GREMLIN Database
Q9HS26 - Na+/H+ antiporter
UniProt: Q9HS26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 521 (438)
Sequences: 2177 (1432)
Seq/√Len: 68.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
335_V340_G6.7531.00
229_A488_F6.3941.00
150_S153_G4.7691.00
389_R502_L4.1091.00
425_E431_S3.8831.00
267_T288_V3.8541.00
166_G176_L3.5111.00
142_G223_A3.4121.00
155_T458_G3.3461.00
224_V228_A3.1731.00
387_T390_R3.0701.00
190_L216_F3.0031.00
76_S79_G2.9741.00
135_A231_L2.9341.00
135_A227_F2.9191.00
214_S433_R2.8721.00
389_R501_A2.8051.00
395_M424_G2.7711.00
163_F173_P2.7471.00
300_D303_E2.7251.00
225_L492_L2.7111.00
379_F383_S2.6531.00
393_L502_L2.5281.00
101_L347_A2.4191.00
268_V285_G2.3891.00
134_P175_L2.3391.00
334_G340_G2.3381.00
368_I418_P2.2261.00
118_G257_T2.2121.00
487_V490_G2.2111.00
404_S449_F2.2101.00
137_T162_F2.2021.00
86_A369_R2.1991.00
138_F223_A2.1941.00
398_G420_I2.1901.00
403_N445_L2.1611.00
480_P484_V2.1521.00
270_G274_A2.1291.00
396_V441_N2.1221.00
205_D431_S2.1171.00
179_A230_Y2.1151.00
396_V498_V2.0691.00
488_F492_L2.0541.00
290_F304_M2.0341.00
69_G80_Y2.0261.00
228_A232_G1.9981.00
118_G122_A1.9651.00
429_I433_R1.9641.00
83_T369_R1.9511.00
109_T286_I1.9431.00
222_A492_L1.9321.00
206_A431_S1.9271.00
285_G289_A1.9241.00
256_P259_L1.8991.00
231_L235_A1.8921.00
225_L496_V1.8831.00
29_K379_F1.8781.00
459_Y480_P1.8701.00
112_T307_F1.8361.00
207_D210_G1.8181.00
102_W279_V1.8131.00
115_F264_S1.8121.00
218_Y440_A1.7951.00
226_S230_Y1.7731.00
118_G262_L1.7231.00
495_G499_F1.7161.00
432_Y508_E1.7051.00
125_A247_S1.6861.00
351_F355_V1.6770.99
488_F491_W1.6760.99
29_K376_I1.6750.99
294_V304_M1.6630.99
386_T390_R1.6440.99
177_F462_L1.6230.99
107_A156_V1.6140.99
271_T284_W1.6100.99
374_R378_D1.6090.99
399_T438_L1.5970.99
63_L283_S1.5900.99
400_A445_L1.5860.99
166_G173_P1.5650.99
487_V491_W1.5530.99
171_A176_L1.5460.99
122_A259_L1.5420.99
93_A361_V1.5380.99
87_G365_Q1.5330.99
292_L296_F1.5130.99
38_F64_V1.5100.99
69_G370_G1.5090.99
393_L498_V1.5070.99
45_V50_L1.4990.99
44_I48_G1.4810.99
206_A210_G1.4740.99
261_H296_F1.4710.99
172_N237_M1.4590.99
86_A89_T1.4570.99
175_L233_A1.4550.99
196_T413_E1.4500.98
176_L180_I1.4480.98
201_A206_A1.4450.98
203_T417_A1.4390.98
201_A205_D1.4360.98
261_H292_L1.4160.98
392_E433_R1.3990.98
481_T484_V1.3990.98
109_T290_F1.3980.98
247_S251_G1.3940.98
500_S506_G1.3920.98
457_V461_A1.3920.98
182_S230_Y1.3900.98
437_I497_F1.3830.98
499_F503_T1.3830.98
189_N439_D1.3800.98
210_G432_Y1.3800.98
181_L455_V1.3790.98
112_T293_N1.3780.98
396_V497_F1.3690.98
266_A270_G1.3680.98
233_A488_F1.3610.98
421_A425_E1.3570.98
291_V295_V1.3550.98
225_L229_A1.3470.98
229_A233_A1.3390.97
477_V480_P1.3360.97
260_L292_L1.3310.97
178_G182_S1.3290.97
446_G454_G1.3140.97
