Q9HS35 - HALSA - GREMLIN Contacts

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Q9HS35 - L-isoaspartyl protein carboxyl methyltransferase

UniProt:	Q9HS35	Sequences: MLLVRGDREFLVAPGEELHTDLGVIEAPDDPTPGETVETHLGEPFTVRELRGPDLFNHFERTGAPMMPKDIGLVMGHTGVSGADRVLDAGTGTGVLAAYLGRAGADVTTYEQDADFAAVARENMSLAGVSDAVSVRAGDVTADLDALGTFDVLTLDTQDAPDVVAHADDLLVSGGQVAVYSPFVENARATTQAARDAGLVDIDAMETIQRRMDFDDRGSRPSTAGVGHTGYLLFARNP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	238 (229)
Sequences:	1146 (695)
Seq/√Len:	45.9

HALSA - Q9HS35
SULSO - Q97ZZ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_A	107_V	6.386	1.00
15_G	28_P	5.711	1.00
106_D	134_S	5.445	1.00
114_A	118_A	3.927	1.00
87_L	150_F	3.613	1.00
91_T	109_T	2.889	1.00
159_D	162_D	2.887	1.00
85_R	108_T	2.845	1.00
66_M	71_I	2.742	1.00
13_A	16_E	2.677	1.00
101_G	132_A	2.662	1.00
193_A	196_D	2.636	1.00
121_R	125_S	2.617	1.00
151_D	172_V	2.526	1.00
77_H	203_D	2.518	1.00
204_A	233_L	2.516	1.00
32_T	35_E	2.466	1.00
31_P	35_E	2.244	1.00
117_A	137_A	2.241	1.00
26_E	29_D	2.227	1.00
111_E	117_A	2.213	1.00
83_A	105_A	2.175	1.00
138_G	143_D	1.987	0.99
17_E	26_E	1.976	0.99
100_L	107_V	1.941	0.99
117_A	135_V	1.881	0.99
73_L	205_M	1.853	0.99
108_T	136_R	1.822	0.99
191_T	233_L	1.811	0.99
203_D	211_R	1.800	0.99
118_A	121_R	1.796	0.99
75_M	80_V	1.762	0.98
88_D	97_A	1.761	0.98
176_Q	236_R	1.746	0.98
114_A	137_A	1.745	0.98
73_L	77_H	1.732	0.98
158_Q	182_P	1.730	0.98
81_S	84_D	1.698	0.98
164_V	167_A	1.677	0.98
110_Y	145_D	1.671	0.98
167_A	177_V	1.652	0.98
17_E	24_V	1.641	0.97
179_V	190_T	1.640	0.97
208_I	225_G	1.636	0.97
89_A	140_V	1.580	0.97
181_S	233_L	1.560	0.96
168_D	199_L	1.554	0.96
66_M	74_V	1.543	0.96
177_V	194_A	1.541	0.96
37_V	47_V	1.524	0.96
89_A	155_L	1.486	0.95
153_L	167_A	1.485	0.95
141_T	163_V	1.467	0.95
206_E	210_R	1.456	0.95
171_L	175_G	1.455	0.95
15_G	27_A	1.444	0.95
164_V	193_A	1.443	0.95
211_R	222_S	1.440	0.94
180_Y	230_G	1.438	0.94
98_A	127_A	1.419	0.94
80_V	86_V	1.417	0.94
194_A	235_A	1.367	0.93
96_L	230_G	1.358	0.93
165_A	197_A	1.351	0.92
187_A	204_A	1.349	0.92
71_I	75_M	1.343	0.92
136_R	146_A	1.312	0.91
178_A	234_F	1.290	0.90
161_P	189_A	1.287	0.90
55_L	127_A	1.276	0.90
202_I	235_A	1.262	0.89
87_L	153_L	1.260	0.89
85_R	106_D	1.254	0.89
125_S	130_S	1.252	0.89
85_R	150_F	1.243	0.89
97_A	100_L	1.240	0.89
101_G	133_V	1.239	0.89
14_P	28_P	1.199	0.87
147_L	169_D	1.195	0.87
8_R	18_L	1.171	0.86
194_A	199_L	1.162	0.85
97_A	124_M	1.149	0.84
78_T	178_A	1.140	0.84
165_A	193_A	1.120	0.83
140_V	145_D	1.118	0.83
140_V	163_V	1.115	0.83
212_M	231_Y	1.104	0.82
77_H	205_M	1.096	0.82
91_T	135_V	1.093	0.81
109_T	135_V	1.081	0.81
164_V	197_A	1.068	0.80
52_G	185_E	1.043	0.78
124_M	133_V	1.042	0.78
39_T	42_G	1.041	0.78
213_D	222_S	1.035	0.78
83_A	160_A	1.033	0.77
185_E	188_R	1.033	0.77
12_V	15_G	1.030	0.77
79_G	127_A	1.023	0.77
67_M	180_Y	1.020	0.77
78_T	176_Q	1.017	0.76
141_T	162_D	0.995	0.75
19_H	24_V	0.993	0.75
163_V	207_T	0.987	0.74
