GREMLIN Database
Q9HS22 - Uncharacterized protein
UniProt: Q9HS22 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (353)
Sequences: 441 (279)
Seq/√Len: 14.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_V73_V6.7691.00
158_A165_I4.9891.00
310_G314_A4.3511.00
144_V246_L4.0641.00
169_I239_F4.0421.00
32_F44_A3.6340.99
229_A238_V3.3730.99
102_G106_A3.3120.99
85_E89_S3.2570.99
169_I217_I3.2110.99
136_V163_A3.1710.98
286_D313_A3.1100.98
311_S314_A3.0340.98
167_H193_V2.9230.97
213_D226_V2.8490.97
331_D335_T2.7230.96
32_F37_V2.7130.96
254_D296_T2.6730.96
120_V135_L2.6280.95
272_G326_R2.6200.95
296_T320_S2.5390.94
74_V80_G2.5310.94
6_V80_G2.2900.90
80_G84_A2.2880.90
135_L144_V2.2460.89
111_V116_L2.2430.89
50_M81_E2.2340.89
119_G161_R2.1640.87
165_I217_I2.1200.86
143_V158_A2.0800.85
73_V95_V2.0610.84
50_M53_V2.0420.84
8_V80_G2.0410.84
216_E223_T2.0340.84
181_V192_R2.0170.83
134_L165_I1.9750.82
315_V322_L1.9730.82
155_V187_A1.9600.81
76_V100_L1.9450.81
283_A328_A1.9280.80
236_H257_G1.9170.80
12_Y126_P1.9050.79
49_Y54_A1.8690.78
229_A277_T1.8670.78
49_Y86_V1.8500.77
12_Y15_L1.8390.77
142_A169_I1.8180.76
174_H177_H1.8080.75
23_V39_G1.8000.75
81_E86_V1.7750.74
12_Y16_Q1.7620.73
324_L332_H1.7510.73
129_G365_E1.7360.72
80_G95_V1.7000.71
259_P347_I1.6920.70
238_V250_C1.6730.69
147_L154_Y1.6720.69
29_G33_D1.6630.69
5_T80_G1.6330.67
89_S97_A1.6180.67
28_D49_Y1.6160.67
31_E224_L1.6110.66
120_V246_L1.5890.65
123_F157_A1.5490.63
170_D174_H1.5330.62
144_V239_F1.5140.61
49_Y81_E1.5110.61
15_L21_V1.5000.61
78_A82_A1.4880.60
171_S344_D1.4850.60
155_V188_T1.4820.60
108_G128_S1.4810.60
120_V161_R1.4800.60
91_R97_A1.4570.58
140_A166_T1.4530.58
14_W72_P1.4530.58
81_E105_D1.4480.58
168_A226_V1.4360.57
62_A65_V1.4360.57
50_M86_V1.4200.56
236_H250_C1.4140.56
104_M129_G1.4010.55
74_V100_L1.3930.55
76_V152_D1.3710.54
80_G101_E1.3660.53
96_D358_D1.3550.53
254_D320_S1.3540.53
143_V146_P1.3490.52
277_T357_I1.3360.52
6_V74_V1.3300.51
226_V237_L1.3210.51
7_S101_E1.3180.51
49_Y53_V1.3040.50
195_P348_V1.2980.50
211_A226_V1.2960.49
128_S257_G1.2930.49
74_V326_R1.2920.49
46_H54_A1.2870.49
281_L290_V1.2760.48
170_D177_H1.2690.48
271_A330_V1.2610.47
195_P338_P1.2570.47
127_S236_H1.2540.47
296_T310_G1.2450.47
73_V314_A1.2400.46
127_S211_A1.2340.46
310_G320_S1.2310.46
199_T235_E1.2120.45
63_S241_W1.2080.45
32_F36_C1.2030.44
262_E342_A1.1940.44
37_V76_V1.1850.43
11_L87_A1.1830.43
54_A59_G1.1820.43
31_E44_A1.1720.43
135_L222_R1.1720.43
135_L223_T1.1690.42
20_E243_D1.1640.42
5_T33_D1.1500.41
198_A201_R1.1450.41
49_Y52_V1.1410.41
156_E159_A1.1360.41
15_L299_T1.1250.40
229_A250_C1.1210.40
112_T116_L1.1200.40
169_I224_L1.1160.40
86_V189_A1.1160.40
152_D218_A1.1140.39
121_V157_A1.1130.39
162_D317_A1.1100.39
8_V97_A1.1090.39
81_E85_E1.1050.39
168_A246_L1.1020.39
13_N271_A1.0970.39
128_S210_L1.0960.38
194_L199_T1.0940.38
224_L293_G1.0910.38
234_S269_E1.0870.38
268_R271_A1.0850.38
284_T288_R1.0840.38
14_W19_R1.0840.38
253_L320_S1.0830.38
104_M130_C1.0820.38
71_E91_R1.0790.38
153_A165_I1.0770.37
262_E270_L1.0740.37
146_P362_L1.0670.37
151_V222_R1.0670.37
160_A186_D1.0660.37
21_V74_V1.0650.37
196_A212_T1.0540.36
85_E97_A1.0430.36
189_A314_A1.0420.36
7_S146_P1.0390.35
235_E319_L1.0390.35
253_L296_T1.0370.35
269_E350_V1.0310.35
276_D326_R1.0310.35
13_N356_A1.0270.35
192_R291_M1.0250.35
184_L310_G1.0240.35
166_T178_V1.0210.35