109_T289_A1.3110.97
122_A262_L1.3030.97
108_E112_T1.2880.97
101_L351_F1.2820.97
111_Q345_A1.2810.97
214_S432_Y1.2720.96
484_V491_W1.2710.96
134_P171_A1.2620.96
215_R439_D1.2610.96
446_G452_S1.2580.96
139_I227_F1.2530.96
480_P483_V1.2460.96
85_F89_T1.2450.96
444_A493_L1.2410.96
417_A438_L1.2390.96
222_A493_L1.2320.96
219_A493_L1.2210.96
170_G173_P1.2190.96
422_R426_R1.2170.95
26_Y378_D1.2170.95
159_T177_F1.2050.95
98_V279_V1.2000.95
244_G248_A1.1990.95
189_N443_S1.1980.95
229_A492_L1.1910.95
440_A497_F1.1880.95
52_V55_T1.1810.95
39_F43_A1.1770.95
389_R498_V1.1760.95
163_F177_F1.1730.94
348_Q352_P1.1730.94
263_L292_L1.1630.94
348_Q351_F1.1610.94
77_W280_E1.1580.94
491_W495_G1.1530.94
408_I412_A1.1480.94
448_I491_W1.1450.94
166_G170_G1.1440.94
336_T340_G1.1420.94
293_N299_A1.1390.94
226_S492_L1.1320.93
65_A366_I1.1280.93
337_S341_G1.1270.93
259_L266_A1.1250.93
142_G186_F1.1240.93
185_V458_G1.1230.93
478_V482_E1.1190.93
399_T442_T1.1170.93
389_R393_L1.1130.93
84_I362_A1.1120.93
31_A72_L1.1120.93
122_A257_T1.1100.93
391_A423_L1.1090.93
436_N440_A1.1040.92
375_A379_F1.1030.92
205_D421_A1.0980.92
244_G247_S1.0970.92
88_M98_V1.0920.92
260_L263_L1.0880.92
227_F231_L1.0860.92
392_E501_A1.0830.92
186_F439_D1.0830.92
197_T439_D1.0750.91
137_T179_A1.0750.91
216_F220_G1.0670.91
423_L426_R1.0620.91
423_L427_F1.0610.91
185_V452_S1.0570.91
128_I132_V1.0560.91
28_G32_S1.0520.91
78_A139_I1.0490.90
492_L496_V1.0490.90
368_I374_R1.0480.90
115_F261_H1.0470.90
246_A249_I1.0460.90
32_S35_P1.0430.90
271_T276_R1.0380.90
299_A303_E1.0370.90
353_L454_G1.0360.90
439_D443_S1.0360.90
393_L397_L1.0300.90
162_F180_I1.0280.89
96_A410_T1.0230.89
53_S57_G1.0220.89
128_I136_A1.0220.89
503_T506_G1.0200.89
222_A496_V1.0110.89
79_G82_N1.0030.88
33_A37_V1.0030.88
345_A349_G0.9960.88
245_D249_I0.9930.88
28_G31_A0.9900.88
67_I71_F0.9860.87
267_T270_G0.9860.87
459_Y479_D0.9850.87
211_V435_A0.9840.87
59_V105_M0.9820.87
118_G261_H0.9770.87
190_L220_G0.9760.87
71_F74_K0.9750.87
68_F72_L0.9700.87
448_I487_V0.9690.87
181_L458_G0.9650.86
496_V499_F0.9630.86
263_L288_V0.9610.86
78_A82_N0.9600.86
140_L162_F0.9590.86
299_A307_F0.9560.86
82_N86_A0.9550.86
38_F68_F0.9540.86
221_V224_V0.9520.86
248_A251_G0.9510.85
258_G261_H0.9440.85
204_Q435_A0.9410.85
123_A255_G0.9400.85
388_V427_F0.9370.85
73_V76_S0.9340.84
97_I354_I0.9280.84
385_A390_R0.9270.84
181_L406_I0.9240.84
142_G146_T0.9190.83
422_R425_E0.9170.83
489_H493_L0.9150.83
218_Y436_N0.9150.83
334_G344_Y0.9140.83
219_A439_D0.9100.83
174_A482_E0.9070.83
444_A489_H0.9070.83
97_I357_V0.9070.83
102_W286_I0.9030.82
27_G375_A0.9000.82
141_A158_F0.8980.82
409_N494_V0.8940.82
163_F167_V0.8930.82
169_L176_L0.8910.82
35_P39_F0.8900.81
141_A145_A0.8890.81
496_V500_S0.8890.81
