Q9HS24 - HALSA - GREMLIN Contacts

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Q9HS24 - Uncharacterized protein

UniProt:	Q9HS24	Sequences: MPAHEYDVVVVGAGTAGCYAAATVADAGYDVVVVERKSASEAGHIACGDALKGADNFPDVIPKSQLEPAFTNTGVDHGRFEIPREDTVLNIPVPGELAVIDRREYGRCVIDGAERTGVTFSYDTVVESVIQDDDGRVTGVTGIRDGRGHEFTGDIVIDAAGSLSILQDKVDVSGATFDTNVSYSQFCSAYREIVEVPEPVEWDDALVFKPTDRAAGYLWYFPRTDTEINAGLGFQMTEEPMTLVDDLKADLQQRPEFEGAEVTDKLGAALPTRRPYDSATAPGFMAVGDAAGHVNPTTGGGIAGAAYAGTYAGERAIRAAETGDVSESMLWEYNEHVMDHFGARYAALDVYNIMSTAIDVDDLMGLLAALPGQKLAEALYDGSTQFGLKLKLVTALKSFGYWSEIMDFYRAKQQADRLLDHYRAYPSSPDGLADWQARRDDIMQSVYDVTGADAKY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	456 (350)
Sequences:	11174 (8651)
Seq/√Len:	462.4

ECOLI - FIXC YDIS MHPA UBIF UBII UBIH YGCN CBRA
BACSU - YHJG YETM
HALSA - Q9HS24 Q9HQE5 Q9HS01 Q9HMA0
SULSO - Q97W83 Q97V18 Q97V59 Q97ZK8 Q97W89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_V	121_S	4.061	1.00
36_R	125_V	3.877	1.00
334_N	338_M	3.746	1.00
16_A	305_A	3.609	1.00
7_D	154_D	3.178	1.00
7_D	30_D	3.135	1.00
9_V	153_G	2.960	1.00
20_A	157_I	2.897	1.00
9_V	140_V	2.874	1.00
125_V	143_I	2.841	1.00
6_Y	32_V	2.823	1.00
128_S	169_K	2.800	1.00
69_A	111_D	2.615	1.00
34_V	151_F	2.561	1.00
130_I	139_G	2.528	1.00
112_G	115_R	2.509	1.00
141_T	150_E	2.383	1.00
9_V	34_V	2.296	1.00
128_S	141_T	2.255	1.00
280_T	331_W	2.250	1.00
139_G	150_E	2.222	1.00
158_D	166_L	2.210	1.00
34_V	142_G	2.204	1.00
142_G	151_F	2.153	1.00
126_V	140_V	2.148	1.00
5_E	152_T	2.138	1.00
23_T	313_G	2.119	1.00
16_A	287_V	2.112	1.00
112_G	116_T	2.107	1.00
107_R	111_D	2.047	1.00
121_S	124_T	1.996	1.00
5_E	154_D	1.895	1.00
159_A	287_V	1.876	1.00
129_V	156_V	1.865	1.00
27_A	317_I	1.858	1.00
78_G	82_I	1.857	1.00
21_A	33_V	1.853	1.00
127_E	143_I	1.852	1.00
19_Y	306_A	1.837	1.00
69_A	115_R	1.820	1.00
315_R	336_H	1.810	1.00
139_G	152_T	1.809	1.00
124_T	142_G	1.804	1.00
8_V	29_Y	1.795	1.00
7_D	32_V	1.790	1.00
22_A	112_G	1.762	1.00
278_S	281_A	1.759	1.00
243_L	246_D	1.714	1.00
87_T	90_N	1.708	1.00
25_A	118_V	1.696	1.00
280_T	285_M	1.647	1.00
311_Y	315_R	1.641	1.00
60_V	310_T	1.632	1.00
8_V	24_V	1.628	1.00
143_I	148_G	1.625	1.00
130_I	141_T	1.624	1.00
30_D	119_T	1.623	1.00
315_R	332_E	1.617	1.00
