GREMLIN Database
Q9HS24 - Uncharacterized protein
UniProt: Q9HS24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (350)
Sequences: 11174 (8651)
Seq/√Len: 462.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V121_S4.0611.00
36_R125_V3.8771.00
334_N338_M3.7461.00
16_A305_A3.6091.00
7_D154_D3.1781.00
7_D30_D3.1351.00
9_V153_G2.9601.00
20_A157_I2.8971.00
9_V140_V2.8741.00
125_V143_I2.8411.00
6_Y32_V2.8231.00
128_S169_K2.8001.00
69_A111_D2.6151.00
34_V151_F2.5611.00
130_I139_G2.5281.00
112_G115_R2.5091.00
141_T150_E2.3831.00
9_V34_V2.2961.00
128_S141_T2.2551.00
280_T331_W2.2501.00
139_G150_E2.2221.00
158_D166_L2.2101.00
34_V142_G2.2041.00
142_G151_F2.1531.00
126_V140_V2.1481.00
5_E152_T2.1381.00
23_T313_G2.1191.00
16_A287_V2.1121.00
112_G116_T2.1071.00
107_R111_D2.0471.00
121_S124_T1.9961.00
5_E154_D1.8951.00
159_A287_V1.8761.00
129_V156_V1.8651.00
27_A317_I1.8581.00
78_G82_I1.8571.00
21_A33_V1.8531.00
127_E143_I1.8521.00
19_Y306_A1.8371.00
69_A115_R1.8201.00
315_R336_H1.8101.00
139_G152_T1.8091.00
124_T142_G1.8041.00
8_V29_Y1.7951.00
7_D32_V1.7901.00
22_A112_G1.7621.00
278_S281_A1.7591.00
243_L246_D1.7141.00
87_T90_N1.7081.00
25_A118_V1.6961.00
280_T285_M1.6471.00
311_Y315_R1.6411.00
60_V310_T1.6321.00
8_V24_V1.6281.00
143_I148_G1.6251.00
130_I141_T1.6241.00
30_D119_T1.6231.00
315_R332_E1.6171.00
132_D139_G1.6141.00
245_D249_A1.6131.00
38_S123_D1.5991.00
207_V210_P1.5961.00
278_S334_N1.5921.00
249_A252_Q1.5901.00
113_A118_V1.5861.00
20_A309_G1.5821.00
32_V151_F1.5801.00
68_P72_N1.5681.00
132_D152_T1.5611.00
10_V20_A1.5591.00
255_P258_E1.5451.00
309_G313_G1.5451.00
165_I169_K1.5411.00
208_F211_T1.5411.00
254_R258_E1.5261.00
141_T148_G1.5071.00
157_I287_V1.5071.00
244_V248_K1.5031.00
62_P67_E1.4931.00
172_V276_Y1.4891.00
270_L274_R1.4821.00
246_D249_A1.4691.00
158_D286_A1.4571.00
110_I122_Y1.4541.00
69_A112_G1.4431.00
69_A72_N1.4421.00
126_V129_V1.4401.00
124_T149_H1.4391.00
338_M342_G1.4271.00
314_E336_H1.4171.00
271_P274_R1.4021.00
279_A341_F1.3731.00
155_I330_L1.3721.00
308_A337_V1.3641.00
9_V151_F1.3621.00
110_I114_E1.3491.00
26_D116_T1.3471.00
56_N306_A1.3451.00
248_K252_Q1.3371.00
124_T147_R1.3361.00
142_G149_H1.3301.00
130_I150_E1.3221.00
23_T64_S1.3081.00
206_L210_P1.3061.00
46_A49_D1.2881.00
157_I285_M1.2751.00
206_L209_K1.2751.00
255_P259_G1.2741.00
205_A211_T1.2721.00
195_E261_E1.2621.00
205_A208_F1.2621.00
160_A164_S1.2591.00
315_R329_M1.2591.00
6_Y9_V1.2531.00
56_N303_A1.2521.00
9_V32_V1.2521.00
246_D250_D1.2511.00
292_G308_A1.2461.00
135_G152_T1.2421.00
311_Y336_H1.2181.00
121_S149_H1.2171.00
29_Y317_I1.2171.00
153_G156_V1.2101.00
131_Q281_A1.2091.00
11_V156_V1.2071.00
85_E88_V1.2011.00
126_V166_L1.1951.00
10_V21_A1.1911.00
140_V156_V1.1801.00
187_C191_R1.1751.00
