NAC - HALSA - GREMLIN Contacts

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NAC - Nascent polypeptide-associated complex protein

UniProt:	Q9HS36	Sequences: MFGGGGMNPRKMQQMMEQMGIDVDELDATEVVISLDDGTEVVFSDPDVTKMDARGQETYQVLGDPVERDAADAIEAAPADDSDDTDDDDAIPQGDVDIVVQRASVPEDEAREALEAADGDLAAAIDHVDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	130 (108)
Sequences:	208 (147)
Seq/√Len:	14.1

HALSA - NAC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_T	67_E	4.221	1.00
30_E	34_S	4.108	1.00
106_P	109_E	3.448	0.99
44_S	66_V	2.685	0.95
97_D	101_Q	2.571	0.94
43_F	65_P	2.318	0.89
42_V	96_V	2.214	0.87
112_E	116_A	2.161	0.86
116_A	127_H	2.122	0.85
117_A	127_H	1.992	0.80
40_E	68_R	1.961	0.79
107_E	111_R	1.961	0.79
100_V	103_A	1.865	0.76
26_L	35_L	1.845	0.75
50_K	57_E	1.831	0.74
96_V	111_R	1.816	0.74
11_K	16_M	1.788	0.73
28_A	33_I	1.774	0.72
28_A	50_K	1.762	0.71
28_A	41_V	1.725	0.70
25_E	47_D	1.696	0.68
30_E	44_S	1.691	0.68
32_V	40_E	1.681	0.68
25_E	101_Q	1.598	0.64
26_L	47_D	1.552	0.61
30_E	40_E	1.506	0.59
34_S	70_A	1.488	0.58
123_A	127_H	1.454	0.56
28_A	57_E	1.431	0.55
43_F	63_G	1.382	0.52
100_V	115_E	1.369	0.51
93_Q	106_P	1.205	0.43
52_D	57_E	1.200	0.42
28_A	46_P	1.197	0.42
96_V	107_E	1.194	0.42
61_V	93_Q	1.119	0.38
11_K	18_Q	1.115	0.38
111_R	115_E	1.114	0.38
54_R	99_V	1.091	0.37
97_D	100_V	1.073	0.36
98_I	102_R	1.069	0.36
17_E	123_A	1.067	0.35
19_M	111_R	1.038	0.34
11_K	14_Q	1.030	0.34
16_M	21_I	1.022	0.33
6_G	30_E	1.006	0.32
34_S	40_E	1.005	0.32
100_V	107_E	1.000	0.32
18_Q	60_Q	0.999	0.32
22_D	52_D	0.993	0.32
39_T	50_K	0.965	0.31
9_P	17_E	0.959	0.30
21_I	53_A	0.954	0.30
7_M	125_I	0.947	0.30
15_M	19_M	0.947	0.30
99_V	125_I	0.946	0.30
59_Y	65_P	0.942	0.29
105_V	108_D	0.928	0.29
102_R	126_D	0.926	0.29
35_L	107_E	0.899	0.28
36_D	46_P	0.898	0.28
112_E	115_E	0.897	0.27
19_M	67_E	0.885	0.27
61_V	64_D	0.879	0.27
46_P	54_R	0.877	0.27
8_N	58_T	0.873	0.26
106_P	110_A	0.857	0.26
71_A	93_Q	0.845	0.25
46_P	92_P	0.844	0.25
59_Y	128_V	0.842	0.25
16_M	42_V	0.839	0.25
15_M	20_G	0.835	0.25
43_F	96_V	0.834	0.25
24_D	112_E	0.833	0.25
93_Q	126_D	0.828	0.25
118_D	123_A	0.828	0.25
12_M	47_D	0.828	0.25
24_D	94_G	0.823	0.24
61_V	89_D	0.820	0.24
34_S	44_S	0.820	0.24
24_D	89_D	0.819	0.24
8_N	108_D	0.819	0.24
