G1PDH - HALSA - GREMLIN Contacts

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G1PDH - Glycerol-1-phosphate dehydrogenase [NAD(P)+]

UniProt:	Q9HS49	Sequences: MFEKSTWIRLPRNVVVGHGVLDDAVEVVRDTHLTGRPLVVTSPTPKTVAAENVVAQFEAVGDDPAVVVVEEATFNSVERVLGEAEAVDPGYLVGVGGGKAIDIAKLASDHLNVGFVSVPTAASHDGIVSGRGSVPEGDTRHSVSAAPPLAVIADTGVIADAPWELTTAGCADIISNYTAVKDWRLANRLQHVPYSEYAGALSQMTAEMLVDNAANIKPELEESAWVVVKALVSSGVAMSIADSSRPASGSEHLFSHQLDRIAPGKALHGHQVGVGSILAEYLHSGQEGQWMAVRDALASLDAPTTADELGVADDEVLAALTSAHEIRDRYTILGGGISEVAAREAASRTGVI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (318)
Sequences:	14651 (10367)
Seq/√Len:	581.4

ECOLI - EUTG ADH2 FUCO YQHD GLDA YBDH ADHE
BACSU - GBSB YUGJ YUGK G1PDH
HALSA - G1PDH Q9HHR2 Q9HNB5
SULSO - G1PDH Q97VW4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
281_Y	294_R	3.221	1.00
321_T	339_E	3.190	1.00
317_L	343_R	3.164	1.00
212_N	215_N	3.016	1.00
207_E	299_S	2.711	1.00
82_G	86_A	2.675	1.00
80_V	107_A	2.635	1.00
18_H	156_G	2.604	1.00
92_L	104_A	2.580	1.00
51_E	55_A	2.572	1.00
164_E	270_H	2.545	1.00
114_G	149_L	2.502	1.00
23_D	26_E	2.484	1.00
37_P	91_Y	2.480	1.00
312_A	315_E	2.446	1.00
163_W	167_T	2.389	1.00
36_R	63_D	2.381	1.00
75_N	137_G	2.369	1.00
190_Q	292_A	2.367	1.00
205_T	226_V	2.279	1.00
208_M	215_N	2.271	1.00
19_G	156_G	2.257	1.00
338_S	341_A	2.196	1.00
94_G	104_A	2.094	1.00
197_Y	200_A	2.078	1.00
254_F	346_A	2.062	1.00
295_D	299_S	2.053	1.00
54_V	58_E	2.048	1.00
44_T	48_V	2.010	1.00
159_A	216_I	1.998	1.00
255_S	271_Q	1.997	1.00
22_D	52_N	1.991	1.00
315_E	318_A	1.990	1.00
20_V	23_D	1.988	1.00
101_I	117_S	1.977	1.00
51_E	54_V	1.945	1.00
168_A	270_H	1.891	1.00
284_S	287_E	1.843	1.00
177_Y	198_A	1.828	1.00
76_S	79_R	1.826	1.00
79_R	82_G	1.808	1.00
316_V	343_R	1.799	1.00
208_M	212_N	1.739	1.00
286_Q	289_Q	1.724	1.00
283_H	333_L	1.705	1.00
58_E	64_P	1.703	1.00
305_T	308_E	1.698	1.00
84_A	113_V	1.689	1.00
298_A	304_T	1.680	1.00
42_S	45_P	1.677	1.00
40_V	104_A	1.675	1.00
74_F	78_E	1.664	1.00
35_G	90_G	1.640	1.00
280_E	293_V	1.629	1.00
261_I	319_A	1.601	1.00
339_E	343_R	1.595	1.00
287_E	291_M	1.583	1.00
139_T	142_S	1.568	1.00
207_E	211_D	1.568	1.00
173_I	202_S	1.566	1.00
46_K	50_A	1.557	1.00
25_V	56_Q	1.553	1.00
174_I	199_G	1.540	1.00
37_P	93_V	1.536	1.00
27_V	30_D	1.524	1.00
153_A	228_V	1.522	1.00
291_M	295_D	1.514	1.00
65_A	83_E	1.483	1.00
77_V	103_I	1.473	1.00
116_V	150_A	1.464	1.00
75_N	78_E	1.462	1.00
101_I	126_G	1.454	1.00
