GREMLIN Database
Q9HS32 - Enoyl-CoA hydratase
UniProt: Q9HS32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (246)
Sequences: 30360 (19810)
Seq/√Len: 1263.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_E182_P3.1601.00
127_I165_R3.1251.00
179_E189_H3.0641.00
122_A177_V2.8841.00
189_H192_S2.7591.00
100_A117_C2.7361.00
15_T191_A2.5831.00
43_E95_P2.4691.00
40_D90_A2.4131.00
6_A19_S2.3211.00
24_L58_D2.2751.00
164_D196_D2.2731.00
125_D183_A2.2221.00
219_T222_A2.2091.00
170_D173_E2.1891.00
158_R164_D2.1431.00
167_S170_D2.1351.00
9_V14_A2.1341.00
155_T174_H2.0451.00
134_D200_Q2.0101.00
9_V45_E2.0041.00
160_I208_A1.9881.00
15_T53_T1.9791.00
124_E169_A1.9701.00
24_L59_A1.9251.00
242_E251_R1.9131.00
107_F129_G1.8851.00
185_E188_D1.8851.00
7_L14_A1.8641.00
101_A190_V1.8511.00
12_G48_R1.8441.00
36_R90_A1.8271.00
30_A34_A1.8101.00
19_S55_A1.8011.00
101_A187_D1.7951.00
17_T55_A1.7871.00
121_V181_V1.7781.00
245_Q249_E1.7601.00
158_R178_G1.7401.00
157_R213_N1.7321.00
14_A42_A1.7311.00
17_T53_T1.7121.00
118_D209_K1.7011.00
41_T45_E1.6861.00
124_E183_A1.6851.00
50_V94_F1.6421.00
170_D174_H1.6101.00
191_A195_R1.6031.00
153_D157_R1.5551.00
14_A47_A1.5381.00
169_A173_E1.5381.00
121_V193_L1.5301.00
33_H83_L1.5171.00
123_S183_A1.5051.00
158_R179_E1.4991.00
42_A50_V1.4981.00
122_A128_L1.4891.00
185_E189_H1.4871.00
120_R150_I1.4761.00
43_E90_A1.4761.00
181_V189_H1.4521.00
120_R154_E1.4501.00
11_D195_R1.4361.00
114_A120_R1.4341.00
7_L42_A1.4291.00
157_R212_I1.4191.00
53_T103_D1.4071.00
16_I38_T1.4061.00
10_D191_A1.3941.00
172_S180_V1.3851.00
49_A194_A1.3851.00
157_R161_Y1.3841.00
89_D221_S1.3801.00
103_D125_D1.3501.00
92_E146_R1.3481.00
89_D93_S1.3461.00
102_I114_A1.3451.00
6_A55_A1.3321.00
164_D170_D1.3261.00
103_D123_S1.3261.00
10_D195_R1.3221.00
39_L94_F1.3161.00
91_I98_V1.3141.00
111_M130_Q1.3061.00
207_A233_G1.3041.00
58_D103_D1.3011.00
102_I106_A1.2961.00
29_V68_Y1.2881.00
155_T158_R1.2861.00
159_M166_L1.2831.00
36_R40_D1.2701.00
10_D15_T1.2491.00
73_D76_E1.2351.00
28_N31_T1.2251.00
129_G165_R1.2161.00
18_I31_T1.2081.00
133_I163_G1.2061.00
20_R23_S1.2031.00
210_D214_T1.2001.00
186_I190_V1.1981.00
43_E94_F1.1821.00
15_T187_D1.1801.00
36_R86_S1.1801.00
240_Q244_M1.1731.00
105_Y127_I1.1691.00
53_T187_D1.1641.00
187_D191_A1.1621.00
154_E178_G1.1581.00
155_T170_D1.1541.00
34_A38_T1.1421.00
218_T222_A1.1391.00
123_S186_I1.1361.00
23_S67_S1.1341.00
59_A105_Y1.1261.00
200_Q205_M1.1201.00
8_A17_T1.1091.00
9_V41_T1.0931.00
152_G155_T1.0931.00
187_D190_V1.0891.00
168_A180_V1.0831.00
18_I61_I1.0811.00
218_T226_F1.0801.00
166_L174_H1.0781.00
203_A239_D1.0701.00
61_I110_G1.0581.00