34_V121_S1.1621.00
20_A287_V1.1611.00
196_V199_P1.1561.00
20_A24_V1.1551.00
11_V166_L1.1541.00
205_A210_P1.1511.00
10_V31_V1.1491.00
170_V284_F1.1461.00
363_L367_L1.1371.00
182_S186_F1.1351.00
11_V126_V1.1301.00
270_L273_R1.1301.00
279_A334_N1.1261.00
79_R82_I1.1261.00
245_D248_K1.1221.00
32_V119_T1.1201.00
285_M312_A1.1181.00
165_I168_D1.1171.00
22_A116_T1.1171.00
256_E260_A1.1111.00
206_L211_T1.1081.00
34_V140_V1.1061.00
22_A113_A1.1001.00
285_M333_Y1.1001.00
280_T334_N1.0931.00
121_S151_F1.0901.00
254_R257_F1.0801.00
74_G98_A1.0751.00
187_C190_Y1.0721.00
78_G83_P1.0671.00
269_A272_T1.0571.00
280_T327_E1.0531.00
34_V124_T1.0471.00
287_V333_Y1.0431.00
25_A116_T1.0371.00
268_A271_P1.0321.00
113_A117_G1.0311.00
239_E243_L1.0281.00
111_D114_E1.0281.00
321_E324_D1.0271.00
242_T246_D1.0261.00
257_F260_A1.0261.00
39_A122_Y1.0221.00
7_D29_Y1.0191.00
73_T104_E1.0181.00
173_S277_D1.0051.00
68_P71_T1.0051.00
247_L250_D1.0041.00
272_T349_D1.0031.00
207_V211_T0.9981.00
262_V265_K0.9971.00
279_A291_A0.9961.00
195_E199_P0.9901.00
42_A122_Y0.9871.00
132_D135_G0.9821.00
104_E107_R0.9811.00
208_F212_D0.9721.00
131_Q283_G0.9711.00
13_A18_C0.9671.00
243_L252_Q0.9661.00
19_Y23_T0.9651.00
143_I147_R0.9651.00
55_D59_D0.9631.00
110_I120_F0.9591.00
26_D112_G0.9581.00
364_M367_L0.9541.00
155_I319_A0.9521.00
186_F191_R0.9521.00
85_E89_L0.9481.00
13_A35_E0.9451.00
127_E148_G0.9431.00
62_P71_T0.9431.00
209_K212_D0.9391.00
22_A26_D0.9351.00
127_E141_T0.9331.00
166_L284_F0.9321.00
19_Y64_S0.9291.00
142_G148_G0.9251.00
6_Y119_T0.9221.00
249_A253_Q0.9191.00
6_Y30_D0.9181.00
63_K310_T0.9171.00
73_T108_C0.9161.00
307_Y340_H0.9131.00
31_V118_V0.9111.00
164_S167_Q0.9101.00
255_P260_A0.9091.00
63_K314_E0.9091.00
79_R83_P0.9091.00
195_E226_T0.9051.00
254_R259_G0.9011.00
172_V281_A0.9001.00
42_A110_I0.8991.00
294_V304_G0.8971.00
129_V284_F0.8961.00
157_I312_A0.8951.00
35_E122_Y0.8941.00
363_L366_L0.8931.00
67_E71_T0.8901.00
129_V166_L0.8881.00
244_V247_L0.8841.00
88_V92_P0.8811.00
294_V345_Y0.8791.00
129_V170_V0.8771.00
25_A117_G0.8721.00
15_T302_I0.8721.00
70_F105_Y0.8711.00
264_D267_G0.8701.00
183_Y187_C0.8681.00
61_I66_L0.8671.00
238_E242_T0.8611.00
22_A64_S0.8611.00
216_G223_R0.8571.00
332_E336_H0.8561.00
156_V284_F0.8541.00
78_G81_E0.8501.00
292_G337_V0.8481.00
323_G326_S0.8471.00
183_Y186_F0.8441.00
69_A73_T0.8431.00
205_A209_K0.8431.00
218_L222_P0.8421.00
183_Y188_S0.8421.00
311_Y314_E0.8421.00
80_F83_P0.8411.00
184_S190_Y0.8381.00
82_I86_D0.8351.00
126_V142_G0.8301.00
33_V120_F0.8271.00
142_G147_R0.8211.00
342_G346_A0.8201.00
34_V126_V0.8181.00
254_R260_A0.8141.00
188_S191_R0.8141.00
21_A31_V0.8141.00
286_A290_A0.8131.00
138_T156_V0.8101.00
185_Q190_Y0.8091.00
256_E259_G0.8051.00
162_S293_H0.8041.00
313_G317_I0.8041.00
