GREMLIN Database
Q9HS25 - Uncharacterized protein
UniProt: Q9HS25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (352)
Sequences: 27901 (19817)
Seq/√Len: 1056.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_V168_K3.3461.00
226_D285_S3.1171.00
226_D287_F2.8431.00
70_R74_R2.7211.00
247_A320_C2.5891.00
232_A241_G2.5771.00
98_D166_T2.5661.00
50_Q68_D2.5531.00
138_C401_D2.4941.00
104_T166_T2.4641.00
345_A420_R2.4631.00
349_D420_R2.4471.00
227_F251_A2.4301.00
224_R287_F2.4281.00
228_T285_S2.4001.00
228_T321_T2.3771.00
308_D312_R2.3761.00
349_D416_T2.3751.00
304_K308_D2.3741.00
72_T75_D2.3141.00
157_A415_T2.2301.00
226_D323_E2.2211.00
224_R289_E2.2041.00
248_M273_A2.1901.00
248_M286_A2.1681.00
73_A95_A2.1651.00
274_G287_F2.1601.00
68_D72_T2.1571.00
104_T168_K2.1261.00
96_V166_T2.0891.00
305_S309_R2.0891.00
224_R325_A2.0771.00
248_M288_L2.0411.00
106_G193_V1.9961.00
228_T323_E1.9851.00
272_R289_E1.9731.00
344_G348_A1.9101.00
63_D67_A1.8961.00
76_A156_A1.8911.00
249_A252_I1.8841.00
41_G408_R1.8441.00
250_T253_Q1.8361.00
182_K186_E1.8221.00
43_D156_A1.8121.00
343_F417_A1.7691.00
72_T76_A1.7341.00
251_A311_V1.7341.00
312_R316_E1.7241.00
55_D68_D1.7051.00
71_A75_D1.7041.00
67_A71_A1.6811.00
383_C386_C1.6611.00
64_D67_A1.6581.00
130_G135_H1.6511.00
78_V97_L1.6441.00
346_V420_R1.6031.00
250_T318_H1.5981.00
249_A253_Q1.5911.00
226_D325_A1.5901.00
306_H309_R1.5891.00
156_A160_D1.5861.00
416_T419_T1.5851.00
301_E305_S1.5821.00
244_A286_A1.5801.00
231_G284_D1.5781.00
50_Q53_A1.5671.00
246_Q256_H1.5671.00
70_R93_A1.5621.00
242_R247_A1.5591.00
68_D71_A1.5401.00
106_G170_V1.5291.00
348_A354_D1.5221.00
44_T411_V1.5201.00
183_P186_E1.5131.00
69_W111_I1.5091.00
47_V72_T1.5001.00
299_L302_Y1.4921.00
150_I410_G1.4881.00
106_G196_L1.4851.00
237_H240_D1.4781.00
103_P194_D1.4721.00
63_D91_T1.4681.00
101_E164_Q1.4631.00
66_L111_I1.4621.00
183_P187_S1.4621.00
49_P54_S1.4611.00
46_H50_Q1.4611.00
230_T242_R1.4591.00
42_V46_H1.4551.00
341_A344_G1.4501.00
302_Y306_H1.4491.00
342_C420_R1.4441.00
221_S300_M1.4331.00
266_T303_M1.4311.00
79_D98_D1.4291.00
50_Q64_D1.4291.00
227_F248_M1.4231.00
416_T420_R1.4121.00
254_N310_V1.4091.00
71_A74_R1.4061.00
254_N313_S1.3961.00
74_R80_E1.3871.00
347_A413_A1.3751.00
44_T153_G1.3651.00
275_G286_A1.3561.00
97_L159_A1.3451.00
383_C387_V1.3441.00
409_I412_G1.3441.00
72_T156_A1.3411.00
315_A322_V1.3411.00
50_Q54_S1.3311.00
264_G296_T1.3241.00
99_R166_T1.3241.00
223_L290_G1.3171.00
305_S308_D1.2881.00
250_T317_M1.2801.00
70_R80_E1.2771.00
100_G164_Q1.2751.00
309_R313_S1.2621.00
225_A288_L1.2471.00
346_V416_T1.2431.00
227_F247_A1.2421.00
408_R412_G1.2411.00
107_L418_I1.2401.00
405_Q409_I1.2181.00
344_G359_S1.2161.00
46_H49_P1.2091.00
242_R320_C1.2081.00
342_C346_V1.2021.00
382_A386_C1.1961.00
146_G402_V1.1961.00
