
136_A	140_A	1.038	1.00
22_L	45_R	1.036	1.00
280_K	283_E	1.036	1.00
200_Y	203_D	1.032	1.00
97_Y	145_V	1.032	1.00
146_F	155_A	1.030	1.00
144_I	147_E	1.021	1.00
108_E	112_R	1.018	1.00
19_A	23_A	1.017	1.00
164_Y	200_Y	1.016	1.00
224_G	276_L	1.013	1.00
239_A	245_S	1.013	1.00
228_A	273_P	1.007	1.00
64_R	91_D	0.998	1.00
49_V	62_A	0.998	1.00
292_A	296_Q	0.989	1.00
239_A	246_V	0.983	1.00
221_Y	280_K	0.980	1.00
4_A	70_A	0.975	1.00
185_E	247_E	0.970	1.00
97_Y	157_A	0.965	1.00
86_T	95_Y	0.965	1.00
60_L	64_R	0.964	1.00
58_A	62_A	0.958	1.00
12_F	201_V	0.955	1.00
228_A	275_V	0.953	1.00
252_S	255_E	0.952	1.00
29_T	65_T	0.945	1.00
99_S	142_D	0.944	1.00
57_R	61_D	0.940	1.00
31_F	59_L	0.937	1.00
236_D	239_A	0.931	1.00
241_A	299_V	0.930	1.00
4_A	72_F	0.926	1.00
80_R	84_S	0.918	1.00
148_A	151_R	0.918	1.00
297_R	300_D	0.917	1.00
95_Y	145_V	0.917	1.00
31_F	58_A	0.899	1.00
7_I	75_V	0.899	1.00
207_G	286_Y	0.896	1.00
158_V	223_V	0.895	1.00
3_T	68_P	0.892	1.00
109_V	115_E	0.888	1.00
156_M	211_V	0.887	1.00
193_T	230_T	0.886	1.00
241_A	295_M	0.883	1.00
88_I	91_D	0.879	1.00
226_R	278_T	0.878	1.00
96_V	158_V	0.877	1.00
146_F	149_A	0.875	1.00
163_V	199_V	0.874	1.00
300_D	303_R	0.874	1.00
229_V	233_G	0.873	1.00
57_R	60_L	0.870	1.00
22_L	28_V	0.870	1.00
157_A	220_A	0.867	1.00
242_L	299_V	0.864	1.00
206_R	290_P	0.857	1.00
3_T	69_D	0.853	1.00
86_T	145_V	0.853	1.00
49_V	65_T	0.853	1.00
110_P	113_E	0.852	1.00
195_L	230_T	0.850	1.00
229_V	234_M	0.848	1.00
33_R	52_D	0.846	1.00
59_L	88_I	0.843	1.00
16_H	201_V	0.842	1.00
31_F	62_A	0.841	1.00
63_K	91_D	0.838	1.00
26_Y	69_D	0.834	1.00
101_G	161_P	0.831	1.00
216_E	219_E	0.831	1.00
163_V	204_V	0.830	1.00
224_G	278_T	0.829	1.00
211_V	281_I	0.829	1.00
210_L	286_Y	0.822	1.00
171_E	174_A	0.817	1.00
87_D	148_A	0.817	1.00
210_L	213_E	0.815	1.00
290_P	293_E	0.815	1.00
34_G	37_D	0.813	1.00
7_I	85_A	0.809	1.00
172_R	176_W	0.806	1.00
17_L	21_L	0.801	1.00
84_S	87_D	0.798	1.00
211_V	284_L	0.796	1.00
56_R	90_G	0.794	1.00
63_K	88_I	0.790	1.00
241_A	292_A	0.789	1.00
130_S	135_G	0.788	1.00
63_K	89_F	0.788	1.00
18_V	28_V	0.786	1.00
4_A	212_A	0.785	1.00
175_Y	178_E	0.784	1.00
35_T	50_E	0.784	1.00
210_L	285_G	0.782	1.00
103_A	142_D	0.782	1.00
223_V	281_I	0.779	1.00
86_T	144_I	0.778	1.00
54_T	77_Y	0.776	1.00
101_G	276_L	0.770	1.00
32_N	48_R	0.770	1.00
166_P	297_R	0.768	1.00
82_V	86_T	0.768	1.00
81_D	84_S	0.767	1.00
13_I	204_V	0.765	1.00
185_E	249_S	0.763	1.00
202_E	290_P	0.759	1.00
34_G	50_E	0.759	1.00
195_L	273_P	0.757	1.00
161_P	224_G	0.756	1.00
216_E	283_E	0.753	1.00
203_D	289_T	0.752	1.00
239_A	244_T	0.749	1.00
236_D	240_D	0.742	1.00
192_G	232_D	0.736	1.00
140_A	143_R	0.732	1.00
16_H	19_A	0.731	1.00
21_L	212_A	0.728	1.00
290_P	294_A	0.725	1.00
178_E	181_A	0.722	1.00
16_H	205_A	0.720	1.00
84_S	88_I	0.718	1.00
92_V	154_P	0.714	1.00
55_E	59_L	0.709	1.00
79_P	140_A	0.708	1.00
17_L	208_L	0.702	1.00
5_L	51_G	0.700	1.00
143_R	147_E	0.700	1.00
175_Y	179_R	0.699	1.00
241_A	300_D	0.693	1.00
71_V	95_Y	0.691	1.00
78_K	134_Y	0.690	1.00
89_F	92_V	0.689	1.00
206_R	209_R	0.687	1.00
70_A	94_A	0.685	1.00
16_H	20_E	0.684	1.00
136_A	143_R	0.679	1.00
100_S	138_K	0.675	1.00
179_R	182_E	0.674	1.00
15_R	19_A	0.671	1.00
177_V	299_V	0.667	1.00
40_F	43_D	0.667	1.00
166_P	200_Y	0.667	1.00
100_S	103_A	0.664	1.00