250_L257_T0.8880.81
134_P172_N0.8880.81
54_D57_G0.8870.81
248_A287_V0.8850.81
83_T365_Q0.8850.81
34_F64_V0.8840.81
400_A404_S0.8830.81
189_N219_A0.8830.81
199_V413_E0.8820.81
31_A71_F0.8790.81
387_T427_F0.8790.81
152_Y457_V0.8780.81
54_D453_G0.8730.80
37_V40_V0.8730.80
211_V439_D0.8650.80
142_G145_A0.8640.80
303_E307_F0.8610.79
222_A226_S0.8600.79
105_M286_I0.8570.79
388_V429_I0.8550.79
381_L426_R0.8550.79
256_P295_V0.8500.78
352_P355_V0.8470.78
167_V173_P0.8450.78
385_A391_A0.8410.78
147_G269_I0.8240.76
196_T439_D0.8220.76
449_F452_S0.8140.75
221_V496_V0.8120.75
113_G292_L0.8120.75
479_D482_E0.8100.75
214_S429_I0.8080.75
226_S229_A0.8080.75
500_S503_T0.8040.74
385_A394_T0.8030.74
97_I116_V0.8000.74
54_D58_L0.7960.74
405_M447_Y0.7960.74
224_V251_G0.7940.73
163_F478_V0.7930.73
189_N211_V0.7920.73
396_V501_A0.7920.73
88_M358_L0.7910.73
38_F69_G0.7890.73
99_A103_A0.7870.73
62_M363_G0.7870.73
498_V502_L0.7850.73
445_L490_G0.7850.73
217_K505_F0.7830.72
455_V483_V0.7800.72
151_G195_D0.7800.72
113_G429_I0.7780.72
379_F384_V0.7760.72
151_G196_T0.7740.72
408_I453_G0.7740.72
181_L487_V0.7740.72
424_G434_R0.7730.71
267_T284_W0.7700.71
104_G350_F0.7700.71
300_D307_F0.7680.71
462_L478_V0.7680.71
145_A154_T0.7670.71
416_I442_T0.7620.70
424_G437_I0.7610.70
197_T200_S0.7590.70
135_A145_A0.7590.70
408_I446_G0.7580.70
409_N446_G0.7520.69
43_A47_S0.7500.69
197_T212_V0.7470.69
151_G184_A0.7460.69
87_G361_V0.7460.69
228_A337_S0.7420.68
190_L196_T0.7420.68
413_E443_S0.7420.68
361_V403_N0.7410.68
409_N454_G0.7390.68
337_S340_G0.7380.68
433_R501_A0.7350.68
154_T184_A0.7340.68
188_D439_D0.7340.68
412_A416_I0.7340.68
150_S409_N0.7340.68
288_V292_L0.7320.67
302_S488_F0.7300.67
233_A237_M0.7290.67
29_K375_A0.7290.67
35_P65_A0.7280.67
62_M359_L0.7250.67
206_A430_N0.7240.66
307_F347_A0.7240.66
294_V301_V0.7190.66
103_A155_T0.7190.66
278_I342_S0.7180.66
402_V416_I0.7180.66
134_P166_G0.7160.66
65_A68_F0.7150.65
220_G333_E0.7140.65
408_I452_S0.7100.65
66_L366_I0.7100.65
185_V230_Y0.7090.65
392_E507_L0.7090.65
132_V136_A0.7070.65
205_D425_E0.7000.64
258_G296_F0.7000.64
163_F180_I0.7000.64
59_V359_L0.6990.64
195_D200_S0.6990.64
270_G273_I0.6970.64
441_N497_F0.6970.64
128_I151_G0.6960.63
150_S410_T0.6950.63
153_G264_S0.6950.63
226_S495_G0.6930.63
262_L289_A0.6930.63
396_V400_A0.6930.63
112_T115_F0.6910.63
155_T282_I0.6900.63
216_F229_A0.6860.62
204_Q431_S0.6860.62
189_N195_D0.6850.62
185_V445_L0.6830.62
196_T201_A0.6830.62
132_V135_A0.6810.62
154_T410_T0.6770.61
211_V215_R0.6770.61
414_I449_F0.6760.61
198_I208_I0.6760.61
433_R500_S0.6760.61
169_L234_G0.6750.61
200_S211_V0.6750.61
104_G346_G0.6740.61
198_I202_V0.6730.61
121_W125_A0.6730.61
41_V254_V0.6710.61
447_Y490_G0.6700.60
413_E438_L0.6680.60
263_L378_D0.6670.60
