GREMLIN Database
Q9HS42 - Adenylosuccinate lyase
UniProt: Q9HS42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 495 (423)
Sequences: 10586 (5383)
Seq/√Len: 261.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_A96_V3.7081.00
95_L154_W3.4761.00
79_A104_R3.3241.00
87_D272_R3.2771.00
413_V416_E3.2281.00
178_T240_V3.1731.00
360_D389_A2.9791.00
83_L276_S2.8481.00
186_R233_L2.7971.00
83_L100_R2.7771.00
472_T475_E2.7671.00
73_A175_G2.7641.00
305_N357_A2.7381.00
415_R419_R2.6601.00
189_R230_G2.6411.00
191_D405_D2.6311.00
177_I297_V2.6001.00
353_N396_A2.5601.00
182_T237_T2.5441.00
191_D401_G2.5281.00
69_A391_A2.5101.00
218_F409_P2.4561.00
272_R275_D2.4141.00
182_T233_L2.4021.00
242_G296_A2.3881.00
195_F198_D2.2731.00
302_A361_L2.2701.00
436_E475_E2.2631.00
184_E398_R2.2381.00
201_D411_E2.2321.00
187_G401_G2.1981.00
327_D408_T2.1101.00
186_R237_T2.0971.00
86_A93_L2.0661.00
356_K385_N2.0561.00
416_E420_A2.0521.00
401_G405_D2.0431.00
53_R146_H2.0081.00
457_D465_S1.9871.00
189_R233_L1.9531.00
413_V417_D1.9371.00
92_P95_L1.9351.00
194_S405_D1.9311.00
194_S198_D1.9281.00
272_R276_S1.9091.00
105_D143_L1.8881.00
447_A451_G1.8841.00
460_K477_L1.8671.00
143_L147_A1.8631.00
191_D404_L1.8631.00
306_G358_N1.8501.00
117_L145_E1.8491.00
184_E394_L1.8491.00
312_A350_A1.8421.00
238_D242_G1.8321.00
245_G274_V1.8201.00
233_L237_T1.8181.00
97_G101_T1.8111.00
185_L304_A1.7651.00
235_R296_A1.7651.00
238_D241_D1.7551.00
76_E175_G1.7541.00
93_L97_G1.7471.00
440_D443_E1.7441.00
271_A275_D1.7431.00
447_A466_L1.7371.00
193_V230_G1.7311.00
98_D148_P1.7151.00
79_A100_R1.7121.00
295_T368_L1.7101.00
281_Y287_Q1.6811.00
199_Y202_L1.6801.00
308_L350_A1.6731.00
96_V100_R1.6451.00
451_G455_S1.6241.00
475_E478_A1.6181.00
464_A473_R1.6171.00
473_R477_L1.6111.00
411_E415_R1.6091.00
189_R226_A1.6071.00
232_A307_V1.6031.00
480_T483_R1.5991.00
83_L272_R1.5761.00
247_L269_F1.5761.00
297_V390_F1.5341.00
231_R286_T1.5301.00
356_K388_A1.5291.00
350_A400_L1.5231.00
415_R482_E1.5201.00
312_A400_L1.5051.00
457_D462_L1.5001.00
234_A242_G1.4991.00
109_T146_H1.4991.00
363_F381_T1.4971.00
105_D146_H1.4851.00
79_A107_Y1.4611.00
196_A226_A1.4501.00
268_S271_A1.4471.00
173_V386_I1.4381.00
184_E401_G1.4361.00
302_A365_G1.4271.00
249_G287_Q1.4271.00
104_R108_K1.4151.00
136_V140_E1.4101.00
362_G366_D1.3951.00
231_R292_D1.3941.00
195_F199_Y1.3901.00
410_N413_V1.3801.00
189_R229_L1.3741.00
84_A272_R1.3691.00
72_R76_E1.3681.00
291_C379_D1.3671.00
241_D280_A1.3611.00
239_A300_A1.3541.00
182_T240_V1.3411.00
298_F364_L1.3371.00
412_A416_E1.3321.00
458_D461_E1.3311.00
299_D303_G1.3161.00
311_L400_L1.3091.00
222_M225_Y1.3081.00
86_A97_G1.3031.00
347_F403_G1.3031.00
