GREMLIN Database
G1PDH - Glycerol-1-phosphate dehydrogenase [NAD(P)+]
UniProt: Q9HS49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (318)
Sequences: 14651 (10367)
Seq/√Len: 581.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_Y294_R3.2211.00
321_T339_E3.1901.00
317_L343_R3.1641.00
212_N215_N3.0161.00
207_E299_S2.7111.00
82_G86_A2.6751.00
80_V107_A2.6351.00
18_H156_G2.6041.00
92_L104_A2.5801.00
51_E55_A2.5721.00
164_E270_H2.5451.00
114_G149_L2.5021.00
23_D26_E2.4841.00
37_P91_Y2.4801.00
312_A315_E2.4461.00
163_W167_T2.3891.00
36_R63_D2.3811.00
75_N137_G2.3691.00
190_Q292_A2.3671.00
205_T226_V2.2791.00
208_M215_N2.2711.00
19_G156_G2.2571.00
338_S341_A2.1961.00
94_G104_A2.0941.00
197_Y200_A2.0781.00
254_F346_A2.0621.00
295_D299_S2.0531.00
54_V58_E2.0481.00
44_T48_V2.0101.00
159_A216_I1.9981.00
255_S271_Q1.9971.00
22_D52_N1.9911.00
315_E318_A1.9901.00
20_V23_D1.9881.00
101_I117_S1.9771.00
51_E54_V1.9451.00
168_A270_H1.8911.00
284_S287_E1.8431.00
177_Y198_A1.8281.00
76_S79_R1.8261.00
79_R82_G1.8081.00
316_V343_R1.7991.00
208_M212_N1.7391.00
286_Q289_Q1.7241.00
283_H333_L1.7051.00
58_E64_P1.7031.00
305_T308_E1.6981.00
84_A113_V1.6891.00
298_A304_T1.6801.00
42_S45_P1.6771.00
40_V104_A1.6751.00
74_F78_E1.6641.00
35_G90_G1.6401.00
280_E293_V1.6291.00
261_I319_A1.6011.00
339_E343_R1.5951.00
287_E291_M1.5831.00
139_T142_S1.5681.00
207_E211_D1.5681.00
173_I202_S1.5661.00
46_K50_A1.5571.00
25_V56_Q1.5531.00
174_I199_G1.5401.00
37_P93_V1.5361.00
27_V30_D1.5241.00
153_A228_V1.5221.00
291_M295_D1.5141.00
65_A83_E1.4831.00
77_V103_I1.4731.00
116_V150_A1.4641.00
75_N78_E1.4621.00
101_I126_G1.4541.00
274_V309_L1.4361.00
156_G159_A1.4241.00
320_L343_R1.4061.00
46_K68_V1.3801.00
69_V79_R1.3721.00
162_P165_L1.3701.00
92_L108_S1.3491.00
229_K236_V1.3481.00
52_N156_G1.3421.00
54_V64_P1.3391.00
266_A271_Q1.3381.00
55_A59_A1.3351.00
78_E82_G1.3341.00
168_A267_L1.3331.00
38_L83_E1.3191.00
72_A82_G1.3171.00
13_N27_V1.3161.00
205_T208_M1.3131.00
196_E200_A1.3071.00
215_N218_P1.3031.00
171_A297_L1.2921.00
72_A80_V1.2891.00
38_L84_A1.2881.00
294_R298_A1.2881.00
236_V239_S1.2841.00
261_I318_A1.2801.00
27_V150_A1.2731.00
250_S276_S1.2721.00
65_A87_V1.2711.00
318_A322_S1.2651.00
319_A346_A1.2631.00
17_G23_D1.2601.00
91_Y116_V1.2551.00
18_H159_A1.2491.00
53_V95_V1.2451.00
55_A58_E1.2441.00
83_E86_A1.2311.00
94_G115_F1.2301.00
158_I228_V1.2281.00
36_R87_V1.2261.00
36_R65_A1.2241.00
320_L339_E1.2191.00
254_F275_G1.2161.00
19_G22_D1.2151.00
317_L339_E1.2121.00
