GREMLIN Database
Q9HS35 - L-isoaspartyl protein carboxyl methyltransferase
UniProt: Q9HS35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (229)
Sequences: 1146 (695)
Seq/√Len: 45.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_A107_V6.3861.00
15_G28_P5.7111.00
106_D134_S5.4451.00
114_A118_A3.9271.00
87_L150_F3.6131.00
91_T109_T2.8891.00
159_D162_D2.8871.00
85_R108_T2.8451.00
66_M71_I2.7421.00
13_A16_E2.6771.00
101_G132_A2.6621.00
193_A196_D2.6361.00
121_R125_S2.6171.00
151_D172_V2.5261.00
77_H203_D2.5181.00
204_A233_L2.5161.00
32_T35_E2.4661.00
31_P35_E2.2441.00
117_A137_A2.2411.00
26_E29_D2.2271.00
111_E117_A2.2131.00
83_A105_A2.1751.00
138_G143_D1.9870.99
17_E26_E1.9760.99
100_L107_V1.9410.99
117_A135_V1.8810.99
73_L205_M1.8530.99
108_T136_R1.8220.99
191_T233_L1.8110.99
203_D211_R1.8000.99
118_A121_R1.7960.99
75_M80_V1.7620.98
88_D97_A1.7610.98
176_Q236_R1.7460.98
114_A137_A1.7450.98
73_L77_H1.7320.98
158_Q182_P1.7300.98
81_S84_D1.6980.98
164_V167_A1.6770.98
110_Y145_D1.6710.98
167_A177_V1.6520.98
17_E24_V1.6410.97
179_V190_T1.6400.97
208_I225_G1.6360.97
89_A140_V1.5800.97
181_S233_L1.5600.96
168_D199_L1.5540.96
66_M74_V1.5430.96
177_V194_A1.5410.96
37_V47_V1.5240.96
89_A155_L1.4860.95
153_L167_A1.4850.95
141_T163_V1.4670.95
206_E210_R1.4560.95
171_L175_G1.4550.95
15_G27_A1.4440.95
164_V193_A1.4430.95
211_R222_S1.4400.94
180_Y230_G1.4380.94
98_A127_A1.4190.94
80_V86_V1.4170.94
194_A235_A1.3670.93
96_L230_G1.3580.93
165_A197_A1.3510.92
187_A204_A1.3490.92
71_I75_M1.3430.92
136_R146_A1.3120.91
178_A234_F1.2900.90
161_P189_A1.2870.90
55_L127_A1.2760.90
202_I235_A1.2620.89
87_L153_L1.2600.89
85_R106_D1.2540.89
125_S130_S1.2520.89
85_R150_F1.2430.89
97_A100_L1.2400.89
101_G133_V1.2390.89
14_P28_P1.1990.87
147_L169_D1.1950.87
8_R18_L1.1710.86
194_A199_L1.1620.85
97_A124_M1.1490.84
78_T178_A1.1400.84
165_A193_A1.1200.83
140_V145_D1.1180.83
140_V163_V1.1150.83
212_M231_Y1.1040.82
77_H205_M1.0960.82
91_T135_V1.0930.81
109_T135_V1.0810.81
164_V197_A1.0680.80
52_G185_E1.0430.78
124_M133_V1.0420.78
39_T42_G1.0410.78
213_D222_S1.0350.78
83_A160_A1.0330.77
185_E188_R1.0330.77
12_V15_G1.0300.77
79_G127_A1.0230.77
67_M180_Y1.0200.77
78_T176_Q1.0170.76
141_T162_D0.9950.75
19_H24_V0.9930.75
163_V207_T0.9870.74
139_D142_A0.9850.74
101_G107_V0.9840.74
138_G145_D0.9790.74
112_Q116_F0.9670.73
214_F219_S0.9670.73
193_A197_A0.9530.72
204_A214_F0.9510.71
210_R221_P0.9470.71
37_V200_V0.9260.69
75_M103_A0.9120.68