274_V	309_L	1.436	1.00
156_G	159_A	1.424	1.00
320_L	343_R	1.406	1.00
46_K	68_V	1.380	1.00
69_V	79_R	1.372	1.00
162_P	165_L	1.370	1.00
92_L	108_S	1.349	1.00
229_K	236_V	1.348	1.00
52_N	156_G	1.342	1.00
54_V	64_P	1.339	1.00
266_A	271_Q	1.338	1.00
55_A	59_A	1.335	1.00
78_E	82_G	1.334	1.00
168_A	267_L	1.333	1.00
38_L	83_E	1.319	1.00
72_A	82_G	1.317	1.00
13_N	27_V	1.316	1.00
205_T	208_M	1.313	1.00
196_E	200_A	1.307	1.00
215_N	218_P	1.303	1.00
171_A	297_L	1.292	1.00
72_A	80_V	1.289	1.00
38_L	84_A	1.288	1.00
294_R	298_A	1.288	1.00
236_V	239_S	1.284	1.00
261_I	318_A	1.280	1.00
27_V	150_A	1.273	1.00
250_S	276_S	1.272	1.00
65_A	87_V	1.271	1.00
318_A	322_S	1.265	1.00
319_A	346_A	1.263	1.00
17_G	23_D	1.260	1.00
91_Y	116_V	1.255	1.00
18_H	159_A	1.249	1.00
53_V	95_V	1.245	1.00
55_A	58_E	1.244	1.00
83_E	86_A	1.231	1.00
94_G	115_F	1.230	1.00
158_I	228_V	1.228	1.00
36_R	87_V	1.226	1.00
36_R	65_A	1.224	1.00
320_L	339_E	1.219	1.00
254_F	275_G	1.216	1.00
19_G	22_D	1.215	1.00
317_L	339_E	1.212	1.00
292_A	295_D	1.207	1.00
170_C	206_A	1.203	1.00
284_S	290_W	1.201	1.00
43_P	47_T	1.200	1.00
171_A	302_A	1.197	1.00
21_L	52_N	1.173	1.00
40_V	107_A	1.172	1.00
78_E	81_L	1.167	1.00
83_E	87_V	1.166	1.00
77_V	81_L	1.165	1.00
211_D	299_S	1.162	1.00
318_A	321_T	1.162	1.00
24_A	53_V	1.154	1.00
77_V	134_V	1.145	1.00
283_H	335_G	1.141	1.00
36_R	90_G	1.139	1.00
225_W	229_K	1.137	1.00
15_V	27_V	1.135	1.00
29_R	60_V	1.131	1.00
277_I	294_R	1.122	1.00
44_T	47_T	1.121	1.00
17_G	20_V	1.117	1.00
28_V	91_Y	1.113	1.00
341_A	344_E	1.113	1.00
73_T	76_S	1.103	1.00
281_Y	287_E	1.096	1.00
77_V	107_A	1.094	1.00
317_L	321_T	1.091	1.00
161_A	165_L	1.089	1.00
204_M	226_V	1.088	1.00
170_C	227_V	1.086	1.00
266_A	274_V	1.082	1.00
288_G	291_M	1.073	1.00
94_G	117_S	1.071	1.00
50_A	54_V	1.061	1.00
21_L	118_V	1.051	1.00
281_Y	284_S	1.047	1.00
23_D	27_V	1.046	1.00
84_A	89_P	1.044	1.00
211_D	215_N	1.043	1.00
122_A	166_T	1.042	1.00
79_R	83_E	1.040	1.00
21_L	157_V	1.039	1.00
18_H	216_I	1.039	1.00
65_A	68_V	1.037	1.00
261_I	315_E	1.037	1.00
72_A	84_A	1.032	1.00
131_R	144_S	1.031	1.00
66_V	69_V	1.027	1.00
39_V	64_P	1.019	1.00
38_L	89_P	1.015	1.00
20_V	152_I	1.013	1.00
179_A	293_V	1.012	1.00
45_P	48_V	1.006	1.00
84_A	92_L	1.002	1.00
52_N	56_Q	1.000	1.00
52_N	55_A	0.988	1.00
43_P	68_V	0.986	1.00
18_H	225_W	0.985	1.00
75_N	79_R	0.978	1.00
104_A	115_F	0.977	1.00
321_T	325_E	0.970	1.00
14_V	232_V	0.962	1.00
