GREMLIN Database
Q9HS50 - Uncharacterized protein
UniProt: Q9HS50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (275)
Sequences: 53110 (38146)
Seq/√Len: 2300.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_G30_T3.3211.00
3_T27_D3.0331.00
207_G223_V2.8311.00
237_L292_A2.8271.00
219_E280_K2.6791.00
20_E206_R2.6601.00
221_Y283_E2.4891.00
60_L90_G2.3881.00
76_A80_R2.3871.00
70_A212_A2.3081.00
240_D292_A2.2381.00
98_V208_L2.2251.00
31_F51_G2.1811.00
94_A154_P2.1171.00
7_I73_D2.1101.00
55_E58_A2.1091.00
206_R289_T2.1081.00
20_E24_H2.0941.00
164_Y294_A2.0841.00
73_D97_Y2.0481.00
51_G58_A2.0061.00
20_E209_R1.9941.00
72_F212_A1.9851.00
24_H213_E1.9351.00
6_V18_V1.9271.00
5_L68_P1.9071.00
112_R115_E1.8931.00
241_A296_Q1.8891.00
206_R210_L1.8811.00
160_P208_L1.8761.00
29_T47_A1.8751.00
232_D236_D1.8591.00
29_T68_P1.8591.00
202_E297_R1.8551.00
3_T29_T1.8201.00
158_V211_V1.8011.00
279_T282_A1.7991.00
237_L240_D1.7361.00
17_L205_A1.7241.00
145_V155_A1.7161.00
54_T76_A1.6801.00
27_D47_A1.6731.00
230_T233_G1.6691.00
99_S103_A1.6681.00
29_T49_V1.6651.00
17_L72_F1.6271.00
178_E182_E1.6131.00
200_Y297_R1.6021.00
104_Y222_N1.5921.00
34_G48_R1.5891.00
20_E23_A1.5511.00
60_L88_I1.5311.00
56_R87_D1.5211.00
17_L74_C1.5201.00
83_E144_I1.5171.00
296_Q300_D1.5111.00
161_P276_L1.4791.00
24_H209_R1.4711.00
233_G236_D1.4701.00
19_A167_H1.4621.00
158_V208_L1.4621.00
179_R184_D1.4521.00
209_R213_E1.4401.00
200_Y294_A1.4311.00
61_D65_T1.4301.00
237_L241_A1.4281.00
13_I163_V1.4281.00
83_E87_D1.4241.00
80_R83_E1.4211.00
281_I284_L1.4081.00
65_T68_P1.4071.00
160_P204_V1.4061.00
4_A26_Y1.4031.00
60_L91_D1.4021.00
18_V30_T1.3911.00
20_E205_A1.3851.00
139_A143_R1.3811.00
72_F208_L1.3781.00
69_D93_D1.3761.00
134_Y138_K1.3711.00
128_D139_A1.3681.00
78_K137_R1.3351.00
73_D82_V1.3321.00
201_V205_A1.3271.00
26_Y213_E1.3261.00
82_V141_G1.3141.00
94_A156_M1.2961.00
74_C98_V1.2791.00
293_E296_Q1.2701.00
199_V204_V1.2611.00
71_V89_F1.2581.00
56_R84_S1.2511.00
61_D64_R1.2461.00
197_Q226_R1.2451.00
86_T148_A1.2381.00
85_A95_Y1.2341.00
98_V160_P1.2341.00
87_D90_G1.2271.00
187_V249_S1.2241.00
143_R146_F1.2111.00
12_F165_G1.2041.00
58_A61_D1.2011.00
278_T288_S1.1891.00
293_E297_R1.1881.00
232_D250_Y1.1871.00
159_R220_A1.1681.00
63_K68_P1.1581.00
63_K71_V1.1571.00
10_T32_N1.1551.00
9_G18_V1.1521.00
113_E280_K1.1511.00
219_E283_E1.1491.00
21_L209_R1.1481.00
195_L228_A1.1451.00
97_Y141_G1.1411.00
146_F157_A1.1361.00
4_A21_L1.1321.00
22_L46_V1.1271.00
53_R81_D1.1261.00
206_R286_Y1.1221.00
290_P297_R1.1121.00
15_R167_H1.1121.00
111_K115_E1.1061.00
207_G281_I1.1051.00
89_F95_Y1.1051.00
56_R60_L1.1051.00
112_R277_D1.1051.00
114_G280_K1.1011.00
16_H202_E1.0971.00
203_D225_D1.0941.00
77_Y81_D1.0901.00
142_D159_R1.0871.00
154_P217_P1.0861.00
200_Y290_P1.0851.00
53_R75_V1.0851.00
193_T232_D1.0791.00
146_F220_A1.0751.00
108_E115_E1.0721.00
30_T46_V1.0621.00
