GREMLIN Database
Q9HS47 - Uncharacterized protein
UniProt: Q9HS47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (331)
Sequences: 1295 (1009)
Seq/√Len: 55.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_R105_A5.0831.00
305_A350_L4.8371.00
314_A347_R4.3361.00
167_A207_V4.0511.00
95_A112_V4.0361.00
155_A162_V3.3121.00
232_A319_A3.3021.00
277_G281_A3.1571.00
238_A304_A3.1151.00
119_R123_L2.9731.00
23_A26_R2.9341.00
248_H299_D2.8181.00
98_L110_T2.7751.00
24_A28_P2.7741.00
167_A173_V2.5101.00
171_P197_D2.4451.00
252_R296_T2.3981.00
278_A283_A2.3061.00
174_G177_T2.2701.00
163_G168_G2.2351.00
113_D119_R2.2271.00
275_A278_A2.1751.00
268_S271_V2.1401.00
302_A349_R2.1231.00
298_F342_S2.0941.00
246_R299_D2.0591.00
232_A315_R2.0281.00
47_V90_V2.0241.00
139_W148_R1.9751.00
280_V283_A1.9701.00
173_V196_V1.9691.00
153_L257_V1.9671.00
47_V93_A1.9601.00
231_G312_A1.9321.00
95_A117_T1.9071.00
335_G345_A1.8821.00
335_G338_A1.8680.99
295_W299_D1.8630.99
280_V284_V1.8590.99
44_L93_A1.8510.99
77_V81_L1.8370.99
28_P32_A1.8350.99
122_L126_C1.8260.99
159_I162_V1.8020.99
296_T299_D1.7910.99
183_C190_D1.7880.99
103_A108_T1.7870.99
251_L299_D1.7780.99
327_A330_R1.7630.99
156_A159_I1.7520.99
156_A162_V1.7440.99
162_V165_V1.7400.99
338_A342_S1.7370.99
277_G285_L1.7150.99
26_R322_P1.6990.99
251_L296_T1.6750.99
278_A281_A1.6740.99
335_G342_S1.6630.99
274_G278_A1.6320.99
239_H243_H1.6230.99
186_A303_Y1.6220.99
147_P151_A1.6070.98
112_V117_T1.6050.98
281_A285_L1.6040.98
198_A202_L1.5800.98
310_A350_L1.5740.98
112_V118_V1.5680.98
182_A307_H1.5630.98
180_E193_L1.5200.98
197_D200_G1.5180.98
314_A351_S1.5170.98
342_S345_A1.5050.98
207_V218_V1.4970.97
315_R319_A1.4840.97
110_T116_R1.4760.97
85_V89_G1.4760.97
247_G250_G1.4650.97
273_V280_V1.4510.97
103_A109_R1.4380.97
120_R201_G1.4360.97
68_A82_A1.4310.97
239_H297_E1.4220.97
243_H297_E1.4000.96
155_A160_A1.3990.96
156_A160_A1.3820.96
277_G280_V1.3770.96
26_R29_G1.3680.96
273_V277_G1.3570.95
163_G173_V1.3570.95
65_V69_V1.3510.95
102_P202_L1.3490.95
277_G283_A1.3460.95
43_A46_A1.3440.95
207_V216_R1.3390.95
302_A306_R1.3340.95
195_V225_F1.3330.95
51_T90_V1.3100.95
274_G280_V1.2950.94
204_P227_R1.2940.94
36_R101_R1.2910.94
118_V122_L1.2900.94
155_A158_G1.2820.94
182_A241_A1.2780.94
121_Y125_V1.2760.94
109_R203_G1.2750.94
69_V75_G1.2690.94
227_R323_R1.2650.93
73_P137_A1.2540.93
68_A75_G1.2440.93
96_V100_T1.2410.93
18_R343_V1.2390.93
148_R151_A1.2360.93
173_V207_V1.2310.92
81_L133_F1.2280.92
40_A44_L1.2220.92
309_T312_A1.2120.92
341_P346_R1.2080.92
67_A82_A1.2070.92
164_P168_G1.1940.91
265_C268_S1.1870.91
274_G277_G1.1820.91
204_P335_G1.1810.91
