Q9HS25 - HALSA - GREMLIN Contacts

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Q9HS25 - Uncharacterized protein

UniProt:	Q9HS25	Sequences: MDYTDPAVLTRLRRDLHGIPEPAWCEFQTTARVVDACEDIGVDTLHVGPQAVASDARMAVPDDDTLADWRATARDAGVDEALLDSMAGGHTGAIAVLDRGEGPTVGLRVDIDALHITESEADDHHPAAAGFRSEHDGCMHACGHDGHATIGVGVLAAVADSDFQGTLKVVFQPAEERAGGGKPIAESGHLDDVDYLYAVHLGLDHPTGEVVAGVDGFLAVSHLRADFTGTGAHAGSHPEDGRNAIQAMATAIQNLHAIPRHDGGATRVNAGRAGGGTAPNIVPDSAFLEGEVRGETTALMEYMKSHADRVVRSAAEMHDCTVETATEGQAPSAESDRELAACFGAVAADRAGVDSVLDSDALGGSEDATYLMRRVQNTGGMACYVCVGTDHPGGHHTPTFDVDEQSLRIGVGALTTAITRVAETRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	426 (352)
Sequences:	27901 (19817)
Seq/√Len:	1056.2

ECOLI - ABGA YGEY ARGE DAPE PEPT ABGB PEPD ALLC
BACSU - YTNL YODQ DAPEL YHAA YXEP FAPD PEPT YQJE AMHX PEPVL ALLC
HALSA - Q9HS25
SULSO - CBPX1 Q97Y12 CBPX2 Q97ZB7 Q97V97 LYSK Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_V	168_K	3.346	1.00
226_D	285_S	3.117	1.00
226_D	287_F	2.843	1.00
70_R	74_R	2.721	1.00
247_A	320_C	2.589	1.00
232_A	241_G	2.577	1.00
98_D	166_T	2.566	1.00
50_Q	68_D	2.553	1.00
138_C	401_D	2.494	1.00
104_T	166_T	2.464	1.00
345_A	420_R	2.463	1.00
349_D	420_R	2.447	1.00
227_F	251_A	2.430	1.00
224_R	287_F	2.428	1.00
228_T	285_S	2.400	1.00
228_T	321_T	2.377	1.00
308_D	312_R	2.376	1.00
349_D	416_T	2.375	1.00
304_K	308_D	2.374	1.00
72_T	75_D	2.314	1.00
157_A	415_T	2.230	1.00
226_D	323_E	2.221	1.00
224_R	289_E	2.204	1.00
248_M	273_A	2.190	1.00
248_M	286_A	2.168	1.00
73_A	95_A	2.165	1.00
274_G	287_F	2.160	1.00
68_D	72_T	2.157	1.00
104_T	168_K	2.126	1.00
96_V	166_T	2.089	1.00
305_S	309_R	2.089	1.00
224_R	325_A	2.077	1.00
248_M	288_L	2.041	1.00
106_G	193_V	1.996	1.00
228_T	323_E	1.985	1.00
272_R	289_E	1.973	1.00
344_G	348_A	1.910	1.00
63_D	67_A	1.896	1.00
76_A	156_A	1.891	1.00
249_A	252_I	1.884	1.00
41_G	408_R	1.844	1.00
250_T	253_Q	1.836	1.00
182_K	186_E	1.822	1.00
43_D	156_A	1.812	1.00
343_F	417_A	1.769	1.00
72_T	76_A	1.734	1.00
251_A	311_V	1.734	1.00
312_R	316_E	1.724	1.00
55_D	68_D	1.705	1.00
71_A	75_D	1.704	1.00
67_A	71_A	1.681	1.00
383_C	386_C	1.661	1.00
64_D	67_A	1.658	1.00
130_G	135_H	1.651	1.00
78_V	97_L	1.644	1.00
346_V	420_R	1.603	1.00
250_T	318_H	1.598	1.00
249_A	253_Q	1.591	1.00
226_D	325_A	1.590	1.00
