Q9HS47 - HALSA - GREMLIN Contacts

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Q9HS47 - Uncharacterized protein

UniProt:	Q9HS47	Sequences: MHAVVLGVLPGLSYAVARLAARAAIRRPGRAAATARLRRANRALQAVAALTGLAVAMESLLADAVPAAVPGPPGGGVLVGLASMVAVGGVGPALAVHLGTRPAWAAVTRTAVDYRRTVRRYLLVVCAVALPAFAVVAAWVAAPAGLPRLAAILAAAVGIAAVGPVLAGGHPAVGTPTERERACVPACARDLRLRVVDASGGLGPNAVATGVVPGFRCVFVTAAVFERLDDGAAAAVIAHEAGHHHRGHLGLRLLAVVTALAPLLCVASSAVAVGAGGAAVASAVLLVAVGPVIRWTEFDADAYAARHVTAVAMARALAAVAPRDAAAAERGRVAGALALHPSVSARRRRLSDHNAH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	356 (331)
Sequences:	1295 (1009)
Seq/√Len:	55.5

BACSU - YHFN
HALSA - Q9HS47 Q9HSA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_R	105_A	5.083	1.00
305_A	350_L	4.837	1.00
314_A	347_R	4.336	1.00
167_A	207_V	4.051	1.00
95_A	112_V	4.036	1.00
155_A	162_V	3.312	1.00
232_A	319_A	3.302	1.00
277_G	281_A	3.157	1.00
238_A	304_A	3.115	1.00
119_R	123_L	2.973	1.00
23_A	26_R	2.934	1.00
248_H	299_D	2.818	1.00
98_L	110_T	2.775	1.00
24_A	28_P	2.774	1.00
167_A	173_V	2.510	1.00
171_P	197_D	2.445	1.00
252_R	296_T	2.398	1.00
278_A	283_A	2.306	1.00
174_G	177_T	2.270	1.00
163_G	168_G	2.235	1.00
113_D	119_R	2.227	1.00
275_A	278_A	2.175	1.00
268_S	271_V	2.140	1.00
302_A	349_R	2.123	1.00
298_F	342_S	2.094	1.00
246_R	299_D	2.059	1.00
232_A	315_R	2.028	1.00
47_V	90_V	2.024	1.00
139_W	148_R	1.975	1.00
280_V	283_A	1.970	1.00
173_V	196_V	1.969	1.00
153_L	257_V	1.967	1.00
47_V	93_A	1.960	1.00
231_G	312_A	1.932	1.00
95_A	117_T	1.907	1.00
335_G	345_A	1.882	1.00
335_G	338_A	1.868	0.99
295_W	299_D	1.863	0.99
280_V	284_V	1.859	0.99
44_L	93_A	1.851	0.99
77_V	81_L	1.837	0.99
28_P	32_A	1.835	0.99
122_L	126_C	1.826	0.99
159_I	162_V	1.802	0.99
296_T	299_D	1.791	0.99
183_C	190_D	1.788	0.99
103_A	108_T	1.787	0.99
251_L	299_D	1.778	0.99
327_A	330_R	1.763	0.99
156_A	159_I	1.752	0.99
156_A	162_V	1.744	0.99
162_V	165_V	1.740	0.99
338_A	342_S	1.737	0.99
277_G	285_L	1.715	0.99
26_R	322_P	1.699	0.99
251_L	296_T	1.675	0.99
278_A	281_A	1.674	0.99
335_G	342_S	1.663	0.99
274_G	278_A	1.632	0.99
239_H	243_H	1.623	0.99
186_A	303_Y	1.622	0.99
147_P	151_A	1.607	0.98
112_V	117_T	1.605	0.98
281_A	285_L	1.604	0.98
198_A	202_L	1.580	0.98
310_A	350_L	1.574	0.98
112_V	118_V	1.568	0.98
182_A	307_H	1.563	0.98
180_E	193_L	1.520	0.98
197_D	200_G	1.518	0.98
314_A	351_S	1.517	0.98
342_S	345_A	1.505	0.98
207_V	218_V	1.497	0.97
315_R	319_A	1.484	0.97
110_T	116_R	1.476	0.97
85_V	89_G	1.476	0.97
247_G	250_G	1.465	0.97
273_V	280_V	1.451	0.97
103_A	109_R	1.438	0.97
