Q9HS22 - HALSA - GREMLIN Contacts

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Q9HS22 - Uncharacterized protein

UniProt:	Q9HS22	Sequences: MPAPTVSVRDLYNWLQADREVDVLDVRDGAEFDAWCVDGPGVTARHTPYMEVVAAGVSGDAASVVPDGLREPVVVVCAVGEASAEVAESLRAEGVDAVNLEGGMDAWGAFVTSHDLGNGVVQFERPSSGCLSYLLVDGDAAAVVDPLAAAVDAYVEAAAARDATITHAIDSHVHADHVSGVRGLADATAAARVLPAGATERGLAVDADVLATDGDEIAVGDRTLGVTHAPGHTSEHLVFSWGDDLLTGDCLFLDGVGRPDLEDADAARELAGRQYDTLGALTATADERRVMPGHVTPSTTHDGRDGGVVGSLAAVAAELSMLDLDRAAFVDHVTTGLPPRPANDEAIVAVNLGETAIDEDTLALERGPNNCAVSGD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	376 (353)
Sequences:	441 (279)
Seq/√Len:	14.9

BACSU - YRKH
HALSA - Q9HS22 O54647 O54661

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_V	73_V	6.769	1.00
158_A	165_I	4.989	1.00
310_G	314_A	4.351	1.00
144_V	246_L	4.064	1.00
169_I	239_F	4.042	1.00
32_F	44_A	3.634	0.99
229_A	238_V	3.373	0.99
102_G	106_A	3.312	0.99
85_E	89_S	3.257	0.99
169_I	217_I	3.211	0.99
136_V	163_A	3.171	0.98
286_D	313_A	3.110	0.98
311_S	314_A	3.034	0.98
167_H	193_V	2.923	0.97
213_D	226_V	2.849	0.97
331_D	335_T	2.723	0.96
32_F	37_V	2.713	0.96
254_D	296_T	2.673	0.96
120_V	135_L	2.628	0.95
272_G	326_R	2.620	0.95
296_T	320_S	2.539	0.94
74_V	80_G	2.531	0.94
6_V	80_G	2.290	0.90
80_G	84_A	2.288	0.90
135_L	144_V	2.246	0.89
111_V	116_L	2.243	0.89
50_M	81_E	2.234	0.89
119_G	161_R	2.164	0.87
165_I	217_I	2.120	0.86
143_V	158_A	2.080	0.85
73_V	95_V	2.061	0.84
50_M	53_V	2.042	0.84
8_V	80_G	2.041	0.84
216_E	223_T	2.034	0.84
181_V	192_R	2.017	0.83
134_L	165_I	1.975	0.82
315_V	322_L	1.973	0.82
155_V	187_A	1.960	0.81
76_V	100_L	1.945	0.81
283_A	328_A	1.928	0.80
236_H	257_G	1.917	0.80
12_Y	126_P	1.905	0.79
49_Y	54_A	1.869	0.78
229_A	277_T	1.867	0.78
49_Y	86_V	1.850	0.77
12_Y	15_L	1.839	0.77
142_A	169_I	1.818	0.76
174_H	177_H	1.808	0.75
23_V	39_G	1.800	0.75
81_E	86_V	1.775	0.74
12_Y	16_Q	1.762	0.73
324_L	332_H	1.751	0.73
129_G	365_E	1.736	0.72
80_G	95_V	1.700	0.71
259_P	347_I	1.692	0.70
238_V	250_C	1.673	0.69
147_L	154_Y	1.672	0.69
29_G	33_D	1.663	0.69
5_T	80_G	1.633	0.67
89_S	97_A	1.618	0.67
28_D	49_Y	1.616	0.67
31_E	224_L	1.611	0.66
120_V	246_L	1.589	0.65
123_F	157_A	1.549	0.63
170_D	174_H	1.533	0.62
144_V	239_F	1.514	0.61
49_Y	81_E	1.511	0.61
15_L	21_V	1.500	0.61
78_A	82_A	1.488	0.60
171_S	344_D	1.485	0.60
155_V	188_T	1.482	0.60
108_G	128_S	1.481	0.60
120_V	161_R	1.480	0.60
91_R	97_A	1.457	0.58
140_A	166_T	1.453	0.58
14_W	72_P	1.453	0.58
81_E	105_D	1.448	0.58
168_A	226_V	1.436	0.57
62_A	65_V	1.436	0.57
50_M	86_V	1.420	0.56
236_H	250_C	1.414	0.56
104_M	129_G	1.401	0.55
74_V	100_L	1.393	0.55
76_V	152_D	1.371	0.54
80_G	101_E	1.366	0.53