306_H	309_R	1.589	1.00
156_A	160_D	1.586	1.00
416_T	419_T	1.585	1.00
301_E	305_S	1.582	1.00
244_A	286_A	1.580	1.00
231_G	284_D	1.578	1.00
50_Q	53_A	1.567	1.00
246_Q	256_H	1.567	1.00
70_R	93_A	1.562	1.00
242_R	247_A	1.559	1.00
68_D	71_A	1.540	1.00
106_G	170_V	1.529	1.00
348_A	354_D	1.522	1.00
44_T	411_V	1.520	1.00
183_P	186_E	1.513	1.00
69_W	111_I	1.509	1.00
47_V	72_T	1.500	1.00
299_L	302_Y	1.492	1.00
150_I	410_G	1.488	1.00
106_G	196_L	1.485	1.00
237_H	240_D	1.478	1.00
103_P	194_D	1.472	1.00
63_D	91_T	1.468	1.00
101_E	164_Q	1.463	1.00
66_L	111_I	1.462	1.00
183_P	187_S	1.462	1.00
49_P	54_S	1.461	1.00
46_H	50_Q	1.461	1.00
230_T	242_R	1.459	1.00
42_V	46_H	1.455	1.00
341_A	344_G	1.450	1.00
302_Y	306_H	1.449	1.00
342_C	420_R	1.444	1.00
221_S	300_M	1.433	1.00
266_T	303_M	1.431	1.00
79_D	98_D	1.429	1.00
50_Q	64_D	1.429	1.00
227_F	248_M	1.423	1.00
416_T	420_R	1.412	1.00
254_N	310_V	1.409	1.00
71_A	74_R	1.406	1.00
254_N	313_S	1.396	1.00
74_R	80_E	1.387	1.00
347_A	413_A	1.375	1.00
44_T	153_G	1.365	1.00
275_G	286_A	1.356	1.00
97_L	159_A	1.345	1.00
383_C	387_V	1.344	1.00
409_I	412_G	1.344	1.00
72_T	156_A	1.341	1.00
315_A	322_V	1.341	1.00
50_Q	54_S	1.331	1.00
264_G	296_T	1.324	1.00
99_R	166_T	1.324	1.00
223_L	290_G	1.317	1.00
305_S	308_D	1.288	1.00
250_T	317_M	1.280	1.00
70_R	80_E	1.277	1.00
100_G	164_Q	1.275	1.00
309_R	313_S	1.262	1.00
225_A	288_L	1.247	1.00
346_V	416_T	1.243	1.00
227_F	247_A	1.242	1.00
408_R	412_G	1.241	1.00
107_L	418_I	1.240	1.00
405_Q	409_I	1.218	1.00
344_G	359_S	1.216	1.00
46_H	49_P	1.209	1.00
242_R	320_C	1.208	1.00
342_C	346_V	1.202	1.00
382_A	386_C	1.196	1.00
146_G	402_V	1.196	1.00
49_P	404_E	1.193	1.00
311_V	322_V	1.185	1.00
137_G	405_Q	1.179	1.00
102_G	165_G	1.173	1.00
195_Y	421_V	1.172	1.00
245_I	273_A	1.167	1.00
345_A	349_D	1.166	1.00
45_L	49_P	1.165	1.00
49_P	131_F	1.153	1.00
47_V	68_D	1.153	1.00
153_G	156_A	1.144	1.00
107_L	151_G	1.132	1.00
341_A	345_A	1.131	1.00
304_K	326_T	1.129	1.00
119_S	399_T	1.127	1.00
43_D	46_H	1.126	1.00
203_L	395_H	1.123	1.00
67_A	70_R	1.119	1.00
146_G	201_L	1.119	1.00
309_R	312_R	1.117	1.00
258_I	306_H	1.104	1.00
41_G	45_L	1.101	1.00
337_R	341_A	1.099	1.00
254_N	257_A	1.094	1.00
308_D	324_T	1.093	1.00
302_Y	305_S	1.092	1.00
43_D	47_V	1.088	1.00
