GREMLIN Database
Q9HS48 - Uncharacterized protein
UniProt: Q9HS48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (239)
Sequences: 3266 (2689)
Seq/√Len: 174.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_D248_R3.2671.00
14_C18_V3.1851.00
12_L45_S3.0001.00
20_G38_T2.8031.00
27_L33_G2.7121.00
25_A256_V2.6881.00
9_D12_L2.6321.00
64_K176_W2.4941.00
123_W126_A2.4711.00
184_V188_H2.4151.00
64_K172_A2.3991.00
109_L113_R2.3861.00
35_A61_E2.3751.00
67_A172_A2.3671.00
223_A227_G2.3361.00
215_P248_R2.3231.00
236_A239_T2.3131.00
221_V248_R2.2811.00
108_A112_R2.2771.00
38_T60_W2.2751.00
6_V48_A2.2071.00
23_V37_F2.1941.00
38_T61_E2.1861.00
163_Q167_A2.1851.00
187_L243_A2.1171.00
35_A38_T2.0261.00
60_W64_K1.9691.00
10_R14_C1.9641.00
94_A98_G1.9551.00
195_S198_V1.9481.00
63_A168_V1.8831.00
93_A96_F1.8761.00
8_P13_A1.8381.00
221_V247_F1.8361.00
24_G34_K1.8061.00
209_A224_A1.8031.00
235_H240_L1.7781.00
226_G241_A1.7771.00
240_L244_L1.7681.00
244_L248_R1.7521.00
170_G174_A1.7411.00
61_E64_K1.6811.00
49_T52_Q1.6791.00
39_A54_V1.6671.00
43_G50_T1.6561.00
22_F260_G1.6531.00
16_A41_V1.6131.00
143_R147_G1.6001.00
39_A57_V1.5811.00
152_L156_G1.5711.00
98_G102_T1.5521.00
18_V262_A1.5481.00
225_L244_L1.5241.00
32_L64_K1.5161.00
91_L95_A1.4951.00
257_V261_V1.4911.00
222_D244_L1.4691.00
42_V48_A1.4501.00
182_A247_F1.4171.00
18_V258_V1.4171.00
154_S157_V1.3981.00
209_A228_V1.3951.00
6_V49_T1.3841.00
203_L207_G1.3821.00
60_W214_V1.3741.00
37_F41_V1.3561.00
96_F100_C1.3561.00
11_R15_R1.3511.00
24_G29_A1.3461.00
123_W127_G1.3451.00
107_G111_V1.3401.00
15_R265_R1.3261.00
17_A175_A1.3231.00
161_T164_R1.3191.00
51_A150_A1.2961.00
181_L185_L1.2811.00
123_W128_V1.2771.00
187_L235_H1.2591.00
7_A11_R1.2321.00
19_G41_V1.2291.00
35_A64_K1.2271.00
37_F263_L1.2271.00
75_G204_P1.2191.00
27_L36_A1.2111.00
261_V265_R1.1991.00
214_V244_L1.1861.00
252_Y255_R1.1801.00
56_G253_G1.1711.00
38_T57_V1.1691.00
39_A53_A1.1451.00
225_L228_V1.1301.00
187_L192_L1.1291.00
202_A228_V1.1261.00
102_T106_A1.1241.00
226_G240_L1.1221.00
167_A170_G1.1161.00
179_S251_T1.1131.00
24_G35_A1.1111.00
215_P221_V1.1071.00
182_A251_T1.0971.00
106_A111_V1.0941.00
180_A200_L1.0941.00
203_L213_P1.0941.00
218_L247_F1.0921.00
190_V246_L1.0861.00
150_A153_E1.0861.00
214_V248_R1.0791.00
55_G151_A1.0761.00
172_A180_A1.0721.00
90_G93_A1.0711.00
53_A56_G1.0681.00
101_V105_A1.0531.00
50_T53_A1.0410.99
48_A53_A1.0360.99
186_C247_F1.0230.99
34_K39_A1.0230.99
210_H213_P1.0210.99
22_F259_G1.0120.99
83_G86_V1.0080.99
223_A226_G1.0060.99
186_C189_A1.0020.99