117_A121_R0.9110.68
35_E47_V0.9060.68
91_T120_A0.9020.67
38_E44_P0.8960.67
89_A97_A0.8950.67
63_G116_F0.8950.67
187_A233_L0.8890.66
96_L111_E0.8830.66
61_R112_Q0.8810.65
61_R113_D0.8720.65
143_D166_H0.8700.64
86_V120_A0.8620.64
53_P102_R0.8590.63
15_G195_R0.8550.63
10_F27_A0.8450.62
97_A101_G0.8440.62
140_V143_D0.8410.62
105_A160_A0.8410.62
113_D116_F0.8390.62
111_E137_A0.8390.62
24_V40_H0.8360.61
165_A169_D0.8350.61
65_P95_V0.8310.61
63_G67_M0.8280.61
52_G99_Y0.8270.61
30_D35_E0.8170.60
157_T182_P0.8090.59
96_L204_A0.8080.59
80_V152_V0.8060.59
78_T152_V0.8040.58
89_A135_V0.7970.58
111_E116_F0.7970.58
82_G231_Y0.7950.57
157_T181_S0.7930.57
57_N67_M0.7910.57
69_K123_N0.7910.57
39_T45_F0.7910.57
76_G99_Y0.7910.57
86_V152_V0.7850.57
75_M99_Y0.7840.56
140_V155_L0.7820.56
226_V230_G0.7700.55
123_N127_A0.7690.55
10_F16_E0.7680.55
55_L98_A0.7660.55
49_E223_T0.7660.55
64_A183_F0.7650.55
15_G110_Y0.7600.54
25_I47_V0.7570.54
34_G83_A0.7570.54
192_Q195_R0.7550.54
136_R145_D0.7520.53
205_M211_R0.7490.53
97_A135_V0.7480.53
69_K221_P0.7470.53
168_D197_A0.7470.53
110_Y149_T0.7410.52
65_P72_G0.7400.52
88_D154_T0.7380.52
178_A227_G0.7370.52
73_L207_T0.7360.52
66_M154_T0.7330.51
80_V100_L0.7290.51
133_V150_F0.7270.51
191_T202_I0.7270.51
96_L100_L0.7260.51
140_V144_L0.7260.51
67_M212_M0.7260.51
191_T214_F0.7240.51
222_S227_G0.7230.50
228_H235_A0.7190.50
88_D107_V0.7180.50
18_L110_Y0.7160.50
12_V27_A0.7140.50
20_T139_D0.7070.49
108_T150_F0.7060.49
74_V154_T0.7060.49
111_E217_R0.7050.49
212_M219_S0.7020.48
181_S190_T0.7010.48
74_V96_L0.7000.48
181_S185_E0.7000.48
161_P190_T0.6970.48
85_R172_V0.6950.48
185_E234_F0.6950.48
144_L153_L0.6950.48
164_V190_T0.6950.48
80_V192_Q0.6950.48
101_G218_G0.6930.48
73_L203_D0.6920.47
123_N183_F0.6910.47
77_H234_F0.6910.47
59_F98_A0.6880.47
145_D167_A0.6880.47
182_P204_A0.6870.47
104_G146_A0.6870.47
221_P236_R0.6850.47
87_L110_Y0.6840.47
32_T109_T0.6830.47
69_K113_D0.6820.46
71_I99_Y0.6810.46
95_V159_D0.6780.46
17_E40_H0.6770.46
119_V123_N0.6760.46
64_A143_D0.6740.46
65_P160_A0.6690.45
164_V199_L0.6680.45
116_F123_N0.6670.45
136_R150_F0.6660.45
48_R189_A0.6650.45
89_A157_T0.6620.44
31_P47_V0.6620.44
65_P157_T0.6590.44
167_A170_L0.6570.44
208_I227_G0.6550.44
105_A183_F0.6540.44
38_E42_G0.6520.44
125_S196_D0.6510.43
33_P47_V0.6500.43
91_T133_V0.6490.43
110_Y146_A0.6480.43
114_A121_R0.6480.43
142_A162_D0.6460.43
16_E25_I0.6430.43
11_L25_I0.6420.43
14_P32_T0.6410.42
110_Y144_L0.6400.42
199_L209_Q0.6390.42
