Q9HS40 - HALSA - GREMLIN Contacts

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Q9HS40 - Uncharacterized protein

UniProt:	Q9HS40	Sequences: MPPLQPAQRVAVLADSQNLYHSAQSVYSQNIDYAALLDKGVQDRELTRAIAYVIRAQSEDEDRFFDALRDIGFETKIKAIKTFGDGSKKADWDVGMSLDAVSLADHIDTIVLCTGDGDFSRLCRHLRHEGVRVEVMAFEESAATELVDAADSFVDLSERTETFLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	165 (150)
Sequences:	811 (476)
Seq/√Len:	38.8

HALSA - Q9HS40

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_Y	99_D	5.030	1.00
123_C	133_V	4.523	1.00
11_A	107_I	4.311	1.00
107_I	110_I	3.399	1.00
100_A	126_L	3.321	1.00
19_L	113_C	2.988	1.00
100_A	122_L	2.970	1.00
16_S	51_A	2.837	1.00
98_L	101_V	2.812	1.00
109_T	134_E	2.805	1.00
135_V	150_A	2.719	1.00
10_V	44_R	2.704	1.00
13_L	100_A	2.485	1.00
50_I	74_E	2.227	0.99
44_R	134_E	2.197	0.99
78_K	89_K	2.192	0.99
120_S	145_E	2.170	0.99
92_W	95_G	2.096	0.99
44_R	109_T	2.082	0.99
41_V	46_L	1.851	0.98
105_D	129_E	1.817	0.98
102_S	125_H	1.719	0.97
81_K	145_E	1.717	0.97
107_I	131_V	1.693	0.96
93_D	118_D	1.669	0.96
96_M	112_L	1.666	0.96
50_I	76_K	1.636	0.96
132_R	152_S	1.595	0.95
96_M	114_T	1.553	0.94
137_A	153_F	1.494	0.93
134_E	154_V	1.439	0.91
8_Q	132_R	1.426	0.91
120_S	124_R	1.406	0.90
8_Q	44_R	1.397	0.90
96_M	100_A	1.393	0.90
100_A	110_I	1.363	0.89
32_D	35_A	1.340	0.88
144_T	148_D	1.331	0.88
125_H	129_E	1.330	0.88
8_Q	109_T	1.329	0.88
127_R	151_D	1.282	0.86
91_D	95_G	1.249	0.84
66_D	70_D	1.218	0.83
127_R	133_V	1.193	0.81
12_V	40_G	1.154	0.79
12_V	113_C	1.141	0.78
48_R	151_D	1.120	0.77
18_N	118_D	1.116	0.77
26_V	139_E	1.104	0.76
13_L	103_L	1.097	0.76
50_I	103_L	1.096	0.75
128_H	149_A	1.095	0.75
126_L	131_V	1.093	0.75
49_A	72_G	1.069	0.74
59_E	62_D	1.069	0.74
18_N	93_D	1.063	0.73
100_A	112_L	1.050	0.72
124_R	149_A	1.035	0.71
9_R	45_E	1.033	0.71
103_L	131_V	1.028	0.71
10_V	111_V	1.024	0.70
17_Q	92_W	1.012	0.69
31_I	36_L	1.005	0.69
72_G	90_A	1.000	0.68
26_V	140_E	0.999	0.68
63_R	66_D	0.998	0.68
48_R	103_L	0.990	0.68
120_S	149_A	0.985	0.67
78_K	90_A	0.984	0.67
78_K	95_G	0.982	0.67
127_R	149_A	0.978	0.67
34_A	70_D	0.978	0.67
105_D	131_V	0.977	0.67
53_V	65_F	0.977	0.67
43_D	134_E	0.975	0.67
18_N	89_K	0.971	0.66
101_V	125_H	0.953	0.65
33_Y	36_L	0.952	0.65
78_K	91_D	0.946	0.64
72_G	78_K	0.936	0.63
13_L	110_I	0.935	0.63
60_D	63_R	0.932	0.63
39_K	43_D	0.927	0.63
19_L	131_V	0.925	0.62
14_A	19_L	0.921	0.62
134_E	138_F	0.910	0.61
131_V	140_E	0.909	0.61
42_Q	106_H	0.886	0.59
31_I	137_A	0.876	0.58
155_D	158_E	0.873	0.58
11_A	130_G	0.873	0.58
98_L	125_H	0.872	0.58
38_D	154_V	0.869	0.58
45_E	111_V	0.869	0.58
41_V	44_R	0.865	0.57
8_Q	45_E	0.842	0.55
142_A	147_V	0.833	0.54
10_V	40_G	0.821	0.53
81_K	143_A	0.811	0.52
106_H	131_V	0.809	0.52
17_Q	95_G	0.805	0.52
114_T	119_F	0.805	0.52
67_A	71_I	0.800	0.51
18_N	114_T	0.796	0.51
127_R	130_G	0.794	0.51
126_L	130_G	0.788	0.50
18_N	116_D	0.778	0.49
37_L	49_A	0.775	0.49
29_Q	33_Y	0.767	0.48
80_I	88_K	0.760	0.48
18_N	143_A	0.756	0.47
93_D	119_F	0.755	0.47
9_R	96_M	0.750	0.47