9_V46_G1.0561.00
8_A15_T1.0481.00
50_V96_A1.0291.00
84_G141_W1.0251.00
93_S221_S1.0251.00
214_T226_F1.0211.00
182_P185_E1.0101.00
119_L193_L1.0081.00
34_A37_D1.0081.00
6_A17_T1.0001.00
98_V117_C0.9921.00
29_V33_H0.9921.00
20_R65_D0.9891.00
37_D41_T0.9861.00
47_A96_A0.9741.00
112_E143_G0.9601.00
194_A198_A0.9591.00
151_V155_T0.9561.00
150_I154_E0.9481.00
172_S177_V0.9431.00
56_G103_D0.9421.00
51_V190_V0.9391.00
95_P206_R0.9271.00
124_E180_V0.9241.00
15_T51_V0.9191.00
188_D192_S0.9111.00
202_A206_R0.9031.00
53_T101_A0.9021.00
169_A172_S0.9011.00
38_T41_T0.9001.00
144_T227_E0.8981.00
111_M128_L0.8931.00
50_V98_V0.8891.00
127_I167_S0.8851.00
133_I208_A0.8851.00
103_D186_I0.8851.00
210_D230_T0.8841.00
222_A225_E0.8801.00
13_V49_A0.8711.00
241_Q245_Q0.8691.00
145_Q223_G0.8681.00
102_I128_L0.8621.00
102_I120_R0.8611.00
24_L62_A0.8481.00
119_L178_G0.8461.00
207_A230_T0.8371.00
32_L87_V0.8361.00
9_V47_A0.8361.00
138_I234_L0.8341.00
39_L91_I0.8291.00
207_A210_D0.8291.00
191_A194_A0.8241.00
78_Q82_E0.8231.00
101_A186_I0.8161.00
123_S184_A0.8161.00
36_R83_L0.8041.00
153_D216_H0.8031.00
147_L151_V0.8001.00
112_E132_E0.8001.00
151_V159_M0.7951.00
207_A234_L0.7951.00
226_F229_R0.7891.00
43_E96_A0.7851.00
159_M174_H0.7821.00
189_H193_L0.7801.00
40_D44_S0.7801.00
172_S179_E0.7751.00
160_I212_I0.7741.00
67_S248_L0.7731.00
190_V194_A0.7731.00
211_A230_T0.7691.00
40_D86_S0.7681.00
158_R162_F0.7681.00
108_G131_T0.7671.00
192_S196_D0.7631.00
107_F165_R0.7621.00
52_L117_C0.7621.00
16_I50_V0.7561.00
33_H37_D0.7491.00
42_A47_A0.7451.00
220_L224_L0.7401.00
29_V83_L0.7401.00
168_A177_V0.7371.00
27_L31_T0.7361.00
197_L205_M0.7341.00
36_R87_V0.7321.00
134_D165_R0.7311.00
179_E193_L0.7311.00
238_H241_Q0.7281.00
59_A103_D0.7271.00
152_G156_A0.7261.00
48_R202_A0.7251.00
28_N68_Y0.7231.00
244_M248_L0.7231.00
95_P210_D0.7211.00
188_D191_A0.7211.00
171_A176_L0.7191.00
20_R28_N0.7171.00
94_F98_V0.7141.00
145_Q148_P0.7141.00
196_D200_Q0.7061.00
125_D168_A0.7041.00
7_L38_T0.7031.00
115_L176_L0.7031.00
45_E96_A0.7021.00
226_F230_T0.7011.00
181_V186_I0.6991.00
7_L41_T0.6991.00
230_T233_G0.6971.00
132_E140_G0.6951.00
201_P239_D0.6941.00
88_A116_A0.6881.00
192_S195_R0.6861.00
20_R26_A0.6841.00
102_I126_A0.6841.00
225_E229_R0.6801.00
203_A237_S0.6801.00
51_V191_A0.6761.00
162_F193_L0.6711.00
214_T218_T0.6711.00
177_V180_V0.6691.00
82_E86_S0.6651.00
24_L105_Y0.6611.00
52_L98_V0.6601.00
75_A79_A0.6601.00
228_A232_A0.6601.00
121_V179_E0.6591.00
121_V190_V0.6591.00
103_D183_A0.6571.00
132_E139_P0.6551.00
128_L177_V0.6521.00
74_T233_G0.6511.00
94_F97_P0.6511.00
42_A96_A0.6491.00
13_V51_V0.6491.00