184_V233_L0.6380.42
85_R149_T0.6350.42
67_M183_F0.6350.42
122_E197_A0.6320.42
57_N184_V0.6300.41
56_F67_M0.6270.41
220_R236_R0.6250.41
16_E28_P0.6240.41
34_G93_T0.6210.41
184_V214_F0.6170.40
190_T235_A0.6110.40
68_P210_R0.6100.40
20_T25_I0.6090.39
87_L144_L0.6090.39
59_F95_V0.6080.39
109_T232_L0.6080.39
23_G39_T0.6080.39
107_V217_R0.6060.39
181_S187_A0.6060.39
63_G93_T0.6050.39
190_T198_G0.6030.39
18_L27_A0.6010.39
88_D105_A0.6000.39
62_T119_V0.5990.38
14_P31_P0.5970.38
111_E136_R0.5960.38
68_P221_P0.5920.38
154_T182_P0.5890.38
113_D123_N0.5890.38
188_R192_Q0.5860.37
111_E174_G0.5850.37
110_Y163_V0.5850.37
7_D37_V0.5850.37
54_D61_R0.5840.37
67_M79_G0.5800.37
13_A28_P0.5780.37
189_A195_R0.5760.36
34_G174_G0.5750.36
33_P103_A0.5740.36
95_V178_A0.5730.36
66_M208_I0.5720.36
122_E194_A0.5710.36
39_T135_V0.5690.36
7_D38_E0.5690.36
17_E47_V0.5660.35
158_Q188_R0.5640.35
12_V94_G0.5630.35
33_P57_N0.5610.35
71_I91_T0.5590.35
72_G173_S0.5570.35
110_Y138_G0.5570.35
91_T124_M0.5550.34
165_A231_Y0.5490.34
106_D131_D0.5460.34
37_V52_G0.5450.34
69_K209_Q0.5450.34
218_G223_T0.5440.34
42_G79_G0.5410.33
27_A60_E0.5410.33
13_A18_L0.5410.33
66_M215_D0.5400.33
63_G180_Y0.5390.33
25_I119_V0.5390.33
142_A146_A0.5380.33
231_Y234_F0.5380.33
55_L124_M0.5370.33
190_T233_L0.5360.33
63_G152_V0.5350.33
158_Q183_F0.5310.32
184_V187_A0.5300.32
13_A125_S0.5300.32
188_R219_S0.5290.32
111_E135_V0.5280.32
158_Q186_N0.5230.32
13_A25_I0.5220.32
165_A170_L0.5220.32
66_M230_G0.5210.32
80_V120_A0.5200.31
101_G129_V0.5190.31
138_G144_L0.5190.31
203_D226_V0.5180.31
228_H232_L0.5160.31
158_Q180_Y0.5160.31
129_V212_M0.5150.31
134_S143_D0.5150.31
86_V142_A0.5140.31
135_V145_D0.5140.31
28_P38_E0.5140.31
10_F196_D0.5140.31
102_R155_L0.5130.31
188_R191_T0.5110.31
139_D166_H0.5070.30
107_V115_D0.5050.30
36_T47_V0.5040.30
141_T159_D0.5040.30
9_E103_A0.5040.30
96_L109_T0.5010.30
33_P101_G0.5010.30
25_I39_T0.5010.30
146_A170_L0.5010.30
39_T196_D0.5000.30
64_A160_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o54A 4 0.9916 100 0.459 Contact Map
1i9gA 3 1 100 0.495 Contact Map
2pwyA 3 0.9916 100 0.52 Contact Map
3mb5A 3 0.9916 100 0.522 Contact Map
2b25A 3 0.9412 100 0.564 Contact Map
1yb2A 2 0.8908 100 0.573 Contact Map
2yvlA 4 0.9664 100 0.608 Contact Map
3e05A 4 0.7899 99.8 0.764 Contact Map
3ckkA 1 0.7227 99.8 0.772 Contact Map
1l3iA 5 0.7731 99.8 0.773 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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