GREMLIN Database
Q9HS30 - Uncharacterized protein
UniProt: Q9HS30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (195)
Sequences: 106 (76)
Seq/√Len: 5.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_L69_I6.7041.00
12_A137_S3.9830.92
40_A170_S3.3290.82
165_K173_E3.2080.79
200_G207_L3.0290.75
161_A202_T2.8350.70
38_G88_A2.6570.64
116_A185_P2.6390.64
88_A91_A2.5720.62
138_Y212_Q2.5570.61
58_A69_I2.4310.57
61_A110_G2.3840.56
186_P212_Q2.3310.54
205_A209_D2.0310.44
60_L81_E2.0110.43
10_I31_L1.9770.42
86_G182_E1.9670.42
44_W203_V1.8790.39
66_E84_P1.8520.38
102_D159_V1.8040.36
33_R138_Y1.7260.34
40_A72_F1.6830.33
45_V63_L1.6600.32
44_W173_E1.6340.31
81_E195_I1.6320.31
75_D147_R1.6270.31
57_R114_V1.5910.30
9_R126_I1.5900.30
26_A101_A1.5780.30
96_L99_R1.5650.29
83_L124_L1.5570.29
57_R148_Q1.5540.29
9_R138_Y1.5510.29
89_T181_Y1.5430.29
48_A54_G1.5310.28
98_S116_A1.5110.28
154_G159_V1.5100.28
58_A175_G1.4970.27
115_D138_Y1.4780.27
45_V58_A1.4660.26
84_P99_R1.4570.26
78_V170_S1.4480.26
39_L122_T1.4260.25
138_Y166_A1.4250.25
40_A73_D1.3830.24
172_A210_R1.3820.24
10_I57_R1.3800.24
112_E151_L1.3780.24
42_E138_Y1.3770.24
36_A113_Y1.3700.24
28_T200_G1.3610.24
177_S196_E1.3320.23
169_Q176_G1.3150.23
171_A186_P1.2960.22
199_P211_R1.2760.22
9_R196_E1.2580.21
118_W155_A1.2530.21
124_L166_A1.2400.21
165_K183_P1.2380.21
38_G167_R1.2300.21
95_R133_R1.2280.21
94_T112_E1.2260.21
10_I13_I1.2190.20
38_G177_S1.2150.20
2_A62_D1.2120.20
74_D170_S1.2020.20
138_Y157_G1.1990.20
42_E145_D1.1970.20
117_D163_A1.1960.20
28_T97_T1.1940.20
28_T151_L1.1890.20
13_I79_T1.1860.20
7_V36_A1.1780.20
199_P205_A1.1760.20
77_T126_I1.1740.20
2_A201_A1.1730.19
73_D170_S1.1660.19
8_R122_T1.1640.19
88_A122_T1.1560.19
102_D155_A1.1500.19
45_V62_D1.1350.19
172_A181_Y1.1160.18
13_I120_A1.1130.18
35_V38_G1.0960.18
7_V74_D1.0850.18
138_Y213_R1.0830.18
39_L215_R1.0740.17
44_W200_G1.0720.17
33_R203_V1.0540.17
155_A202_T1.0500.17
66_E173_E1.0340.17
32_R101_A1.0330.17
67_A196_E1.0260.17
69_I81_E1.0190.16
98_S161_A1.0050.16
167_R201_A1.0040.16
13_I57_R0.9990.16
116_A184_E0.9910.16
92_S117_D0.9890.16
69_I90_A0.9880.16
89_T116_A0.9850.16
92_S171_A0.9810.16
99_R112_E0.9810.16
42_E207_L0.9790.16
143_R201_A0.9700.16
20_D207_L0.9680.15
40_A198_G0.9670.15
12_A168_E0.9650.15
7_V99_R0.9640.15
39_L91_A0.9630.15
35_V161_A0.9290.15
165_K185_P0.9270.15
12_A175_G0.9240.15
11_V137_S0.9230.15
35_V98_S0.9120.15
29_T145_D0.9060.14
85_H117_D0.9050.14
72_F170_S0.9050.14
29_T154_G0.9030.14
97_T138_Y0.8980.14
72_F79_T0.8910.14
10_I206_V0.8880.14
198_G213_R0.8830.14
125_A209_D0.8820.14
165_K184_E0.8780.14
35_V92_S0.8750.14
100_P110_G0.8710.14
40_A78_V0.8690.14
102_D196_E0.8650.14
10_I213_R0.8650.14
49_D167_R0.8630.14
72_F203_V0.8580.14
72_F78_V0.8570.14
110_G116_A0.8570.14
78_V198_G0.8540.14
103_G110_G0.8540.14
118_W171_A0.8500.14
76_W202_T0.8450.13
96_L195_I0.8400.13
5_E80_V0.8390.13
66_E196_E0.8390.13
77_T168_E0.8370.13
112_E171_A0.8290.13
84_P87_L0.8280.13
77_T173_E0.8240.13
40_A74_D0.8160.13
65_V171_A0.8150.13
126_I201_A0.8130.13
118_W153_D0.8130.13
89_T100_P0.8120.13
124_L176_G0.8110.13
31_L77_T0.8090.13
186_P189_R0.8080.13
48_A168_E0.8060.13