292_A295_D1.2071.00
170_C206_A1.2031.00
284_S290_W1.2011.00
43_P47_T1.2001.00
171_A302_A1.1971.00
21_L52_N1.1731.00
40_V107_A1.1721.00
78_E81_L1.1671.00
83_E87_V1.1661.00
77_V81_L1.1651.00
211_D299_S1.1621.00
318_A321_T1.1621.00
24_A53_V1.1541.00
77_V134_V1.1451.00
283_H335_G1.1411.00
36_R90_G1.1391.00
225_W229_K1.1371.00
15_V27_V1.1351.00
29_R60_V1.1311.00
277_I294_R1.1221.00
44_T47_T1.1211.00
17_G20_V1.1171.00
28_V91_Y1.1131.00
341_A344_E1.1131.00
73_T76_S1.1031.00
281_Y287_E1.0961.00
77_V107_A1.0941.00
317_L321_T1.0911.00
161_A165_L1.0891.00
204_M226_V1.0881.00
170_C227_V1.0861.00
266_A274_V1.0821.00
288_G291_M1.0731.00
94_G117_S1.0711.00
50_A54_V1.0611.00
21_L118_V1.0511.00
281_Y284_S1.0471.00
23_D27_V1.0461.00
84_A89_P1.0441.00
211_D215_N1.0431.00
122_A166_T1.0421.00
79_R83_E1.0401.00
21_L157_V1.0391.00
18_H216_I1.0391.00
65_A68_V1.0371.00
261_I315_E1.0371.00
72_A84_A1.0321.00
131_R144_S1.0311.00
66_V69_V1.0271.00
39_V64_P1.0191.00
38_L89_P1.0151.00
20_V152_I1.0131.00
179_A293_V1.0121.00
45_P48_V1.0061.00
84_A92_L1.0021.00
52_N56_Q1.0001.00
52_N55_A0.9881.00
43_P68_V0.9861.00
18_H225_W0.9851.00
75_N79_R0.9781.00
104_A115_F0.9771.00
321_T325_E0.9701.00
14_V232_V0.9621.00
19_G154_D0.9611.00
86_A90_G0.9591.00
128_V151_V0.9561.00
320_L323_A0.9531.00
166_T209_L0.9531.00
67_V79_R0.9521.00
251_E276_S0.9521.00
163_W301_D0.9501.00
285_G289_Q0.9481.00
340_V343_R0.9471.00
15_V150_A0.9451.00
208_M211_D0.9451.00
166_T213_A0.9431.00
22_D56_Q0.9411.00
193_P197_Y0.9341.00
39_V54_V0.9301.00
91_Y114_G0.9301.00
163_W210_V0.9241.00
253_L330_Y0.9221.00
109_D112_N0.9221.00
261_I322_S0.9211.00
39_V50_A0.9211.00
217_K226_V0.9161.00
72_A77_V0.9111.00
15_V23_D0.9111.00
72_A81_L0.9091.00
108_S113_V0.9091.00
255_S259_D0.9091.00
21_L156_G0.9091.00
202_S227_V0.9091.00
180_V237_A0.9071.00
251_E272_V0.9031.00
324_H339_E0.8951.00
280_E290_W0.8871.00
192_V195_S0.8861.00
65_A69_V0.8831.00
117_S148_P0.8811.00
295_D298_A0.8811.00
94_G101_I0.8811.00
128_V232_V0.8761.00
281_Y290_W0.8761.00
58_E63_D0.8761.00
36_R88_D0.8731.00
179_A335_G0.8701.00
250_S337_I0.8701.00
13_N30_D0.8631.00
183_W187_N0.8581.00
42_S48_V0.8581.00
171_A273_G0.8571.00
202_S205_T0.8571.00
182_D212_N0.8551.00
81_L85_E0.8541.00
26_E60_V0.8531.00
264_G315_E0.8531.00
197_Y201_L0.8511.00
282_L341_A0.8481.00
54_V66_V0.8461.00
65_A89_P0.8441.00
26_E29_R0.8441.00
267_L270_H0.8371.00
156_G216_I0.8341.00
38_L86_A0.8341.00
41_T100_A0.8311.00
26_E30_D0.8301.00
101_I119_P0.8301.00
22_D156_G0.8291.00
103_I107_A0.8261.00
