GREMLIN Database
Q9HS43 - Phosphoribosylaminoimidazole-succinocarboxamide formyltransferase
UniProt: Q9HS43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 595 (464)
Sequences: 2852 (1413)
Seq/√Len: 65.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
571_D575_E5.6111.00
469_K578_N5.3681.00
470_R476_E4.3061.00
389_E410_G3.9681.00
233_R245_R3.9361.00
547_P551_A3.7421.00
389_E412_T3.7351.00
314_D429_D3.5901.00
283_R286_V3.5641.00
397_R400_D3.3761.00
392_A418_V3.2601.00
410_G429_D3.2021.00
215_T246_A3.1501.00
411_Y427_V2.9471.00
346_A360_T2.8151.00
392_A414_D2.7891.00
169_F186_S2.7801.00
174_A180_D2.7791.00
550_I561_V2.7651.00
358_C486_V2.7621.00
391_D394_T2.6431.00
171_G178_V2.6131.00
145_R149_E2.5731.00
215_T227_A2.4951.00
230_L245_R2.4401.00
457_W589_H2.4351.00
347_A386_L2.4181.00
392_A396_T2.4121.00
563_Q584_M2.3561.00
518_E522_K2.3381.00
176_E180_D2.3161.00
551_A579_E2.3061.00
328_Y445_L2.2381.00
363_T366_D2.2351.00
547_P572_Q2.2181.00
508_V511_V2.2001.00
285_D322_A2.1701.00
125_R128_A2.1351.00
483_A498_A2.1321.00
146_V150_V2.0521.00
202_S205_T2.0501.00
473_T476_E2.0341.00
174_A181_A2.0221.00
569_N572_Q2.0211.00
281_T449_R2.0061.00
228_A237_D1.9811.00
497_F521_A1.9781.00
479_T498_A1.9641.00
365_A369_S1.9021.00
364_L386_L1.9001.00
517_V549_G1.8971.00
236_Q241_E1.8971.00
575_E578_N1.8861.00
575_E579_E1.8861.00
144_M148_S1.8791.00
512_S523_K1.8761.00
386_L390_C1.8631.00
547_P579_E1.8531.00
361_A370_D1.8521.00
538_M553_A1.8471.00
413_D417_D1.8221.00
284_E301_R1.8211.00
398_V403_K1.8071.00
476_E559_E1.7751.00
126_V237_D1.7661.00
155_M178_V1.7471.00
325_Y441_T1.7361.00
329_N353_T1.7351.00
126_V228_A1.7281.00
416_V420_T1.7100.99
329_N443_T1.6970.99
384_V398_V1.6960.99
369_S397_R1.6890.99
194_T256_D1.6860.99
537_V560_A1.6850.99
468_T584_M1.6790.99
497_F504_V1.6770.99
479_T499_A1.6640.99
126_V187_G1.6630.99
362_D366_D1.6600.99
460_T463_D1.6240.99
345_P364_L1.6190.99
551_A555_E1.6150.99
175_H178_V1.6070.99
361_A366_D1.6010.99
317_N420_T1.5930.99
173_N176_E1.5890.99
317_N425_L1.5860.99
331_A405_V1.5840.99
576_A579_E1.5750.99
154_A217_E1.5690.99
174_A178_V1.5660.99
230_L233_R1.5360.99
551_A580_H1.5320.99
515_D523_K1.5210.99
536_A558_I1.5210.99
174_A182_G1.5180.99
464_L481_L1.5140.99
534_D559_E1.5140.99
178_V182_G1.5070.99
576_A580_H1.5060.99
465_E588_G1.5040.99
167_P183_V1.5010.99
470_R559_E1.4930.99
215_T229_T1.4910.99
154_A181_A1.4830.98
299_V445_L1.4820.98
316_L429_D1.4740.98
461_A481_L1.4620.98