120_R	201_G	1.436	0.97
68_A	82_A	1.431	0.97
239_H	297_E	1.422	0.97
243_H	297_E	1.400	0.96
155_A	160_A	1.399	0.96
156_A	160_A	1.382	0.96
277_G	280_V	1.377	0.96
26_R	29_G	1.368	0.96
273_V	277_G	1.357	0.95
163_G	173_V	1.357	0.95
65_V	69_V	1.351	0.95
102_P	202_L	1.349	0.95
277_G	283_A	1.346	0.95
43_A	46_A	1.344	0.95
207_V	216_R	1.339	0.95
302_A	306_R	1.334	0.95
195_V	225_F	1.333	0.95
51_T	90_V	1.310	0.95
274_G	280_V	1.295	0.94
204_P	227_R	1.294	0.94
36_R	101_R	1.291	0.94
118_V	122_L	1.290	0.94
155_A	158_G	1.282	0.94
182_A	241_A	1.278	0.94
121_Y	125_V	1.276	0.94
109_R	203_G	1.275	0.94
69_V	75_G	1.269	0.94
227_R	323_R	1.265	0.93
73_P	137_A	1.254	0.93
68_A	75_G	1.244	0.93
96_V	100_T	1.241	0.93
18_R	343_V	1.239	0.93
148_R	151_A	1.236	0.93
173_V	207_V	1.231	0.92
81_L	133_F	1.228	0.92
40_A	44_L	1.222	0.92
309_T	312_A	1.212	0.92
341_P	346_R	1.208	0.92
67_A	82_A	1.207	0.92
164_P	168_G	1.194	0.91
265_C	268_S	1.187	0.91
274_G	277_G	1.182	0.91
204_P	335_G	1.181	0.91
279_A	283_A	1.179	0.91
228_L	236_V	1.177	0.91
171_P	196_V	1.163	0.90
236_V	340_H	1.162	0.90
196_V	207_V	1.161	0.90
49_A	53_L	1.146	0.89
127_A	132_A	1.142	0.89
173_V	216_R	1.137	0.89
50_L	122_L	1.134	0.89
303_Y	334_A	1.123	0.89
213_P	342_S	1.122	0.88
275_A	280_V	1.118	0.88
36_R	104_W	1.106	0.88
47_V	51_T	1.100	0.87
298_F	349_R	1.094	0.87
274_G	283_A	1.094	0.87
121_Y	124_V	1.087	0.87
137_A	141_A	1.086	0.87
288_A	292_V	1.081	0.87
188_A	208_A	1.080	0.87
327_A	331_G	1.079	0.86
72_P	144_A	1.076	0.86
176_P	195_V	1.072	0.86
235_A	313_M	1.070	0.86
138_A	151_A	1.069	0.86
334_A	338_A	1.062	0.86
157_V	162_V	1.060	0.85
305_A	310_A	1.060	0.85
19_L	25_I	1.048	0.85
29_G	96_V	1.047	0.85
54_A	58_E	1.041	0.84
94_L	121_Y	1.041	0.84
64_A	150_A	1.034	0.84
158_G	162_V	1.032	0.84
330_R	338_A	1.028	0.84
104_W	172_A	1.025	0.83
204_P	323_R	1.022	0.83
240_E	340_H	1.020	0.83
186_A	307_H	1.018	0.83
276_G	279_A	1.016	0.83
308_V	312_A	1.015	0.83
55_V	60_L	1.014	0.83
153_L	253_L	1.011	0.83
274_G	285_L	1.005	0.82
23_A	28_P	1.004	0.82
293_I	339_L	1.003	0.82
199_S	222_A	1.002	0.82
255_A	292_V	0.999	0.82
27_R	31_A	0.997	0.82
239_H	340_H	0.994	0.82
99_G	108_T	0.992	0.81
50_L	89_G	0.992	0.81
297_E	340_H	0.992	0.81
22_R	328_A	0.987	0.81
100_T	103_A	0.985	0.81
340_H	346_R	0.983	0.81
163_G	166_L	0.980	0.81
278_A	282_S	0.974	0.80
76_G	140_V	0.973	0.80
171_P	207_V	0.970	0.80
248_H	296_T	0.969	0.80
180_E	184_V	0.968	0.80
64_A	86_A	0.968	0.80
134_A	137_A	0.966	0.80
206_A	340_H	0.961	0.79
147_P	287_V	0.956	0.79
277_G	284_V	0.942	0.78