74_F137_G0.8261.00
41_T68_V0.8261.00
28_V116_V0.8251.00
158_I166_T0.8241.00
203_Q207_E0.8231.00
194_Y233_S0.8231.00
274_V277_I0.8211.00
340_V344_E0.8211.00
215_N225_W0.8191.00
198_A202_S0.8181.00
67_V83_E0.8121.00
41_T46_K0.8111.00
25_V29_R0.8071.00
108_S115_F0.8041.00
170_C173_I0.8021.00
27_V152_I0.8021.00
209_L213_A0.8001.00
277_I297_L0.7931.00
252_H268_H0.7841.00
167_T210_V0.7821.00
82_G85_E0.7791.00
58_E61_G0.7751.00
21_L154_D0.7731.00
316_V320_L0.7711.00
146_A149_L0.7701.00
291_M294_R0.7701.00
25_V59_A0.7701.00
25_V60_V0.7681.00
187_N190_Q0.7671.00
273_G297_L0.7651.00
254_F278_L0.7651.00
75_N138_D0.7631.00
71_E265_K0.7631.00
177_Y213_A0.7621.00
72_A76_S0.7601.00
80_V84_A0.7601.00
73_T265_K0.7561.00
124_H173_I0.7561.00
175_S276_S0.7551.00
250_S279_A0.7551.00
84_A107_A0.7551.00
73_T137_G0.7541.00
56_Q59_A0.7531.00
46_K51_E0.7471.00
74_F134_V0.7461.00
290_W294_R0.7441.00
161_A169_G0.7401.00
193_P200_A0.7371.00
164_E168_A0.7301.00
304_T308_E0.7281.00
142_S145_A0.7251.00
322_S325_E0.7241.00
180_V192_V0.7191.00
317_L320_L0.7181.00
255_S272_V0.7171.00
294_R304_T0.7161.00
254_F342_A0.7161.00
155_T225_W0.7141.00
49_A95_V0.7111.00
250_S342_A0.7071.00
67_V80_V0.7071.00
46_K66_V0.7021.00
199_G203_Q0.6981.00
203_Q292_A0.6981.00
233_S238_M0.6951.00
80_V103_I0.6911.00
282_L337_I0.6911.00
207_E210_V0.6911.00
27_V31_T0.6911.00
278_L281_Y0.6911.00
210_V301_D0.6901.00
185_L188_R0.6851.00
18_H155_T0.6831.00
37_P62_D0.6831.00
229_K233_S0.6811.00
92_L113_V0.6811.00
74_F77_V0.6791.00
61_G64_P0.6791.00
21_L53_V0.6771.00
324_H342_A0.6751.00
159_A214_A0.6751.00
117_S151_V0.6731.00
200_A204_M0.6701.00
167_T301_D0.6691.00
174_I300_L0.6681.00
38_L67_V0.6671.00
205_T209_L0.6661.00
208_M217_K0.6641.00
46_K54_V0.6621.00
288_G292_A0.6601.00
257_Q322_S0.6571.00
40_V100_A0.6551.00
243_S249_G0.6551.00
258_L271_Q0.6541.00
37_P90_G0.6541.00
141_H145_A0.6521.00
43_P69_V0.6501.00
201_L226_V0.6501.00
77_V106_L0.6491.00
165_L168_A0.6471.00
282_L335_G0.6461.00
273_G302_A0.6421.00
22_D59_A0.6411.00
24_A118_V0.6411.00
72_A78_E0.6381.00
186_A190_Q0.6381.00
40_V80_V0.6361.00
174_I178_T0.6351.00
257_Q346_A0.6351.00
123_S158_I0.6341.00
177_Y234_S0.6331.00
303_P308_E0.6301.00
73_T77_V0.6291.00
210_V300_L0.6271.00
176_N180_V0.6251.00
335_G341_A0.6251.00
188_R209_L0.6241.00
293_V297_L0.6231.00
175_S251_E0.6221.00
14_V214_A0.6221.00
314_D317_L0.6211.00
178_T199_G0.6201.00
185_L242_D0.6181.00
260_R319_A0.6161.00
164_E267_L0.6151.00
136_E143_V0.6131.00
47_T51_E0.6101.00
40_V92_L0.6071.00