42_W57_G0.6670.60
66_L84_I0.6650.60
40_V402_V0.6610.59
219_A440_A0.6610.59
100_W185_V0.6610.59
161_L358_L0.6600.59
298_L347_A0.6590.59
232_G254_V0.6580.59
388_V504_G0.6570.59
172_N486_F0.6570.59
485_P488_F0.6550.59
437_I441_N0.6540.59
246_A339_V0.6540.59
177_F478_V0.6530.59
141_A154_T0.6530.59
143_L266_A0.6530.59
181_L452_S0.6520.58
230_Y343_L0.6510.58
495_G498_V0.6510.58
360_I364_A0.6500.58
37_V270_G0.6490.58
240_I267_T0.6480.58
272_A289_A0.6480.58
52_V57_G0.6470.58
96_A153_G0.6470.58
58_L100_W0.6460.58
100_W354_I0.6460.58
403_N446_G0.6460.58
138_F153_G0.6450.58
277_H280_E0.6440.57
333_E337_S0.6440.57
56_T415_A0.6430.57
378_D426_R0.6430.57
479_D484_V0.6430.57
340_G344_Y0.6420.57
106_F282_I0.6420.57
152_Y453_G0.6410.57
71_F143_L0.6410.57
384_V387_T0.6410.57
63_L301_V0.6400.57
31_A68_F0.6390.57
403_N409_N0.6390.57
391_A395_M0.6380.57
66_L69_G0.6370.57
217_K221_V0.6360.57
444_A494_V0.6330.56
459_Y477_V0.6330.56
232_G508_E0.6320.56
66_L70_M0.6310.56
82_N306_V0.6310.56
455_V459_Y0.6310.56
197_T211_V0.6310.56
62_M84_I0.6300.56
152_Y446_G0.6300.56
261_H265_M0.6290.56
378_D495_G0.6290.56
214_S436_N0.6280.56
355_V419_Y0.6280.56
447_Y458_G0.6270.55
61_G65_A0.6270.55
284_W288_V0.6260.55
185_V490_G0.6250.55
361_V417_A0.6240.55
27_G30_L0.6230.55
182_S487_V0.6230.55
166_G169_L0.6220.55
142_G305_L0.6210.55
117_S255_G0.6200.55
139_I146_T0.6180.54
392_E395_M0.6180.54
347_A355_V0.6170.54
35_P261_H0.6170.54
263_L307_F0.6160.54
459_Y483_V0.6150.54
276_R284_W0.6150.54
156_V461_A0.6150.54
399_T416_I0.6140.54
36_L39_F0.6140.54
367_M370_G0.6140.54
228_A388_V0.6130.54
116_V360_I0.6120.54
206_A405_M0.6100.53
186_F504_G0.6090.53
303_E306_V0.6090.53
146_T195_D0.6090.53
98_V116_V0.6090.53
401_F405_M0.6090.53
137_T141_A0.6090.53
153_G410_T0.6080.53
248_A333_E0.6070.53
78_A378_D0.6070.53
198_I416_I0.6070.53
223_A489_H0.6060.53
214_S508_E0.6050.53
335_V339_V0.6030.53
129_G136_A0.6020.52
294_V303_E0.6020.52
156_V160_A0.6010.52
166_G171_A0.6010.52
71_F287_V0.6010.52
108_E261_H0.6000.52
285_G414_I0.6000.52
233_A486_F0.5990.52
37_V383_S0.5990.52
142_G227_F0.5990.52
230_Y489_H0.5980.52
35_P372_G0.5980.52
295_V298_L0.5970.52
229_A232_G0.5960.52
113_G262_L0.5960.52
156_V457_V0.5960.52
153_G409_N0.5960.52
38_F42_W0.5940.52
271_T281_A0.5940.52
202_V494_V0.5940.52
34_F38_F0.5930.51
103_A282_I0.5920.51
429_I508_E0.5920.51
214_S506_G0.5910.51
381_L423_L0.5900.51
88_M280_E0.5890.51
301_V305_L0.5870.51
94_A97_I0.5860.51
338_S341_G0.5860.51
395_M437_I0.5850.50
39_F489_H0.5840.50
403_N412_A0.5840.50
81_A116_V0.5840.50
66_L80_Y0.5830.50
62_M66_L0.5820.50
421_A431_S0.5820.50
253_N291_V0.5820.50
134_P179_A0.5820.50
407_T446_G0.5810.50
108_E304_M0.5810.50
392_E437_I0.5810.50
119_L195_D0.5810.50
339_V415_A0.5800.50