274_V280_A1.2981.00
59_D63_P1.2961.00
69_A176_A1.2891.00
306_G368_L1.2881.00
317_L372_R1.2871.00
74_R164_V1.2751.00
359_S363_F1.2691.00
142_F146_H1.2691.00
218_F222_M1.2641.00
464_A477_L1.2621.00
187_G405_D1.2561.00
225_Y374_Q1.2531.00
457_D461_E1.2511.00
176_A394_L1.2511.00
79_A83_L1.2471.00
298_F386_I1.2401.00
90_A157_F1.2371.00
295_T303_G1.2311.00
142_F145_E1.2221.00
358_N366_D1.2211.00
193_V197_H1.2211.00
188_L401_G1.2191.00
72_R107_Y1.2121.00
75_V106_A1.2121.00
185_L229_L1.2051.00
218_F414_L1.2041.00
173_V297_V1.2001.00
202_L411_E1.1961.00
100_R104_R1.1941.00
180_V394_L1.1921.00
144_R152_H1.1911.00
440_D468_I1.1821.00
199_Y411_E1.1771.00
87_D268_S1.1761.00
304_A393_C1.1751.00
268_S272_R1.1721.00
75_V136_V1.1671.00
350_A396_A1.1661.00
191_D194_S1.1601.00
357_A393_C1.1571.00
188_L404_L1.1441.00
59_D62_A1.1421.00
158_G258_T1.1411.00
304_A397_Y1.1381.00
326_Q410_N1.1321.00
82_V91_V1.1261.00
197_H200_A1.1241.00
364_L386_I1.1221.00
361_L365_G1.1151.00
177_I240_V1.1101.00
236_I304_A1.1081.00
98_D101_T1.1061.00
181_L393_C1.0961.00
75_V107_Y1.0941.00
294_L386_I1.0931.00
354_L358_N1.0891.00
72_R111_D1.0861.00
182_T186_R1.0811.00
305_N393_C1.0781.00
192_L311_L1.0761.00
80_E276_S1.0741.00
104_R107_Y1.0721.00
68_A112_A1.0691.00
309_E351_E1.0681.00
201_D219_G1.0631.00
158_G261_F1.0601.00
215_P418_L1.0591.00
200_A219_G1.0581.00
101_T147_A1.0571.00
187_G398_R1.0541.00
169_Y386_I1.0471.00
184_E187_G1.0461.00
298_F389_A1.0451.00
169_Y383_K1.0441.00
234_A241_D1.0431.00
186_R190_D1.0421.00
72_R175_G1.0421.00
202_L414_L1.0401.00
105_D109_T1.0401.00
204_M414_L1.0391.00
195_F404_L1.0391.00
76_E276_S1.0381.00
315_A347_F1.0371.00
225_Y311_L1.0371.00
193_V226_A1.0361.00
77_V164_V1.0341.00
48_S63_P1.0301.00
188_L229_L1.0291.00
174_D279_L1.0271.00
315_A407_V1.0261.00
185_L233_L1.0211.00
200_A217_T1.0171.00
451_G462_L1.0141.00
250_A337_T1.0091.00
223_A283_E1.0091.00
238_D296_A1.0091.00
167_L245_G1.0071.00
297_V386_I1.0071.00
300_A304_A1.0061.00
169_Y294_L1.0061.00
176_A180_V1.0001.00
68_A72_R0.9981.00
174_D240_V0.9961.00
105_D110_F0.9901.00
195_F222_M0.9851.00
317_L373_L0.9851.00
227_A231_R0.9841.00
57_R333_T0.9801.00
87_D276_S0.9771.00
227_A282_A0.9761.00
54_Y59_D0.9711.00
53_R111_D0.9681.00
174_D178_T0.9651.00
101_T105_D0.9601.00
308_L400_L0.9561.00
74_R77_V0.9531.00
356_K392_H0.9521.00
327_D406_A0.9511.00
73_A171_L0.9501.00
121_I141_Y0.9461.00
111_D143_L0.9441.00
72_R112_A0.9441.00
468_I471_D0.9411.00
212_P321_Q0.9401.00
98_D102_A0.9401.00
216_T251_S0.9391.00
207_R212_P0.9391.00
451_G457_D0.9371.00
177_I236_I0.9351.00
234_A238_D0.9341.00
447_A462_L0.9321.00
49_P52_G0.9301.00
206_A216_T0.9291.00
97_G100_R0.9241.00