29_G	40_A	0.941	0.78
230_D	234_A	0.938	0.78
37_L	97_H	0.938	0.78
218_V	223_A	0.938	0.78
155_A	161_A	0.937	0.78
311_V	351_S	0.937	0.78
25_I	29_G	0.933	0.77
228_L	319_A	0.933	0.77
276_G	280_V	0.927	0.77
196_V	220_V	0.920	0.76
135_V	151_A	0.917	0.76
31_A	35_A	0.916	0.76
229_D	319_A	0.911	0.76
313_M	317_L	0.909	0.75
261_A	264_L	0.899	0.75
176_P	179_R	0.893	0.74
274_G	279_A	0.893	0.74
56_A	59_S	0.891	0.74
225_F	230_D	0.889	0.74
205_N	223_A	0.885	0.73
77_V	133_F	0.884	0.73
321_A	343_V	0.883	0.73
273_V	281_A	0.882	0.73
208_A	223_A	0.881	0.73
240_E	243_H	0.880	0.73
344_S	348_R	0.867	0.72
71_G	74_G	0.867	0.72
107_V	220_V	0.866	0.72
331_G	335_G	0.861	0.71
235_A	317_L	0.851	0.70
62_A	345_A	0.850	0.70
206_A	222_A	0.849	0.70
77_V	263_L	0.849	0.70
201_G	220_V	0.848	0.70
20_A	24_A	0.846	0.70
297_E	300_A	0.846	0.70
301_D	346_R	0.845	0.70
33_A	102_P	0.844	0.70
240_E	297_E	0.838	0.69
202_L	237_I	0.831	0.69
116_R	119_R	0.828	0.68
167_A	209_T	0.826	0.68
219_F	225_F	0.826	0.68
208_A	244_H	0.825	0.68
88_G	125_V	0.823	0.68
317_L	343_V	0.820	0.68
29_G	109_R	0.820	0.68
66_P	288_A	0.818	0.67
99_G	111_A	0.816	0.67
47_V	311_V	0.808	0.66
183_C	241_A	0.804	0.66
196_V	234_A	0.801	0.66
68_A	78_L	0.797	0.65
88_G	121_Y	0.797	0.65
170_H	222_A	0.796	0.65
50_L	266_V	0.794	0.65
198_A	201_G	0.793	0.65
66_P	94_L	0.792	0.65
21_A	27_R	0.791	0.65
116_R	123_L	0.785	0.64
55_V	90_V	0.784	0.64
251_L	266_V	0.783	0.64
95_A	118_V	0.777	0.63
19_L	258_T	0.776	0.63
120_R	222_A	0.775	0.63
163_G	182_A	0.774	0.63
39_R	46_A	0.774	0.63
130_L	134_A	0.772	0.63
155_A	159_I	0.772	0.63
272_A	275_A	0.771	0.63
92_P	168_G	0.769	0.63
43_A	151_A	0.767	0.62
127_A	165_V	0.763	0.62
217_C	303_Y	0.760	0.62
164_P	214_G	0.755	0.61
277_G	282_S	0.751	0.61
298_F	345_A	0.749	0.61
243_H	301_D	0.747	0.60
18_R	347_R	0.733	0.59
22_R	27_R	0.731	0.59
100_T	104_W	0.730	0.59
167_A	171_P	0.727	0.58
120_R	205_N	0.727	0.58
120_R	199_S	0.727	0.58
248_H	303_Y	0.726	0.58
110_T	113_D	0.725	0.58
214_G	287_V	0.723	0.58
242_G	303_Y	0.723	0.58
297_E	301_D	0.722	0.58
70_P	74_G	0.721	0.58
338_A	345_A	0.721	0.58
85_V	88_G	0.719	0.57
71_G	130_L	0.718	0.57
272_A	283_A	0.716	0.57
347_R	351_S	0.715	0.57
334_A	345_A	0.714	0.57
85_V	258_T	0.711	0.57
319_A	323_R	0.710	0.56
190_D	244_H	0.709	0.56
197_D	201_G	0.704	0.56
343_V	347_R	0.701	0.55
183_C	189_R	0.700	0.55
27_R	325_A	0.698	0.55
232_A	325_A	0.697	0.55
241_A	244_H	0.697	0.55
132_A	136_V	0.693	0.55
32_A	36_R	0.689	0.54
204_P	244_H	0.688	0.54
47_V	70_P	0.687	0.54
201_G	223_A	0.683	0.54