279_A283_A1.1790.91
228_L236_V1.1770.91
171_P196_V1.1630.90
236_V340_H1.1620.90
196_V207_V1.1610.90
49_A53_L1.1460.89
127_A132_A1.1420.89
173_V216_R1.1370.89
50_L122_L1.1340.89
303_Y334_A1.1230.89
213_P342_S1.1220.88
275_A280_V1.1180.88
36_R104_W1.1060.88
47_V51_T1.1000.87
298_F349_R1.0940.87
274_G283_A1.0940.87
121_Y124_V1.0870.87
137_A141_A1.0860.87
288_A292_V1.0810.87
188_A208_A1.0800.87
327_A331_G1.0790.86
72_P144_A1.0760.86
176_P195_V1.0720.86
235_A313_M1.0700.86
138_A151_A1.0690.86
334_A338_A1.0620.86
157_V162_V1.0600.85
305_A310_A1.0600.85
19_L25_I1.0480.85
29_G96_V1.0470.85
54_A58_E1.0410.84
94_L121_Y1.0410.84
64_A150_A1.0340.84
158_G162_V1.0320.84
330_R338_A1.0280.84
104_W172_A1.0250.83
204_P323_R1.0220.83
240_E340_H1.0200.83
186_A307_H1.0180.83
276_G279_A1.0160.83
308_V312_A1.0150.83
55_V60_L1.0140.83
153_L253_L1.0110.83
274_G285_L1.0050.82
23_A28_P1.0040.82
293_I339_L1.0030.82
199_S222_A1.0020.82
255_A292_V0.9990.82
27_R31_A0.9970.82
239_H340_H0.9940.82
99_G108_T0.9920.81
50_L89_G0.9920.81
297_E340_H0.9920.81
22_R328_A0.9870.81
100_T103_A0.9850.81
340_H346_R0.9830.81
163_G166_L0.9800.81
278_A282_S0.9740.80
76_G140_V0.9730.80
171_P207_V0.9700.80
248_H296_T0.9690.80
180_E184_V0.9680.80
64_A86_A0.9680.80
134_A137_A0.9660.80
206_A340_H0.9610.79
147_P287_V0.9560.79
277_G284_V0.9420.78
29_G40_A0.9410.78
230_D234_A0.9380.78
37_L97_H0.9380.78
218_V223_A0.9380.78
155_A161_A0.9370.78
311_V351_S0.9370.78
25_I29_G0.9330.77
228_L319_A0.9330.77
276_G280_V0.9270.77
196_V220_V0.9200.76
135_V151_A0.9170.76
31_A35_A0.9160.76
229_D319_A0.9110.76
313_M317_L0.9090.75
261_A264_L0.8990.75
176_P179_R0.8930.74
274_G279_A0.8930.74
56_A59_S0.8910.74
225_F230_D0.8890.74
205_N223_A0.8850.73
77_V133_F0.8840.73
321_A343_V0.8830.73
273_V281_A0.8820.73
208_A223_A0.8810.73
240_E243_H0.8800.73
344_S348_R0.8670.72
71_G74_G0.8670.72
107_V220_V0.8660.72
331_G335_G0.8610.71
235_A317_L0.8510.70
62_A345_A0.8500.70
206_A222_A0.8490.70
77_V263_L0.8490.70
201_G220_V0.8480.70
20_A24_A0.8460.70
297_E300_A0.8460.70
301_D346_R0.8450.70
33_A102_P0.8440.70
240_E297_E0.8380.69
202_L237_I0.8310.69
116_R119_R0.8280.68
167_A209_T0.8260.68
219_F225_F0.8260.68
208_A244_H0.8250.68
88_G125_V0.8230.68
317_L343_V0.8200.68
29_G109_R0.8200.68
66_P288_A0.8180.67
99_G111_A0.8160.67
47_V311_V0.8080.66
183_C241_A0.8040.66
196_V234_A0.8010.66
68_A78_L0.7970.65
88_G121_Y0.7970.65
170_H222_A0.7960.65
50_L266_V0.7940.65
198_A201_G0.7930.65
66_P94_L0.7920.65
21_A27_R0.7910.65
116_R123_L0.7850.64
55_V90_V0.7840.64
251_L266_V0.7830.64
95_A118_V0.7770.63
19_L258_T0.7760.63
120_R222_A0.7750.63
163_G182_A0.7740.63