308_L397_Y0.9221.00
245_G273_F0.9201.00
481_P485_V0.9161.00
384_R388_A0.9161.00
299_D361_L0.9101.00
209_H348_E0.9071.00
69_A175_G0.9061.00
176_A390_F0.9051.00
88_L258_T0.9031.00
331_G402_D0.8991.00
77_V167_L0.8931.00
290_P307_V0.8901.00
174_D280_A0.8901.00
189_R193_V0.8891.00
482_E485_V0.8851.00
349_N399_K0.8841.00
73_A172_L0.8831.00
356_K384_R0.8831.00
84_A269_F0.8811.00
360_D388_A0.8801.00
327_D410_N0.8801.00
202_L409_P0.8781.00
216_T285_T0.8761.00
298_F361_L0.8731.00
98_D151_A0.8721.00
198_D408_T0.8711.00
299_D365_G0.8681.00
326_Q408_T0.8671.00
76_E107_Y0.8661.00
221_E374_Q0.8651.00
203_P418_L0.8631.00
262_P267_R0.8611.00
220_K284_P0.8561.00
196_A223_A0.8531.00
210_G317_L0.8521.00
116_D120_R0.8501.00
150_R153_S0.8450.99
301_V393_C0.8430.99
481_P484_Y0.8400.99
76_E273_F0.8370.99
92_P154_W0.8340.99
84_A88_L0.8340.99
226_A230_G0.8330.99
481_P486_G0.8330.99
192_L222_M0.8310.99
461_E465_S0.8300.99
93_L96_V0.8240.99
192_L226_A0.8230.99
476_L479_L0.8200.99
74_R136_V0.8200.99
221_E318_Y0.8180.99
105_D111_D0.8170.99
460_K473_R0.8160.99
190_D194_S0.8160.99
474_D478_A0.8150.99
447_A465_S0.8150.99
289_N374_Q0.8130.99
309_E369_T0.8120.99
109_T142_F0.8120.99
451_G454_V0.8100.99
212_P421_N0.8050.99
83_L104_R0.8040.99
210_G320_S0.8010.99
419_R460_K0.8000.99
429_V463_F0.8000.99
198_D411_E0.7970.99
328_A406_A0.7940.99
443_E447_A0.7920.99
141_Y145_E0.7920.99
66_S399_K0.7910.99
66_S377_L0.7900.99
460_K464_A0.7890.99
103_L140_E0.7870.99
94_E97_G0.7860.99
109_T112_A0.7850.99
432_I436_E0.7820.99
229_L397_Y0.7810.99
457_D466_L0.7800.99
140_E155_I0.7800.99
188_L397_Y0.7790.99
244_T293_D0.7780.99
83_L87_D0.7770.99
355_A363_F0.7770.99
192_L404_L0.7770.99
247_L273_F0.7750.99
90_A258_T0.7740.99
463_F466_L0.7720.99
306_G365_G0.7720.99
102_A147_A0.7700.99
56_G328_A0.7690.99
178_T279_L0.7670.99
87_D93_L0.7650.99
231_R244_T0.7630.99
191_D195_F0.7610.99
60_A63_P0.7610.99
363_F385_N0.7610.99
123_T134_H0.7600.99
81_Y159_L0.7550.99
95_L151_A0.7540.99
199_Y409_P0.7540.99
121_I138_A0.7540.99
418_L481_P0.7530.99
91_V95_L0.7520.99
292_D307_V0.7510.99
106_A112_A0.7500.99
65_V176_A0.7500.99
296_A299_D0.7490.99
185_L397_Y0.7480.99
86_A100_R0.7480.99
227_A283_E0.7470.99
461_E473_R0.7450.99
49_P53_R0.7450.99
285_T374_Q0.7400.99
70_L165_N0.7380.99
367_S381_T0.7380.99
99_E151_A0.7370.99
177_I243_L0.7370.99
329_A406_A0.7370.99
55_S62_A0.7350.99
432_I435_R0.7340.99
294_L364_L0.7330.99
403_G407_V0.7320.99
205_L322_R0.7310.98
205_L418_L0.7300.98
356_K360_D0.7300.98
235_R292_D0.7300.98
246_K287_Q0.7280.98
103_L143_L0.7280.98
86_A91_V0.7270.98
133_N329_A0.7270.98
325_G410_N0.7260.98
192_L229_L0.7260.98
204_M221_E0.7230.98
79_A276_S0.7190.98
82_V96_V0.7160.98
