GREMLIN Database
NAC - Nascent polypeptide-associated complex protein
UniProt: Q9HS36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (108)
Sequences: 208 (147)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T67_E4.2211.00
30_E34_S4.1081.00
106_P109_E3.4480.99
44_S66_V2.6850.95
97_D101_Q2.5710.94
43_F65_P2.3180.89
42_V96_V2.2140.87
112_E116_A2.1610.86
116_A127_H2.1220.85
117_A127_H1.9920.80
40_E68_R1.9610.79
107_E111_R1.9610.79
100_V103_A1.8650.76
26_L35_L1.8450.75
50_K57_E1.8310.74
96_V111_R1.8160.74
11_K16_M1.7880.73
28_A33_I1.7740.72
28_A50_K1.7620.71
28_A41_V1.7250.70
25_E47_D1.6960.68
30_E44_S1.6910.68
32_V40_E1.6810.68
25_E101_Q1.5980.64
26_L47_D1.5520.61
30_E40_E1.5060.59
34_S70_A1.4880.58
123_A127_H1.4540.56
28_A57_E1.4310.55
43_F63_G1.3820.52
100_V115_E1.3690.51
93_Q106_P1.2050.43
52_D57_E1.2000.42
28_A46_P1.1970.42
96_V107_E1.1940.42
61_V93_Q1.1190.38
11_K18_Q1.1150.38
111_R115_E1.1140.38
54_R99_V1.0910.37
97_D100_V1.0730.36
98_I102_R1.0690.36
17_E123_A1.0670.35
19_M111_R1.0380.34
11_K14_Q1.0300.34
16_M21_I1.0220.33
6_G30_E1.0060.32
34_S40_E1.0050.32
100_V107_E1.0000.32
18_Q60_Q0.9990.32
22_D52_D0.9930.32
39_T50_K0.9650.31
9_P17_E0.9590.30
21_I53_A0.9540.30
7_M125_I0.9470.30
15_M19_M0.9470.30
99_V125_I0.9460.30
59_Y65_P0.9420.29
105_V108_D0.9280.29
102_R126_D0.9260.29
35_L107_E0.8990.28
36_D46_P0.8980.28
112_E115_E0.8970.27
19_M67_E0.8850.27
61_V64_D0.8790.27
46_P54_R0.8770.27
8_N58_T0.8730.26
106_P110_A0.8570.26
71_A93_Q0.8450.25
46_P92_P0.8440.25
59_Y128_V0.8420.25
16_M42_V0.8390.25
15_M20_G0.8350.25
43_F96_V0.8340.25
24_D112_E0.8330.25
93_Q126_D0.8280.25
118_D123_A0.8280.25
12_M47_D0.8280.25
24_D94_G0.8230.24
61_V89_D0.8200.24
34_S44_S0.8200.24
24_D89_D0.8190.24
8_N108_D0.8190.24
92_P121_L0.8180.24
15_M61_V0.8110.24
88_D108_D0.8030.24
100_V105_V0.7950.23
51_M59_Y0.7920.23
39_T125_I0.7870.23
33_I61_V0.7830.23
109_E113_A0.7800.23
96_V120_D0.7750.23
96_V101_Q0.7710.22
19_M68_R0.7660.22
26_L69_D0.7490.22
23_V98_I0.7410.21
17_E91_I0.7380.21
49_T60_Q0.7350.21
21_I58_T0.7330.21
28_A115_E0.7250.21
25_E49_T0.7210.21
23_V51_M0.7190.20
30_E121_L0.7160.20
32_V35_L0.7120.20
90_A111_R0.7120.20
24_D64_D0.7090.20
42_V68_R0.7040.20
24_D109_E0.6950.20
12_M127_H0.6950.20
102_R123_A0.6930.20
45_D53_A0.6920.20
41_V64_D0.6690.19
40_E70_A0.6670.19
6_G9_P0.6640.19
93_Q97_D0.6560.18
15_M63_G0.6460.18
10_R65_P0.6390.18
100_V117_A0.6350.18
29_T36_D0.6340.18
98_I116_A0.6300.17
23_V60_Q0.6240.17
10_R14_Q0.6140.17
16_M63_G0.6080.17
30_E66_V0.6070.17
87_D92_P0.5930.16
57_E62_L0.5920.16
48_V107_E0.5920.16
108_D113_A0.5850.16
41_V103_A0.5850.16
68_R101_Q0.5830.16
16_M58_T0.5800.16
43_F67_E0.5780.16
105_V109_E0.5770.16
8_N115_E0.5750.16
28_A59_Y0.5740.16
31_V62_L0.5740.16
18_Q21_I0.5720.16
90_A100_V0.5690.16
94_G98_I0.5660.16
41_V50_K0.5640.15
28_A64_D0.5510.15
40_E121_L0.5460.15
8_N16_M0.5440.15
109_E112_E0.5390.15
14_Q54_R0.5380.15
51_M65_P0.5370.15
14_Q69_D0.5360.15
29_T70_A0.5280.14
36_D45_D0.5260.14
41_V104_S0.5230.14
34_S121_L0.5220.14
90_A118_D0.5200.14
28_A125_I0.5150.14
122_A125_I0.5120.14
102_R117_A0.5120.14
91_I121_L0.5100.14
22_D117_A0.5100.14
41_V59_Y0.5080.14
107_E115_E0.5050.14
31_V93_Q0.5030.14
61_V69_D0.5020.14
16_M20_G0.5020.14
45_D69_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tr8A 4 0.7 100 0.465 Contact Map
2cp9A 1 0.3615 98.3 0.805 Contact Map
1wj7A 1 0.5923 96.7 0.858 Contact Map
2mr9A 1 0.3308 95.7 0.871 Contact Map
2g3qA 1 0.3154 95 0.877 Contact Map
3mcbA 1 0.4154 94.3 0.881 Contact Map
1z96A 1 0.2923 92.6 0.888 Contact Map
3mceA 2 0.4692 92 0.89 Contact Map
2ooaA 1 0.2923 91.6 0.892 Contact Map
2jy5A 1 0.3769 89.1 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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