132_D	139_G	1.614	1.00
245_D	249_A	1.613	1.00
38_S	123_D	1.599	1.00
207_V	210_P	1.596	1.00
278_S	334_N	1.592	1.00
249_A	252_Q	1.590	1.00
113_A	118_V	1.586	1.00
20_A	309_G	1.582	1.00
32_V	151_F	1.580	1.00
68_P	72_N	1.568	1.00
132_D	152_T	1.561	1.00
10_V	20_A	1.559	1.00
255_P	258_E	1.545	1.00
309_G	313_G	1.545	1.00
165_I	169_K	1.541	1.00
208_F	211_T	1.541	1.00
254_R	258_E	1.526	1.00
141_T	148_G	1.507	1.00
157_I	287_V	1.507	1.00
244_V	248_K	1.503	1.00
62_P	67_E	1.493	1.00
172_V	276_Y	1.489	1.00
270_L	274_R	1.482	1.00
246_D	249_A	1.469	1.00
158_D	286_A	1.457	1.00
110_I	122_Y	1.454	1.00
69_A	112_G	1.443	1.00
69_A	72_N	1.442	1.00
126_V	129_V	1.440	1.00
124_T	149_H	1.439	1.00
338_M	342_G	1.427	1.00
314_E	336_H	1.417	1.00
271_P	274_R	1.402	1.00
279_A	341_F	1.373	1.00
155_I	330_L	1.372	1.00
308_A	337_V	1.364	1.00
9_V	151_F	1.362	1.00
110_I	114_E	1.349	1.00
26_D	116_T	1.347	1.00
56_N	306_A	1.345	1.00
248_K	252_Q	1.337	1.00
124_T	147_R	1.336	1.00
142_G	149_H	1.330	1.00
130_I	150_E	1.322	1.00
23_T	64_S	1.308	1.00
206_L	210_P	1.306	1.00
46_A	49_D	1.288	1.00
157_I	285_M	1.275	1.00
206_L	209_K	1.275	1.00
255_P	259_G	1.274	1.00
205_A	211_T	1.272	1.00
195_E	261_E	1.262	1.00
205_A	208_F	1.262	1.00
160_A	164_S	1.259	1.00
315_R	329_M	1.259	1.00
6_Y	9_V	1.253	1.00
56_N	303_A	1.252	1.00
9_V	32_V	1.252	1.00
246_D	250_D	1.251	1.00
292_G	308_A	1.246	1.00
135_G	152_T	1.242	1.00
311_Y	336_H	1.218	1.00
121_S	149_H	1.217	1.00
29_Y	317_I	1.217	1.00
153_G	156_V	1.210	1.00
131_Q	281_A	1.209	1.00
11_V	156_V	1.207	1.00
85_E	88_V	1.201	1.00
126_V	166_L	1.195	1.00
10_V	21_A	1.191	1.00
140_V	156_V	1.180	1.00
187_C	191_R	1.175	1.00
34_V	121_S	1.162	1.00
20_A	287_V	1.161	1.00
196_V	199_P	1.156	1.00
20_A	24_V	1.155	1.00
11_V	166_L	1.154	1.00
205_A	210_P	1.151	1.00
10_V	31_V	1.149	1.00
170_V	284_F	1.146	1.00
363_L	367_L	1.137	1.00
182_S	186_F	1.135	1.00
11_V	126_V	1.130	1.00
270_L	273_R	1.130	1.00
279_A	334_N	1.126	1.00
79_R	82_I	1.126	1.00
245_D	248_K	1.122	1.00
32_V	119_T	1.120	1.00
285_M	312_A	1.118	1.00
165_I	168_D	1.117	1.00
22_A	116_T	1.117	1.00
256_E	260_A	1.111	1.00
206_L	211_T	1.108	1.00
34_V	140_V	1.106	1.00
22_A	113_A	1.100	1.00
285_M	333_Y	1.100	1.00
280_T	334_N	1.093	1.00
121_S	151_F	1.090	1.00