198_A209_L0.6051.00
205_T227_V0.6031.00
167_T302_A0.6031.00
163_W211_D0.6021.00
13_N150_A0.5991.00
165_L267_L0.5981.00
53_V56_Q0.5971.00
270_H303_P0.5951.00
76_S103_I0.5951.00
51_E58_E0.5921.00
106_L134_V0.5921.00
272_V275_G0.5911.00
181_K216_I0.5901.00
15_V20_V0.5891.00
45_P49_A0.5891.00
280_E289_Q0.5881.00
337_I341_A0.5871.00
122_A158_I0.5841.00
238_M243_S0.5831.00
182_D280_E0.5801.00
52_N157_V0.5791.00
49_A52_N0.5791.00
194_Y197_Y0.5771.00
279_A283_H0.5751.00
226_V239_S0.5751.00
170_C300_L0.5741.00
201_L230_A0.5721.00
285_G288_G0.5711.00
115_F149_L0.5671.00
298_A308_E0.5650.99
186_A337_I0.5640.99
49_A157_V0.5640.99
122_A228_V0.5580.99
216_I225_W0.5570.99
259_D271_Q0.5560.99
22_D55_A0.5560.99
15_V152_I0.5550.99
276_S297_L0.5540.99
319_A323_A0.5540.99
336_G339_E0.5530.99
93_V116_V0.5510.99
205_T218_P0.5510.99
320_L324_H0.5500.99
147_P231_L0.5490.99
266_A270_H0.5490.99
204_M208_M0.5470.99
94_G100_A0.5470.99
202_S230_A0.5460.99
208_M218_P0.5460.99
175_S272_V0.5450.99
239_S340_V0.5440.99
45_P50_A0.5430.99
106_L132_G0.5410.99
39_V95_V0.5410.99
129_S235_G0.5390.99
163_W201_L0.5390.99
41_T45_P0.5390.99
81_L107_A0.5380.99
294_R305_T0.5370.99
139_T145_A0.5360.99
254_F279_A0.5360.99
184_R187_N0.5360.99
140_R268_H0.5330.99
184_R336_G0.5310.99
209_L227_V0.5310.99
209_L218_P0.5300.99
35_G87_V0.5270.99
81_L110_H0.5270.99
311_V316_V0.5260.99
322_S326_I0.5250.99
118_V152_I0.5240.99
174_I296_A0.5230.99
16_V229_K0.5230.99
35_G63_D0.5230.99
179_A186_A0.5230.99
41_T66_V0.5180.99
24_A152_I0.5180.99
275_G345_A0.5170.99
28_V31_T0.5160.99
306_A316_V0.5150.99
84_A111_L0.5140.99
198_A205_T0.5130.99
206_A210_V0.5130.99
186_A192_V0.5130.99
139_T143_V0.5120.99
218_P228_V0.5110.99
213_A216_I0.5100.99
25_V28_V0.5100.99
250_S293_V0.5080.99
64_P67_V0.5080.99
40_V103_I0.5080.99
198_A234_S0.5080.99
16_V225_W0.5070.99
77_V80_V0.5070.99
174_I297_L0.5050.99
28_V93_V0.5050.99
82_G138_D0.5050.99
266_A309_L0.5040.99
281_Y291_M0.5030.99
181_K225_W0.5030.99
71_E259_D0.5010.99
163_W166_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bfjA 5 0.9403 100 0.141 Contact Map
3ox4A 2 0.9432 100 0.147 Contact Map
4fr2A 2 0.9403 100 0.159 Contact Map
1rrmA 2 0.9432 100 0.163 Contact Map
1vljA 2 0.9688 100 0.167 Contact Map
3zdrA 2 0.9403 100 0.18 Contact Map
4mcaA 7 0.9574 100 0.181 Contact Map
3uhjA 5 0.9375 100 0.185 Contact Map
3iv7A 2 0.9375 100 0.186 Contact Map
1o2dA 1 0.9347 100 0.188 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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