Q9HS48 - HALSA - GREMLIN Contacts

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Q9HS48 - Uncharacterized protein

UniProt:	Q9HS48	Sequences: MGVSRVAPDRRLACRAAVGGMFVGAVLPAGGLGKAAFTAYVVGRSDAATTAQAVGGVTGWEVAKMAASATVAVAGVAGVLAAGGAVETAGLVAAAFGGVCVTGVAAGALVVRRRRLVVGLAVWLLAGVARVLPGRWEPPTRERVRAGLDAALESVGVLARTPQRLAAVTGAAHAAWLCSALALVLCLHAVGLWVSPAVALVALPVAGFAHVVPVPGGLGPVDAALGGVIAALTGHALATLASALVLFRVATYGTRVVVGGVALWRLRAALR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	271 (239)
Sequences:	3266 (2689)
Seq/√Len:	174.0

ECOLI - YBHN
HALSA - Q9HS48 Q9HSJ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
222_D	248_R	3.267	1.00
14_C	18_V	3.185	1.00
12_L	45_S	3.000	1.00
20_G	38_T	2.803	1.00
27_L	33_G	2.712	1.00
25_A	256_V	2.688	1.00
9_D	12_L	2.632	1.00
64_K	176_W	2.494	1.00
123_W	126_A	2.471	1.00
184_V	188_H	2.415	1.00
64_K	172_A	2.399	1.00
109_L	113_R	2.386	1.00
35_A	61_E	2.375	1.00
67_A	172_A	2.367	1.00
223_A	227_G	2.336	1.00
215_P	248_R	2.323	1.00
236_A	239_T	2.313	1.00
221_V	248_R	2.281	1.00
108_A	112_R	2.277	1.00
38_T	60_W	2.275	1.00
6_V	48_A	2.207	1.00
23_V	37_F	2.194	1.00
38_T	61_E	2.186	1.00
163_Q	167_A	2.185	1.00
187_L	243_A	2.117	1.00
35_A	38_T	2.026	1.00
60_W	64_K	1.969	1.00
10_R	14_C	1.964	1.00
94_A	98_G	1.955	1.00
195_S	198_V	1.948	1.00
63_A	168_V	1.883	1.00
93_A	96_F	1.876	1.00
8_P	13_A	1.838	1.00
221_V	247_F	1.836	1.00
24_G	34_K	1.806	1.00
209_A	224_A	1.803	1.00
235_H	240_L	1.778	1.00
226_G	241_A	1.777	1.00
240_L	244_L	1.768	1.00
244_L	248_R	1.752	1.00
170_G	174_A	1.741	1.00
61_E	64_K	1.681	1.00
49_T	52_Q	1.679	1.00
39_A	54_V	1.667	1.00
43_G	50_T	1.656	1.00
22_F	260_G	1.653	1.00
16_A	41_V	1.613	1.00
143_R	147_G	1.600	1.00
39_A	57_V	1.581	1.00
152_L	156_G	1.571	1.00
98_G	102_T	1.552	1.00
18_V	262_A	1.548	1.00
225_L	244_L	1.524	1.00
32_L	64_K	1.516	1.00
91_L	95_A	1.495	1.00
257_V	261_V	1.491	1.00
222_D	244_L	1.469	1.00
42_V	48_A	1.450	1.00
182_A	247_F	1.417	1.00
18_V	258_V	1.417	1.00
154_S	157_V	1.398	1.00
209_A	228_V	1.395	1.00
6_V	49_T	1.384	1.00
203_L	207_G	1.382	1.00
60_W	214_V	1.374	1.00
37_F	41_V	1.356	1.00
96_F	100_C	1.356	1.00
11_R	15_R	1.351	1.00
24_G	29_A	1.346	1.00
123_W	127_G	1.345	1.00
107_G	111_V	1.340	1.00
15_R	265_R	1.326	1.00
17_A	175_A	1.323	1.00
161_T	164_R	1.319	1.00
51_A	150_A	1.296	1.00