62_A	65_V	0.683	0.54
120_R	171_P	0.680	0.53
168_G	223_A	0.680	0.53
167_A	196_V	0.679	0.53
335_G	350_L	0.677	0.53
204_P	324_D	0.677	0.53
318_A	347_R	0.672	0.52
317_L	324_D	0.671	0.52
266_V	288_A	0.671	0.52
82_A	158_G	0.670	0.52
207_V	223_A	0.668	0.52
300_A	346_R	0.668	0.52
313_M	350_L	0.667	0.52
20_A	23_A	0.665	0.52
301_D	341_P	0.663	0.51
34_T	38_R	0.662	0.51
168_G	222_A	0.662	0.51
120_R	170_H	0.659	0.51
127_A	131_P	0.657	0.51
292_V	295_W	0.655	0.51
205_N	340_H	0.655	0.51
81_L	125_V	0.654	0.50
135_V	155_A	0.654	0.50
138_A	250_G	0.654	0.50
215_F	334_A	0.653	0.50
202_L	248_H	0.652	0.50
20_A	138_A	0.651	0.50
105_A	150_A	0.651	0.50
319_A	328_A	0.649	0.50
63_D	67_A	0.648	0.50
107_V	201_G	0.647	0.50
236_V	316_A	0.647	0.50
186_A	241_A	0.645	0.49
147_P	155_A	0.642	0.49
175_T	320_V	0.640	0.49
244_H	247_G	0.638	0.49
28_P	126_C	0.637	0.49
84_M	136_V	0.636	0.48
146_L	187_C	0.634	0.48
71_G	75_G	0.633	0.48
231_G	308_V	0.633	0.48
95_A	110_T	0.632	0.48
85_V	125_V	0.632	0.48
92_P	218_V	0.632	0.48
33_A	342_S	0.628	0.48
35_A	38_R	0.625	0.47
25_I	126_C	0.624	0.47
220_V	227_R	0.623	0.47
120_R	223_A	0.623	0.47
107_V	170_H	0.623	0.47
72_P	76_G	0.622	0.47
170_H	199_S	0.620	0.47
217_C	222_A	0.620	0.47
171_P	201_G	0.618	0.47
70_P	82_A	0.617	0.46
243_H	340_H	0.617	0.46
171_P	290_G	0.616	0.46
130_L	178_E	0.616	0.46
196_V	218_V	0.616	0.46
89_G	303_Y	0.613	0.46
181_R	306_R	0.613	0.46
201_G	207_V	0.612	0.46
43_A	288_A	0.611	0.46
132_A	281_A	0.610	0.46
67_A	255_A	0.610	0.46
156_A	161_A	0.609	0.46
108_T	111_A	0.607	0.45
65_V	68_A	0.607	0.45
278_A	285_L	0.605	0.45
290_G	325_A	0.604	0.45
22_R	30_R	0.603	0.45
143_P	274_G	0.602	0.45
99_G	102_P	0.601	0.45
180_E	190_D	0.600	0.45
44_L	48_A	0.600	0.45
202_L	208_A	0.599	0.45
101_R	256_V	0.598	0.44
211_V	214_G	0.595	0.44
101_R	232_A	0.594	0.44
77_V	140_V	0.593	0.44
45_Q	157_V	0.593	0.44
170_H	198_A	0.592	0.44
102_P	107_V	0.591	0.44
54_A	284_V	0.591	0.44
213_P	216_R	0.589	0.43
205_N	240_E	0.588	0.43
275_A	285_L	0.587	0.43
219_F	331_G	0.586	0.43
188_A	334_A	0.585	0.43
205_N	320_V	0.585	0.43
243_H	248_H	0.584	0.43
171_P	198_A	0.584	0.43
333_V	336_A	0.583	0.43
205_N	222_A	0.583	0.43
153_L	158_G	0.582	0.43
49_A	57_M	0.582	0.43
225_F	241_A	0.582	0.43
101_R	236_V	0.578	0.42
321_A	328_A	0.578	0.42
43_A	63_D	0.577	0.42
120_R	218_V	0.577	0.42
148_R	262_P	0.575	0.42
129_A	154_A	0.574	0.42
163_G	216_R	0.574	0.42
56_A	60_L	0.571	0.42
54_A	139_W	0.571	0.42
220_V	224_V	0.570	0.41
95_A	98_L	0.570	0.41
92_P	173_V	0.568	0.41