254_R	257_F	1.080	1.00
74_G	98_A	1.075	1.00
187_C	190_Y	1.072	1.00
78_G	83_P	1.067	1.00
269_A	272_T	1.057	1.00
280_T	327_E	1.053	1.00
34_V	124_T	1.047	1.00
287_V	333_Y	1.043	1.00
25_A	116_T	1.037	1.00
268_A	271_P	1.032	1.00
113_A	117_G	1.031	1.00
239_E	243_L	1.028	1.00
111_D	114_E	1.028	1.00
321_E	324_D	1.027	1.00
242_T	246_D	1.026	1.00
257_F	260_A	1.026	1.00
39_A	122_Y	1.022	1.00
7_D	29_Y	1.019	1.00
73_T	104_E	1.018	1.00
173_S	277_D	1.005	1.00
68_P	71_T	1.005	1.00
247_L	250_D	1.004	1.00
272_T	349_D	1.003	1.00
207_V	211_T	0.998	1.00
262_V	265_K	0.997	1.00
279_A	291_A	0.996	1.00
195_E	199_P	0.990	1.00
42_A	122_Y	0.987	1.00
132_D	135_G	0.982	1.00
104_E	107_R	0.981	1.00
208_F	212_D	0.972	1.00
131_Q	283_G	0.971	1.00
13_A	18_C	0.967	1.00
243_L	252_Q	0.966	1.00
19_Y	23_T	0.965	1.00
143_I	147_R	0.965	1.00
55_D	59_D	0.963	1.00
110_I	120_F	0.959	1.00
26_D	112_G	0.958	1.00
364_M	367_L	0.954	1.00
155_I	319_A	0.952	1.00
186_F	191_R	0.952	1.00
85_E	89_L	0.948	1.00
13_A	35_E	0.945	1.00
127_E	148_G	0.943	1.00
62_P	71_T	0.943	1.00
209_K	212_D	0.939	1.00
22_A	26_D	0.935	1.00
127_E	141_T	0.933	1.00
166_L	284_F	0.932	1.00
19_Y	64_S	0.929	1.00
142_G	148_G	0.925	1.00
6_Y	119_T	0.922	1.00
249_A	253_Q	0.919	1.00
6_Y	30_D	0.918	1.00
63_K	310_T	0.917	1.00
73_T	108_C	0.916	1.00
307_Y	340_H	0.913	1.00
31_V	118_V	0.911	1.00
164_S	167_Q	0.910	1.00
255_P	260_A	0.909	1.00
63_K	314_E	0.909	1.00
79_R	83_P	0.909	1.00
195_E	226_T	0.905	1.00
254_R	259_G	0.901	1.00
172_V	281_A	0.900	1.00
42_A	110_I	0.899	1.00
294_V	304_G	0.897	1.00
129_V	284_F	0.896	1.00
157_I	312_A	0.895	1.00
35_E	122_Y	0.894	1.00
363_L	366_L	0.893	1.00
67_E	71_T	0.890	1.00
129_V	166_L	0.888	1.00
244_V	247_L	0.884	1.00
88_V	92_P	0.881	1.00
294_V	345_Y	0.879	1.00
129_V	170_V	0.877	1.00
25_A	117_G	0.872	1.00
15_T	302_I	0.872	1.00
70_F	105_Y	0.871	1.00
264_D	267_G	0.870	1.00
183_Y	187_C	0.868	1.00
61_I	66_L	0.867	1.00
238_E	242_T	0.861	1.00
22_A	64_S	0.861	1.00
216_G	223_R	0.857	1.00
332_E	336_H	0.856	1.00
156_V	284_F	0.854	1.00
78_G	81_E	0.850	1.00
292_G	337_V	0.848	1.00
323_G	326_S	0.847	1.00
183_Y	186_F	0.844	1.00
69_A	73_T	0.843	1.00
205_A	209_K	0.843	1.00
218_L	222_P	0.842	1.00
183_Y	188_S	0.842	1.00
311_Y	314_E	0.842	1.00