181_L	185_L	1.281	1.00
123_W	128_V	1.277	1.00
187_L	235_H	1.259	1.00
7_A	11_R	1.232	1.00
19_G	41_V	1.229	1.00
35_A	64_K	1.227	1.00
37_F	263_L	1.227	1.00
75_G	204_P	1.219	1.00
27_L	36_A	1.211	1.00
261_V	265_R	1.199	1.00
214_V	244_L	1.186	1.00
252_Y	255_R	1.180	1.00
56_G	253_G	1.171	1.00
38_T	57_V	1.169	1.00
39_A	53_A	1.145	1.00
225_L	228_V	1.130	1.00
187_L	192_L	1.129	1.00
202_A	228_V	1.126	1.00
102_T	106_A	1.124	1.00
226_G	240_L	1.122	1.00
167_A	170_G	1.116	1.00
179_S	251_T	1.113	1.00
24_G	35_A	1.111	1.00
215_P	221_V	1.107	1.00
182_A	251_T	1.097	1.00
106_A	111_V	1.094	1.00
180_A	200_L	1.094	1.00
203_L	213_P	1.094	1.00
218_L	247_F	1.092	1.00
190_V	246_L	1.086	1.00
150_A	153_E	1.086	1.00
214_V	248_R	1.079	1.00
55_G	151_A	1.076	1.00
172_A	180_A	1.072	1.00
90_G	93_A	1.071	1.00
53_A	56_G	1.068	1.00
101_V	105_A	1.053	1.00
50_T	53_A	1.041	0.99
48_A	53_A	1.036	0.99
186_C	247_F	1.023	0.99
34_K	39_A	1.023	0.99
210_H	213_P	1.021	0.99
22_F	259_G	1.012	0.99
83_G	86_V	1.008	0.99
223_A	226_G	1.006	0.99
186_C	189_A	1.002	0.99
64_K	175_A	0.999	0.99
38_T	64_K	0.992	0.99
125_L	128_V	0.992	0.99
52_Q	154_S	0.990	0.99
227_G	230_A	0.989	0.99
199_A	229_I	0.988	0.99
43_G	53_A	0.983	0.99
182_A	250_A	0.980	0.99
28_P	34_K	0.980	0.99
181_L	196_P	0.976	0.99
193_W	196_P	0.973	0.99
241_A	245_V	0.969	0.99
67_A	70_T	0.969	0.99
215_P	244_L	0.967	0.99
17_A	21_M	0.961	0.99
15_R	262_A	0.960	0.99
33_G	248_R	0.960	0.99
165_L	168_V	0.958	0.99
17_A	64_K	0.957	0.99
35_A	60_W	0.951	0.99
209_A	220_P	0.951	0.99
225_L	243_A	0.951	0.99
77_A	80_L	0.947	0.99
147_G	150_A	0.940	0.99
221_V	244_L	0.937	0.99
188_H	192_L	0.934	0.99
92_V	96_F	0.931	0.99
210_H	228_V	0.929	0.99
60_W	172_A	0.928	0.99
192_L	235_H	0.912	0.99
248_R	253_G	0.912	0.99
203_L	206_A	0.910	0.99
20_G	61_E	0.900	0.98
21_M	247_F	0.891	0.98
175_A	179_S	0.883	0.98
146_A	150_A	0.881	0.98
27_L	248_R	0.879	0.98
206_A	210_H	0.871	0.98
105_A	123_W	0.870	0.98
82_A	85_A	0.869	0.98
183_L	225_L	0.866	0.98
16_A	45_S	0.865	0.98
68_S	207_G	0.863	0.98
18_V	209_A	0.858	0.98
89_A	92_V	0.852	0.98
222_D	245_V	0.851	0.98
248_R	252_Y	0.847	0.98
42_V	57_V	0.847	0.98
124_L	127_G	0.847	0.98
71_V	177_L	0.845	0.98
224_A	227_G	0.837	0.98
106_A	110_V	0.833	0.97
214_V	220_P	0.830	0.97
23_V	41_V	0.828	0.97
75_G	79_V	0.821	0.97