20_E202_E1.0611.00
5_L31_F1.0591.00
74_C208_L1.0561.00
210_L284_L1.0531.00
159_R222_N1.0471.00
136_A140_A1.0381.00
22_L45_R1.0361.00
280_K283_E1.0361.00
200_Y203_D1.0321.00
97_Y145_V1.0321.00
146_F155_A1.0301.00
144_I147_E1.0211.00
108_E112_R1.0181.00
19_A23_A1.0171.00
164_Y200_Y1.0161.00
224_G276_L1.0131.00
239_A245_S1.0131.00
228_A273_P1.0071.00
64_R91_D0.9981.00
49_V62_A0.9981.00
292_A296_Q0.9891.00
239_A246_V0.9831.00
221_Y280_K0.9801.00
4_A70_A0.9751.00
185_E247_E0.9701.00
97_Y157_A0.9651.00
86_T95_Y0.9651.00
60_L64_R0.9641.00
58_A62_A0.9581.00
12_F201_V0.9551.00
228_A275_V0.9531.00
252_S255_E0.9521.00
29_T65_T0.9451.00
99_S142_D0.9441.00
57_R61_D0.9401.00
31_F59_L0.9371.00
236_D239_A0.9311.00
241_A299_V0.9301.00
4_A72_F0.9261.00
80_R84_S0.9181.00
148_A151_R0.9181.00
297_R300_D0.9171.00
95_Y145_V0.9171.00
31_F58_A0.8991.00
7_I75_V0.8991.00
207_G286_Y0.8961.00
158_V223_V0.8951.00
3_T68_P0.8921.00
109_V115_E0.8881.00
156_M211_V0.8871.00
193_T230_T0.8861.00
241_A295_M0.8831.00
88_I91_D0.8791.00
226_R278_T0.8781.00
96_V158_V0.8771.00
146_F149_A0.8751.00
163_V199_V0.8741.00
300_D303_R0.8741.00
229_V233_G0.8731.00
57_R60_L0.8701.00
22_L28_V0.8701.00
157_A220_A0.8671.00
242_L299_V0.8641.00
206_R290_P0.8571.00
3_T69_D0.8531.00
86_T145_V0.8531.00
49_V65_T0.8531.00
110_P113_E0.8521.00
195_L230_T0.8501.00
229_V234_M0.8481.00
33_R52_D0.8461.00
59_L88_I0.8431.00
16_H201_V0.8421.00
31_F62_A0.8411.00
63_K91_D0.8381.00
26_Y69_D0.8341.00
101_G161_P0.8311.00
216_E219_E0.8311.00
163_V204_V0.8301.00
224_G278_T0.8291.00
211_V281_I0.8291.00
210_L286_Y0.8221.00
171_E174_A0.8171.00
87_D148_A0.8171.00
210_L213_E0.8151.00
290_P293_E0.8151.00
34_G37_D0.8131.00
7_I85_A0.8091.00
172_R176_W0.8061.00
17_L21_L0.8011.00
84_S87_D0.7981.00
211_V284_L0.7961.00
56_R90_G0.7941.00
63_K88_I0.7901.00
241_A292_A0.7891.00
130_S135_G0.7881.00
63_K89_F0.7881.00
18_V28_V0.7861.00
4_A212_A0.7851.00
175_Y178_E0.7841.00
35_T50_E0.7841.00
210_L285_G0.7821.00
103_A142_D0.7821.00
223_V281_I0.7791.00
86_T144_I0.7781.00
54_T77_Y0.7761.00
101_G276_L0.7701.00
32_N48_R0.7701.00
166_P297_R0.7681.00
82_V86_T0.7681.00
81_D84_S0.7671.00
13_I204_V0.7651.00
185_E249_S0.7631.00
202_E290_P0.7591.00
34_G50_E0.7591.00
195_L273_P0.7571.00
161_P224_G0.7561.00
216_E283_E0.7531.00
203_D289_T0.7521.00
239_A244_T0.7491.00
236_D240_D0.7421.00
192_G232_D0.7361.00
140_A143_R0.7321.00
16_H19_A0.7311.00
21_L212_A0.7281.00
290_P294_A0.7251.00
178_E181_A0.7221.00
16_H205_A0.7201.00
84_S88_I0.7181.00
92_V154_P0.7141.00
55_E59_L0.7091.00
79_P140_A0.7081.00
17_L208_L0.7021.00
5_L51_G0.7001.00
143_R147_E0.7001.00
175_Y179_R0.6991.00
241_A300_D0.6931.00
71_V95_Y0.6911.00
78_K134_Y0.6901.00
89_F92_V0.6891.00
206_R209_R0.6871.00
70_A94_A0.6851.00
16_H20_E0.6841.00
136_A143_R0.6791.00
100_S138_K0.6751.00
179_R182_E0.6741.00
15_R19_A0.6711.00
177_V299_V0.6671.00
40_F43_D0.6671.00
166_P200_Y0.6671.00
