GREMLIN Database
Q9HS38 - Uncharacterized protein
UniProt: Q9HS38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (144)
Sequences: 417 (316)
Seq/√Len: 26.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_A132_A4.3361.00
132_A139_M3.6901.00
79_P82_R3.5021.00
121_H125_R3.3711.00
107_V136_A3.2561.00
128_A150_V3.1681.00
14_A22_G2.7751.00
135_D138_S2.6230.99
14_A20_A2.5850.99
104_V147_A2.3760.99
107_V111_A2.2200.98
111_A117_L2.1810.97
51_A67_A2.1720.97
13_A25_L2.1620.97
118_A126_L2.1570.97
67_A70_Q2.1310.97
87_D122_E1.9980.96
111_A136_A1.9900.95
90_E121_H1.9560.95
119_V148_V1.8830.94
10_R22_G1.8750.94
17_Y64_L1.6740.89
116_E151_R1.6700.89
132_A136_A1.5880.86
106_D140_R1.5720.86
13_A64_L1.5540.85
134_L142_F1.5500.85
83_V139_M1.5380.85
69_G129_V1.4610.81
111_A139_M1.4440.81
62_L96_G1.4210.80
99_V119_V1.4080.79
108_D136_A1.4080.79
98_N146_M1.3860.78
129_V152_A1.3770.77
120_V124_G1.3690.77
139_M147_A1.3680.77
119_V128_A1.3390.75
85_V99_V1.3370.75
79_P124_G1.2770.72
68_G71_R1.2680.71
66_P152_A1.2490.70
13_A20_A1.2460.70
32_H46_H1.2430.70
38_S43_Q1.2250.68
73_I124_G1.2240.68
107_V132_A1.2080.67
81_A110_D1.1870.66
82_R108_D1.1860.66
99_V141_D1.1800.65
83_V148_V1.1700.65
128_A147_A1.1600.64
21_A24_A1.1500.63
16_Q116_E1.1350.62
98_N131_R1.1240.62
92_F147_A1.1200.61
17_Y62_L1.1170.61
52_R65_G1.0960.60
89_S131_R1.0940.59
106_D141_D1.0870.59
90_E94_R1.0840.59
22_G64_L1.0770.58
119_V150_V1.0650.57
24_A120_V1.0550.57
39_T42_P1.0390.55
52_R63_T1.0350.55
84_V118_A1.0180.54
108_D120_V1.0070.53
87_D123_D0.9920.52
40_G43_Q0.9870.52
13_A22_G0.9650.50
101_A147_A0.9630.50
59_D72_L0.9400.48
104_V113_Q0.9240.47
86_G105_T0.9110.46
20_A27_P0.9100.46
78_H140_R0.9030.45
64_L68_G0.8870.44
44_Q52_R0.8860.44
85_V89_S0.8830.44
62_L85_V0.8780.44
81_A117_L0.8760.43
99_V102_K0.8710.43
70_Q109_D0.8620.42
26_F150_V0.8620.42
30_K133_E0.8610.42
45_I62_L0.8570.42
86_G89_S0.8540.42
89_S129_V0.8530.42
68_G138_S0.8520.42
87_D90_E0.8450.41
97_K103_F0.8340.40
31_P37_S0.8340.40
9_L129_V0.8320.40
102_K142_F0.8300.40
70_Q74_D0.8180.39
104_V146_M0.8150.39
17_Y139_M0.8150.39
64_L69_G0.8150.39
17_Y111_A0.8080.39
62_L72_L0.8050.38
103_F142_F0.7980.38
9_L150_V0.7960.38
107_V139_M0.7960.38
39_T138_S0.7950.38
13_A54_V0.7920.37
54_V62_L0.7910.37
38_S41_R0.7870.37
101_A112_R0.7840.37
17_Y115_D0.7780.36
114_G144_T0.7740.36
90_E112_R0.7700.36
100_F131_R0.7700.36
101_A134_L0.7660.36
6_I34_V0.7580.35
105_T123_D0.7500.35