37_F	183_L	0.815	0.97
16_A	42_V	0.813	0.97
166_A	170_G	0.813	0.97
96_F	99_V	0.808	0.97
95_A	127_G	0.807	0.97
185_L	189_A	0.805	0.97
248_R	251_T	0.797	0.97
218_L	248_R	0.794	0.97
108_A	111_V	0.792	0.97
107_G	110_V	0.789	0.97
40_Y	44_R	0.782	0.96
210_H	248_R	0.779	0.96
106_A	109_L	0.777	0.96
100_C	104_V	0.776	0.96
32_L	248_R	0.775	0.96
255_R	258_V	0.774	0.96
90_G	107_G	0.764	0.96
247_F	251_T	0.758	0.96
225_L	248_R	0.757	0.96
206_A	224_A	0.757	0.96
68_S	176_W	0.753	0.95
66_A	95_A	0.752	0.95
54_V	237_L	0.749	0.95
245_V	248_R	0.749	0.95
12_L	46_D	0.748	0.95
189_A	250_A	0.743	0.95
20_G	34_K	0.743	0.95
187_L	199_A	0.743	0.95
166_A	169_T	0.739	0.95
64_K	68_S	0.739	0.95
153_E	156_G	0.738	0.95
145_R	149_D	0.729	0.95
89_A	93_A	0.724	0.94
27_L	42_V	0.721	0.94
21_M	179_S	0.716	0.94
13_A	17_A	0.715	0.94
222_D	243_A	0.713	0.94
24_G	38_T	0.713	0.94
202_A	229_I	0.708	0.94
164_R	167_A	0.704	0.94
87_E	97_G	0.704	0.94
73_V	146_A	0.704	0.94
41_V	263_L	0.703	0.93
19_G	262_A	0.701	0.93
206_A	220_P	0.700	0.93
8_P	12_L	0.697	0.93
247_F	253_G	0.692	0.93
29_A	32_L	0.692	0.93
24_G	221_V	0.690	0.93
101_V	108_A	0.689	0.93
26_V	37_F	0.688	0.93
61_E	65_M	0.682	0.92
185_L	188_H	0.677	0.92
71_V	203_L	0.674	0.92
176_W	179_S	0.674	0.92
249_V	253_G	0.673	0.92
206_A	217_G	0.673	0.92
84_G	178_C	0.669	0.92
181_L	184_V	0.669	0.92
107_G	112_R	0.669	0.92
187_L	214_V	0.665	0.91
61_E	176_W	0.664	0.91
178_C	181_L	0.663	0.91
45_S	63_A	0.662	0.91
32_L	57_V	0.661	0.91
61_E	68_S	0.660	0.91
243_A	247_F	0.658	0.91
155_V	232_L	0.657	0.91
32_L	35_A	0.657	0.91
73_V	97_G	0.657	0.91
254_T	258_V	0.656	0.91
33_G	39_A	0.655	0.91
208_F	241_A	0.652	0.91
245_V	249_V	0.651	0.91
25_A	29_A	0.647	0.90
71_V	196_P	0.646	0.90
75_G	78_G	0.645	0.90
204_P	207_G	0.643	0.90
226_G	230_A	0.642	0.90
70_T	169_T	0.640	0.90
42_V	46_D	0.639	0.90
24_G	56_G	0.638	0.90
170_G	177_L	0.634	0.89
33_G	220_P	0.633	0.89
25_A	252_Y	0.632	0.89
74_A	161_T	0.631	0.89
163_Q	166_A	0.630	0.89
179_S	183_L	0.628	0.89
144_V	148_L	0.622	0.89
177_L	197_A	0.618	0.88
109_L	112_R	0.617	0.88
216_G	221_V	0.615	0.88
144_V	147_G	0.615	0.88
18_V	158_L	0.612	0.88
50_T	54_V	0.611	0.88
91_L	105_A	0.611	0.88
69_A	73_V	0.611	0.88
24_G	33_G	0.609	0.88
190_V	239_T	0.608	0.87
186_C	243_A	0.606	0.87
89_A	96_F	0.603	0.87
20_G	186_C	0.603	0.87