11_V160_A0.8041.00
238_E241_M0.8031.00
138_T152_T0.8031.00
268_A274_R0.8031.00
267_G270_L0.8021.00
276_Y286_A0.7991.00
242_T250_D0.7971.00
368_A371_P0.7931.00
348_L351_Y0.7921.00
140_V153_G0.7911.00
185_Q191_R0.7861.00
69_A108_C0.7841.00
349_D353_I0.7831.00
111_D115_R0.7831.00
317_I321_E0.7821.00
226_T229_N0.7811.00
126_V169_K0.7811.00
138_T283_G0.7751.00
243_L247_L0.7751.00
239_E242_T0.7701.00
315_R318_R0.7701.00
318_R332_E0.7681.00
114_E119_T0.7631.00
193_I196_V0.7621.00
155_I285_M0.7611.00
129_V169_K0.7571.00
324_D328_S0.7561.00
332_E335_E0.7561.00
39_A42_A0.7551.00
66_L108_C0.7541.00
286_A291_A0.7541.00
5_E30_D0.7531.00
302_I306_A0.7521.00
155_I320_A0.7501.00
66_L112_G0.7491.00
261_E264_D0.7481.00
59_D62_P0.7431.00
364_M368_A0.7421.00
275_P342_G0.7421.00
206_L212_D0.7421.00
269_A273_R0.7401.00
184_S188_S0.7381.00
55_D307_Y0.7371.00
39_A43_G0.7371.00
34_V153_G0.7361.00
50_A99_V0.7321.00
269_A274_R0.7301.00
70_F98_A0.7291.00
250_D253_Q0.7271.00
15_T306_A0.7251.00
275_P338_M0.7241.00
366_L370_L0.7231.00
134_D138_T0.7211.00
318_R324_D0.7201.00
62_P95_G0.7201.00
195_E227_E0.7171.00
25_A31_V0.7171.00
219_W231_G0.7161.00
298_T348_L0.7161.00
100_I105_Y0.7151.00
114_E117_G0.7151.00
185_Q189_A0.7131.00
243_L248_K0.7111.00
361_D365_G0.7071.00
25_A113_A0.7011.00
238_E250_D0.7011.00
196_V200_V0.6991.00
18_C110_I0.6981.00
181_V187_C0.6961.00
185_Q188_S0.6951.00
367_L371_P0.6951.00
200_V203_D0.6941.00
361_D364_M0.6931.00
170_V281_A0.6911.00
13_A42_A0.6901.00
347_A350_V0.6901.00
79_R90_N0.6891.00
86_D89_L0.6881.00
186_F190_Y0.6851.00
238_E244_V0.6851.00
275_P279_A0.6841.00
158_D170_V0.6831.00
280_T330_L0.6821.00
184_S187_C0.6811.00
113_A116_T0.6771.00
61_I306_A0.6731.00
20_A316_A0.6721.00
336_H339_D0.6701.00
23_T26_D0.6701.00
349_D352_N0.6691.00
217_Y221_F0.6671.00
42_A106_G0.6661.00
57_F67_E0.6661.00
337_V344_R0.6631.00
84_R87_T0.6631.00
262_V266_L0.6611.00
55_D340_H0.6611.00
365_G368_A0.6601.00
157_I316_A0.6581.00
264_D268_A0.6581.00
22_A66_L0.6571.00
190_Y194_V0.6561.00
192_E195_E0.6551.00
21_A113_A0.6541.00
81_E87_T0.6531.00
47_C102_R0.6531.00
70_F108_C0.6521.00
266_L270_L0.6521.00
265_K268_A0.6501.00
242_T247_L0.6501.00
207_V212_D0.6491.00
195_E198_E0.6491.00
104_E224_T0.6481.00
21_A118_V0.6481.00
304_G341_F0.6441.00
108_C111_D0.6431.00
166_L169_K0.6431.00
331_W335_E0.6411.00
156_V283_G0.6411.00
60_V64_S0.6401.00
158_D164_S0.6391.00
181_V190_Y0.6350.99
135_G138_T0.6350.99
266_L271_P0.6350.99
239_E244_V0.6350.99
65_Q68_P0.6300.99
155_I326_S0.6290.99
219_W222_P0.6280.99
7_D153_G0.6280.99
29_Y320_A0.6260.99
268_A272_T0.6260.99
230_A233_G0.6230.99
182_S185_Q0.6220.99
106_G122_Y0.6190.99
361_D366_L0.6190.99
126_V165_I0.6170.99
195_E263_T0.6160.99
183_Y190_Y0.6150.99
106_G110_I0.6150.99
19_Y61_I0.6120.99