202_L217_T0.7140.98
177_I239_A0.7120.98
258_T268_S0.7110.98
98_D147_A0.7100.98
170_R293_D0.7080.98
451_G465_S0.7070.98
358_N362_G0.7070.98
297_V301_V0.7050.98
143_L146_H0.7040.98
318_Y373_L0.7040.98
228_R307_V0.7030.98
103_L106_A0.7030.98
228_R289_N0.7030.98
443_E466_L0.7010.98
447_A450_R0.7000.98
450_R454_V0.6990.98
286_T292_D0.6980.98
217_T485_V0.6980.98
409_P414_L0.6970.98
239_A243_L0.6950.98
358_N365_G0.6930.98
109_T114_D0.6920.98
295_T364_L0.6910.98
462_L466_L0.6910.98
203_P485_V0.6880.98
229_L232_A0.6880.98
286_T307_V0.6880.98
143_L155_I0.6860.98
207_R321_Q0.6860.98
448_L468_I0.6860.98
224_V310_D0.6860.98
312_A347_F0.6840.98
222_M414_L0.6830.98
190_D193_V0.6810.98
90_A158_G0.6800.98
194_S197_H0.6800.98
295_T365_G0.6790.98
80_E83_L0.6760.97
199_Y218_F0.6760.97
429_V476_L0.6750.97
201_D482_E0.6720.97
106_A140_E0.6720.97
397_Y401_G0.6720.97
88_L272_R0.6720.97
107_Y111_D0.6710.97
451_G468_I0.6700.97
122_E134_H0.6680.97
108_K112_A0.6670.97
186_R230_G0.6670.97
313_V351_E0.6670.97
202_L415_R0.6660.97
455_S466_L0.6660.97
355_A367_S0.6660.97
232_A303_G0.6660.97
88_L268_S0.6660.97
187_G191_D0.6660.97
413_V420_A0.6650.97
91_V157_F0.6620.97
385_N388_A0.6620.97
62_A346_D0.6610.97
178_T237_T0.6570.97
447_A467_D0.6560.97
355_A366_D0.6560.97
228_R290_P0.6540.97
452_E462_L0.6540.97
197_H201_D0.6530.97
181_L390_F0.6520.97
150_R439_D0.6500.97
309_E366_D0.6490.97
111_D114_D0.6480.97
447_A457_D0.6480.97
186_R189_R0.6470.97
323_Y413_V0.6470.97
177_I182_T0.6450.97
399_K402_D0.6430.97
180_V184_E0.6430.97
101_T104_R0.6430.97
270_A274_V0.6430.97
270_A281_Y0.6410.97
303_G368_L0.6410.97
232_A235_R0.6400.97
362_G365_G0.6400.97
419_R458_D0.6390.96
235_R242_G0.6380.96
412_A415_R0.6380.96
102_A105_D0.6360.96
295_T299_D0.6350.96
315_A400_L0.6340.96
79_A96_V0.6330.96
464_A476_L0.6320.96
95_L98_D0.6310.96
323_Y410_N0.6310.96
172_L387_G0.6290.96
388_A392_H0.6280.96
64_Y69_A0.6260.96
82_V155_I0.6240.96
331_G406_A0.6240.96
173_V390_F0.6240.96
386_I390_F0.6240.96
274_V279_L0.6220.96
235_R238_D0.6200.96
229_L308_L0.6200.96
462_L465_S0.6180.96
95_L99_E0.6170.96
204_M216_T0.6150.96
121_I131_A0.6150.96
115_A142_F0.6150.96
451_G466_L0.6130.96
151_A154_W0.6120.96
172_L390_F0.6110.95
94_E98_D0.6110.95
458_D462_L0.6100.95
120_R123_T0.6100.95
312_A351_E0.6090.95
357_A389_A0.6060.95
62_A66_S0.6060.95
195_F407_V0.6040.95
87_D262_P0.6040.95
236_I300_A0.6010.95
411_E414_L0.6010.95
244_T281_Y0.6010.95
234_A237_T0.6000.95
184_E397_Y0.5990.95
418_L423_E0.5980.95
350_A403_G0.5980.95
181_L301_V0.5970.95
357_A392_H0.5960.95
66_S402_D0.5940.95
363_F382_V0.5930.95
117_L121_I0.5930.95
302_A306_G0.5920.95
309_E370_T0.5900.95
353_N392_H0.5900.95