96_D	358_D	1.355	0.53
254_D	320_S	1.354	0.53
143_V	146_P	1.349	0.52
277_T	357_I	1.336	0.52
6_V	74_V	1.330	0.51
226_V	237_L	1.321	0.51
7_S	101_E	1.318	0.51
49_Y	53_V	1.304	0.50
195_P	348_V	1.298	0.50
211_A	226_V	1.296	0.49
128_S	257_G	1.293	0.49
74_V	326_R	1.292	0.49
46_H	54_A	1.287	0.49
281_L	290_V	1.276	0.48
170_D	177_H	1.269	0.48
271_A	330_V	1.261	0.47
195_P	338_P	1.257	0.47
127_S	236_H	1.254	0.47
296_T	310_G	1.245	0.47
73_V	314_A	1.240	0.46
127_S	211_A	1.234	0.46
310_G	320_S	1.231	0.46
199_T	235_E	1.212	0.45
63_S	241_W	1.208	0.45
32_F	36_C	1.203	0.44
262_E	342_A	1.194	0.44
37_V	76_V	1.185	0.43
11_L	87_A	1.183	0.43
54_A	59_G	1.182	0.43
31_E	44_A	1.172	0.43
135_L	222_R	1.172	0.43
135_L	223_T	1.169	0.42
20_E	243_D	1.164	0.42
5_T	33_D	1.150	0.41
198_A	201_R	1.145	0.41
49_Y	52_V	1.141	0.41
156_E	159_A	1.136	0.41
15_L	299_T	1.125	0.40
229_A	250_C	1.121	0.40
112_T	116_L	1.120	0.40
169_I	224_L	1.116	0.40
86_V	189_A	1.116	0.40
152_D	218_A	1.114	0.39
121_V	157_A	1.113	0.39
162_D	317_A	1.110	0.39
8_V	97_A	1.109	0.39
81_E	85_E	1.105	0.39
168_A	246_L	1.102	0.39
13_N	271_A	1.097	0.39
128_S	210_L	1.096	0.38
194_L	199_T	1.094	0.38
224_L	293_G	1.091	0.38
234_S	269_E	1.087	0.38
268_R	271_A	1.085	0.38
284_T	288_R	1.084	0.38
14_W	19_R	1.084	0.38
253_L	320_S	1.083	0.38
104_M	130_C	1.082	0.38
71_E	91_R	1.079	0.38
153_A	165_I	1.077	0.37
262_E	270_L	1.074	0.37
146_P	362_L	1.067	0.37
151_V	222_R	1.067	0.37
160_A	186_D	1.066	0.37
21_V	74_V	1.065	0.37
196_A	212_T	1.054	0.36
85_E	97_A	1.043	0.36
189_A	314_A	1.042	0.36
7_S	146_P	1.039	0.35
235_E	319_L	1.039	0.35
253_L	296_T	1.037	0.35
269_E	350_V	1.031	0.35
276_D	326_R	1.031	0.35
13_N	356_A	1.027	0.35
192_R	291_M	1.025	0.35
184_L	310_G	1.024	0.35
166_T	178_V	1.021	0.35
144_V	241_W	1.020	0.35
304_R	307_G	1.018	0.34
147_L	310_G	1.014	0.34
26_V	31_E	1.011	0.34
250_C	257_G	1.008	0.34
59_G	189_A	1.008	0.34
162_D	318_E	1.007	0.34
215_D	221_D	1.007	0.34
151_V	154_Y	1.007	0.34
93_E	333_V	1.003	0.34
282_T	322_L	1.002	0.34
66_P	235_E	0.999	0.33
144_V	169_I	0.998	0.33
236_H	274_Q	0.997	0.33
33_D	80_G	0.997	0.33
152_D	165_I	0.991	0.33
143_V	184_L	0.989	0.33
260_D	347_I	0.988	0.33
20_E	208_D	0.984	0.33
162_D	178_V	0.983	0.33
310_G	318_E	0.983	0.33
229_A	275_Y	0.981	0.33
178_V	323_D	0.977	0.32
255_G	278_L	0.973	0.32
233_T	260_D	0.968	0.32
127_S	132_S	0.966	0.32
366_R	373_V	0.964	0.32
50_M	54_A	0.955	0.31
127_S	150_A	0.943	0.31
89_S	98_V	0.943	0.31
151_V	187_A	0.942	0.31
6_V	9_R	0.940	0.31
120_V	142_A	0.938	0.31
33_D	216_E	0.937	0.30
63_S	144_V	0.930	0.30
6_V	193_V	0.929	0.30
35_W	104_M	0.929	0.30
104_M	365_E	0.927	0.30
147_L	184_L	0.927	0.30
10_D	120_V	0.924	0.30
