GREMLIN Database
Q9HS40 - Uncharacterized protein
UniProt: Q9HS40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (150)
Sequences: 811 (476)
Seq/√Len: 38.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_Y99_D5.0301.00
123_C133_V4.5231.00
11_A107_I4.3111.00
107_I110_I3.3991.00
100_A126_L3.3211.00
19_L113_C2.9881.00
100_A122_L2.9701.00
16_S51_A2.8371.00
98_L101_V2.8121.00
109_T134_E2.8051.00
135_V150_A2.7191.00
10_V44_R2.7041.00
13_L100_A2.4851.00
50_I74_E2.2270.99
44_R134_E2.1970.99
78_K89_K2.1920.99
120_S145_E2.1700.99
92_W95_G2.0960.99
44_R109_T2.0820.99
41_V46_L1.8510.98
105_D129_E1.8170.98
102_S125_H1.7190.97
81_K145_E1.7170.97
107_I131_V1.6930.96
93_D118_D1.6690.96
96_M112_L1.6660.96
50_I76_K1.6360.96
132_R152_S1.5950.95
96_M114_T1.5530.94
137_A153_F1.4940.93
134_E154_V1.4390.91
8_Q132_R1.4260.91
120_S124_R1.4060.90
8_Q44_R1.3970.90
96_M100_A1.3930.90
100_A110_I1.3630.89
32_D35_A1.3400.88
144_T148_D1.3310.88
125_H129_E1.3300.88
8_Q109_T1.3290.88
127_R151_D1.2820.86
91_D95_G1.2490.84
66_D70_D1.2180.83
127_R133_V1.1930.81
12_V40_G1.1540.79
12_V113_C1.1410.78
48_R151_D1.1200.77
18_N118_D1.1160.77
26_V139_E1.1040.76
13_L103_L1.0970.76
50_I103_L1.0960.75
128_H149_A1.0950.75
126_L131_V1.0930.75
49_A72_G1.0690.74
59_E62_D1.0690.74
18_N93_D1.0630.73
100_A112_L1.0500.72
124_R149_A1.0350.71
9_R45_E1.0330.71
103_L131_V1.0280.71
10_V111_V1.0240.70
17_Q92_W1.0120.69
31_I36_L1.0050.69
72_G90_A1.0000.68
26_V140_E0.9990.68
63_R66_D0.9980.68
48_R103_L0.9900.68
120_S149_A0.9850.67
78_K90_A0.9840.67
78_K95_G0.9820.67
127_R149_A0.9780.67
34_A70_D0.9780.67
105_D131_V0.9770.67
53_V65_F0.9770.67
43_D134_E0.9750.67
18_N89_K0.9710.66
101_V125_H0.9530.65
33_Y36_L0.9520.65
78_K91_D0.9460.64
72_G78_K0.9360.63
13_L110_I0.9350.63
60_D63_R0.9320.63
39_K43_D0.9270.63
19_L131_V0.9250.62
14_A19_L0.9210.62
134_E138_F0.9100.61
131_V140_E0.9090.61
42_Q106_H0.8860.59
31_I137_A0.8760.58
155_D158_E0.8730.58
11_A130_G0.8730.58
98_L125_H0.8720.58
38_D154_V0.8690.58
45_E111_V0.8690.58
41_V44_R0.8650.57
8_Q45_E0.8420.55
142_A147_V0.8330.54
10_V40_G0.8210.53
81_K143_A0.8110.52
106_H131_V0.8090.52
17_Q95_G0.8050.52
114_T119_F0.8050.52
67_A71_I0.8000.51
18_N114_T0.7960.51
127_R130_G0.7940.51
126_L130_G0.7880.50
18_N116_D0.7780.49
37_L49_A0.7750.49
29_Q33_Y0.7670.48
80_I88_K0.7600.48
18_N143_A0.7560.47
93_D119_F0.7550.47
9_R96_M0.7500.47
16_S19_L0.7470.47
33_Y78_K0.7470.47
34_A66_D0.7430.46
32_D38_D0.7400.46
94_V97_S0.7380.46
36_L77_I0.7360.46
30_N70_D0.7350.45