173_N180_D1.4580.98
475_A479_T1.4470.98
340_E489_H1.4410.98
538_M558_I1.4400.98
399_A421_A1.4240.98
384_V403_K1.4230.98
479_T500_G1.4230.98
475_A500_G1.4190.98
464_L562_I1.4180.98
480_M560_A1.4180.98
186_S213_I1.4180.98
129_A133_Y1.4080.98
340_E488_T1.4030.98
173_N177_Q1.4030.98
552_A555_E1.4010.98
124_R146_V1.4010.98
273_F298_A1.3950.98
323_L328_Y1.3890.98
440_V453_E1.3850.98
229_T249_Q1.3830.98
174_A177_Q1.3810.98
550_I573_V1.3750.98
178_V181_A1.3720.97
317_N419_L1.3680.97
177_Q180_D1.3650.97
547_P580_H1.3570.97
479_T501_T1.3560.97
349_V379_A1.3510.97
127_V147_L1.3440.97
204_R261_G1.3400.97
244_P248_R1.3400.97
561_V582_M1.3400.97
335_L430_V1.3350.97
478_E501_T1.3340.97
366_D370_D1.3210.97
174_A179_L1.3110.97
238_A242_A1.2920.96
296_D453_E1.2870.96
227_A246_A1.2840.96
442_E449_R1.2790.96
172_R224_D1.2660.96
390_C411_Y1.2570.96
416_V427_V1.2530.96
547_P576_A1.2520.96
244_P261_G1.2430.95
273_F296_D1.2320.95
200_D203_V1.2310.95
129_A132_D1.2270.95
176_E179_L1.2180.95
555_E580_H1.2130.95
135_I185_V1.2130.95
124_R150_V1.2120.95
497_F536_A1.2040.95
194_T249_Q1.2020.95
194_T198_A1.2020.95
521_A556_A1.2000.94
552_A556_A1.1970.94
354_N508_V1.1960.94
213_I218_S1.1950.94
213_I217_E1.1940.94
466_V585_V1.1740.94
222_F240_F1.1660.94
474_A478_E1.1600.93
155_M177_Q1.1570.93
200_D204_R1.1520.93
177_Q181_A1.1470.93
338_V385_A1.1430.93
461_A477_V1.1360.93
272_T296_D1.1310.93
365_A397_R1.1220.92
365_A393_E1.1200.92
204_R240_F1.1190.92
554_A582_M1.1160.92
125_R235_R1.1130.92
508_V519_I1.1120.92
455_N591_A1.1100.92
175_H180_D1.1080.92
374_T503_T1.1050.92
394_T398_V1.1030.92
299_V311_V1.1000.91
131_D137_V1.0990.91
407_V430_V1.0990.91
380_F568_K1.0990.91
497_F558_I1.0980.91
332_D336_A1.0950.91
414_D417_D1.0930.91
171_G175_H1.0920.91
226_T242_A1.0910.91
392_A412_T1.0860.91
204_R222_F1.0850.91
568_K571_D1.0830.91
317_N427_V1.0810.91
470_R581_G1.0770.91
550_I577_A1.0750.91
396_T400_D1.0690.90
574_I586_F1.0660.90
369_S373_S1.0630.90
476_E583_A1.0520.90
121_D232_T1.0510.90
118_S192_V1.0490.89
315_Q322_A1.0470.89
466_V472_P1.0470.89
338_V346_A1.0420.89
364_L394_T1.0370.89
393_E396_T1.0360.89
373_S502_E1.0280.88
374_T502_E1.0280.88
504_V533_A1.0280.88
233_R236_Q1.0210.88
194_T252_A1.0200.88
195_N199_E1.0180.88
237_D242_A1.0180.88
481_L562_I1.0130.88
166_L217_E1.0110.88
335_L339_R1.0100.88
169_F214_V1.0060.87
229_T233_R1.0050.87
511_V519_I1.0040.87
503_T506_L1.0020.87
238_A241_E0.9990.87
222_F243_Y0.9950.87
337_L348_A0.9870.86
372_L376_A0.9840.86