6_V	95_V	0.921	0.30
168_A	181_V	0.917	0.30
195_P	237_L	0.915	0.29
198_A	348_V	0.914	0.29
146_P	154_Y	0.909	0.29
18_D	95_V	0.909	0.29
233_T	259_P	0.904	0.29
11_L	74_V	0.901	0.29
143_V	165_I	0.899	0.29
281_L	364_L	0.899	0.29
94_G	107_W	0.899	0.29
216_E	226_V	0.898	0.29
111_V	115_D	0.895	0.29
50_M	79_V	0.895	0.29
49_Y	82_A	0.887	0.28
295_V	319_L	0.887	0.28
135_L	215_D	0.885	0.28
130_C	174_H	0.885	0.28
53_V	224_L	0.883	0.28
20_E	96_D	0.876	0.28
277_T	295_V	0.873	0.28
211_A	291_M	0.871	0.27
29_G	152_D	0.868	0.27
150_A	362_L	0.866	0.27
28_D	31_E	0.864	0.27
173_V	235_E	0.861	0.27
6_V	163_A	0.859	0.27
225_G	240_S	0.859	0.27
198_A	202_G	0.857	0.27
122_Q	125_R	0.856	0.27
9_R	23_V	0.853	0.27
256_V	278_L	0.852	0.27
59_G	187_A	0.852	0.27
255_G	357_I	0.849	0.26
189_A	356_A	0.846	0.26
20_E	70_R	0.846	0.26
83_S	102_G	0.844	0.26
213_D	317_A	0.843	0.26
247_T	290_V	0.842	0.26
108_G	368_P	0.839	0.26
141_A	163_A	0.839	0.26
108_G	362_L	0.828	0.26
199_T	338_P	0.821	0.25
178_V	361_T	0.820	0.25
128_S	149_A	0.820	0.25
171_S	285_A	0.820	0.25
255_G	348_V	0.819	0.25
59_G	165_I	0.818	0.25
90_L	107_W	0.817	0.25
28_D	295_V	0.814	0.25
83_S	89_S	0.811	0.25
15_L	356_A	0.811	0.25
72_P	317_A	0.808	0.25
108_G	342_A	0.808	0.25
18_D	45_R	0.807	0.25
83_S	219_V	0.807	0.25
201_R	349_A	0.807	0.25
85_E	98_V	0.804	0.25
162_D	243_D	0.804	0.25
58_S	277_T	0.801	0.24
156_E	215_D	0.799	0.24
62_A	153_A	0.797	0.24
134_L	222_R	0.793	0.24
182_R	186_D	0.789	0.24
21_V	53_V	0.785	0.24
49_Y	78_A	0.783	0.24
108_G	131_L	0.779	0.24
216_E	221_D	0.778	0.23
281_L	337_L	0.776	0.23
122_Q	292_P	0.774	0.23
127_S	182_R	0.773	0.23
325_D	330_V	0.772	0.23
101_E	293_G	0.771	0.23
13_N	33_D	0.769	0.23
263_D	319_L	0.767	0.23
138_G	327_A	0.765	0.23
276_D	280_A	0.765	0.23
78_A	81_E	0.764	0.23
6_V	20_E	0.762	0.23
250_C	275_Y	0.760	0.23
67_D	221_D	0.754	0.23
22_D	51_E	0.754	0.23
330_V	335_T	0.753	0.22
16_Q	23_V	0.753	0.22
70_R	140_A	0.752	0.22
31_E	72_P	0.750	0.22
33_D	221_D	0.748	0.22
98_V	277_T	0.747	0.22
248_G	252_F	0.743	0.22
187_A	346_A	0.743	0.22
29_G	62_A	0.743	0.22
194_L	206_D	0.741	0.22
221_D	287_E	0.741	0.22
135_L	227_T	0.741	0.22
106_A	166_T	0.739	0.22
95_V	152_D	0.738	0.22
262_E	370_N	0.735	0.22
188_T	243_D	0.735	0.22
62_A	66_P	0.733	0.22
154_Y	347_I	0.733	0.22
176_D	294_H	0.729	0.22
29_G	81_E	0.728	0.22
301_H	308_V	0.728	0.22
102_G	159_A	0.727	0.21
71_E	97_A	0.723	0.21
142_A	215_D	0.722	0.21
202_G	262_E	0.721	0.21
141_A	365_E	0.720	0.21
128_S	202_G	0.720	0.21
61_A	65_V	0.720	0.21
239_F	285_A	0.719	0.21
120_V	268_R	0.718	0.21
263_D	270_L	0.713	0.21
23_V	120_V	0.713	0.21
17_A	221_D	0.713	0.21
96_D	283_A	0.707	0.21
79_V	82_A	0.705	0.21