117_T	136_D	1.084	1.00
103_P	165_G	1.084	1.00
384_Y	387_V	1.083	1.00
296_T	299_L	1.082	1.00
47_V	153_G	1.080	1.00
270_A	290_G	1.080	1.00
69_W	148_A	1.078	1.00
50_Q	55_D	1.076	1.00
54_S	128_A	1.073	1.00
254_N	314_A	1.072	1.00
345_A	348_A	1.070	1.00
64_D	68_D	1.063	1.00
223_L	304_K	1.060	1.00
57_R	65_T	1.060	1.00
403_D	406_S	1.054	1.00
252_I	288_L	1.053	1.00
199_V	414_L	1.052	1.00
131_F	404_E	1.051	1.00
41_G	405_Q	1.047	1.00
109_V	146_G	1.047	1.00
55_D	64_D	1.033	1.00
44_T	149_T	1.031	1.00
128_A	131_F	1.031	1.00
76_A	159_A	1.029	1.00
250_T	257_A	1.027	1.00
104_T	194_D	1.027	1.00
78_V	95_A	1.023	1.00
253_Q	257_A	1.016	1.00
386_C	389_T	1.010	1.00
310_V	313_S	1.010	1.00
120_E	129_A	1.009	1.00
66_L	93_A	1.008	1.00
310_V	314_A	1.005	1.00
255_L	307_A	0.999	1.00
59_A	177_R	0.999	1.00
50_Q	72_T	0.998	1.00
246_Q	252_I	0.998	1.00
278_A	281_I	0.995	1.00
92_G	173_P	0.992	1.00
191_D	374_R	0.990	1.00
304_K	328_G	0.990	1.00
97_L	163_F	0.986	1.00
382_A	385_V	0.985	1.00
146_G	407_L	0.984	1.00
252_I	270_A	0.974	1.00
155_L	169_V	0.974	1.00
412_G	416_T	0.970	1.00
411_V	415_T	0.970	1.00
52_V	68_D	0.968	1.00
138_C	403_D	0.968	1.00
250_T	254_N	0.959	1.00
306_H	310_V	0.949	1.00
224_R	279_P	0.949	1.00
154_V	415_T	0.946	1.00
182_K	370_Y	0.945	1.00
313_S	317_M	0.941	1.00
348_A	353_V	0.941	1.00
155_L	159_A	0.941	1.00
168_K	193_V	0.936	1.00
228_T	284_D	0.931	1.00
59_A	62_D	0.930	1.00
273_A	286_A	0.930	1.00
195_Y	339_L	0.929	1.00
346_V	349_D	0.923	1.00
354_D	357_L	0.922	1.00
415_T	419_T	0.922	1.00
111_I	171_F	0.920	1.00
49_P	129_A	0.918	1.00
279_P	289_E	0.916	1.00
43_D	72_T	0.915	1.00
225_A	251_A	0.914	1.00
248_M	252_I	0.907	1.00
66_L	70_R	0.904	1.00
60_V	174_A	0.901	1.00
105_V	195_Y	0.899	1.00
313_S	316_E	0.897	1.00
214_V	341_A	0.895	1.00
225_A	311_V	0.895	1.00
94_I	168_K	0.894	1.00
156_A	159_A	0.891	1.00
312_R	315_A	0.891	1.00
245_I	275_G	0.887	1.00
79_D	96_V	0.886	1.00
73_A	152_V	0.883	1.00
157_A	412_G	0.881	1.00
252_I	273_A	0.881	1.00
385_V	389_T	0.876	1.00
402_V	407_L	0.873	1.00
406_S	409_I	0.873	1.00
342_C	417_A	0.870	1.00
309_R	316_E	0.864	1.00
384_Y	388_G	0.863	1.00
151_G	169_V	0.860	1.00
274_G	277_T	0.859	1.00
342_C	345_A	0.858	1.00
382_A	387_V	0.857	1.00
394_G	397_T	0.851	1.00
336_D	339_L	0.851	1.00