49_P404_E1.1931.00
311_V322_V1.1851.00
137_G405_Q1.1791.00
102_G165_G1.1731.00
195_Y421_V1.1721.00
245_I273_A1.1671.00
345_A349_D1.1661.00
45_L49_P1.1651.00
49_P131_F1.1531.00
47_V68_D1.1531.00
153_G156_A1.1441.00
107_L151_G1.1321.00
341_A345_A1.1311.00
304_K326_T1.1291.00
119_S399_T1.1271.00
43_D46_H1.1261.00
203_L395_H1.1231.00
67_A70_R1.1191.00
146_G201_L1.1191.00
309_R312_R1.1171.00
258_I306_H1.1041.00
41_G45_L1.1011.00
337_R341_A1.0991.00
254_N257_A1.0941.00
308_D324_T1.0931.00
302_Y305_S1.0921.00
43_D47_V1.0881.00
117_T136_D1.0841.00
103_P165_G1.0841.00
384_Y387_V1.0831.00
296_T299_L1.0821.00
47_V153_G1.0801.00
270_A290_G1.0801.00
69_W148_A1.0781.00
50_Q55_D1.0761.00
54_S128_A1.0731.00
254_N314_A1.0721.00
345_A348_A1.0701.00
64_D68_D1.0631.00
223_L304_K1.0601.00
57_R65_T1.0601.00
403_D406_S1.0541.00
252_I288_L1.0531.00
199_V414_L1.0521.00
131_F404_E1.0511.00
41_G405_Q1.0471.00
109_V146_G1.0471.00
55_D64_D1.0331.00
44_T149_T1.0311.00
128_A131_F1.0311.00
76_A159_A1.0291.00
250_T257_A1.0271.00
104_T194_D1.0271.00
78_V95_A1.0231.00
253_Q257_A1.0161.00
386_C389_T1.0101.00
310_V313_S1.0101.00
120_E129_A1.0091.00
66_L93_A1.0081.00
310_V314_A1.0051.00
255_L307_A0.9991.00
59_A177_R0.9991.00
50_Q72_T0.9981.00
246_Q252_I0.9981.00
278_A281_I0.9951.00
92_G173_P0.9921.00
191_D374_R0.9901.00
304_K328_G0.9901.00
97_L163_F0.9861.00
382_A385_V0.9851.00
146_G407_L0.9841.00
252_I270_A0.9741.00
155_L169_V0.9741.00
412_G416_T0.9701.00
411_V415_T0.9701.00
52_V68_D0.9681.00
138_C403_D0.9681.00
250_T254_N0.9591.00
306_H310_V0.9491.00
224_R279_P0.9491.00
154_V415_T0.9461.00
182_K370_Y0.9451.00
313_S317_M0.9411.00
348_A353_V0.9411.00
155_L159_A0.9411.00
168_K193_V0.9361.00
228_T284_D0.9311.00
59_A62_D0.9301.00
273_A286_A0.9301.00
195_Y339_L0.9291.00
346_V349_D0.9231.00
354_D357_L0.9221.00
415_T419_T0.9221.00
111_I171_F0.9201.00
49_P129_A0.9181.00
279_P289_E0.9161.00
43_D72_T0.9151.00
225_A251_A0.9141.00
248_M252_I0.9071.00
66_L70_R0.9041.00
60_V174_A0.9011.00
105_V195_Y0.8991.00
313_S316_E0.8971.00
214_V341_A0.8951.00
225_A311_V0.8951.00
94_I168_K0.8941.00
156_A159_A0.8911.00
312_R315_A0.8911.00
245_I275_G0.8871.00
79_D96_V0.8861.00
73_A152_V0.8831.00
157_A412_G0.8811.00
252_I273_A0.8811.00
385_V389_T0.8761.00
402_V407_L0.8731.00
406_S409_I0.8731.00
342_C417_A0.8701.00
309_R316_E0.8641.00
384_Y388_G0.8631.00
151_G169_V0.8601.00
274_G277_T0.8591.00
342_C345_A0.8581.00
382_A387_V0.8571.00
394_G397_T0.8511.00
336_D339_L0.8511.00
338_E341_A0.8491.00
351_A416_T0.8481.00
250_T256_H0.8481.00
407_L411_V0.8471.00
245_I286_A0.8441.00
246_Q249_A0.8441.00
346_V417_A0.8401.00
197_Y421_V0.8401.00
154_V414_L0.8371.00
246_Q257_A0.8341.00
150_I154_V0.8341.00
65_T111_I0.8271.00
340_A344_G0.8261.00
70_R87_A0.8221.00
255_L268_V0.8211.00
314_A317_M0.8201.00