64_K175_A0.9990.99
38_T64_K0.9920.99
125_L128_V0.9920.99
52_Q154_S0.9900.99
227_G230_A0.9890.99
199_A229_I0.9880.99
43_G53_A0.9830.99
182_A250_A0.9800.99
28_P34_K0.9800.99
181_L196_P0.9760.99
193_W196_P0.9730.99
241_A245_V0.9690.99
67_A70_T0.9690.99
215_P244_L0.9670.99
17_A21_M0.9610.99
15_R262_A0.9600.99
33_G248_R0.9600.99
165_L168_V0.9580.99
17_A64_K0.9570.99
35_A60_W0.9510.99
209_A220_P0.9510.99
225_L243_A0.9510.99
77_A80_L0.9470.99
147_G150_A0.9400.99
221_V244_L0.9370.99
188_H192_L0.9340.99
92_V96_F0.9310.99
210_H228_V0.9290.99
60_W172_A0.9280.99
192_L235_H0.9120.99
248_R253_G0.9120.99
203_L206_A0.9100.99
20_G61_E0.9000.98
21_M247_F0.8910.98
175_A179_S0.8830.98
146_A150_A0.8810.98
27_L248_R0.8790.98
206_A210_H0.8710.98
105_A123_W0.8700.98
82_A85_A0.8690.98
183_L225_L0.8660.98
16_A45_S0.8650.98
68_S207_G0.8630.98
18_V209_A0.8580.98
89_A92_V0.8520.98
222_D245_V0.8510.98
248_R252_Y0.8470.98
42_V57_V0.8470.98
124_L127_G0.8470.98
71_V177_L0.8450.98
224_A227_G0.8370.98
106_A110_V0.8330.97
214_V220_P0.8300.97
23_V41_V0.8280.97
75_G79_V0.8210.97
37_F183_L0.8150.97
16_A42_V0.8130.97
166_A170_G0.8130.97
96_F99_V0.8080.97
95_A127_G0.8070.97
185_L189_A0.8050.97
248_R251_T0.7970.97
218_L248_R0.7940.97
108_A111_V0.7920.97
107_G110_V0.7890.97
40_Y44_R0.7820.96
210_H248_R0.7790.96
106_A109_L0.7770.96
100_C104_V0.7760.96
32_L248_R0.7750.96
255_R258_V0.7740.96
90_G107_G0.7640.96
247_F251_T0.7580.96
225_L248_R0.7570.96
206_A224_A0.7570.96
68_S176_W0.7530.95
66_A95_A0.7520.95
54_V237_L0.7490.95
245_V248_R0.7490.95
12_L46_D0.7480.95
189_A250_A0.7430.95
20_G34_K0.7430.95
187_L199_A0.7430.95
166_A169_T0.7390.95
64_K68_S0.7390.95
153_E156_G0.7380.95
145_R149_D0.7290.95
89_A93_A0.7240.94
27_L42_V0.7210.94
21_M179_S0.7160.94
13_A17_A0.7150.94
222_D243_A0.7130.94
24_G38_T0.7130.94
202_A229_I0.7080.94
164_R167_A0.7040.94
87_E97_G0.7040.94
73_V146_A0.7040.94
41_V263_L0.7030.93
19_G262_A0.7010.93
206_A220_P0.7000.93
8_P12_L0.6970.93
247_F253_G0.6920.93
29_A32_L0.6920.93
24_G221_V0.6900.93
101_V108_A0.6890.93
26_V37_F0.6880.93
61_E65_M0.6820.92
185_L188_H0.6770.92
71_V203_L0.6740.92
176_W179_S0.6740.92
249_V253_G0.6730.92
206_A217_G0.6730.92
84_G178_C0.6690.92
181_L184_V0.6690.92
107_G112_R0.6690.92
187_L214_V0.6650.91
61_E176_W0.6640.91
178_C181_L0.6630.91
45_S63_A0.6620.91
32_L57_V0.6610.91
61_E68_S0.6600.91
243_A247_F0.6580.91
155_V232_L0.6570.91
32_L35_A0.6570.91
73_V97_G0.6570.91
254_T258_V0.6560.91
33_G39_A0.6550.91
208_F241_A0.6520.91
245_V249_V0.6510.91
25_A29_A0.6470.90
71_V196_P0.6460.90