338_E	341_A	0.849	1.00
351_A	416_T	0.848	1.00
250_T	256_H	0.848	1.00
407_L	411_V	0.847	1.00
245_I	286_A	0.844	1.00
246_Q	249_A	0.844	1.00
346_V	417_A	0.840	1.00
197_Y	421_V	0.840	1.00
154_V	414_L	0.837	1.00
246_Q	257_A	0.834	1.00
150_I	154_V	0.834	1.00
65_T	111_I	0.827	1.00
340_A	344_G	0.826	1.00
70_R	87_A	0.822	1.00
255_L	268_V	0.821	1.00
314_A	317_M	0.820	1.00
270_A	288_L	0.819	1.00
78_V	155_L	0.814	1.00
386_C	390_D	0.814	1.00
389_T	393_G	0.814	1.00
137_G	403_D	0.814	1.00
77_G	80_E	0.810	1.00
338_E	342_C	0.807	1.00
80_E	95_A	0.806	1.00
44_T	407_L	0.805	1.00
297_T	301_E	0.797	1.00
97_L	155_L	0.793	1.00
301_E	304_K	0.792	1.00
343_F	383_C	0.789	1.00
76_A	152_V	0.788	1.00
109_V	148_A	0.785	1.00
57_R	147_H	0.785	1.00
294_G	300_M	0.785	1.00
197_Y	417_A	0.785	1.00
118_E	121_A	0.784	1.00
50_Q	71_A	0.780	1.00
224_R	327_E	0.779	1.00
370_Y	374_R	0.772	1.00
253_Q	256_H	0.771	1.00
157_A	411_V	0.770	1.00
383_C	388_G	0.768	1.00
150_I	411_V	0.763	1.00
78_V	159_A	0.760	1.00
370_Y	373_R	0.758	1.00
247_A	318_H	0.757	1.00
60_V	177_R	0.755	1.00
179_G	183_P	0.754	1.00
157_A	160_D	0.753	1.00
54_S	129_A	0.752	1.00
69_W	171_F	0.749	1.00
405_Q	408_R	0.745	1.00
221_S	304_K	0.745	1.00
315_A	320_C	0.744	1.00
111_I	148_A	0.743	1.00
153_G	411_V	0.739	1.00
75_D	156_A	0.739	1.00
72_T	152_V	0.738	1.00
100_G	162_D	0.735	1.00
196_L	375_V	0.735	1.00
53_A	141_A	0.731	1.00
214_V	337_R	0.728	1.00
47_V	52_V	0.726	1.00
230_T	397_T	0.724	1.00
150_I	199_V	0.723	1.00
301_E	328_G	0.721	1.00
232_A	282_V	0.719	1.00
297_T	373_R	0.719	1.00
131_F	137_G	0.716	1.00
242_R	319_D	0.716	1.00
107_L	154_V	0.716	1.00
298_A	302_Y	0.713	1.00
300_M	304_K	0.712	1.00
161_S	419_T	0.712	1.00
343_F	413_A	0.712	1.00
52_V	148_A	0.712	1.00
190_L	375_V	0.710	1.00
197_Y	339_L	0.710	1.00
66_L	91_T	0.709	1.00
129_A	139_M	0.709	1.00
227_F	288_L	0.708	1.00
213_G	217_F	0.706	1.00
165_G	194_D	0.706	1.00
292_V	303_M	0.706	1.00
47_V	149_T	0.705	1.00
113_A	142_C	0.702	1.00
58_M	115_H	0.701	1.00
53_A	144_H	0.699	1.00
342_C	421_V	0.698	1.00
347_A	351_A	0.698	1.00
188_G	191_D	0.698	1.00
154_V	411_V	0.696	1.00
259_P	268_V	0.694	1.00
88_G	92_G	0.692	1.00
104_T	165_G	0.691	1.00
223_L	307_A	0.684	1.00
97_L	169_V	0.684	1.00
394_G	399_T	0.683	1.00
244_A	283_P	0.681	1.00