139_D	142_A	0.985	0.74
101_G	107_V	0.984	0.74
138_G	145_D	0.979	0.74
112_Q	116_F	0.967	0.73
214_F	219_S	0.967	0.73
193_A	197_A	0.953	0.72
204_A	214_F	0.951	0.71
210_R	221_P	0.947	0.71
37_V	200_V	0.926	0.69
75_M	103_A	0.912	0.68
117_A	121_R	0.911	0.68
35_E	47_V	0.906	0.68
91_T	120_A	0.902	0.67
38_E	44_P	0.896	0.67
89_A	97_A	0.895	0.67
63_G	116_F	0.895	0.67
187_A	233_L	0.889	0.66
96_L	111_E	0.883	0.66
61_R	112_Q	0.881	0.65
61_R	113_D	0.872	0.65
143_D	166_H	0.870	0.64
86_V	120_A	0.862	0.64
53_P	102_R	0.859	0.63
15_G	195_R	0.855	0.63
10_F	27_A	0.845	0.62
97_A	101_G	0.844	0.62
140_V	143_D	0.841	0.62
105_A	160_A	0.841	0.62
113_D	116_F	0.839	0.62
111_E	137_A	0.839	0.62
24_V	40_H	0.836	0.61
165_A	169_D	0.835	0.61
65_P	95_V	0.831	0.61
63_G	67_M	0.828	0.61
52_G	99_Y	0.827	0.61
30_D	35_E	0.817	0.60
157_T	182_P	0.809	0.59
96_L	204_A	0.808	0.59
80_V	152_V	0.806	0.59
78_T	152_V	0.804	0.58
89_A	135_V	0.797	0.58
111_E	116_F	0.797	0.58
82_G	231_Y	0.795	0.57
157_T	181_S	0.793	0.57
57_N	67_M	0.791	0.57
69_K	123_N	0.791	0.57
39_T	45_F	0.791	0.57
76_G	99_Y	0.791	0.57
86_V	152_V	0.785	0.57
75_M	99_Y	0.784	0.56
140_V	155_L	0.782	0.56
226_V	230_G	0.770	0.55
123_N	127_A	0.769	0.55
10_F	16_E	0.768	0.55
55_L	98_A	0.766	0.55
49_E	223_T	0.766	0.55
64_A	183_F	0.765	0.55
15_G	110_Y	0.760	0.54
25_I	47_V	0.757	0.54
34_G	83_A	0.757	0.54
192_Q	195_R	0.755	0.54
136_R	145_D	0.752	0.53
205_M	211_R	0.749	0.53
97_A	135_V	0.748	0.53
69_K	221_P	0.747	0.53
168_D	197_A	0.747	0.53
110_Y	149_T	0.741	0.52
65_P	72_G	0.740	0.52
88_D	154_T	0.738	0.52
178_A	227_G	0.737	0.52
73_L	207_T	0.736	0.52
66_M	154_T	0.733	0.51
80_V	100_L	0.729	0.51
133_V	150_F	0.727	0.51
191_T	202_I	0.727	0.51
96_L	100_L	0.726	0.51
140_V	144_L	0.726	0.51
67_M	212_M	0.726	0.51
191_T	214_F	0.724	0.51
222_S	227_G	0.723	0.50
228_H	235_A	0.719	0.50
88_D	107_V	0.718	0.50
18_L	110_Y	0.716	0.50
12_V	27_A	0.714	0.50
20_T	139_D	0.707	0.49
108_T	150_F	0.706	0.49
74_V	154_T	0.706	0.49
111_E	217_R	0.705	0.49
212_M	219_S	0.702	0.48
181_S	190_T	0.701	0.48
74_V	96_L	0.700	0.48
181_S	185_E	0.700	0.48
161_P	190_T	0.697	0.48
85_R	172_V	0.695	0.48
185_E	234_F	0.695	0.48
144_L	153_L	0.695	0.48
164_V	190_T	0.695	0.48
80_V	192_Q	0.695	0.48
101_G	218_G	0.693	0.48
73_L	203_D	0.692	0.47
123_N	183_F	0.691	0.47
77_H	234_F	0.691	0.47
59_F	98_A	0.688	0.47
145_D	167_A	0.688	0.47
182_P	204_A	0.687	0.47
104_G	146_A	0.687	0.47
221_P	236_R	0.685	0.47
87_L	110_Y	0.684	0.47
32_T	109_T	0.683	0.47
69_K	113_D	0.682	0.46
71_I	99_Y	0.681	0.46
95_V	159_D	0.678	0.46
17_E	40_H	0.677	0.46
119_V	123_N	0.676	0.46
64_A	143_D	0.674	0.46
65_P	160_A	0.669	0.45
164_V	199_L	0.668	0.45
116_F	123_N	0.667	0.45
136_R	150_F	0.666	0.45
48_R	189_A	0.665	0.45
89_A	157_T	0.662	0.44
31_P	47_V	0.662	0.44
65_P	157_T	0.659	0.44
167_A	170_L	0.657	0.44
208_I	227_G	0.655	0.44
105_A	183_F	0.654	0.44
38_E	42_G	0.652	0.44
125_S	196_D	0.651	0.43
33_P	47_V	0.650	0.43
91_T	133_V	0.649	0.43
110_Y	146_A	0.648	0.43