472_P585_V0.9830.86
466_V471_E0.9830.86
175_H179_L0.9830.86
341_F346_A0.9820.86
155_M172_R0.9820.86
398_V406_V0.9820.86
467_V586_F0.9790.86
396_T421_A0.9760.86
411_Y429_D0.9730.86
214_V217_E0.9730.86
550_I554_A0.9720.85
128_A132_D0.9710.85
310_V313_A0.9700.85
173_N179_L0.9690.85
472_P476_E0.9690.85
386_L394_T0.9670.85
399_A425_L0.9670.85
363_T393_E0.9660.85
419_L427_V0.9610.85
331_A428_L0.9610.85
495_I541_D0.9590.85
515_D518_E0.9560.85
377_K515_D0.9550.84
364_L388_R0.9550.84
372_L401_S0.9490.84
464_L477_V0.9480.84
173_N178_V0.9480.84
122_H125_R0.9470.84
472_P583_A0.9450.84
186_S227_A0.9440.84
248_R252_A0.9430.84
490_V496_L0.9420.84
313_A428_L0.9390.83
459_P464_L0.9330.83
347_A398_V0.9270.83
274_P298_A0.9240.82
470_R583_A0.9190.82
169_F215_T0.9110.82
514_V549_G0.9100.81
460_T481_L0.9060.81
255_L280_G0.9050.81
360_T501_T0.9040.81
560_A583_A0.9010.81
343_D388_R0.9000.81
331_A407_V0.9000.81
388_R409_P0.8960.80
410_G431_G0.8910.80
478_E481_L0.8910.80
364_L391_D0.8880.80
169_F227_A0.8870.80
551_A576_A0.8860.80
350_I385_A0.8860.80
131_D147_L0.8840.80
368_Y401_S0.8810.79
497_F538_M0.8810.79
369_S400_D0.8800.79
549_G573_V0.8790.79
386_L398_V0.8780.79
496_L503_T0.8780.79
391_D412_T0.8770.79
155_M167_P0.8740.79
279_T449_R0.8720.79
572_Q575_E0.8720.79
554_A580_H0.8710.79
439_P454_R0.8700.78
123_E137_V0.8670.78
550_I558_I0.8620.78
563_Q586_F0.8570.77
194_T282_T0.8560.77
483_A537_V0.8560.77
166_L213_I0.8550.77
559_E581_G0.8550.77
511_V515_D0.8540.77
123_E127_V0.8540.77
156_P174_A0.8520.77
347_A384_V0.8490.77
154_A167_P0.8470.77
137_V150_V0.8470.77
124_R128_A0.8440.76
226_T238_A0.8420.76
518_E552_A0.8390.76
299_V328_Y0.8380.76
333_A353_T0.8360.76
341_F486_V0.8360.76
251_A258_T0.8350.76
333_A354_N0.8290.75
345_P388_R0.8280.75
146_V149_E0.8280.75
465_E571_D0.8280.75
366_D369_S0.8230.75
497_F533_A0.8190.74
273_F283_R0.8160.74
346_A358_C0.8140.74
283_R298_A0.8140.74
523_K533_A0.8070.73
226_T237_D0.8040.73
167_P178_V0.8020.73
196_A207_D0.8000.72
321_K404_E0.7980.72
199_E207_D0.7980.72
377_K512_S0.7950.72
517_V550_I0.7950.72
201_G204_R0.7910.72
411_Y428_L0.7860.71
154_A183_V0.7830.71
533_A536_A0.7820.71
167_P181_A0.7820.71
248_R258_T0.7810.71
282_T301_R0.7800.70
348_A358_C0.7800.70
416_V429_D0.7790.70
166_L214_V0.7790.70
547_P573_V0.7790.70
538_M550_I0.7780.70
337_L486_V0.7770.70
475_A478_E0.7750.70
145_R148_S0.7750.70
497_F517_V0.7740.70
420_T425_L0.7740.70
137_V322_A0.7710.70
155_M174_A0.7710.70
199_E202_S0.7690.69