107_E	115_E	0.664	1.00
5_L	71_V	0.663	1.00
195_L	275_V	0.658	1.00
251_T	254_R	0.657	1.00
140_A	144_I	0.656	1.00
162_V	196_W	0.655	1.00
141_G	145_V	0.655	1.00
132_A	135_G	0.654	1.00
73_D	85_A	0.650	1.00
82_V	145_V	0.643	1.00
203_D	206_R	0.642	1.00
5_L	62_A	0.641	1.00
59_L	84_S	0.640	1.00
52_D	55_E	0.638	1.00
3_T	26_Y	0.638	1.00
298_T	301_A	0.638	1.00
74_C	160_P	0.636	1.00
187_V	251_T	0.635	1.00
180_V	239_A	0.633	1.00
158_V	207_G	0.630	1.00
176_W	179_R	0.629	1.00
136_A	147_E	0.626	1.00
183_R	244_T	0.624	1.00
164_Y	225_D	0.624	1.00
10_T	34_G	0.624	1.00
71_V	85_A	0.623	1.00
62_A	68_P	0.623	1.00
93_D	154_P	0.622	1.00
29_T	62_A	0.622	1.00
239_A	242_L	0.621	1.00
24_H	206_R	0.621	1.00
39_P	42_D	0.620	1.00
109_V	113_E	0.618	1.00
155_A	218_G	0.616	1.00
27_D	45_R	0.615	1.00
221_Y	281_I	0.613	1.00
26_Y	70_A	0.613	1.00
133_T	137_R	0.611	1.00
70_A	96_V	0.610	1.00
5_L	63_K	0.608	1.00
39_P	43_D	0.608	1.00
70_A	93_D	0.606	1.00
73_D	95_Y	0.601	1.00
177_V	238_I	0.600	1.00
34_G	39_P	0.595	1.00
144_I	148_A	0.593	1.00
168_D	171_E	0.593	1.00
16_H	167_H	0.593	1.00
145_V	157_A	0.592	1.00
47_A	65_T	0.592	1.00
19_A	202_E	0.591	1.00
180_V	186_I	0.590	1.00
233_G	237_L	0.589	1.00
96_V	212_A	0.587	1.00
271_D	274_H	0.583	1.00
79_P	137_R	0.577	1.00
137_R	141_G	0.575	1.00
205_A	209_R	0.575	1.00
130_S	139_A	0.574	1.00
102_A	135_G	0.571	1.00
299_V	303_R	0.571	1.00
21_L	72_F	0.569	1.00
250_Y	254_R	0.568	1.00
194_N	231_L	0.567	1.00
39_P	50_E	0.567	1.00
210_L	214_D	0.567	1.00
62_A	65_T	0.567	1.00
197_Q	225_D	0.565	1.00
237_L	295_M	0.564	1.00
134_Y	137_R	0.561	1.00
147_E	150_A	0.557	1.00
227_N	292_A	0.556	1.00
17_L	209_R	0.555	1.00
166_P	202_E	0.554	1.00
82_V	97_Y	0.551	1.00
177_V	181_A	0.550	1.00
99_S	157_A	0.549	1.00
179_R	183_R	0.548	1.00
289_T	293_E	0.548	1.00
133_T	136_A	0.547	1.00
165_G	201_V	0.547	1.00
204_V	223_V	0.544	1.00
197_Q	228_A	0.543	1.00
250_Y	253_P	0.542	1.00
182_E	185_E	0.537	1.00
103_A	128_D	0.536	1.00
96_V	211_V	0.534	1.00
30_T	48_R	0.534	1.00
49_V	58_A	0.533	1.00
239_A	248_R	0.530	1.00
18_V	22_L	0.529	1.00
209_R	212_A	0.525	1.00
37_D	41_A	0.524	1.00
53_R	77_Y	0.521	1.00
229_V	237_L	0.520	1.00
113_E	281_I	0.518	1.00
110_P	277_D	0.518	1.00
12_F	16_H	0.518	1.00
96_V	208_L	0.517	1.00
85_A	89_F	0.517	1.00
56_R	88_I	0.515	1.00
238_I	299_V	0.513	1.00
162_V	198_R	0.512	1.00
167_H	301_A	0.512	1.00
176_W	180_V	0.512	1.00
79_P	83_E	0.512	1.00
109_V	112_R	0.510	1.00
63_K	92_V	0.508	1.00
179_R	185_E	0.508	1.00
6_V	30_T	0.508	1.00
18_V	46_V	0.506	1.00
109_V	273_P	0.506	1.00
142_D	157_A	0.506	1.00
235_L	239_A	0.505	1.00
173_L	234_M	0.504	1.00
288_S	291_P	0.502	1.00
101_G	274_H	0.502	1.00
179_R	187_V	0.502	1.00
227_N	291_P	0.501	1.00
186_I	248_R	0.501	1.00
89_F	153_V	0.500	1.00
198_R	231_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rkxA	3	0.9027	100	0.28	Contact Map
2q1sA	2	0.8754	100	0.286	Contact Map
1orrA	3	0.8845	100	0.287	Contact Map
2c20A	2	0.8693	100	0.293	Contact Map
1sb8A	2	0.8693	100	0.293	Contact Map
3m2pA	2	0.848	100	0.295	Contact Map
3rufA	2	0.8541	100	0.297	Contact Map
2pzmA	2	0.8754	100	0.297	Contact Map
1oc2A	2	0.9088	100	0.303	Contact Map
3sxpA	3	0.8328	100	0.307	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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