366_L369_A0.6060.99
181_V184_S0.6050.99
45_I49_D0.6030.99
183_Y189_A0.6020.99
247_L251_L0.6020.99
181_V186_F0.6020.99
197_P200_V0.6010.99
24_V316_A0.6010.99
219_W229_N0.6010.99
160_A166_L0.5970.99
328_S332_E0.5970.99
201_E204_D0.5950.99
27_A313_G0.5950.99
365_G369_A0.5940.99
294_V348_L0.5940.99
189_A192_E0.5940.99
339_D343_A0.5910.99
198_E201_E0.5900.99
194_V197_P0.5900.99
180_N183_Y0.5900.99
31_V117_G0.5890.99
50_A97_L0.5890.99
18_C33_V0.5880.99
20_A159_A0.5860.99
362_D365_G0.5850.99
79_R87_T0.5850.99
13_A33_V0.5800.99
31_V113_A0.5790.99
268_A273_R0.5790.99
276_Y279_A0.5780.99
244_V250_D0.5780.99
180_N191_R0.5770.99
327_E331_W0.5760.99
347_A351_Y0.5750.99
191_R229_N0.5750.99
18_C106_G0.5750.99
359_D362_D0.5740.99
229_N233_G0.5730.99
19_Y109_V0.5700.99
343_A346_A0.5690.99
341_F345_Y0.5680.99
20_A313_G0.5680.99
8_V155_I0.5680.99
279_A338_M0.5650.99
294_V344_R0.5650.99
57_F98_A0.5640.99
194_V199_P0.5620.99
242_T248_K0.5610.99
46_A50_A0.5600.99
85_E91_I0.5560.99
167_Q286_A0.5560.99
23_T310_T0.5550.99
22_A25_A0.5540.99
181_V191_R0.5480.99
154_D320_A0.5470.99
281_A284_F0.5460.98
73_T107_R0.5430.98
229_N232_L0.5430.98
28_G31_V0.5410.98
87_T91_I0.5410.98
45_I50_A0.5410.98
238_E246_D0.5390.98
158_D284_F0.5390.98
24_V313_G0.5380.98
138_T141_T0.5370.98
184_S191_R0.5360.98
88_V91_I0.5340.98
138_T142_G0.5320.98
240_P244_V0.5320.98
155_I327_E0.5310.98
101_D104_E0.5310.98
135_G139_G0.5300.98
160_A286_A0.5290.98
239_E247_L0.5270.98
24_V29_Y0.5270.98
184_S189_A0.5270.98
131_Q282_P0.5250.98
337_V341_F0.5230.98
242_T245_D0.5220.98
287_V309_G0.5220.98
139_G283_G0.5210.98
30_D154_D0.5200.98
16_A302_I0.5190.98
13_A122_Y0.5180.98
363_L368_A0.5170.98
20_A312_A0.5170.98
265_K269_A0.5170.98
343_A347_A0.5170.98
319_A332_E0.5160.98
49_D102_R0.5150.98
325_V328_S0.5150.98
226_T230_A0.5150.98
67_E70_F0.5140.98
331_W334_N0.5130.98
294_V298_T0.5130.98
158_D292_G0.5120.98
318_R336_H0.5120.98
102_R106_G0.5110.98
18_C120_F0.5100.98
108_C112_G0.5100.98
232_L251_L0.5100.98
286_A333_Y0.5090.98
261_E265_K0.5080.98
172_V277_D0.5060.98
230_A234_F0.5060.98
85_E90_N0.5040.97
71_T74_G0.5040.97
42_A107_R0.5040.97
180_N189_A0.5020.97
131_Q138_T0.5020.97
242_T252_Q0.5020.97
328_S331_W0.5010.97
79_R86_D0.5010.97
183_Y191_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4opcA 1 0.9693 100 0.302 Contact Map
1pn0A 3 0.8816 100 0.418 Contact Map
2qa1A 2 0.8794 100 0.42 Contact Map
2x3nA 1 0.75 100 0.422 Contact Map
3oz2A 1 0.8443 100 0.423 Contact Map
2qa2A 2 0.8816 100 0.424 Contact Map
2dkhA 2 0.8377 100 0.429 Contact Map
3ihgA 3 0.8684 100 0.43 Contact Map
4k5sA 2 0.8794 100 0.43 Contact Map
4bjzA 2 0.7961 100 0.431 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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