571_D578_N0.7660.69
571_D579_E0.7650.69
411_Y416_V0.7640.69
218_S225_D0.7640.69
196_A199_E0.7640.69
354_N511_V0.7640.69
512_S515_D0.7620.69
342_D388_R0.7580.68
252_A256_D0.7570.68
368_Y397_R0.7520.68
197_V260_D0.7500.67
440_V451_V0.7490.67
554_A576_A0.7480.67
457_W463_D0.7470.67
123_E146_V0.7470.67
156_P172_R0.7460.67
521_A549_G0.7450.67
165_L217_E0.7440.67
468_T563_Q0.7420.67
396_T399_A0.7420.67
287_L328_Y0.7410.67
377_K518_E0.7400.66
399_A418_V0.7390.66
231_K234_V0.7380.66
477_V562_I0.7380.66
128_A131_D0.7370.66
477_V481_L0.7360.66
359_A379_A0.7350.66
421_A425_L0.7350.66
248_R276_R0.7340.66
406_V419_L0.7340.66
482_F498_A0.7290.65
465_E471_E0.7290.65
480_M585_V0.7270.65
517_V538_M0.7270.65
267_S270_A0.7270.65
156_P177_Q0.7260.65
343_D360_T0.7250.65
364_L390_C0.7230.65
511_V523_K0.7210.64
255_L278_L0.7170.64
195_N198_A0.7160.64
223_E240_F0.7160.64
506_L511_V0.7150.64
138_V165_L0.7140.64
215_T226_T0.7110.63
164_S182_G0.7110.63
547_P569_N0.7090.63
453_E456_T0.7090.63
390_C394_T0.7070.63
331_A385_A0.7050.63
537_V583_A0.7040.63
441_T444_P0.7030.62
393_E412_T0.7030.62
314_D410_G0.7030.62
121_D231_K0.7020.62
335_L431_G0.7020.62
502_E532_T0.7000.62
362_D388_R0.6990.62
326_N404_E0.6960.62
470_R578_N0.6920.61
155_M171_G0.6880.61
524_A533_A0.6870.61
302_D444_P0.6870.61
119_R195_N0.6870.61
176_E181_A0.6850.60
459_P589_H0.6840.60
213_I240_F0.6830.60
241_E244_P0.6830.60
515_D529_N0.6820.60
349_V491_K0.6810.60
403_K425_L0.6810.60
310_V331_A0.6800.60
349_V359_A0.6790.60
530_G533_A0.6790.60
414_D418_V0.6780.60
416_V419_L0.6780.60
353_T443_T0.6770.60
277_R281_T0.6760.59
406_V425_L0.6710.59
504_V532_T0.6700.59
198_A256_D0.6700.59
515_D549_G0.6690.59
173_N181_A0.6680.59
332_D448_G0.6670.58
531_K534_D0.6670.58
154_A177_Q0.6660.58
573_V577_A0.6660.58
361_A502_E0.6650.58
257_A261_G0.6650.58
468_T578_N0.6640.58
511_V516_A0.6640.58
423_S568_K0.6640.58
461_A478_E0.6630.58
329_N332_D0.6620.58
499_A559_E0.6620.58
374_T515_D0.6600.58
490_V511_V0.6580.57
377_K529_N0.6570.57
353_T405_V0.6560.57
516_A519_I0.6560.57
497_F531_K0.6540.57
479_T537_V0.6530.57
361_A394_T0.6530.57
283_R300_Y0.6530.57
512_S533_A0.6500.56
337_L358_C0.6490.56
483_A539_A0.6490.56
312_H431_G0.6490.56
124_R149_E0.6490.56
169_F246_A0.6480.56
497_F512_S0.6470.56
550_I582_M0.6470.56
379_A403_K0.6430.56
240_F244_P0.6430.56
467_V574_I0.6400.55
169_F217_E0.6400.55
382_G403_K0.6400.55
266_D271_A0.6400.55
561_V573_V0.6390.55
413_D416_V0.6380.55
370_D501_T0.6380.55