120_V126_L0.7430.34
82_R124_G0.7410.34
49_D143_E0.7330.33
6_I30_K0.7310.33
50_G69_G0.7310.33
56_V62_L0.7290.33
120_V153_G0.7240.33
101_A123_D0.7240.33
90_E125_R0.7200.33
20_A50_G0.7200.33
108_D146_M0.7160.32
100_F121_H0.7160.32
23_R98_N0.7140.32
46_H150_V0.7130.32
53_L104_V0.7100.32
140_R154_V0.7080.32
38_S46_H0.7050.32
84_V122_E0.7030.31
105_T126_L0.7010.31
93_V144_T0.7000.31
41_R62_L0.6990.31
52_R88_E0.6970.31
82_R120_V0.6910.31
32_H103_F0.6860.30
88_E150_V0.6840.30
40_G60_G0.6810.30
77_E119_V0.6810.30
113_Q140_R0.6800.30
32_H139_M0.6730.30
31_P50_G0.6500.28
27_P30_K0.6490.28
70_Q140_R0.6480.28
45_I51_A0.6470.28
82_R118_A0.6430.28
27_P129_V0.6420.28
34_V44_Q0.6410.28
72_L126_L0.6370.27
67_A123_D0.6370.27
13_A21_A0.6360.27
73_I128_A0.6360.27
89_S115_D0.6340.27
104_V148_V0.6330.27
34_V60_G0.6310.27
93_V121_H0.6310.27
38_S49_D0.6260.27
40_G61_R0.6240.27
109_D140_R0.6240.27
24_A28_E0.6210.26
9_L57_G0.6200.26
49_D133_E0.6180.26
25_L64_L0.6150.26
42_P59_D0.6110.26
37_S44_Q0.6020.25
122_E131_R0.6010.25
82_R126_L0.5990.25
66_P141_D0.5970.25
113_Q134_L0.5960.25
68_G92_F0.5950.25
29_D50_G0.5920.25
133_E148_V0.5910.25
121_H131_R0.5890.25
86_G103_F0.5870.25
134_L154_V0.5830.24
62_L83_V0.5790.24
97_K151_R0.5790.24
22_G97_K0.5770.24
8_A32_H0.5740.24
37_S103_F0.5680.23
89_S93_V0.5680.23
113_Q135_D0.5670.23
80_R118_A0.5640.23
109_D137_A0.5620.23
87_D91_P0.5600.23
26_F146_M0.5510.23
100_F124_G0.5500.23
98_N142_F0.5460.22
37_S60_G0.5450.22
23_R105_T0.5440.22
121_H124_G0.5440.22
66_P70_Q0.5420.22
63_T85_V0.5370.22
22_G27_P0.5300.22
34_V37_S0.5290.21
11_T25_L0.5280.21
109_D127_L0.5240.21
49_D58_L0.5240.21
50_G70_Q0.5230.21
9_L80_R0.5200.21
126_L153_G0.5190.21
29_D85_V0.5180.21
93_V129_V0.5170.21
29_D148_V0.5150.21
56_V133_E0.5060.20
106_D137_A0.5050.20
110_D134_L0.5040.20
31_P53_L0.5040.20
119_V141_D0.5040.20
7_P123_D0.5040.20
105_T109_D0.5020.20
43_Q57_G0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iq8A 2 0.9434 100 0.431 Contact Map
3d79A 1 0.9748 100 0.489 Contact Map
2q07A 1 0.8113 99.9 0.516 Contact Map
3r90A 5 0.9623 99.9 0.528 Contact Map
1q7hA 2 0.8994 99.9 0.531 Contact Map
2cx0A 1 0.9497 99.9 0.56 Contact Map
2p38A 4 0.8302 99.8 0.634 Contact Map
3zv0C 2 0.7233 99.6 0.687 Contact Map
2apoA 1 0.8742 98.9 0.782 Contact Map
2ausC 1 0.9686 98.9 0.784 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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