104_M	108_G	0.705	0.21
197_G	234_S	0.700	0.20
46_H	70_R	0.699	0.20
49_Y	235_E	0.697	0.20
102_G	105_D	0.697	0.20
67_D	76_V	0.697	0.20
278_L	322_L	0.695	0.20
23_V	50_M	0.691	0.20
75_V	306_G	0.688	0.20
326_R	357_I	0.686	0.20
28_D	81_E	0.686	0.20
156_E	184_L	0.686	0.20
250_C	255_G	0.683	0.20
74_V	84_A	0.675	0.20
191_A	276_D	0.674	0.20
104_M	174_H	0.671	0.19
95_V	286_D	0.670	0.19
188_T	310_G	0.670	0.19
130_C	365_E	0.667	0.19
26_V	86_V	0.667	0.19
127_S	340_R	0.666	0.19
131_L	177_H	0.665	0.19
50_M	82_A	0.665	0.19
173_V	198_A	0.661	0.19
59_G	72_P	0.660	0.19
46_H	49_Y	0.659	0.19
115_D	121_V	0.659	0.19
181_V	263_D	0.658	0.19
83_S	99_N	0.658	0.19
47_T	91_R	0.658	0.19
156_E	166_T	0.657	0.19
13_N	189_A	0.655	0.19
177_H	194_L	0.653	0.19
253_L	310_G	0.652	0.19
173_V	348_V	0.652	0.19
100_L	163_A	0.652	0.19
349_A	373_V	0.650	0.19
50_M	85_E	0.650	0.19
340_R	348_V	0.650	0.19
150_A	361_T	0.649	0.19
271_A	343_N	0.648	0.19
187_A	217_I	0.646	0.19
35_W	129_G	0.646	0.19
334_T	337_L	0.643	0.18
127_S	339_P	0.643	0.18
134_L	163_A	0.642	0.18
144_V	282_T	0.640	0.18
247_T	272_G	0.640	0.18
115_D	157_A	0.639	0.18
316_A	342_A	0.639	0.18
201_R	354_E	0.638	0.18
35_W	365_E	0.638	0.18
33_D	47_T	0.630	0.18
24_L	132_S	0.630	0.18
8_V	74_V	0.630	0.18
121_V	309_V	0.630	0.18
157_A	340_R	0.629	0.18
60_D	63_S	0.629	0.18
277_T	281_L	0.628	0.18
130_C	177_H	0.625	0.18
130_C	170_D	0.625	0.18
16_Q	126_P	0.622	0.18
80_G	100_L	0.621	0.18
131_L	174_H	0.617	0.18
60_D	276_D	0.616	0.18
144_V	326_R	0.615	0.18
178_V	284_T	0.614	0.18
20_E	45_R	0.614	0.18
214_G	288_R	0.613	0.18
195_P	198_A	0.612	0.17
135_L	225_G	0.611	0.17
143_V	299_T	0.610	0.17
246_L	291_M	0.608	0.17
132_S	257_G	0.607	0.17
160_A	280_A	0.605	0.17
237_L	339_P	0.605	0.17
78_A	319_L	0.605	0.17
299_T	327_A	0.600	0.17
97_A	100_L	0.600	0.17
241_W	246_L	0.600	0.17
79_V	180_G	0.599	0.17
21_V	80_G	0.598	0.17
129_G	141_A	0.598	0.17
30_A	37_V	0.597	0.17
286_D	305_D	0.597	0.17
61_A	92_A	0.597	0.17
122_Q	261_L	0.595	0.17
28_D	86_V	0.594	0.17
268_R	276_D	0.592	0.17
234_S	322_L	0.592	0.17
16_Q	184_L	0.591	0.17
137_D	313_A	0.590	0.17
85_E	91_R	0.589	0.17
145_D	233_T	0.588	0.17
102_G	109_A	0.587	0.17
52_V	86_V	0.586	0.17
35_W	130_C	0.586	0.17
169_I	356_A	0.584	0.17
261_L	329_F	0.583	0.17
348_V	364_L	0.583	0.17
287_E	327_A	0.582	0.17
235_E	295_V	0.582	0.17
170_D	176_D	0.581	0.16
128_S	340_R	0.580	0.16
132_S	154_Y	0.580	0.16
39_G	358_D	0.580	0.16
343_N	364_L	0.579	0.16
159_A	216_E	0.578	0.16
204_A	250_C	0.577	0.16
75_V	214_G	0.577	0.16
175_A	258_R	0.576	0.16
172_H	258_R	0.576	0.16
172_H	175_A	0.576	0.16
255_G	350_V	0.574	0.16
160_A	327_A	0.574	0.16
259_P	329_F	0.573	0.16
215_D	218_A	0.573	0.16