19_G	154_D	0.961	1.00
86_A	90_G	0.959	1.00
128_V	151_V	0.956	1.00
320_L	323_A	0.953	1.00
166_T	209_L	0.953	1.00
67_V	79_R	0.952	1.00
251_E	276_S	0.952	1.00
163_W	301_D	0.950	1.00
285_G	289_Q	0.948	1.00
340_V	343_R	0.947	1.00
15_V	150_A	0.945	1.00
208_M	211_D	0.945	1.00
166_T	213_A	0.943	1.00
22_D	56_Q	0.941	1.00
193_P	197_Y	0.934	1.00
39_V	54_V	0.930	1.00
91_Y	114_G	0.930	1.00
163_W	210_V	0.924	1.00
253_L	330_Y	0.922	1.00
109_D	112_N	0.922	1.00
261_I	322_S	0.921	1.00
39_V	50_A	0.921	1.00
217_K	226_V	0.916	1.00
72_A	77_V	0.911	1.00
15_V	23_D	0.911	1.00
72_A	81_L	0.909	1.00
108_S	113_V	0.909	1.00
255_S	259_D	0.909	1.00
21_L	156_G	0.909	1.00
202_S	227_V	0.909	1.00
180_V	237_A	0.907	1.00
251_E	272_V	0.903	1.00
324_H	339_E	0.895	1.00
280_E	290_W	0.887	1.00
192_V	195_S	0.886	1.00
65_A	69_V	0.883	1.00
117_S	148_P	0.881	1.00
295_D	298_A	0.881	1.00
94_G	101_I	0.881	1.00
128_V	232_V	0.876	1.00
281_Y	290_W	0.876	1.00
58_E	63_D	0.876	1.00
36_R	88_D	0.873	1.00
179_A	335_G	0.870	1.00
250_S	337_I	0.870	1.00
13_N	30_D	0.863	1.00
183_W	187_N	0.858	1.00
42_S	48_V	0.858	1.00
171_A	273_G	0.857	1.00
202_S	205_T	0.857	1.00
182_D	212_N	0.855	1.00
81_L	85_E	0.854	1.00
26_E	60_V	0.853	1.00
264_G	315_E	0.853	1.00
197_Y	201_L	0.851	1.00
282_L	341_A	0.848	1.00
54_V	66_V	0.846	1.00
65_A	89_P	0.844	1.00
26_E	29_R	0.844	1.00
267_L	270_H	0.837	1.00
156_G	216_I	0.834	1.00
38_L	86_A	0.834	1.00
41_T	100_A	0.831	1.00
26_E	30_D	0.830	1.00
101_I	119_P	0.830	1.00
22_D	156_G	0.829	1.00
103_I	107_A	0.826	1.00
74_F	137_G	0.826	1.00
41_T	68_V	0.826	1.00
28_V	116_V	0.825	1.00
158_I	166_T	0.824	1.00
203_Q	207_E	0.823	1.00
194_Y	233_S	0.823	1.00
274_V	277_I	0.821	1.00
340_V	344_E	0.821	1.00
215_N	225_W	0.819	1.00
198_A	202_S	0.818	1.00
67_V	83_E	0.812	1.00
41_T	46_K	0.811	1.00
25_V	29_R	0.807	1.00
108_S	115_F	0.804	1.00
170_C	173_I	0.802	1.00
27_V	152_I	0.802	1.00
209_L	213_A	0.800	1.00
277_I	297_L	0.793	1.00
252_H	268_H	0.784	1.00
167_T	210_V	0.782	1.00
82_G	85_E	0.779	1.00
58_E	61_G	0.775	1.00
21_L	154_D	0.773	1.00
316_V	320_L	0.771	1.00
146_A	149_L	0.770	1.00
291_M	294_R	0.770	1.00
25_V	59_A	0.770	1.00
25_V	60_V	0.768	1.00
187_N	190_Q	0.767	1.00
273_G	297_L	0.765	1.00
254_F	278_L	0.765	1.00
75_N	138_D	0.763	1.00
71_E	265_K	0.763	1.00
177_Y	213_A	0.762	1.00
72_A	76_S	0.760	1.00
80_V	84_A	0.760	1.00
73_T	265_K	0.756	1.00
124_H	173_I	0.756	1.00
175_S	276_S	0.755	1.00
250_S	279_A	0.755	1.00