337_L340_E0.6360.55
274_P300_Y0.6350.55
276_R280_G0.6350.55
140_L156_P0.6340.55
349_V372_L0.6330.54
457_W460_T0.6330.54
203_V222_F0.6320.54
175_H224_D0.6310.54
309_S446_V0.6310.54
248_R261_G0.6300.54
169_F219_V0.6270.54
380_F400_D0.6230.53
420_T427_V0.6220.53
325_Y444_P0.6210.53
515_D519_I0.6210.53
498_A539_A0.6200.53
190_V215_T0.6190.53
197_V201_G0.6190.53
148_S287_L0.6180.53
248_R275_A0.6180.53
341_F345_P0.6170.53
189_T231_K0.6170.53
512_S531_K0.6160.53
273_F440_V0.6150.52
553_A558_I0.6150.52
118_S207_D0.6150.52
508_V523_K0.6140.52
196_A200_D0.6140.52
275_A282_T0.6140.52
515_D521_A0.6120.52
243_Y261_G0.6110.52
347_A368_Y0.6110.52
277_R451_V0.6100.52
346_A361_A0.6100.52
331_A335_L0.6090.52
308_A335_L0.6080.52
370_D500_G0.6080.52
313_A331_A0.6070.51
461_A464_L0.6060.51
247_I254_E0.6050.51
349_V405_V0.6030.51
185_V226_T0.6010.51
551_A572_Q0.5950.50
496_L506_L0.5950.50
469_K581_G0.5940.50
554_A579_E0.5930.50
178_V183_V0.5930.50
314_D416_V0.5930.50
175_H182_G0.5920.50
317_N416_V0.5910.50
484_W587_T0.5910.50
167_P217_E0.5900.49
417_D420_T0.5890.49
156_P217_E0.5880.49
161_V166_L0.5880.49
584_M587_T0.5860.49
154_A213_I0.5860.49
197_V256_D0.5850.49
171_G213_I0.5850.49
155_M175_H0.5840.49
187_G228_A0.5810.48
317_N577_A0.5810.48
217_E257_A0.5800.48
469_K579_E0.5790.48
329_N379_A0.5790.48
127_V213_I0.5780.48
309_S313_A0.5780.48
337_L593_R0.5770.48
410_G413_D0.5770.48
126_V129_A0.5760.48
544_F549_G0.5750.48
355_P506_L0.5750.48
248_R280_G0.5750.48
368_Y403_K0.5750.48
459_P481_L0.5740.48
480_M483_A0.5720.47
158_T163_P0.5710.47
368_Y372_L0.5710.47
335_L446_V0.5710.47
174_A183_V0.5710.47
391_D414_D0.5700.47
390_C398_V0.5700.47
441_T454_R0.5660.47
365_A394_T0.5660.47
486_V511_V0.5660.47
281_T442_E0.5650.47
412_T415_A0.5650.47
213_I247_I0.5630.46
380_F544_F0.5630.46
498_A537_V0.5630.46
496_L508_V0.5630.46
245_R275_A0.5620.46
487_L494_G0.5610.46
192_V195_N0.5600.46
359_A479_T0.5590.46
396_T418_V0.5580.46
486_V503_T0.5580.46
187_G234_V0.5580.46
538_M561_V0.5570.46
337_L489_H0.5560.45
334_A385_A0.5550.45
494_G541_D0.5540.45
515_D552_A0.5540.45
139_C212_P0.5540.45
498_A501_T0.5540.45
293_P483_A0.5540.45
118_S123_E0.5530.45
179_L182_G0.5510.45
147_L150_V0.5500.45
345_P394_T0.5500.45
468_T586_F0.5500.45
395_A418_V0.5490.45
490_V506_L0.5480.45
321_K424_N0.5480.45
266_D270_A0.5470.44
390_C415_A0.5470.44
341_F489_H0.5460.44
197_V202_S0.5460.44
512_S522_K0.5450.44
140_L299_V0.5430.44
279_T442_E0.5430.44
226_T239_E0.5420.44
163_P167_P0.5410.44