64_F87_S0.7310.45
30_N67_A0.7290.45
9_R108_D0.7190.44
40_G136_M0.7190.44
109_T132_R0.7060.43
19_L133_V0.7060.43
68_L79_A0.7010.42
65_F92_W0.6980.42
13_L123_C0.6980.42
34_A67_A0.6940.42
142_A153_F0.6910.42
86_G142_A0.6790.41
11_A103_L0.6730.40
51_A54_I0.6720.40
30_N63_R0.6720.40
89_K95_G0.6700.40
72_G153_F0.6690.40
63_R70_D0.6680.40
102_S128_H0.6680.40
54_I90_A0.6630.39
18_N117_G0.6630.39
49_A73_F0.6570.39
151_D155_D0.6560.39
17_Q122_L0.6540.38
100_A107_I0.6470.38
31_I79_A0.6460.38
63_R67_A0.6430.37
17_Q117_G0.6420.37
96_M136_M0.6390.37
50_I110_I0.6380.37
124_R128_H0.6370.37
64_F80_I0.6370.37
28_S158_E0.6330.37
93_D116_D0.6290.36
59_E96_M0.6280.36
49_A112_L0.6240.36
38_D63_R0.6200.36
109_T140_E0.6180.35
34_A60_D0.6160.35
10_V46_L0.6110.35
72_G115_G0.6080.35
52_Y121_R0.6070.34
63_R113_C0.6070.34
55_R75_T0.6050.34
81_K147_V0.6000.34
140_E157_S0.5970.34
130_G140_E0.5950.33
131_V143_A0.5940.33
92_W135_V0.5920.33
83_F156_L0.5860.33
25_S128_H0.5850.33
104_A126_L0.5830.33
59_E132_R0.5800.32
33_Y85_D0.5790.32
39_K74_E0.5780.32
55_R62_D0.5780.32
89_K98_L0.5760.32
65_F76_K0.5750.32
20_Y64_F0.5730.32
23_A109_T0.5730.32
43_D152_S0.5690.31
75_T80_I0.5640.31
137_A142_A0.5630.31
78_K117_G0.5610.31
30_N93_D0.5610.31
12_V52_Y0.5570.30
132_R151_D0.5510.30
22_S156_L0.5500.30
47_T107_I0.5500.30
20_Y24_Q0.5490.30
62_D123_C0.5490.30
18_N112_L0.5470.30
130_G133_V0.5460.30
64_F120_S0.5430.29
75_T151_D0.5420.29
38_D41_V0.5410.29
100_A123_C0.5400.29
40_G50_I0.5400.29
49_A78_K0.5370.29
39_K42_Q0.5360.29
136_M154_V0.5360.29
91_D96_M0.5240.28
8_Q36_L0.5220.28
31_I155_D0.5210.28
110_I131_V0.5210.28
95_G121_R0.5200.28
95_G117_G0.5190.28
139_E158_E0.5180.28
12_V99_D0.5180.28
110_I126_L0.5170.28
18_N135_V0.5150.27
35_A50_I0.5140.27
36_L113_C0.5130.27
39_K157_S0.5130.27
25_S48_R0.5100.27
37_L73_F0.5100.27
124_R148_D0.5100.27
104_A129_E0.5090.27
15_D18_N0.5080.27
8_Q46_L0.5080.27
19_L31_I0.5070.27
42_Q136_M0.5040.27
90_A95_G0.5030.27
81_K88_K0.5020.26
124_R127_R0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qipA 2 0.9758 100 0.284 Contact Map
1exnA 1 0.8 87 0.903 Contact Map
1bgxT 1 0.8303 79.9 0.91 Contact Map
4kzkA 1 0.9879 76.3 0.913 Contact Map
3uk0A 1 0.9394 72.7 0.916 Contact Map
1vimA 4 0.8061 71.5 0.917 Contact Map
3lopA 1 0.9394 71.2 0.917 Contact Map
3lkbA 2 0.9394 69.3 0.918 Contact Map
3h7iA 1 0.8606 68.9 0.918 Contact Map
4wt7A 1 0.9576 66.9 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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