39_R46_A0.7740.63
130_L134_A0.7720.63
155_A159_I0.7720.63
272_A275_A0.7710.63
92_P168_G0.7690.63
43_A151_A0.7670.62
127_A165_V0.7630.62
217_C303_Y0.7600.62
164_P214_G0.7550.61
277_G282_S0.7510.61
298_F345_A0.7490.61
243_H301_D0.7470.60
18_R347_R0.7330.59
22_R27_R0.7310.59
100_T104_W0.7300.59
167_A171_P0.7270.58
120_R205_N0.7270.58
120_R199_S0.7270.58
248_H303_Y0.7260.58
110_T113_D0.7250.58
214_G287_V0.7230.58
242_G303_Y0.7230.58
297_E301_D0.7220.58
70_P74_G0.7210.58
338_A345_A0.7210.58
85_V88_G0.7190.57
71_G130_L0.7180.57
272_A283_A0.7160.57
347_R351_S0.7150.57
334_A345_A0.7140.57
85_V258_T0.7110.57
319_A323_R0.7100.56
190_D244_H0.7090.56
197_D201_G0.7040.56
343_V347_R0.7010.55
183_C189_R0.7000.55
27_R325_A0.6980.55
232_A325_A0.6970.55
241_A244_H0.6970.55
132_A136_V0.6930.55
32_A36_R0.6890.54
204_P244_H0.6880.54
47_V70_P0.6870.54
201_G223_A0.6830.54
62_A65_V0.6830.54
120_R171_P0.6800.53
168_G223_A0.6800.53
167_A196_V0.6790.53
335_G350_L0.6770.53
204_P324_D0.6770.53
318_A347_R0.6720.52
317_L324_D0.6710.52
266_V288_A0.6710.52
82_A158_G0.6700.52
207_V223_A0.6680.52
300_A346_R0.6680.52
313_M350_L0.6670.52
20_A23_A0.6650.52
301_D341_P0.6630.51
34_T38_R0.6620.51
168_G222_A0.6620.51
120_R170_H0.6590.51
127_A131_P0.6570.51
292_V295_W0.6550.51
205_N340_H0.6550.51
81_L125_V0.6540.50
135_V155_A0.6540.50
138_A250_G0.6540.50
215_F334_A0.6530.50
202_L248_H0.6520.50
20_A138_A0.6510.50
105_A150_A0.6510.50
319_A328_A0.6490.50
63_D67_A0.6480.50
107_V201_G0.6470.50
236_V316_A0.6470.50
186_A241_A0.6450.49
147_P155_A0.6420.49
175_T320_V0.6400.49
244_H247_G0.6380.49
28_P126_C0.6370.49
84_M136_V0.6360.48
146_L187_C0.6340.48
71_G75_G0.6330.48
231_G308_V0.6330.48
95_A110_T0.6320.48
85_V125_V0.6320.48
92_P218_V0.6320.48
33_A342_S0.6280.48
35_A38_R0.6250.47
25_I126_C0.6240.47
220_V227_R0.6230.47
120_R223_A0.6230.47
107_V170_H0.6230.47
72_P76_G0.6220.47
170_H199_S0.6200.47
217_C222_A0.6200.47
171_P201_G0.6180.47
70_P82_A0.6170.46
243_H340_H0.6170.46
171_P290_G0.6160.46
130_L178_E0.6160.46
196_V218_V0.6160.46
89_G303_Y0.6130.46
181_R306_R0.6130.46
201_G207_V0.6120.46
43_A288_A0.6110.46
132_A281_A0.6100.46
67_A255_A0.6100.46
156_A161_A0.6090.46
108_T111_A0.6070.45
65_V68_A0.6070.45
278_A285_L0.6050.45
290_G325_A0.6040.45
22_R30_R0.6030.45
143_P274_G0.6020.45
99_G102_P0.6010.45
180_E190_D0.6000.45
44_L48_A0.6000.45
202_L208_A0.5990.45
101_R256_V0.5980.44
211_V214_G0.5950.44
101_R232_A0.5940.44
77_V140_V0.5930.44
45_Q157_V0.5930.44
170_H198_A0.5920.44
102_P107_V0.5910.44
54_A284_V0.5910.44
213_P216_R0.5890.43
205_N240_E0.5880.43
275_A285_L0.5870.43
219_F331_G0.5860.43
188_A334_A0.5850.43