78_Q229_R0.6471.00
12_G46_G0.6441.00
121_V186_I0.6411.00
82_E228_A0.6381.00
99_V194_A0.6371.00
107_F131_T0.6351.00
7_L16_I0.6351.00
153_D213_N0.6321.00
229_R233_G0.6311.00
51_V101_A0.6291.00
9_V12_G0.6291.00
132_E231_W0.6291.00
112_E140_G0.6281.00
138_I211_A0.6271.00
195_R199_A0.6241.00
242_E249_E0.6241.00
30_A33_H0.6231.00
49_A99_V0.6191.00
38_T42_A0.6181.00
35_L87_V0.6181.00
211_A226_F0.6171.00
153_D212_I0.6151.00
193_L196_D0.6151.00
169_A180_V0.6121.00
243_G246_A0.6091.00
31_T34_A0.6091.00
100_A120_R0.6071.00
122_A126_A0.6051.00
139_P208_A0.6021.00
129_G163_G0.6001.00
155_T172_S0.6001.00
37_D40_D0.5991.00
70_V245_Q0.5981.00
239_D243_G0.5981.00
121_V189_H0.5951.00
23_S65_D0.5921.00
13_V194_A0.5921.00
40_D43_E0.5921.00
161_Y205_M0.5871.00
112_E142_G0.5851.00
242_E246_A0.5821.00
138_I208_A0.5801.00
49_A198_A0.5801.00
64_A69_M0.5791.00
13_V191_A0.5781.00
242_E245_Q0.5761.00
221_S225_E0.5741.00
158_R170_D0.5741.00
166_L171_A0.5741.00
74_T78_Q0.5721.00
16_I52_L0.5701.00
103_D126_A0.5701.00
167_S173_E0.5701.00
86_S89_D0.5681.00
245_Q248_L0.5681.00
105_Y165_R0.5641.00
130_Q160_I0.5641.00
16_I39_L0.5611.00
157_R209_K0.5601.00
168_A172_S0.5591.00
151_V156_A0.5581.00
133_I200_Q0.5581.00
162_F197_L0.5581.00
208_A211_A0.5581.00
238_H242_E0.5561.00
150_I178_G0.5551.00
39_L90_A0.5541.00
78_Q232_A0.5531.00
48_R198_A0.5531.00
30_A68_Y0.5451.00
137_I240_Q0.5451.00
151_V174_H0.5411.00
144_T223_G0.5401.00
203_A234_L0.5401.00
114_A117_C0.5391.00
79_A83_L0.5391.00
51_V187_D0.5371.00
123_S126_A0.5371.00
47_A50_V0.5351.00
162_F196_D0.5341.00
148_P151_V0.5331.00
130_Q143_G0.5331.00
112_E130_Q0.5331.00
185_E192_S0.5301.00
119_L197_L0.5291.00
5_V38_T0.5291.00
116_A146_R0.5281.00
133_I205_M0.5281.00
164_D179_E0.5281.00
28_N65_D0.5241.00
155_T173_E0.5231.00
108_G130_Q0.5231.00
111_M176_L0.5221.00
112_E146_R0.5221.00
145_Q149_R0.5191.00
66_I135_I0.5171.00
64_A109_G0.5171.00
111_M115_L0.5131.00
39_L98_V0.5111.00
39_L50_V0.5091.00
101_A194_A0.5091.00
32_L36_R0.5071.00
56_G59_A0.5031.00
148_P215_S0.5021.00
86_S90_A0.5011.00
130_Q147_L0.5001.00
139_P160_I0.5001.00
158_R193_L0.5001.00
41_T44_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jfcA 3 0.9883 100 0.045 Contact Map
3kqfA 3 0.9922 100 0.05 Contact Map
3hinA 5 0.9883 100 0.05 Contact Map
2fbmA 3 0.9609 100 0.051 Contact Map
1nzyA 4 0.9961 100 0.051 Contact Map
3qxzA 3 0.9922 100 0.052 Contact Map
2ej5A 3 0.9688 100 0.053 Contact Map
3sllA 6 0.9805 100 0.056 Contact Map
4lk5A 3 0.9648 100 0.057 Contact Map
3g64A 6 0.9961 100 0.058 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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