270_A288_L0.8191.00
78_V155_L0.8141.00
386_C390_D0.8141.00
389_T393_G0.8141.00
137_G403_D0.8141.00
77_G80_E0.8101.00
338_E342_C0.8071.00
80_E95_A0.8061.00
44_T407_L0.8051.00
297_T301_E0.7971.00
97_L155_L0.7931.00
301_E304_K0.7921.00
343_F383_C0.7891.00
76_A152_V0.7881.00
109_V148_A0.7851.00
57_R147_H0.7851.00
294_G300_M0.7851.00
197_Y417_A0.7851.00
118_E121_A0.7841.00
50_Q71_A0.7801.00
224_R327_E0.7791.00
370_Y374_R0.7721.00
253_Q256_H0.7711.00
157_A411_V0.7701.00
383_C388_G0.7681.00
150_I411_V0.7631.00
78_V159_A0.7601.00
370_Y373_R0.7581.00
247_A318_H0.7571.00
60_V177_R0.7551.00
179_G183_P0.7541.00
157_A160_D0.7531.00
54_S129_A0.7521.00
69_W171_F0.7491.00
405_Q408_R0.7451.00
221_S304_K0.7451.00
315_A320_C0.7441.00
111_I148_A0.7431.00
153_G411_V0.7391.00
75_D156_A0.7391.00
72_T152_V0.7381.00
100_G162_D0.7351.00
196_L375_V0.7351.00
53_A141_A0.7311.00
214_V337_R0.7281.00
47_V52_V0.7261.00
230_T397_T0.7241.00
150_I199_V0.7231.00
301_E328_G0.7211.00
232_A282_V0.7191.00
297_T373_R0.7191.00
131_F137_G0.7161.00
242_R319_D0.7161.00
107_L154_V0.7161.00
298_A302_Y0.7131.00
300_M304_K0.7121.00
161_S419_T0.7121.00
343_F413_A0.7121.00
52_V148_A0.7121.00
190_L375_V0.7101.00
197_Y339_L0.7101.00
66_L91_T0.7091.00
129_A139_M0.7091.00
227_F288_L0.7081.00
213_G217_F0.7061.00
165_G194_D0.7061.00
292_V303_M0.7061.00
47_V149_T0.7051.00
113_A142_C0.7021.00
58_M115_H0.7011.00
53_A144_H0.6991.00
342_C421_V0.6981.00
347_A351_A0.6981.00
188_G191_D0.6981.00
154_V411_V0.6961.00
259_P268_V0.6941.00
88_G92_G0.6921.00
104_T165_G0.6911.00
223_L307_A0.6841.00
97_L169_V0.6841.00
394_G399_T0.6831.00
244_A283_P0.6811.00
149_T153_G0.6801.00
168_K192_D0.6791.00
69_W93_A0.6791.00
383_C389_T0.6761.00
85_S88_G0.6761.00
243_N283_P0.6761.00
268_V292_V0.6761.00
47_V156_A0.6751.00
107_L197_Y0.6751.00
150_I414_L0.6751.00
58_M138_C0.6741.00
222_H279_P0.6731.00
351_A413_A0.6711.00
198_A368_A0.6711.00
176_E396_H0.6701.00
52_V65_T0.6681.00
250_T314_A0.6671.00
404_E408_R0.6671.00
93_A171_F0.6661.00
251_A288_L0.6651.00
389_T402_V0.6641.00
272_R287_F0.6641.00
105_V418_I0.6621.00
116_I119_S0.6601.00
74_R79_D0.6591.00
44_T48_G0.6571.00
58_M61_P0.6551.00
153_G157_A0.6531.00
48_G139_M0.6521.00
274_G289_E0.6521.00
135_H138_C0.6511.00
412_G415_T0.6501.00
78_V169_V0.6501.00
158_V161_S0.6491.00
328_G331_P0.6451.00
262_D267_R0.6431.00
326_T329_Q0.6431.00
98_D101_E0.6431.00
346_V413_A0.6421.00
213_G361_A0.6421.00
314_A318_H0.6411.00
413_A417_A0.6391.00
148_A171_F0.6381.00
196_L368_A0.6351.00
151_G199_V0.6311.00
170_V184_I0.6301.00
336_D341_A0.6301.00
69_W152_V0.6301.00
225_A324_T0.6281.00
64_D71_A0.6251.00
246_Q250_T0.6251.00
148_A151_G0.6251.00
73_A78_V0.6241.00
247_A314_A0.6221.00
116_I141_A0.6181.00
140_H401_D0.6171.00
274_G285_S0.6171.00
56_A61_P0.6161.00
154_V158_V0.6161.00