205_N320_V0.5850.43
243_H248_H0.5840.43
171_P198_A0.5840.43
333_V336_A0.5830.43
205_N222_A0.5830.43
153_L158_G0.5820.43
49_A57_M0.5820.43
225_F241_A0.5820.43
101_R236_V0.5780.42
321_A328_A0.5780.42
43_A63_D0.5770.42
120_R218_V0.5770.42
148_R262_P0.5750.42
129_A154_A0.5740.42
163_G216_R0.5740.42
56_A60_L0.5710.42
54_A139_W0.5710.42
220_V224_V0.5700.41
95_A98_L0.5700.41
92_P173_V0.5680.41
317_L350_L0.5670.41
331_G334_A0.5660.41
27_R328_A0.5660.41
159_I255_A0.5650.41
43_A93_A0.5650.41
148_R315_R0.5650.41
320_V325_A0.5650.41
97_H178_E0.5650.41
145_G235_A0.5620.41
215_F244_H0.5610.41
194_R216_R0.5600.40
168_G216_R0.5590.40
77_V137_A0.5580.40
251_L292_V0.5580.40
116_R201_G0.5550.40
275_A279_A0.5550.40
53_L57_M0.5530.40
309_T316_A0.5530.40
250_G254_L0.5530.40
220_V223_A0.5520.40
239_H301_D0.5520.40
208_A224_V0.5510.39
218_V241_A0.5500.39
113_D130_L0.5500.39
243_H300_A0.5490.39
28_P288_A0.5480.39
150_A154_A0.5470.39
152_I260_L0.5460.39
18_R58_E0.5450.39
254_L258_T0.5440.39
170_H201_G0.5440.39
208_A317_L0.5430.39
228_L323_R0.5430.39
225_F233_A0.5430.39
90_V150_A0.5430.39
181_R262_P0.5410.38
66_P181_R0.5370.38
209_T249_L0.5370.38
64_A176_P0.5370.38
57_M72_P0.5360.38
25_I66_P0.5360.38
124_V128_V0.5360.38
252_R256_V0.5330.38
108_T203_G0.5320.38
259_A289_V0.5320.38
278_A284_V0.5320.38
205_N304_A0.5300.37
168_G171_P0.5300.37
199_S206_A0.5290.37
105_A183_C0.5290.37
92_P222_A0.5270.37
219_F233_A0.5260.37
52_G61_L0.5240.37
204_P345_A0.5230.37
34_T49_A0.5220.37
190_D204_P0.5200.36
290_G339_L0.5200.36
25_I28_P0.5200.36
21_A24_A0.5190.36
273_V283_A0.5170.36
321_A327_A0.5160.36
203_G227_R0.5160.36
196_V208_A0.5150.36
192_R216_R0.5150.36
154_A158_G0.5140.36
130_L348_R0.5120.36
220_V317_L0.5110.35
273_V276_G0.5110.35
280_V285_L0.5100.35
74_G332_R0.5100.35
190_D215_F0.5100.35
187_C191_L0.5090.35
163_G209_T0.5090.35
330_R342_S0.5080.35
334_A337_L0.5080.35
81_L129_A0.5080.35
99_G202_L0.5070.35
259_A287_V0.5060.35
19_L50_L0.5040.35
23_A299_D0.5040.35
206_A218_V0.5040.35
40_A47_V0.5030.35
310_A313_M0.5020.35
258_T279_A0.5020.35
146_L244_H0.5010.34
51_T93_A0.5000.34
29_G48_A0.5000.34
166_L207_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.9831 100 0.222 Contact Map
4il3A 1 0.9803 100 0.238 Contact Map
3c37A 1 0.5112 100 0.677 Contact Map
3cqbA 4 0.264 99.7 0.795 Contact Map
4qhjA 2 0.2865 95.1 0.93 Contact Map
4jiuA 1 0.2837 89.1 0.942 Contact Map
3dteA 2 0.4382 88.6 0.942 Contact Map
4jixA 2 0.2978 86.1 0.944 Contact Map
4o66A 2 0.191 37.4 0.961 Contact Map
3zvsA 1 0.427 21.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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