65_V332_E0.5890.95
446_K450_R0.5880.94
239_A297_V0.5870.94
154_W157_F0.5860.94
350_A354_L0.5860.94
230_G234_A0.5850.94
227_A230_G0.5850.94
193_V196_A0.5850.94
301_V304_A0.5850.94
84_A268_S0.5850.94
311_L404_L0.5840.94
123_T131_A0.5810.94
432_I475_E0.5810.94
241_D244_T0.5790.94
229_L304_A0.5780.94
196_A200_A0.5770.94
443_E450_R0.5760.94
71_M110_F0.5750.94
83_L96_V0.5750.94
363_F367_S0.5720.94
105_D147_A0.5710.94
225_Y228_R0.5690.93
478_A483_R0.5680.93
444_R463_F0.5670.93
292_D296_A0.5660.93
422_P425_I0.5660.93
182_T300_A0.5660.93
296_A303_G0.5650.93
231_R242_G0.5640.93
351_E378_S0.5620.93
417_D420_A0.5610.93
221_E314_D0.5610.93
442_Y446_K0.5600.93
346_D403_G0.5580.93
161_S246_K0.5580.93
82_V100_R0.5530.92
92_P96_V0.5530.92
247_L262_P0.5520.92
76_E80_E0.5520.92
175_G178_T0.5520.92
271_A274_V0.5510.92
214_T251_S0.5510.92
75_V112_A0.5500.92
188_L191_D0.5490.92
216_T220_K0.5480.92
209_H377_L0.5480.92
202_L219_G0.5470.92
216_T253_T0.5450.92
448_L451_G0.5450.92
244_T282_A0.5450.92
483_R486_G0.5450.92
239_A296_A0.5420.92
82_V99_E0.5410.92
185_L236_I0.5400.92
303_G307_V0.5390.92
237_T241_D0.5390.92
222_M407_V0.5370.91
86_A94_E0.5360.91
223_A226_A0.5350.91
246_K288_V0.5340.91
439_D443_E0.5340.91
332_E345_I0.5340.91
359_S362_G0.5330.91
73_A76_E0.5330.91
428_A483_R0.5330.91
474_D477_L0.5320.91
234_A244_T0.5310.91
77_V247_L0.5300.91
301_V389_A0.5300.91
81_Y273_F0.5300.91
245_G270_A0.5300.91
236_I297_V0.5290.91
471_D475_E0.5290.91
428_A484_Y0.5280.91
76_E277_L0.5260.91
199_Y219_G0.5260.91
136_V168_A0.5250.90
262_P270_A0.5250.90
408_T411_E0.5240.90
177_I390_F0.5230.90
393_C397_Y0.5230.90
108_K111_D0.5220.90
231_R296_A0.5190.90
147_A151_A0.5190.90
117_L120_R0.5190.90
467_D470_A0.5160.90
444_R466_L0.5160.90
171_L273_F0.5140.90
77_V168_A0.5130.89
315_A404_L0.5130.89
457_D463_F0.5120.89
257_H431_T0.5100.89
148_P152_H0.5090.89
117_L135_D0.5070.89
68_A75_V0.5060.89
183_P187_G0.5060.89
460_K476_L0.5050.89
157_F434_R0.5050.89
214_T255_A0.5050.89
444_R462_L0.5040.89
174_D243_L0.5030.88
195_F218_F0.5030.88
383_K387_G0.5030.88
99_E147_A0.5020.88
206_A252_G0.5020.88
204_M318_Y0.5010.88
404_L407_V0.5000.88
416_E419_R0.5000.88
317_L320_S0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ptrA 4 0.897 100 0.26 Contact Map
3bhgA 4 0.8848 100 0.265 Contact Map
1re5A 4 0.8606 100 0.275 Contact Map
3c8tA 4 0.8263 100 0.281 Contact Map
4efcA 4 0.8909 100 0.281 Contact Map
4eeiA 4 0.8121 100 0.285 Contact Map
1q5nA 4 0.8364 100 0.286 Contact Map
1c3cA 4 0.8303 100 0.288 Contact Map
4mx2A 5 0.8727 100 0.289 Contact Map
2qgaB 4 0.8848 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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