GREMLIN Database
Q9HS29 - Diadenosine tetraphosphate pyrophosphohydrolase
UniProt: Q9HS29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (126)
Sequences: 1969 (1318)
Seq/√Len: 117.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_V48_T4.0711.00
10_A53_V3.4571.00
14_R21_E3.2771.00
109_Q119_T3.2381.00
54_Q60_E3.1201.00
117_V130_E2.9871.00
10_A92_A2.9601.00
70_D131_D2.6781.00
111_R119_T2.5821.00
53_V92_A2.4871.00
25_L105_H2.1781.00
91_I132_A2.1571.00
63_R93_K2.1431.00
26_K106_S2.0371.00
44_E47_Q2.0191.00
112_D115_Q1.9721.00
113_Y133_H1.8661.00
70_D128_I1.8441.00
6_T88_H1.8161.00
15_D93_K1.7541.00
74_Y87_V1.7131.00
99_A108_L1.6311.00
16_T21_E1.6311.00
39_V45_L1.5941.00
24_L111_R1.5791.00
45_L88_H1.5311.00
12_L59_I1.4481.00
15_D20_R1.3971.00
99_A102_S1.3711.00
6_T45_L1.3651.00
36_K85_K1.3591.00
50_I64_L1.3291.00
12_L53_V1.3151.00
46_Q64_L1.3111.00
45_L48_T1.2740.99
22_Y113_Y1.2660.99
102_S105_H1.2620.99
32_W109_Q1.2350.99
26_K107_D1.2240.99
73_D84_H1.2030.99
63_R95_F1.1910.99
6_T86_T1.1810.99
120_I129_L1.1730.99
5_A38_G1.1580.99
115_Q118_N1.1440.99
62_F92_A1.1340.99
50_I54_Q1.1250.99
26_K30_G1.1230.99
33_E105_H1.1150.99
13_F91_I1.1150.99
71_E88_H1.1140.99
16_T19_R1.1130.99
75_V84_H1.0890.98
22_Y133_H1.0680.98
59_I62_F1.0370.98
22_Y129_L1.0360.98
23_L108_L1.0300.98
67_G88_H1.0250.98
8_A48_T1.0230.98
34_F128_I1.0210.98
72_Y128_I1.0160.97
66_D135_F1.0100.97
9_G36_K1.0050.97
27_S33_E1.0050.97
71_E86_T1.0040.97
32_W107_D0.9900.97
5_A76_F0.9890.97
123_D126_R0.9770.97
65_V91_I0.9730.97
60_E96_E0.9710.97
34_F129_L0.9710.97
67_G70_D0.9550.96
15_D18_D0.9530.96
120_I125_P0.9470.96
22_Y34_F0.9150.95
8_A45_L0.9140.95
10_A64_L0.9010.95
85_K104_E0.8880.94
72_Y89_L0.8660.94
57_A97_A0.8630.94
68_F135_F0.8630.94
25_L33_E0.8600.93
28_R106_S0.8480.93
15_D19_R0.8440.93
109_Q115_Q0.8400.93
21_E112_D0.8360.92
116_A129_L0.8350.92
73_D86_T0.8210.92
8_A49_A0.8120.91
115_Q119_T0.8110.91
12_L23_L0.8090.91
74_Y85_K0.8080.91
27_S31_D0.8060.91
36_K49_A0.7940.90
50_I62_F0.7840.90
111_R116_A0.7770.89
36_K89_L0.7710.89
122_Q128_I0.7580.88
123_D130_E0.7570.88
9_G49_A0.7540.88
31_D105_H0.7450.87
23_L59_I0.7370.87
9_G85_K0.7240.86
64_L92_A0.7230.86
13_F65_V0.7160.85
11_I22_Y0.7130.85
19_R112_D0.7120.85
29_P106_S0.7120.85
13_F132_A0.7080.85
59_I94_S0.6960.84
87_V104_E0.6900.83
14_R110_W0.6860.83
10_A62_F0.6820.82
11_I132_A0.6620.80
30_G106_S0.6600.80
98_S134_V0.6580.80
35_P49_A0.6580.80
28_R57_A0.6520.79
78_A83_I0.6490.79
36_K74_Y0.6470.79
105_H125_P0.6470.79
33_E125_P0.6440.79
36_K120_I0.6370.78
32_W111_R0.6370.78
128_I132_A0.6340.78
40_E124_G0.6340.78
131_D134_V0.6320.77
20_R133_H0.6300.77
11_I34_F0.6270.77
50_I92_A0.6180.76
25_L102_S0.6120.75
33_E87_V0.6110.75
44_E48_T0.6030.74
11_I72_Y0.6020.74
34_F125_P0.6020.74
68_F88_H0.6020.74
10_A76_F0.6000.74
11_I128_I0.5980.73
7_S87_V0.5980.73
21_E60_E0.5970.73
65_V93_K0.5960.73
105_H110_W0.5940.73
76_F79_N0.5870.72
74_Y78_A0.5850.72
59_I96_E0.5770.71
36_K87_V0.5750.70
19_R123_D0.5730.70
46_Q50_I0.5690.70
33_E38_G0.5670.69
50_I134_V0.5670.69
7_S104_E0.5640.69
118_N130_E0.5640.69
129_L133_H0.5630.69
12_L15_D0.5630.69
24_L34_F0.5630.69
10_A49_A0.5620.69
98_S114_D0.5610.69
68_F132_A0.5590.68
27_S89_L0.5580.68
76_F83_I0.5560.68
112_D116_A0.5530.67
109_Q126_R0.5520.67
17_R114_D0.5520.67
130_E134_V0.5490.67
15_D95_F0.5480.67
54_Q58_G0.5470.67
31_D38_G0.5450.66
27_S104_E0.5440.66
85_K89_L0.5440.66
111_R115_Q0.5440.66
5_A83_I0.5430.66
46_Q90_F0.5430.66
22_Y68_F0.5400.66
38_G45_L0.5360.65
63_R118_N0.5340.65
117_V133_H0.5310.64
12_L49_A0.5300.64
13_F22_Y0.5260.64
89_L125_P0.5240.63
36_K122_Q0.5210.63
47_Q50_I0.5210.63
24_L116_A0.5210.63
27_S90_F0.5170.62
60_E98_S0.5160.62
105_H108_L0.5110.61
94_S97_A0.5080.61
123_D127_E0.5070.61
49_A92_A0.5010.60
23_L62_F0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i7uA 4 0.9437 99.9 0.387 Contact Map
3fjyA 2 0.9577 99.9 0.389 Contact Map
4ickA 1 0.9296 99.9 0.408 Contact Map
1ktgA 1 0.9155 99.9 0.427 Contact Map
2azwA 1 0.9155 99.9 0.438 Contact Map
4mpoA 4 0.9789 99.9 0.44 Contact Map
1vcdA 1 0.8873 99.9 0.448 Contact Map
2qjtB 2 0.9225 99.9 0.462 Contact Map
1k2eA 2 0.8803 99.9 0.468 Contact Map
3sonA 2 0.9507 99.9 0.474 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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