100_S103_A0.6641.00
107_E115_E0.6641.00
5_L71_V0.6631.00
195_L275_V0.6581.00
251_T254_R0.6571.00
140_A144_I0.6561.00
162_V196_W0.6551.00
141_G145_V0.6551.00
132_A135_G0.6541.00
73_D85_A0.6501.00
82_V145_V0.6431.00
203_D206_R0.6421.00
5_L62_A0.6411.00
59_L84_S0.6401.00
52_D55_E0.6381.00
3_T26_Y0.6381.00
298_T301_A0.6381.00
74_C160_P0.6361.00
187_V251_T0.6351.00
180_V239_A0.6331.00
158_V207_G0.6301.00
176_W179_R0.6291.00
136_A147_E0.6261.00
183_R244_T0.6241.00
164_Y225_D0.6241.00
10_T34_G0.6241.00
71_V85_A0.6231.00
62_A68_P0.6231.00
93_D154_P0.6221.00
29_T62_A0.6221.00
239_A242_L0.6211.00
24_H206_R0.6211.00
39_P42_D0.6201.00
109_V113_E0.6181.00
155_A218_G0.6161.00
27_D45_R0.6151.00
221_Y281_I0.6131.00
26_Y70_A0.6131.00
133_T137_R0.6111.00
70_A96_V0.6101.00
5_L63_K0.6081.00
39_P43_D0.6081.00
70_A93_D0.6061.00
73_D95_Y0.6011.00
177_V238_I0.6001.00
34_G39_P0.5951.00
144_I148_A0.5931.00
168_D171_E0.5931.00
16_H167_H0.5931.00
145_V157_A0.5921.00
47_A65_T0.5921.00
19_A202_E0.5911.00
180_V186_I0.5901.00
233_G237_L0.5891.00
96_V212_A0.5871.00
271_D274_H0.5831.00
79_P137_R0.5771.00
137_R141_G0.5751.00
205_A209_R0.5751.00
130_S139_A0.5741.00
102_A135_G0.5711.00
299_V303_R0.5711.00
21_L72_F0.5691.00
250_Y254_R0.5681.00
194_N231_L0.5671.00
39_P50_E0.5671.00
210_L214_D0.5671.00
62_A65_T0.5671.00
197_Q225_D0.5651.00
237_L295_M0.5641.00
134_Y137_R0.5611.00
147_E150_A0.5571.00
227_N292_A0.5561.00
17_L209_R0.5551.00
166_P202_E0.5541.00
82_V97_Y0.5511.00
177_V181_A0.5501.00
99_S157_A0.5491.00
179_R183_R0.5481.00
289_T293_E0.5481.00
133_T136_A0.5471.00
165_G201_V0.5471.00
204_V223_V0.5441.00
197_Q228_A0.5431.00
250_Y253_P0.5421.00
182_E185_E0.5371.00
103_A128_D0.5361.00
96_V211_V0.5341.00
30_T48_R0.5341.00
49_V58_A0.5331.00
239_A248_R0.5301.00
18_V22_L0.5291.00
209_R212_A0.5251.00
37_D41_A0.5241.00
53_R77_Y0.5211.00
229_V237_L0.5201.00
113_E281_I0.5181.00
110_P277_D0.5181.00
12_F16_H0.5181.00
96_V208_L0.5171.00
85_A89_F0.5171.00
56_R88_I0.5151.00
238_I299_V0.5131.00
162_V198_R0.5121.00
167_H301_A0.5121.00
176_W180_V0.5121.00
79_P83_E0.5121.00
109_V112_R0.5101.00
63_K92_V0.5081.00
179_R185_E0.5081.00
6_V30_T0.5081.00
18_V46_V0.5061.00
109_V273_P0.5061.00
142_D157_A0.5061.00
235_L239_A0.5051.00
173_L234_M0.5041.00
288_S291_P0.5021.00
101_G274_H0.5021.00
179_R187_V0.5021.00
227_N291_P0.5011.00
186_I248_R0.5011.00
89_F153_V0.5001.00
198_R231_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkxA 3 0.9027 100 0.28 Contact Map
2q1sA 2 0.8754 100 0.286 Contact Map
1orrA 3 0.8845 100 0.287 Contact Map
2c20A 2 0.8693 100 0.293 Contact Map
1sb8A 2 0.8693 100 0.293 Contact Map
3m2pA 2 0.848 100 0.295 Contact Map
3rufA 2 0.8541 100 0.297 Contact Map
2pzmA 2 0.8754 100 0.297 Contact Map
1oc2A 2 0.9088 100 0.303 Contact Map
3sxpA 3 0.8328 100 0.307 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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