84_A	107_A	0.755	1.00
73_T	137_G	0.754	1.00
56_Q	59_A	0.753	1.00
46_K	51_E	0.747	1.00
74_F	134_V	0.746	1.00
290_W	294_R	0.744	1.00
161_A	169_G	0.740	1.00
193_P	200_A	0.737	1.00
164_E	168_A	0.730	1.00
304_T	308_E	0.728	1.00
142_S	145_A	0.725	1.00
322_S	325_E	0.724	1.00
180_V	192_V	0.719	1.00
317_L	320_L	0.718	1.00
255_S	272_V	0.717	1.00
294_R	304_T	0.716	1.00
254_F	342_A	0.716	1.00
155_T	225_W	0.714	1.00
49_A	95_V	0.711	1.00
250_S	342_A	0.707	1.00
67_V	80_V	0.707	1.00
46_K	66_V	0.702	1.00
199_G	203_Q	0.698	1.00
203_Q	292_A	0.698	1.00
233_S	238_M	0.695	1.00
80_V	103_I	0.691	1.00
282_L	337_I	0.691	1.00
207_E	210_V	0.691	1.00
27_V	31_T	0.691	1.00
278_L	281_Y	0.691	1.00
210_V	301_D	0.690	1.00
185_L	188_R	0.685	1.00
18_H	155_T	0.683	1.00
37_P	62_D	0.683	1.00
229_K	233_S	0.681	1.00
92_L	113_V	0.681	1.00
74_F	77_V	0.679	1.00
61_G	64_P	0.679	1.00
21_L	53_V	0.677	1.00
324_H	342_A	0.675	1.00
159_A	214_A	0.675	1.00
117_S	151_V	0.673	1.00
200_A	204_M	0.670	1.00
167_T	301_D	0.669	1.00
174_I	300_L	0.668	1.00
38_L	67_V	0.667	1.00
205_T	209_L	0.666	1.00
208_M	217_K	0.664	1.00
46_K	54_V	0.662	1.00
288_G	292_A	0.660	1.00
257_Q	322_S	0.657	1.00
40_V	100_A	0.655	1.00
243_S	249_G	0.655	1.00
258_L	271_Q	0.654	1.00
37_P	90_G	0.654	1.00
141_H	145_A	0.652	1.00
43_P	69_V	0.650	1.00
201_L	226_V	0.650	1.00
77_V	106_L	0.649	1.00
165_L	168_A	0.647	1.00
282_L	335_G	0.646	1.00
273_G	302_A	0.642	1.00
22_D	59_A	0.641	1.00
24_A	118_V	0.641	1.00
72_A	78_E	0.638	1.00
186_A	190_Q	0.638	1.00
40_V	80_V	0.636	1.00
174_I	178_T	0.635	1.00
257_Q	346_A	0.635	1.00
123_S	158_I	0.634	1.00
177_Y	234_S	0.633	1.00
303_P	308_E	0.630	1.00
73_T	77_V	0.629	1.00
210_V	300_L	0.627	1.00
176_N	180_V	0.625	1.00
335_G	341_A	0.625	1.00
188_R	209_L	0.624	1.00
293_V	297_L	0.623	1.00
175_S	251_E	0.622	1.00
14_V	214_A	0.622	1.00
314_D	317_L	0.621	1.00
178_T	199_G	0.620	1.00
185_L	242_D	0.618	1.00
260_R	319_A	0.616	1.00
164_E	267_L	0.615	1.00
136_E	143_V	0.613	1.00
47_T	51_E	0.610	1.00
40_V	92_L	0.607	1.00
198_A	209_L	0.605	1.00
205_T	227_V	0.603	1.00
167_T	302_A	0.603	1.00
163_W	211_D	0.602	1.00
13_N	150_A	0.599	1.00
165_L	267_L	0.598	1.00
53_V	56_Q	0.597	1.00
270_H	303_P	0.595	1.00
76_S	103_I	0.595	1.00
51_E	58_E	0.592	1.00
106_L	134_V	0.592	1.00
272_V	275_G	0.591	1.00
181_K	216_I	0.590	1.00
15_V	20_V	0.589	1.00
45_P	49_A	0.589	1.00
280_E	289_Q	0.588	1.00
337_I	341_A	0.587	1.00
122_A	158_I	0.584	1.00