149_T	153_G	0.680	1.00
168_K	192_D	0.679	1.00
69_W	93_A	0.679	1.00
383_C	389_T	0.676	1.00
85_S	88_G	0.676	1.00
243_N	283_P	0.676	1.00
268_V	292_V	0.676	1.00
47_V	156_A	0.675	1.00
107_L	197_Y	0.675	1.00
150_I	414_L	0.675	1.00
58_M	138_C	0.674	1.00
222_H	279_P	0.673	1.00
351_A	413_A	0.671	1.00
198_A	368_A	0.671	1.00
176_E	396_H	0.670	1.00
52_V	65_T	0.668	1.00
250_T	314_A	0.667	1.00
404_E	408_R	0.667	1.00
93_A	171_F	0.666	1.00
251_A	288_L	0.665	1.00
389_T	402_V	0.664	1.00
272_R	287_F	0.664	1.00
105_V	418_I	0.662	1.00
116_I	119_S	0.660	1.00
74_R	79_D	0.659	1.00
44_T	48_G	0.657	1.00
58_M	61_P	0.655	1.00
153_G	157_A	0.653	1.00
48_G	139_M	0.652	1.00
274_G	289_E	0.652	1.00
135_H	138_C	0.651	1.00
412_G	415_T	0.650	1.00
78_V	169_V	0.650	1.00
158_V	161_S	0.649	1.00
328_G	331_P	0.645	1.00
262_D	267_R	0.643	1.00
326_T	329_Q	0.643	1.00
98_D	101_E	0.643	1.00
346_V	413_A	0.642	1.00
213_G	361_A	0.642	1.00
314_A	318_H	0.641	1.00
413_A	417_A	0.639	1.00
148_A	171_F	0.638	1.00
196_L	368_A	0.635	1.00
151_G	199_V	0.631	1.00
170_V	184_I	0.630	1.00
336_D	341_A	0.630	1.00
69_W	152_V	0.630	1.00
225_A	324_T	0.628	1.00
64_D	71_A	0.625	1.00
246_Q	250_T	0.625	1.00
148_A	151_G	0.625	1.00
73_A	78_V	0.624	1.00
247_A	314_A	0.622	1.00
116_I	141_A	0.618	1.00
140_H	401_D	0.617	1.00
274_G	285_S	0.617	1.00
56_A	61_P	0.616	1.00
154_V	158_V	0.616	1.00
53_A	57_R	0.613	1.00
179_G	330_A	0.613	1.00
256_H	318_H	0.612	1.00
251_A	310_V	0.611	1.00
139_M	144_H	0.609	1.00
90_H	183_P	0.608	1.00
80_E	93_A	0.607	1.00
108_R	172_Q	0.607	1.00
227_F	244_A	0.606	1.00
311_V	315_A	0.606	1.00
45_L	408_R	0.606	1.00
225_A	322_V	0.605	1.00
394_G	401_D	0.604	1.00
102_G	166_T	0.604	1.00
186_E	374_R	0.601	1.00
344_G	358_D	0.600	1.00
214_V	217_F	0.599	1.00
92_G	184_I	0.597	1.00
102_G	164_Q	0.597	1.00
45_L	131_F	0.595	1.00
215_D	218_L	0.594	1.00
261_H	306_H	0.590	1.00
181_G	185_A	0.590	1.00
222_H	291_E	0.590	1.00
294_G	303_M	0.589	1.00
315_A	321_T	0.588	1.00
59_A	178_A	0.588	1.00
231_G	244_A	0.587	1.00
47_V	152_V	0.587	1.00
45_L	48_G	0.586	1.00
249_A	256_H	0.585	1.00
247_A	250_T	0.585	1.00
119_S	398_P	0.582	1.00
209_E	357_L	0.582	1.00
55_D	65_T	0.579	1.00
139_M	404_E	0.578	1.00
246_Q	253_Q	0.578	1.00
99_R	102_G	0.577	1.00
170_V	196_L	0.576	1.00