80_F	83_P	0.841	1.00
184_S	190_Y	0.838	1.00
82_I	86_D	0.835	1.00
126_V	142_G	0.830	1.00
33_V	120_F	0.827	1.00
142_G	147_R	0.821	1.00
342_G	346_A	0.820	1.00
34_V	126_V	0.818	1.00
254_R	260_A	0.814	1.00
188_S	191_R	0.814	1.00
21_A	31_V	0.814	1.00
286_A	290_A	0.813	1.00
138_T	156_V	0.810	1.00
185_Q	190_Y	0.809	1.00
256_E	259_G	0.805	1.00
162_S	293_H	0.804	1.00
313_G	317_I	0.804	1.00
11_V	160_A	0.804	1.00
238_E	241_M	0.803	1.00
138_T	152_T	0.803	1.00
268_A	274_R	0.803	1.00
267_G	270_L	0.802	1.00
276_Y	286_A	0.799	1.00
242_T	250_D	0.797	1.00
368_A	371_P	0.793	1.00
348_L	351_Y	0.792	1.00
140_V	153_G	0.791	1.00
185_Q	191_R	0.786	1.00
69_A	108_C	0.784	1.00
349_D	353_I	0.783	1.00
111_D	115_R	0.783	1.00
317_I	321_E	0.782	1.00
226_T	229_N	0.781	1.00
126_V	169_K	0.781	1.00
138_T	283_G	0.775	1.00
243_L	247_L	0.775	1.00
239_E	242_T	0.770	1.00
315_R	318_R	0.770	1.00
318_R	332_E	0.768	1.00
114_E	119_T	0.763	1.00
193_I	196_V	0.762	1.00
155_I	285_M	0.761	1.00
129_V	169_K	0.757	1.00
324_D	328_S	0.756	1.00
332_E	335_E	0.756	1.00
39_A	42_A	0.755	1.00
66_L	108_C	0.754	1.00
286_A	291_A	0.754	1.00
5_E	30_D	0.753	1.00
302_I	306_A	0.752	1.00
155_I	320_A	0.750	1.00
66_L	112_G	0.749	1.00
261_E	264_D	0.748	1.00
59_D	62_P	0.743	1.00
364_M	368_A	0.742	1.00
275_P	342_G	0.742	1.00
206_L	212_D	0.742	1.00
269_A	273_R	0.740	1.00
184_S	188_S	0.738	1.00
55_D	307_Y	0.737	1.00
39_A	43_G	0.737	1.00
34_V	153_G	0.736	1.00
50_A	99_V	0.732	1.00
269_A	274_R	0.730	1.00
70_F	98_A	0.729	1.00
250_D	253_Q	0.727	1.00
15_T	306_A	0.725	1.00
275_P	338_M	0.724	1.00
366_L	370_L	0.723	1.00
134_D	138_T	0.721	1.00
318_R	324_D	0.720	1.00
62_P	95_G	0.720	1.00
195_E	227_E	0.717	1.00
25_A	31_V	0.717	1.00
219_W	231_G	0.716	1.00
298_T	348_L	0.716	1.00
100_I	105_Y	0.715	1.00
114_E	117_G	0.715	1.00
185_Q	189_A	0.713	1.00
243_L	248_K	0.711	1.00
361_D	365_G	0.707	1.00
25_A	113_A	0.701	1.00
238_E	250_D	0.701	1.00
196_V	200_V	0.699	1.00
18_C	110_I	0.698	1.00
181_V	187_C	0.696	1.00
185_Q	188_S	0.695	1.00
367_L	371_P	0.695	1.00
200_V	203_D	0.694	1.00
361_D	364_M	0.693	1.00
170_V	281_A	0.691	1.00
13_A	42_A	0.690	1.00
347_A	350_V	0.690	1.00
79_R	90_N	0.689	1.00
86_D	89_L	0.688	1.00
186_F	190_Y	0.685	1.00
238_E	244_V	0.685	1.00
275_P	279_A	0.684	1.00