36_C	320_S	0.573	0.16
115_D	226_V	0.572	0.16
125_R	261_L	0.572	0.16
47_T	61_A	0.571	0.16
215_D	331_D	0.570	0.16
347_I	367_G	0.570	0.16
347_I	369_N	0.570	0.16
64_V	309_V	0.570	0.16
113_S	116_L	0.570	0.16
227_T	283_A	0.565	0.16
170_D	179_S	0.564	0.16
94_G	103_G	0.562	0.16
214_G	306_G	0.562	0.16
128_S	131_L	0.560	0.16
98_V	134_L	0.556	0.16
135_L	204_A	0.556	0.16
34_A	366_R	0.556	0.16
180_G	368_P	0.556	0.16
113_S	242_G	0.553	0.16
162_D	206_D	0.551	0.16
36_C	304_R	0.551	0.16
146_P	276_D	0.551	0.16
126_P	296_T	0.550	0.16
153_A	222_R	0.550	0.16
85_E	88_E	0.549	0.16
237_L	267_A	0.548	0.16
223_T	227_T	0.548	0.16
134_L	158_A	0.548	0.16
45_R	243_D	0.547	0.15
28_D	85_E	0.547	0.15
52_V	81_E	0.546	0.15
29_G	238_V	0.545	0.15
80_G	174_H	0.545	0.15
176_D	329_F	0.545	0.15
7_S	165_I	0.544	0.15
13_N	357_I	0.544	0.15
240_S	284_T	0.541	0.15
146_P	226_V	0.539	0.15
7_S	283_A	0.539	0.15
317_A	359_E	0.538	0.15
171_S	288_R	0.538	0.15
29_G	46_H	0.537	0.15
8_V	164_T	0.537	0.15
106_A	110_F	0.536	0.15
151_V	287_E	0.533	0.15
5_T	29_G	0.531	0.15
219_V	276_D	0.530	0.15
15_L	91_R	0.530	0.15
11_L	247_T	0.529	0.15
190_A	246_L	0.528	0.15
53_V	81_E	0.528	0.15
259_P	270_L	0.527	0.15
7_S	155_V	0.526	0.15
195_P	339_P	0.526	0.15
162_D	328_A	0.526	0.15
252_F	312_L	0.524	0.15
114_H	254_D	0.524	0.15
149_A	342_A	0.524	0.15
120_V	298_S	0.524	0.15
342_A	347_I	0.523	0.15
343_N	348_V	0.523	0.15
171_S	220_G	0.522	0.15
159_A	327_A	0.522	0.15
252_F	294_H	0.521	0.15
137_D	292_P	0.520	0.15
124_E	295_V	0.518	0.15
32_F	169_I	0.517	0.15
33_D	96_D	0.517	0.15
92_A	143_V	0.516	0.15
224_L	254_D	0.515	0.15
23_V	298_S	0.514	0.15
23_V	346_A	0.513	0.15
7_S	210_L	0.513	0.15
246_L	326_R	0.512	0.14
10_D	23_V	0.512	0.14
255_G	336_G	0.511	0.14
132_S	157_A	0.510	0.14
236_H	348_V	0.510	0.14
7_S	33_D	0.508	0.14
31_E	75_V	0.508	0.14
238_V	257_G	0.506	0.14
84_A	276_D	0.506	0.14
191_A	286_D	0.506	0.14
254_D	275_Y	0.506	0.14
104_M	131_L	0.506	0.14
128_S	181_V	0.505	0.14
289_R	360_D	0.504	0.14
144_V	163_A	0.503	0.14
136_V	305_D	0.503	0.14
174_H	194_L	0.503	0.14
94_G	248_G	0.502	0.14
219_V	242_G	0.502	0.14
149_A	181_V	0.500	0.14
80_G	106_A	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tp9A	2	0.6915	100	0.69	Contact Map
4efzA	2	0.6649	100	0.71	Contact Map
4yslA	2	0.6702	100	0.715	Contact Map
3r2uA	4	0.6915	100	0.717	Contact Map
4chlA	2	0.609	100	0.74	Contact Map
4ysbA	2	0.5878	100	0.74	Contact Map
2gcuA	3	0.609	100	0.749	Contact Map
1qh5A	1	0.5984	100	0.767	Contact Map
2qedA	1	0.5957	100	0.772	Contact Map
2p18A	1	0.6676	100	0.778	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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