310_V407_V0.5400.44
472_P578_N0.5400.44
233_R242_A0.5390.44
372_L379_A0.5390.44
299_V323_L0.5380.43
384_V401_S0.5380.43
514_V552_A0.5370.43
187_G308_A0.5360.43
301_R312_H0.5350.43
554_A577_A0.5350.43
510_Q541_D0.5350.43
365_A391_D0.5340.43
521_A536_A0.5340.43
196_A202_S0.5340.43
380_F406_V0.5340.43
468_T583_A0.5340.43
196_A201_G0.5340.43
291_E326_N0.5330.43
332_D593_R0.5330.43
341_F387_N0.5330.43
281_T302_D0.5320.43
461_A474_A0.5310.43
369_S393_E0.5290.42
310_V328_Y0.5290.42
338_V350_I0.5290.42
158_T161_V0.5280.42
217_E249_Q0.5280.42
347_A482_F0.5280.42
510_Q519_I0.5280.42
468_T472_P0.5280.42
481_L485_R0.5280.42
379_A514_V0.5280.42
442_E451_V0.5270.42
332_D441_T0.5260.42
248_R266_D0.5260.42
521_A552_A0.5260.42
345_P386_L0.5250.42
308_A312_H0.5240.42
169_F183_V0.5240.42
296_D463_D0.5240.42
197_V261_G0.5240.42
277_R440_V0.5230.42
135_I172_R0.5230.42
353_T546_F0.5230.42
167_P171_G0.5230.42
169_F213_I0.5220.42
285_D328_Y0.5220.42
504_V536_A0.5220.42
261_G286_V0.5220.42
133_Y226_T0.5210.41
358_C503_T0.5210.41
127_V187_G0.5200.41
497_F520_A0.5200.41
239_E253_G0.5160.41
385_A406_V0.5150.41
127_V131_D0.5150.41
122_H128_A0.5150.41
392_A417_D0.5140.41
523_K549_G0.5140.41
373_S376_A0.5140.41
372_L397_R0.5140.41
213_I249_Q0.5130.41
317_N399_A0.5130.41
228_A234_V0.5120.40
197_V200_D0.5120.40
213_I246_A0.5110.40
549_G577_A0.5100.40
373_S532_T0.5100.40
538_M573_V0.5090.40
556_A577_A0.5090.40
198_A345_P0.5080.40
135_I184_S0.5080.40
158_T169_F0.5070.40
268_D271_A0.5070.40
335_L338_V0.5070.40
347_A364_L0.5070.40
355_P490_V0.5060.40
514_V517_V0.5060.40
269_D272_T0.5060.40
341_F358_C0.5060.40
499_A504_V0.5060.40
350_I358_C0.5060.40
467_V584_M0.5050.40
309_S335_L0.5050.40
137_V147_L0.5050.40
122_H134_D0.5050.40
516_A549_G0.5050.40
317_N405_V0.5050.40
325_Y451_V0.5040.40
154_A224_D0.5040.40
325_Y563_Q0.5030.39
368_Y398_V0.5030.39
294_H455_N0.5030.39
370_D502_E0.5030.39
406_V552_A0.5020.39
127_V150_V0.5010.39
204_R558_I0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zzmA 2 0.805 100 0.309 Contact Map
4ehiA 2 0.8 100 0.321 Contact Map
1zczA 2 0.7277 100 0.342 Contact Map
1g8mA 2 0.7815 100 0.344 Contact Map
4j6eA 2 0.3529 100 0.862 Contact Map
2ywrA 2 0.3563 99.6 0.941 Contact Map
3p9xA 2 0.321 99.5 0.941 Contact Map
4ew1A 2 0.3378 99.5 0.942 Contact Map
1jkxA 2 0.3445 99.5 0.942 Contact Map
3av3A 1 0.3092 99.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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