238_M	243_S	0.583	1.00
182_D	280_E	0.580	1.00
52_N	157_V	0.579	1.00
49_A	52_N	0.579	1.00
194_Y	197_Y	0.577	1.00
279_A	283_H	0.575	1.00
226_V	239_S	0.575	1.00
170_C	300_L	0.574	1.00
201_L	230_A	0.572	1.00
285_G	288_G	0.571	1.00
115_F	149_L	0.567	1.00
298_A	308_E	0.565	0.99
186_A	337_I	0.564	0.99
49_A	157_V	0.564	0.99
122_A	228_V	0.558	0.99
216_I	225_W	0.557	0.99
259_D	271_Q	0.556	0.99
22_D	55_A	0.556	0.99
15_V	152_I	0.555	0.99
276_S	297_L	0.554	0.99
319_A	323_A	0.554	0.99
336_G	339_E	0.553	0.99
93_V	116_V	0.551	0.99
205_T	218_P	0.551	0.99
320_L	324_H	0.550	0.99
147_P	231_L	0.549	0.99
266_A	270_H	0.549	0.99
204_M	208_M	0.547	0.99
94_G	100_A	0.547	0.99
202_S	230_A	0.546	0.99
208_M	218_P	0.546	0.99
175_S	272_V	0.545	0.99
239_S	340_V	0.544	0.99
45_P	50_A	0.543	0.99
106_L	132_G	0.541	0.99
39_V	95_V	0.541	0.99
129_S	235_G	0.539	0.99
163_W	201_L	0.539	0.99
41_T	45_P	0.539	0.99
81_L	107_A	0.538	0.99
294_R	305_T	0.537	0.99
139_T	145_A	0.536	0.99
254_F	279_A	0.536	0.99
184_R	187_N	0.536	0.99
140_R	268_H	0.533	0.99
184_R	336_G	0.531	0.99
209_L	227_V	0.531	0.99
209_L	218_P	0.530	0.99
35_G	87_V	0.527	0.99
81_L	110_H	0.527	0.99
311_V	316_V	0.526	0.99
322_S	326_I	0.525	0.99
118_V	152_I	0.524	0.99
174_I	296_A	0.523	0.99
16_V	229_K	0.523	0.99
35_G	63_D	0.523	0.99
179_A	186_A	0.523	0.99
41_T	66_V	0.518	0.99
24_A	152_I	0.518	0.99
275_G	345_A	0.517	0.99
28_V	31_T	0.516	0.99
306_A	316_V	0.515	0.99
84_A	111_L	0.514	0.99
198_A	205_T	0.513	0.99
206_A	210_V	0.513	0.99
186_A	192_V	0.513	0.99
139_T	143_V	0.512	0.99
218_P	228_V	0.511	0.99
213_A	216_I	0.510	0.99
25_V	28_V	0.510	0.99
250_S	293_V	0.508	0.99
64_P	67_V	0.508	0.99
40_V	103_I	0.508	0.99
198_A	234_S	0.508	0.99
16_V	225_W	0.507	0.99
77_V	80_V	0.507	0.99
174_I	297_L	0.505	0.99
28_V	93_V	0.505	0.99
82_G	138_D	0.505	0.99
266_A	309_L	0.504	0.99
281_Y	291_M	0.503	0.99
181_K	225_W	0.503	0.99
71_E	259_D	0.501	0.99
163_W	166_T	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bfjA	5	0.9403	100	0.141	Contact Map
3ox4A	2	0.9432	100	0.147	Contact Map
4fr2A	2	0.9403	100	0.159	Contact Map
1rrmA	2	0.9432	100	0.163	Contact Map
1vljA	2	0.9688	100	0.167	Contact Map
3zdrA	2	0.9403	100	0.18	Contact Map
4mcaA	7	0.9574	100	0.181	Contact Map
3uhjA	5	0.9375	100	0.185	Contact Map
3iv7A	2	0.9375	100	0.186	Contact Map
1o2dA	1	0.9347	100	0.188	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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