89_T113_Y0.8060.13
99_R203_V0.8040.13
197_G210_R0.8030.13
39_L42_E0.8010.13
11_V91_A0.8000.13
91_A180_D0.7990.13
35_V150_R0.7920.13
45_V133_R0.7890.13
57_R69_I0.7810.12
67_A121_H0.7800.12
76_W90_A0.7790.12
83_L175_G0.7790.12
36_A122_T0.7770.12
54_G110_G0.7760.12
154_G166_A0.7730.12
90_A215_R0.7690.12
72_F158_Y0.7660.12
149_F164_A0.7620.12
7_V72_F0.7610.12
202_T205_A0.7540.12
84_P93_G0.7540.12
151_L164_A0.7530.12
37_L119_K0.7490.12
79_T172_A0.7350.12
43_V204_Q0.7330.12
57_R60_L0.7330.12
20_D63_L0.7280.12
86_G177_S0.7280.12
155_A186_P0.7270.12
29_T163_A0.7250.12
75_D114_V0.7210.12
116_A139_V0.7180.12
155_A181_Y0.7150.12
114_V180_D0.7120.11
145_D188_W0.7100.11
79_T201_A0.7000.11
120_A124_L0.6980.11
10_I184_E0.6970.11
61_A111_F0.6930.11
102_D170_S0.6930.11
45_V49_D0.6880.11
65_V152_V0.6870.11
65_V196_E0.6850.11
25_D61_A0.6820.11
111_F147_R0.6770.11
200_G206_V0.6750.11
56_Q70_L0.6720.11
169_Q184_E0.6700.11
40_A149_F0.6690.11
155_A158_Y0.6670.11
73_D99_R0.6590.11
5_E89_T0.6550.11
92_S110_G0.6530.11
99_R184_E0.6510.11
150_R213_R0.6500.11
122_T215_R0.6490.11
29_T200_G0.6490.11
171_A188_W0.6480.11
199_P203_V0.6480.11
159_V173_E0.6470.11
91_A166_A0.6470.11
151_L183_P0.6420.11
152_V196_E0.6410.11
137_S214_R0.6390.11
5_E101_A0.6320.10
38_G90_A0.6320.10
139_V208_A0.6260.10
11_V79_T0.6230.10
145_D213_R0.6220.10
198_G201_A0.6100.10
84_P183_P0.6090.10
122_T148_Q0.6070.10
184_E188_W0.6060.10
58_A62_D0.6050.10
149_F170_S0.6050.10
67_A161_A0.6010.10
20_D126_I0.6000.10
12_A38_G0.5950.10
122_T126_I0.5930.10
147_R189_R0.5900.10
5_E131_F0.5860.10
76_W213_R0.5850.10
65_V177_S0.5830.10
173_E176_G0.5820.10
81_E152_V0.5820.10
177_S183_P0.5820.10
78_V155_A0.5770.10
35_V159_V0.5760.10
63_L166_A0.5740.10
37_L93_G0.5730.10
185_P188_W0.5720.10
11_V148_Q0.5710.10
11_V168_E0.5690.10
26_A71_V0.5690.10
111_F133_R0.5690.10
75_D154_G0.5670.10
37_L190_Q0.5660.10
74_D78_V0.5650.10
54_G112_E0.5640.10
61_A133_R0.5640.10
31_L161_A0.5630.10
28_T55_V0.5560.09
25_D62_D0.5550.09
138_Y215_R0.5490.09
71_V175_G0.5460.09
147_R197_G0.5460.09
20_D198_G0.5410.09
9_R42_E0.5390.09
38_G101_A0.5370.09
102_D149_F0.5370.09
203_V209_D0.5350.09
202_T209_D0.5350.09
80_V125_A0.5340.09
43_V67_A0.5340.09
165_K186_P0.5330.09
66_E185_P0.5330.09
10_I153_D0.5330.09
38_G126_I0.5320.09
7_V122_T0.5280.09
152_V165_K0.5260.09
65_V211_R0.5240.09
2_A45_V0.5230.09
115_D179_A0.5180.09
42_E182_E0.5180.09
93_G119_K0.5170.09
25_D49_D0.5160.09
113_Y143_R0.5150.09
77_T86_G0.5140.09
94_T185_P0.5120.09
75_D121_H0.5110.09
62_D125_A0.5100.09
82_W199_P0.5080.09
96_L116_A0.5070.09
89_T102_D0.5040.09
73_D157_G0.5010.09
31_L55_V0.5000.09
171_A176_G0.5000.09
73_D158_Y0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dnxA 2 0.4954 38.6 0.966 Contact Map
4ldvA 2 0.2315 4.5 0.978 Contact Map
1z0jA 1 0.287 4.2 0.979 Contact Map
4hi0E 2 0.2824 4.1 0.979 Contact Map
3sxuA 1 0.4676 3.8 0.979 Contact Map
4lduA 2 0.2315 3.8 0.979 Contact Map
1z08A 2 0.2917 3.6 0.979 Contact Map
3rlgA 1 0.537 3.5 0.979 Contact Map
3c5hA 1 0.2824 3.1 0.98 Contact Map
3vdpA 2 0.4491 3.1 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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