75_G78_G0.6450.90
204_P207_G0.6430.90
226_G230_A0.6420.90
70_T169_T0.6400.90
42_V46_D0.6390.90
24_G56_G0.6380.90
170_G177_L0.6340.89
33_G220_P0.6330.89
25_A252_Y0.6320.89
74_A161_T0.6310.89
163_Q166_A0.6300.89
179_S183_L0.6280.89
144_V148_L0.6220.89
177_L197_A0.6180.88
109_L112_R0.6170.88
216_G221_V0.6150.88
144_V147_G0.6150.88
18_V158_L0.6120.88
50_T54_V0.6110.88
91_L105_A0.6110.88
69_A73_V0.6110.88
24_G33_G0.6090.88
190_V239_T0.6080.87
186_C243_A0.6060.87
89_A96_F0.6030.87
20_G186_C0.6030.87
97_G112_R0.6010.87
21_M38_T0.6010.87
66_A75_G0.5990.87
37_F209_A0.5970.86
148_L155_V0.5960.86
111_V114_R0.5930.86
20_G60_W0.5930.86
256_V262_A0.5920.86
22_F33_G0.5920.86
29_A175_A0.5920.86
13_A16_A0.5910.86
25_A64_K0.5910.86
176_W210_H0.5910.86
213_P222_D0.5890.86
29_A221_V0.5870.86
179_S207_G0.5810.85
63_A169_T0.5800.85
248_R258_V0.5780.85
87_E90_G0.5770.85
84_G87_E0.5760.84
228_V241_A0.5760.84
63_A110_V0.5740.84
34_K64_K0.5730.84
16_A176_W0.5730.84
99_V115_R0.5700.84
95_A98_G0.5650.83
24_G175_A0.5630.83
93_A97_G0.5610.83
39_A222_D0.5590.83
164_R236_A0.5540.82
215_P218_L0.5530.82
183_L243_A0.5530.82
200_L205_V0.5510.82
244_L247_F0.5470.81
200_L216_G0.5470.81
221_V253_G0.5460.81
36_A60_W0.5460.81
243_A248_R0.5420.81
184_V199_A0.5420.81
56_G62_V0.5410.81
23_V29_A0.5390.80
182_A185_L0.5380.80
63_A172_A0.5370.80
25_A255_R0.5360.80
105_A113_R0.5360.80
29_A179_S0.5360.80
69_A101_V0.5360.80
21_M255_R0.5350.80
32_L38_T0.5340.80
139_P193_W0.5310.79
32_L61_E0.5310.79
16_A38_T0.5290.79
32_L217_G0.5280.79
67_A169_T0.5280.79
38_T176_W0.5280.79
177_L188_H0.5270.79
222_D249_V0.5270.79
12_L15_R0.5270.79
140_T143_R0.5250.79
22_F217_G0.5250.79
142_E146_A0.5230.78
22_F27_L0.5210.78
220_P244_L0.5210.78
238_A241_A0.5210.78
74_A77_A0.5200.78
16_A189_A0.5190.78
17_A20_G0.5180.78
183_L229_I0.5150.77
76_V206_A0.5130.77
221_V251_T0.5100.77
39_A245_V0.5100.77
32_L208_F0.5070.76
57_V61_E0.5060.76
97_G101_V0.5050.76
15_R18_V0.5050.76
99_V105_A0.5030.76
6_V52_Q0.5010.75
93_A100_C0.5010.75
174_A178_C0.5010.75
217_G254_T0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.2989 12.2 0.944 Contact Map
4k0jA 3 0.4096 6.1 0.951 Contact Map
4r0cA 3 0.2989 4 0.955 Contact Map
4mt1A 3 0.4207 3.8 0.956 Contact Map
3w9iA 3 0.428 3.4 0.957 Contact Map
4gycB 2 0.2251 3.2 0.957 Contact Map
4gx0A 3 0.3358 2.7 0.959 Contact Map
4r1iA 2 0.3137 2.5 0.96 Contact Map
2lzrA 1 0.1808 2.5 0.96 Contact Map
3pjsK 4 0.3358 2.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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