114_A	121_R	0.648	0.43
142_A	162_D	0.646	0.43
16_E	25_I	0.643	0.43
11_L	25_I	0.642	0.43
14_P	32_T	0.641	0.42
110_Y	144_L	0.640	0.42
199_L	209_Q	0.639	0.42
184_V	233_L	0.638	0.42
85_R	149_T	0.635	0.42
67_M	183_F	0.635	0.42
122_E	197_A	0.632	0.42
57_N	184_V	0.630	0.41
56_F	67_M	0.627	0.41
220_R	236_R	0.625	0.41
16_E	28_P	0.624	0.41
34_G	93_T	0.621	0.41
184_V	214_F	0.617	0.40
190_T	235_A	0.611	0.40
68_P	210_R	0.610	0.40
20_T	25_I	0.609	0.39
87_L	144_L	0.609	0.39
59_F	95_V	0.608	0.39
109_T	232_L	0.608	0.39
23_G	39_T	0.608	0.39
107_V	217_R	0.606	0.39
181_S	187_A	0.606	0.39
63_G	93_T	0.605	0.39
190_T	198_G	0.603	0.39
18_L	27_A	0.601	0.39
88_D	105_A	0.600	0.39
62_T	119_V	0.599	0.38
14_P	31_P	0.597	0.38
111_E	136_R	0.596	0.38
68_P	221_P	0.592	0.38
154_T	182_P	0.589	0.38
113_D	123_N	0.589	0.38
188_R	192_Q	0.586	0.37
111_E	174_G	0.585	0.37
110_Y	163_V	0.585	0.37
7_D	37_V	0.585	0.37
54_D	61_R	0.584	0.37
67_M	79_G	0.580	0.37
13_A	28_P	0.578	0.37
189_A	195_R	0.576	0.36
34_G	174_G	0.575	0.36
33_P	103_A	0.574	0.36
95_V	178_A	0.573	0.36
66_M	208_I	0.572	0.36
122_E	194_A	0.571	0.36
39_T	135_V	0.569	0.36
7_D	38_E	0.569	0.36
17_E	47_V	0.566	0.35
158_Q	188_R	0.564	0.35
12_V	94_G	0.563	0.35
33_P	57_N	0.561	0.35
71_I	91_T	0.559	0.35
72_G	173_S	0.557	0.35
110_Y	138_G	0.557	0.35
91_T	124_M	0.555	0.34
165_A	231_Y	0.549	0.34
106_D	131_D	0.546	0.34
37_V	52_G	0.545	0.34
69_K	209_Q	0.545	0.34
218_G	223_T	0.544	0.34
42_G	79_G	0.541	0.33
27_A	60_E	0.541	0.33
13_A	18_L	0.541	0.33
66_M	215_D	0.540	0.33
63_G	180_Y	0.539	0.33
25_I	119_V	0.539	0.33
142_A	146_A	0.538	0.33
231_Y	234_F	0.538	0.33
55_L	124_M	0.537	0.33
190_T	233_L	0.536	0.33
63_G	152_V	0.535	0.33
158_Q	183_F	0.531	0.32
184_V	187_A	0.530	0.32
13_A	125_S	0.530	0.32
188_R	219_S	0.529	0.32
111_E	135_V	0.528	0.32
158_Q	186_N	0.523	0.32
13_A	25_I	0.522	0.32
165_A	170_L	0.522	0.32
66_M	230_G	0.521	0.32
80_V	120_A	0.520	0.31
101_G	129_V	0.519	0.31
138_G	144_L	0.519	0.31
203_D	226_V	0.518	0.31
228_H	232_L	0.516	0.31
158_Q	180_Y	0.516	0.31
129_V	212_M	0.515	0.31
134_S	143_D	0.515	0.31
86_V	142_A	0.514	0.31
135_V	145_D	0.514	0.31
28_P	38_E	0.514	0.31
10_F	196_D	0.514	0.31
102_R	155_L	0.513	0.31
188_R	191_T	0.511	0.31
139_D	166_H	0.507	0.30
107_V	115_D	0.505	0.30
36_T	47_V	0.504	0.30
141_T	159_D	0.504	0.30
9_E	103_A	0.504	0.30
96_L	109_T	0.501	0.30
33_P	101_G	0.501	0.30
25_I	39_T	0.501	0.30
146_A	170_L	0.501	0.30
39_T	196_D	0.500	0.30
64_A	160_A	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o54A	4	0.9916	100	0.459	Contact Map
1i9gA	3	1	100	0.495	Contact Map
2pwyA	3	0.9916	100	0.52	Contact Map
3mb5A	3	0.9916	100	0.522	Contact Map
2b25A	3	0.9412	100	0.564	Contact Map
1yb2A	2	0.8908	100	0.573	Contact Map
2yvlA	4	0.9664	100	0.608	Contact Map
3e05A	4	0.7899	99.8	0.764	Contact Map
3ckkA	1	0.7227	99.8	0.772	Contact Map
1l3iA	5	0.7731	99.8	0.773	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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