158_D	170_V	0.683	1.00
280_T	330_L	0.682	1.00
184_S	187_C	0.681	1.00
113_A	116_T	0.677	1.00
61_I	306_A	0.673	1.00
20_A	316_A	0.672	1.00
336_H	339_D	0.670	1.00
23_T	26_D	0.670	1.00
349_D	352_N	0.669	1.00
217_Y	221_F	0.667	1.00
42_A	106_G	0.666	1.00
57_F	67_E	0.666	1.00
337_V	344_R	0.663	1.00
84_R	87_T	0.663	1.00
262_V	266_L	0.661	1.00
55_D	340_H	0.661	1.00
365_G	368_A	0.660	1.00
157_I	316_A	0.658	1.00
264_D	268_A	0.658	1.00
22_A	66_L	0.657	1.00
190_Y	194_V	0.656	1.00
192_E	195_E	0.655	1.00
21_A	113_A	0.654	1.00
81_E	87_T	0.653	1.00
47_C	102_R	0.653	1.00
70_F	108_C	0.652	1.00
266_L	270_L	0.652	1.00
265_K	268_A	0.650	1.00
242_T	247_L	0.650	1.00
207_V	212_D	0.649	1.00
195_E	198_E	0.649	1.00
104_E	224_T	0.648	1.00
21_A	118_V	0.648	1.00
304_G	341_F	0.644	1.00
108_C	111_D	0.643	1.00
166_L	169_K	0.643	1.00
331_W	335_E	0.641	1.00
156_V	283_G	0.641	1.00
60_V	64_S	0.640	1.00
158_D	164_S	0.639	1.00
181_V	190_Y	0.635	0.99
135_G	138_T	0.635	0.99
266_L	271_P	0.635	0.99
239_E	244_V	0.635	0.99
65_Q	68_P	0.630	0.99
155_I	326_S	0.629	0.99
219_W	222_P	0.628	0.99
7_D	153_G	0.628	0.99
29_Y	320_A	0.626	0.99
268_A	272_T	0.626	0.99
230_A	233_G	0.623	0.99
182_S	185_Q	0.622	0.99
106_G	122_Y	0.619	0.99
361_D	366_L	0.619	0.99
126_V	165_I	0.617	0.99
195_E	263_T	0.616	0.99
183_Y	190_Y	0.615	0.99
106_G	110_I	0.615	0.99
19_Y	61_I	0.612	0.99
366_L	369_A	0.606	0.99
181_V	184_S	0.605	0.99
45_I	49_D	0.603	0.99
183_Y	189_A	0.602	0.99
247_L	251_L	0.602	0.99
181_V	186_F	0.602	0.99
197_P	200_V	0.601	0.99
24_V	316_A	0.601	0.99
219_W	229_N	0.601	0.99
160_A	166_L	0.597	0.99
328_S	332_E	0.597	0.99
201_E	204_D	0.595	0.99
27_A	313_G	0.595	0.99
365_G	369_A	0.594	0.99
294_V	348_L	0.594	0.99
189_A	192_E	0.594	0.99
339_D	343_A	0.591	0.99
198_E	201_E	0.590	0.99
194_V	197_P	0.590	0.99
180_N	183_Y	0.590	0.99
31_V	117_G	0.589	0.99
50_A	97_L	0.589	0.99
18_C	33_V	0.588	0.99
20_A	159_A	0.586	0.99
362_D	365_G	0.585	0.99
79_R	87_T	0.585	0.99
13_A	33_V	0.580	0.99
31_V	113_A	0.579	0.99
268_A	273_R	0.579	0.99
276_Y	279_A	0.578	0.99
244_V	250_D	0.578	0.99
180_N	191_R	0.577	0.99
327_E	331_W	0.576	0.99
347_A	351_Y	0.575	0.99
191_R	229_N	0.575	0.99
18_C	106_G	0.575	0.99
359_D	362_D	0.574	0.99
229_N	233_G	0.573	0.99