16_S	19_L	0.747	0.47
33_Y	78_K	0.747	0.47
34_A	66_D	0.743	0.46
32_D	38_D	0.740	0.46
94_V	97_S	0.738	0.46
36_L	77_I	0.736	0.46
30_N	70_D	0.735	0.45
64_F	87_S	0.731	0.45
30_N	67_A	0.729	0.45
9_R	108_D	0.719	0.44
40_G	136_M	0.719	0.44
109_T	132_R	0.706	0.43
19_L	133_V	0.706	0.43
68_L	79_A	0.701	0.42
65_F	92_W	0.698	0.42
13_L	123_C	0.698	0.42
34_A	67_A	0.694	0.42
142_A	153_F	0.691	0.42
86_G	142_A	0.679	0.41
11_A	103_L	0.673	0.40
51_A	54_I	0.672	0.40
30_N	63_R	0.672	0.40
89_K	95_G	0.670	0.40
72_G	153_F	0.669	0.40
63_R	70_D	0.668	0.40
102_S	128_H	0.668	0.40
54_I	90_A	0.663	0.39
18_N	117_G	0.663	0.39
49_A	73_F	0.657	0.39
151_D	155_D	0.656	0.39
17_Q	122_L	0.654	0.38
100_A	107_I	0.647	0.38
31_I	79_A	0.646	0.38
63_R	67_A	0.643	0.37
17_Q	117_G	0.642	0.37
96_M	136_M	0.639	0.37
50_I	110_I	0.638	0.37
124_R	128_H	0.637	0.37
64_F	80_I	0.637	0.37
28_S	158_E	0.633	0.37
93_D	116_D	0.629	0.36
59_E	96_M	0.628	0.36
49_A	112_L	0.624	0.36
38_D	63_R	0.620	0.36
109_T	140_E	0.618	0.35
34_A	60_D	0.616	0.35
10_V	46_L	0.611	0.35
72_G	115_G	0.608	0.35
52_Y	121_R	0.607	0.34
63_R	113_C	0.607	0.34
55_R	75_T	0.605	0.34
81_K	147_V	0.600	0.34
140_E	157_S	0.597	0.34
130_G	140_E	0.595	0.33
131_V	143_A	0.594	0.33
92_W	135_V	0.592	0.33
83_F	156_L	0.586	0.33
25_S	128_H	0.585	0.33
104_A	126_L	0.583	0.33
59_E	132_R	0.580	0.32
33_Y	85_D	0.579	0.32
39_K	74_E	0.578	0.32
55_R	62_D	0.578	0.32
89_K	98_L	0.576	0.32
65_F	76_K	0.575	0.32
20_Y	64_F	0.573	0.32
23_A	109_T	0.573	0.32
43_D	152_S	0.569	0.31
75_T	80_I	0.564	0.31
137_A	142_A	0.563	0.31
78_K	117_G	0.561	0.31
30_N	93_D	0.561	0.31
12_V	52_Y	0.557	0.30
132_R	151_D	0.551	0.30
22_S	156_L	0.550	0.30
47_T	107_I	0.550	0.30
20_Y	24_Q	0.549	0.30
62_D	123_C	0.549	0.30
18_N	112_L	0.547	0.30
130_G	133_V	0.546	0.30
64_F	120_S	0.543	0.29
75_T	151_D	0.542	0.29
38_D	41_V	0.541	0.29
100_A	123_C	0.540	0.29
40_G	50_I	0.540	0.29
49_A	78_K	0.537	0.29
39_K	42_Q	0.536	0.29
136_M	154_V	0.536	0.29
91_D	96_M	0.524	0.28
8_Q	36_L	0.522	0.28
31_I	155_D	0.521	0.28
110_I	131_V	0.521	0.28
95_G	121_R	0.520	0.28
95_G	117_G	0.519	0.28
139_E	158_E	0.518	0.28
12_V	99_D	0.518	0.28
110_I	126_L	0.517	0.28
18_N	135_V	0.515	0.27
35_A	50_I	0.514	0.27
36_L	113_C	0.513	0.27
39_K	157_S	0.513	0.27
25_S	48_R	0.510	0.27
37_L	73_F	0.510	0.27
124_R	148_D	0.510	0.27
104_A	129_E	0.509	0.27
15_D	18_N	0.508	0.27
8_Q	46_L	0.508	0.27
19_L	31_I	0.507	0.27
42_Q	136_M	0.504	0.27
90_A	95_G	0.503	0.27
81_K	88_K	0.502	0.26
124_R	127_R	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qipA	2	0.9758	100	0.284	Contact Map
1exnA	1	0.8	87	0.903	Contact Map
1bgxT	1	0.8303	79.9	0.91	Contact Map
4kzkA	1	0.9879	76.3	0.913	Contact Map
3uk0A	1	0.9394	72.7	0.916	Contact Map
1vimA	4	0.8061	71.5	0.917	Contact Map
3lopA	1	0.9394	71.2	0.917	Contact Map
3lkbA	2	0.9394	69.3	0.918	Contact Map
3h7iA	1	0.8606	68.9	0.918	Contact Map
4wt7A	1	0.9576	66.9	0.919	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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