108_R	170_V	0.576	1.00
199_V	410_G	0.573	1.00
47_V	50_Q	0.571	1.00
89_G	187_S	0.571	1.00
235_G	363_G	0.570	1.00
94_I	170_V	0.568	1.00
104_T	193_V	0.568	1.00
225_A	290_G	0.567	1.00
305_S	312_R	0.565	1.00
196_L	371_L	0.564	1.00
385_V	388_G	0.561	1.00
157_A	419_T	0.561	1.00
48_G	404_E	0.560	1.00
382_A	388_G	0.559	1.00
172_Q	367_D	0.555	1.00
383_C	390_D	0.555	1.00
298_A	301_E	0.554	1.00
292_V	298_A	0.554	1.00
202_G	395_H	0.554	1.00
339_L	342_C	0.552	1.00
170_V	371_L	0.552	1.00
227_F	320_C	0.551	1.00
290_G	307_A	0.550	1.00
334_E	337_R	0.547	1.00
135_H	140_H	0.547	1.00
96_V	104_T	0.547	1.00
101_E	166_T	0.545	1.00
174_A	177_R	0.545	1.00
184_I	188_G	0.544	1.00
393_G	399_T	0.544	1.00
80_E	85_S	0.543	1.00
217_F	333_A	0.542	1.00
244_A	282_V	0.542	1.00
185_A	370_Y	0.541	1.00
180_G	187_S	0.540	1.00
390_D	393_G	0.539	1.00
208_G	211_V	0.538	1.00
329_Q	332_S	0.538	1.00
141_A	144_H	0.536	1.00
227_F	311_V	0.535	1.00
43_D	75_D	0.535	1.00
272_R	277_T	0.534	1.00
185_A	374_R	0.531	1.00
207_T	406_S	0.531	1.00
198_A	201_L	0.529	1.00
269_N	291_E	0.529	1.00
408_R	411_V	0.528	1.00
255_L	270_A	0.527	1.00
223_L	324_T	0.525	1.00
264_G	299_L	0.521	1.00
63_D	66_L	0.517	1.00
297_T	331_P	0.517	1.00
266_T	299_L	0.517	1.00
43_D	153_G	0.515	1.00
393_G	397_T	0.515	1.00
149_T	152_V	0.514	1.00
280_N	293_R	0.513	1.00
251_A	314_A	0.513	1.00
231_G	398_P	0.513	1.00
387_V	402_V	0.511	1.00
106_G	168_K	0.510	1.00
235_G	271_G	0.510	1.00
55_D	135_H	0.507	1.00
395_H	400_F	0.505	1.00
292_V	307_A	0.505	1.00
382_A	389_T	0.504	1.00
220_V	365_S	0.504	1.00
184_I	189_H	0.504	1.00
80_E	96_V	0.503	1.00
273_A	288_L	0.502	1.00
311_V	324_T	0.502	1.00
245_I	252_I	0.502	1.00
243_N	269_N	0.501	1.00
45_L	404_E	0.500	1.00
251_A	255_L	0.500	1.00
94_I	189_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3io1A	4	0.838	100	0.293	Contact Map
3pfoA	2	0.8897	100	0.322	Contact Map
4ewtA	4	0.8803	100	0.328	Contact Map
3iszA	2	0.8333	100	0.353	Contact Map
1xmbA	1	0.8404	100	0.353	Contact Map
1ysjA	2	0.8286	100	0.353	Contact Map
4pqaA	2	0.8427	100	0.354	Contact Map
1cg2A	4	0.8732	100	0.36	Contact Map
2zogA	2	0.9108	100	0.368	Contact Map
3dljA	2	0.8967	100	0.368	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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