478_V484_V0.5780.50
166_G172_N0.5750.49
357_V411_A0.5720.49
256_P296_F0.5720.49
185_V447_Y0.5720.49
351_F354_I0.5720.49
179_A222_A0.5710.49
54_D352_P0.5710.49
31_A34_F0.5710.49
175_L182_S0.5690.49
249_I336_T0.5690.49
409_N489_H0.5680.48
333_E344_Y0.5670.48
59_V361_V0.5660.48
32_S50_L0.5660.48
85_F94_A0.5660.48
228_A231_L0.5650.48
190_L212_V0.5650.48
154_T168_A0.5640.48
433_R437_I0.5640.48
135_A180_I0.5630.48
145_A192_P0.5630.48
264_S272_A0.5620.48
44_I47_S0.5620.48
109_T112_T0.5600.47
219_A443_S0.5590.47
138_F264_S0.5580.47
503_T507_L0.5580.47
32_S375_A0.5580.47
97_I358_L0.5540.47
128_I143_L0.5530.47
152_Y493_L0.5530.47
188_D194_S0.5510.46
334_G337_S0.5460.46
162_F456_L0.5460.46
62_M490_G0.5450.46
208_I456_L0.5440.46
79_G306_V0.5440.46
211_V443_S0.5410.45
46_Q52_V0.5410.45
218_Y497_F0.5410.45
232_G236_V0.5410.45
165_A168_A0.5410.45
115_F265_M0.5390.45
69_G394_T0.5390.45
163_F461_A0.5390.45
83_T356_L0.5380.45
26_Y374_R0.5360.45
287_V428_N0.5360.45
269_I273_I0.5360.45
88_M360_I0.5350.44
138_F226_S0.5350.44
151_G154_T0.5350.44
152_Y454_G0.5350.44
70_M73_V0.5340.44
126_A225_L0.5330.44
118_G504_G0.5320.44
177_F458_G0.5300.44
123_A192_P0.5300.44
161_L395_M0.5300.44
244_G249_I0.5290.44
201_A204_Q0.5280.44
50_L301_V0.5270.44
163_F172_N0.5260.43
33_A36_L0.5250.43
245_D341_G0.5250.43
39_F65_A0.5250.43
116_V285_G0.5250.43
58_L347_A0.5240.43
500_S505_F0.5240.43
380_L398_G0.5240.43
376_I386_T0.5230.43
355_V358_L0.5230.43
123_A164_P0.5210.43
265_M282_I0.5210.43
70_M80_Y0.5200.43
196_T454_G0.5200.43
211_V436_N0.5200.43
339_V362_A0.5200.43
27_G72_L0.5190.43
224_V300_D0.5190.43
128_I300_D0.5190.43
96_A453_G0.5180.42
178_G415_A0.5180.42
133_F173_P0.5170.42
403_N452_S0.5160.42
263_L295_V0.5160.42
116_V120_V0.5150.42
70_M343_L0.5150.42
69_G271_T0.5130.42
115_F192_P0.5130.42
207_D213_A0.5120.42
242_V495_G0.5120.42
156_V273_I0.5120.42
153_G411_A0.5110.42
285_G460_A0.5100.42
78_A81_A0.5100.42
390_R502_L0.5100.42
147_G193_V0.5090.41
407_T452_S0.5090.41
398_G435_A0.5080.41
412_A477_V0.5080.41
230_Y488_F0.5060.41
304_M307_F0.5060.41
231_L495_G0.5050.41
105_M112_T0.5050.41
245_D248_A0.5040.41
37_V171_A0.5040.41
70_M76_S0.5030.41
86_A267_T0.5020.41
171_A237_M0.5020.41
333_E336_T0.5010.40
34_F257_T0.5010.40
109_T351_F0.5010.40
80_Y370_G0.5010.40
54_D408_I0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.7735 99.9 0.826 Contact Map
4r1iA 2 0.858 99.9 0.849 Contact Map
4r0cA 3 0.453 99.7 0.872 Contact Map
3qe7A 2 0.6641 70.7 0.971 Contact Map
4ikvA 1 0.7658 46.9 0.975 Contact Map
4pd6A 3 0.4069 45.9 0.975 Contact Map
4eneA 2 0.6353 31.1 0.977 Contact Map
2jlnA 1 0.7774 22.4 0.979 Contact Map
2kncA 1 0.0979 21 0.979 Contact Map
3nd0A 2 0.6296 20 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.013 seconds.