92_P	121_L	0.818	0.24
15_M	61_V	0.811	0.24
88_D	108_D	0.803	0.24
100_V	105_V	0.795	0.23
51_M	59_Y	0.792	0.23
39_T	125_I	0.787	0.23
33_I	61_V	0.783	0.23
109_E	113_A	0.780	0.23
96_V	120_D	0.775	0.23
96_V	101_Q	0.771	0.22
19_M	68_R	0.766	0.22
26_L	69_D	0.749	0.22
23_V	98_I	0.741	0.21
17_E	91_I	0.738	0.21
49_T	60_Q	0.735	0.21
21_I	58_T	0.733	0.21
28_A	115_E	0.725	0.21
25_E	49_T	0.721	0.21
23_V	51_M	0.719	0.20
30_E	121_L	0.716	0.20
32_V	35_L	0.712	0.20
90_A	111_R	0.712	0.20
24_D	64_D	0.709	0.20
42_V	68_R	0.704	0.20
24_D	109_E	0.695	0.20
12_M	127_H	0.695	0.20
102_R	123_A	0.693	0.20
45_D	53_A	0.692	0.20
41_V	64_D	0.669	0.19
40_E	70_A	0.667	0.19
6_G	9_P	0.664	0.19
93_Q	97_D	0.656	0.18
15_M	63_G	0.646	0.18
10_R	65_P	0.639	0.18
100_V	117_A	0.635	0.18
29_T	36_D	0.634	0.18
98_I	116_A	0.630	0.17
23_V	60_Q	0.624	0.17
10_R	14_Q	0.614	0.17
16_M	63_G	0.608	0.17
30_E	66_V	0.607	0.17
87_D	92_P	0.593	0.16
57_E	62_L	0.592	0.16
48_V	107_E	0.592	0.16
108_D	113_A	0.585	0.16
41_V	103_A	0.585	0.16
68_R	101_Q	0.583	0.16
16_M	58_T	0.580	0.16
43_F	67_E	0.578	0.16
105_V	109_E	0.577	0.16
8_N	115_E	0.575	0.16
28_A	59_Y	0.574	0.16
31_V	62_L	0.574	0.16
18_Q	21_I	0.572	0.16
90_A	100_V	0.569	0.16
94_G	98_I	0.566	0.16
41_V	50_K	0.564	0.15
28_A	64_D	0.551	0.15
40_E	121_L	0.546	0.15
8_N	16_M	0.544	0.15
109_E	112_E	0.539	0.15
14_Q	54_R	0.538	0.15
51_M	65_P	0.537	0.15
14_Q	69_D	0.536	0.15
29_T	70_A	0.528	0.14
36_D	45_D	0.526	0.14
41_V	104_S	0.523	0.14
34_S	121_L	0.522	0.14
90_A	118_D	0.520	0.14
28_A	125_I	0.515	0.14
122_A	125_I	0.512	0.14
102_R	117_A	0.512	0.14
91_I	121_L	0.510	0.14
22_D	117_A	0.510	0.14
41_V	59_Y	0.508	0.14
107_E	115_E	0.505	0.14
31_V	93_Q	0.503	0.14
61_V	69_D	0.502	0.14
16_M	20_G	0.502	0.14
45_D	69_D	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1tr8A	4	0.7	100	0.465	Contact Map
2cp9A	1	0.3615	98.3	0.805	Contact Map
1wj7A	1	0.5923	96.7	0.858	Contact Map
2mr9A	1	0.3308	95.7	0.871	Contact Map
2g3qA	1	0.3154	95	0.877	Contact Map
3mcbA	1	0.4154	94.3	0.881	Contact Map
1z96A	1	0.2923	92.6	0.888	Contact Map
3mceA	2	0.4692	92	0.89	Contact Map
2ooaA	1	0.2923	91.6	0.892	Contact Map
2jy5A	1	0.3769	89.1	0.897	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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