53_A57_R0.6131.00
179_G330_A0.6131.00
256_H318_H0.6121.00
251_A310_V0.6111.00
139_M144_H0.6091.00
90_H183_P0.6081.00
80_E93_A0.6071.00
108_R172_Q0.6071.00
227_F244_A0.6061.00
311_V315_A0.6061.00
45_L408_R0.6061.00
225_A322_V0.6051.00
394_G401_D0.6041.00
102_G166_T0.6041.00
186_E374_R0.6011.00
344_G358_D0.6001.00
214_V217_F0.5991.00
92_G184_I0.5971.00
102_G164_Q0.5971.00
45_L131_F0.5951.00
215_D218_L0.5941.00
261_H306_H0.5901.00
181_G185_A0.5901.00
222_H291_E0.5901.00
294_G303_M0.5891.00
315_A321_T0.5881.00
59_A178_A0.5881.00
231_G244_A0.5871.00
47_V152_V0.5871.00
45_L48_G0.5861.00
249_A256_H0.5851.00
247_A250_T0.5851.00
119_S398_P0.5821.00
209_E357_L0.5821.00
55_D65_T0.5791.00
139_M404_E0.5781.00
246_Q253_Q0.5781.00
99_R102_G0.5771.00
170_V196_L0.5761.00
108_R170_V0.5761.00
199_V410_G0.5731.00
47_V50_Q0.5711.00
89_G187_S0.5711.00
235_G363_G0.5701.00
94_I170_V0.5681.00
104_T193_V0.5681.00
225_A290_G0.5671.00
305_S312_R0.5651.00
196_L371_L0.5641.00
385_V388_G0.5611.00
157_A419_T0.5611.00
48_G404_E0.5601.00
382_A388_G0.5591.00
172_Q367_D0.5551.00
383_C390_D0.5551.00
298_A301_E0.5541.00
292_V298_A0.5541.00
202_G395_H0.5541.00
339_L342_C0.5521.00
170_V371_L0.5521.00
227_F320_C0.5511.00
290_G307_A0.5501.00
334_E337_R0.5471.00
135_H140_H0.5471.00
96_V104_T0.5471.00
101_E166_T0.5451.00
174_A177_R0.5451.00
184_I188_G0.5441.00
393_G399_T0.5441.00
80_E85_S0.5431.00
217_F333_A0.5421.00
244_A282_V0.5421.00
185_A370_Y0.5411.00
180_G187_S0.5401.00
390_D393_G0.5391.00
208_G211_V0.5381.00
329_Q332_S0.5381.00
141_A144_H0.5361.00
227_F311_V0.5351.00
43_D75_D0.5351.00
272_R277_T0.5341.00
185_A374_R0.5311.00
207_T406_S0.5311.00
198_A201_L0.5291.00
269_N291_E0.5291.00
408_R411_V0.5281.00
255_L270_A0.5271.00
223_L324_T0.5251.00
264_G299_L0.5211.00
63_D66_L0.5171.00
297_T331_P0.5171.00
266_T299_L0.5171.00
43_D153_G0.5151.00
393_G397_T0.5151.00
149_T152_V0.5141.00
280_N293_R0.5131.00
251_A314_A0.5131.00
231_G398_P0.5131.00
387_V402_V0.5111.00
106_G168_K0.5101.00
235_G271_G0.5101.00
55_D135_H0.5071.00
395_H400_F0.5051.00
292_V307_A0.5051.00
382_A389_T0.5041.00
220_V365_S0.5041.00
184_I189_H0.5041.00
80_E96_V0.5031.00
273_A288_L0.5021.00
311_V324_T0.5021.00
245_I252_I0.5021.00
243_N269_N0.5011.00
45_L404_E0.5001.00
251_A255_L0.5001.00
94_I189_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3io1A 4 0.838 100 0.293 Contact Map
3pfoA 2 0.8897 100 0.322 Contact Map
4ewtA 4 0.8803 100 0.328 Contact Map
3iszA 2 0.8333 100 0.353 Contact Map
1xmbA 1 0.8404 100 0.353 Contact Map
1ysjA 2 0.8286 100 0.353 Contact Map
4pqaA 2 0.8427 100 0.354 Contact Map
1cg2A 4 0.8732 100 0.36 Contact Map
2zogA 2 0.9108 100 0.368 Contact Map
3dljA 2 0.8967 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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