97_G	112_R	0.601	0.87
21_M	38_T	0.601	0.87
66_A	75_G	0.599	0.87
37_F	209_A	0.597	0.86
148_L	155_V	0.596	0.86
111_V	114_R	0.593	0.86
20_G	60_W	0.593	0.86
256_V	262_A	0.592	0.86
22_F	33_G	0.592	0.86
29_A	175_A	0.592	0.86
13_A	16_A	0.591	0.86
25_A	64_K	0.591	0.86
176_W	210_H	0.591	0.86
213_P	222_D	0.589	0.86
29_A	221_V	0.587	0.86
179_S	207_G	0.581	0.85
63_A	169_T	0.580	0.85
248_R	258_V	0.578	0.85
87_E	90_G	0.577	0.85
84_G	87_E	0.576	0.84
228_V	241_A	0.576	0.84
63_A	110_V	0.574	0.84
34_K	64_K	0.573	0.84
16_A	176_W	0.573	0.84
99_V	115_R	0.570	0.84
95_A	98_G	0.565	0.83
24_G	175_A	0.563	0.83
93_A	97_G	0.561	0.83
39_A	222_D	0.559	0.83
164_R	236_A	0.554	0.82
215_P	218_L	0.553	0.82
183_L	243_A	0.553	0.82
200_L	205_V	0.551	0.82
244_L	247_F	0.547	0.81
200_L	216_G	0.547	0.81
221_V	253_G	0.546	0.81
36_A	60_W	0.546	0.81
243_A	248_R	0.542	0.81
184_V	199_A	0.542	0.81
56_G	62_V	0.541	0.81
23_V	29_A	0.539	0.80
182_A	185_L	0.538	0.80
63_A	172_A	0.537	0.80
25_A	255_R	0.536	0.80
105_A	113_R	0.536	0.80
29_A	179_S	0.536	0.80
69_A	101_V	0.536	0.80
21_M	255_R	0.535	0.80
32_L	38_T	0.534	0.80
139_P	193_W	0.531	0.79
32_L	61_E	0.531	0.79
16_A	38_T	0.529	0.79
32_L	217_G	0.528	0.79
67_A	169_T	0.528	0.79
38_T	176_W	0.528	0.79
177_L	188_H	0.527	0.79
222_D	249_V	0.527	0.79
12_L	15_R	0.527	0.79
140_T	143_R	0.525	0.79
22_F	217_G	0.525	0.79
142_E	146_A	0.523	0.78
22_F	27_L	0.521	0.78
220_P	244_L	0.521	0.78
238_A	241_A	0.521	0.78
74_A	77_A	0.520	0.78
16_A	189_A	0.519	0.78
17_A	20_G	0.518	0.78
183_L	229_I	0.515	0.77
76_V	206_A	0.513	0.77
221_V	251_T	0.510	0.77
39_A	245_V	0.510	0.77
32_L	208_F	0.507	0.76
57_V	61_E	0.506	0.76
97_G	101_V	0.505	0.76
15_R	18_V	0.505	0.76
99_V	105_A	0.503	0.76
6_V	52_Q	0.501	0.75
93_A	100_C	0.501	0.75
174_A	178_C	0.501	0.75
217_G	254_T	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nwlA	3	0.2989	12.2	0.944	Contact Map
4k0jA	3	0.4096	6.1	0.951	Contact Map
4r0cA	3	0.2989	4	0.955	Contact Map
4mt1A	3	0.4207	3.8	0.956	Contact Map
3w9iA	3	0.428	3.4	0.957	Contact Map
4gycB	2	0.2251	3.2	0.957	Contact Map
4gx0A	3	0.3358	2.7	0.959	Contact Map
4r1iA	2	0.3137	2.5	0.96	Contact Map
2lzrA	1	0.1808	2.5	0.96	Contact Map
3pjsK	4	0.3358	2.4	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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