19_Y	109_V	0.570	0.99
343_A	346_A	0.569	0.99
341_F	345_Y	0.568	0.99
20_A	313_G	0.568	0.99
8_V	155_I	0.568	0.99
279_A	338_M	0.565	0.99
294_V	344_R	0.565	0.99
57_F	98_A	0.564	0.99
194_V	199_P	0.562	0.99
242_T	248_K	0.561	0.99
46_A	50_A	0.560	0.99
85_E	91_I	0.556	0.99
167_Q	286_A	0.556	0.99
23_T	310_T	0.555	0.99
22_A	25_A	0.554	0.99
181_V	191_R	0.548	0.99
154_D	320_A	0.547	0.99
281_A	284_F	0.546	0.98
73_T	107_R	0.543	0.98
229_N	232_L	0.543	0.98
28_G	31_V	0.541	0.98
87_T	91_I	0.541	0.98
45_I	50_A	0.541	0.98
238_E	246_D	0.539	0.98
158_D	284_F	0.539	0.98
24_V	313_G	0.538	0.98
138_T	141_T	0.537	0.98
184_S	191_R	0.536	0.98
88_V	91_I	0.534	0.98
138_T	142_G	0.532	0.98
240_P	244_V	0.532	0.98
155_I	327_E	0.531	0.98
101_D	104_E	0.531	0.98
135_G	139_G	0.530	0.98
160_A	286_A	0.529	0.98
239_E	247_L	0.527	0.98
24_V	29_Y	0.527	0.98
184_S	189_A	0.527	0.98
131_Q	282_P	0.525	0.98
337_V	341_F	0.523	0.98
242_T	245_D	0.522	0.98
287_V	309_G	0.522	0.98
139_G	283_G	0.521	0.98
30_D	154_D	0.520	0.98
16_A	302_I	0.519	0.98
13_A	122_Y	0.518	0.98
363_L	368_A	0.517	0.98
20_A	312_A	0.517	0.98
265_K	269_A	0.517	0.98
343_A	347_A	0.517	0.98
319_A	332_E	0.516	0.98
49_D	102_R	0.515	0.98
325_V	328_S	0.515	0.98
226_T	230_A	0.515	0.98
67_E	70_F	0.514	0.98
331_W	334_N	0.513	0.98
294_V	298_T	0.513	0.98
158_D	292_G	0.512	0.98
318_R	336_H	0.512	0.98
102_R	106_G	0.511	0.98
18_C	120_F	0.510	0.98
108_C	112_G	0.510	0.98
232_L	251_L	0.510	0.98
286_A	333_Y	0.509	0.98
261_E	265_K	0.508	0.98
172_V	277_D	0.506	0.98
230_A	234_F	0.506	0.98
85_E	90_N	0.504	0.97
71_T	74_G	0.504	0.97
42_A	107_R	0.504	0.97
180_N	189_A	0.502	0.97
131_Q	138_T	0.502	0.97
242_T	252_Q	0.502	0.97
328_S	331_W	0.501	0.97
79_R	86_D	0.501	0.97
183_Y	191_R	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4opcA	1	0.9693	100	0.302	Contact Map
1pn0A	3	0.8816	100	0.418	Contact Map
2qa1A	2	0.8794	100	0.42	Contact Map
2x3nA	1	0.75	100	0.422	Contact Map
3oz2A	1	0.8443	100	0.423	Contact Map
2qa2A	2	0.8816	100	0.424	Contact Map
2dkhA	2	0.8377	100	0.429	Contact Map
3ihgA	3	0.8684	100	0.43	Contact Map
4k5sA	2	0.8794	100	0.43	Contact Map
4bjzA	2	0.7961	100	0.431	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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