317_L	350_L	0.567	0.41
331_G	334_A	0.566	0.41
27_R	328_A	0.566	0.41
159_I	255_A	0.565	0.41
43_A	93_A	0.565	0.41
148_R	315_R	0.565	0.41
320_V	325_A	0.565	0.41
97_H	178_E	0.565	0.41
145_G	235_A	0.562	0.41
215_F	244_H	0.561	0.41
194_R	216_R	0.560	0.40
168_G	216_R	0.559	0.40
77_V	137_A	0.558	0.40
251_L	292_V	0.558	0.40
116_R	201_G	0.555	0.40
275_A	279_A	0.555	0.40
53_L	57_M	0.553	0.40
309_T	316_A	0.553	0.40
250_G	254_L	0.553	0.40
220_V	223_A	0.552	0.40
239_H	301_D	0.552	0.40
208_A	224_V	0.551	0.39
218_V	241_A	0.550	0.39
113_D	130_L	0.550	0.39
243_H	300_A	0.549	0.39
28_P	288_A	0.548	0.39
150_A	154_A	0.547	0.39
152_I	260_L	0.546	0.39
18_R	58_E	0.545	0.39
254_L	258_T	0.544	0.39
170_H	201_G	0.544	0.39
208_A	317_L	0.543	0.39
228_L	323_R	0.543	0.39
225_F	233_A	0.543	0.39
90_V	150_A	0.543	0.39
181_R	262_P	0.541	0.38
66_P	181_R	0.537	0.38
209_T	249_L	0.537	0.38
64_A	176_P	0.537	0.38
57_M	72_P	0.536	0.38
25_I	66_P	0.536	0.38
124_V	128_V	0.536	0.38
252_R	256_V	0.533	0.38
108_T	203_G	0.532	0.38
259_A	289_V	0.532	0.38
278_A	284_V	0.532	0.38
205_N	304_A	0.530	0.37
168_G	171_P	0.530	0.37
199_S	206_A	0.529	0.37
105_A	183_C	0.529	0.37
92_P	222_A	0.527	0.37
219_F	233_A	0.526	0.37
52_G	61_L	0.524	0.37
204_P	345_A	0.523	0.37
34_T	49_A	0.522	0.37
190_D	204_P	0.520	0.36
290_G	339_L	0.520	0.36
25_I	28_P	0.520	0.36
21_A	24_A	0.519	0.36
273_V	283_A	0.517	0.36
321_A	327_A	0.516	0.36
203_G	227_R	0.516	0.36
196_V	208_A	0.515	0.36
192_R	216_R	0.515	0.36
154_A	158_G	0.514	0.36
130_L	348_R	0.512	0.36
220_V	317_L	0.511	0.35
273_V	276_G	0.511	0.35
280_V	285_L	0.510	0.35
74_G	332_R	0.510	0.35
190_D	215_F	0.510	0.35
187_C	191_L	0.509	0.35
163_G	209_T	0.509	0.35
330_R	342_S	0.508	0.35
334_A	337_L	0.508	0.35
81_L	129_A	0.508	0.35
99_G	202_L	0.507	0.35
259_A	287_V	0.506	0.35
19_L	50_L	0.504	0.35
23_A	299_D	0.504	0.35
206_A	218_V	0.504	0.35
40_A	47_V	0.503	0.35
310_A	313_M	0.502	0.35
258_T	279_A	0.502	0.35
146_L	244_H	0.501	0.34
51_T	93_A	0.500	0.34
29_G	48_A	0.500	0.34
166_L	207_V	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4aw6A	2	0.9831	100	0.222	Contact Map
4il3A	1	0.9803	100	0.238	Contact Map
3c37A	1	0.5112	100	0.677	Contact Map
3cqbA	4	0.264	99.7	0.795	Contact Map
4qhjA	2	0.2865	95.1	0.93	Contact Map
4jiuA	1	0.2837	89.1	0.942	Contact Map
3dteA	2	0.4382	88.6	0.942	Contact Map
4jixA	2	0.2978	86.1	0.944	Contact Map
4o66A	2	0.191	37.4	0.961	Contact Map
3zvsA	1	0.427	21.4	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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