144_V241_W1.0200.35
304_R307_G1.0180.34
147_L310_G1.0140.34
26_V31_E1.0110.34
250_C257_G1.0080.34
59_G189_A1.0080.34
162_D318_E1.0070.34
215_D221_D1.0070.34
151_V154_Y1.0070.34
93_E333_V1.0030.34
282_T322_L1.0020.34
66_P235_E0.9990.33
144_V169_I0.9980.33
236_H274_Q0.9970.33
33_D80_G0.9970.33
152_D165_I0.9910.33
143_V184_L0.9890.33
260_D347_I0.9880.33
20_E208_D0.9840.33
162_D178_V0.9830.33
310_G318_E0.9830.33
229_A275_Y0.9810.33
178_V323_D0.9770.32
255_G278_L0.9730.32
233_T260_D0.9680.32
127_S132_S0.9660.32
366_R373_V0.9640.32
50_M54_A0.9550.31
127_S150_A0.9430.31
89_S98_V0.9430.31
151_V187_A0.9420.31
6_V9_R0.9400.31
120_V142_A0.9380.31
33_D216_E0.9370.30
63_S144_V0.9300.30
6_V193_V0.9290.30
35_W104_M0.9290.30
104_M365_E0.9270.30
147_L184_L0.9270.30
10_D120_V0.9240.30
6_V95_V0.9210.30
168_A181_V0.9170.30
195_P237_L0.9150.29
198_A348_V0.9140.29
146_P154_Y0.9090.29
18_D95_V0.9090.29
233_T259_P0.9040.29
11_L74_V0.9010.29
143_V165_I0.8990.29
281_L364_L0.8990.29
94_G107_W0.8990.29
216_E226_V0.8980.29
111_V115_D0.8950.29
50_M79_V0.8950.29
49_Y82_A0.8870.28
295_V319_L0.8870.28
135_L215_D0.8850.28
130_C174_H0.8850.28
53_V224_L0.8830.28
20_E96_D0.8760.28
277_T295_V0.8730.28
211_A291_M0.8710.27
29_G152_D0.8680.27
150_A362_L0.8660.27
28_D31_E0.8640.27
173_V235_E0.8610.27
6_V163_A0.8590.27
225_G240_S0.8590.27
198_A202_G0.8570.27
122_Q125_R0.8560.27
9_R23_V0.8530.27
256_V278_L0.8520.27
59_G187_A0.8520.27
255_G357_I0.8490.26
189_A356_A0.8460.26
20_E70_R0.8460.26
83_S102_G0.8440.26
213_D317_A0.8430.26
247_T290_V0.8420.26
108_G368_P0.8390.26
141_A163_A0.8390.26
108_G362_L0.8280.26
199_T338_P0.8210.25
178_V361_T0.8200.25
128_S149_A0.8200.25
171_S285_A0.8200.25
255_G348_V0.8190.25
59_G165_I0.8180.25
90_L107_W0.8170.25
28_D295_V0.8140.25
83_S89_S0.8110.25
15_L356_A0.8110.25
72_P317_A0.8080.25
108_G342_A0.8080.25
18_D45_R0.8070.25
83_S219_V0.8070.25
201_R349_A0.8070.25
85_E98_V0.8040.25
162_D243_D0.8040.25
58_S277_T0.8010.24
156_E215_D0.7990.24
62_A153_A0.7970.24
134_L222_R0.7930.24
182_R186_D0.7890.24
21_V53_V0.7850.24
49_Y78_A0.7830.24
108_G131_L0.7790.24
216_E221_D0.7780.23
281_L337_L0.7760.23
122_Q292_P0.7740.23
127_S182_R0.7730.23
325_D330_V0.7720.23
101_E293_G0.7710.23
13_N33_D0.7690.23
263_D319_L0.7670.23
138_G327_A0.7650.23
276_D280_A0.7650.23
78_A81_E0.7640.23
6_V20_E0.7620.23
250_C275_Y0.7600.23
67_D221_D0.7540.23
22_D51_E0.7540.23
330_V335_T0.7530.22
16_Q23_V0.7530.22
70_R140_A0.7520.22
31_E72_P0.7500.22
33_D221_D0.7480.22
98_V277_T0.7470.22
248_G252_F0.7430.22
187_A346_A0.7430.22
29_G62_A0.7430.22
194_L206_D0.7410.22
221_D287_E0.7410.22
135_L227_T0.7410.22
106_A166_T0.7390.22
95_V152_D0.7380.22
262_E370_N0.7350.22
188_T243_D0.7350.22
62_A66_P0.7330.22
154_Y347_I0.7330.22
176_D294_H0.7290.22
29_G81_E0.7280.22
301_H308_V0.7280.22
102_G159_A0.7270.21
71_E97_A0.7230.21
142_A215_D0.7220.21
202_G262_E0.7210.21
141_A365_E0.7200.21
128_S202_G0.7200.21
61_A65_V0.7200.21
239_F285_A0.7190.21
120_V268_R0.7180.21
263_D270_L0.7130.21
23_V120_V0.7130.21
17_A221_D0.7130.21
96_D283_A0.7070.21
79_V82_A0.7050.21
104_M108_G0.7050.21
197_G234_S0.7000.20
46_H70_R0.6990.20
49_Y235_E0.6970.20
102_G105_D0.6970.20
67_D76_V0.6970.20
278_L322_L0.6950.20
23_V50_M0.6910.20
75_V306_G0.6880.20
326_R357_I0.6860.20
28_D81_E0.6860.20
156_E184_L0.6860.20
250_C255_G0.6830.20
74_V84_A0.6750.20
191_A276_D0.6740.20
104_M174_H0.6710.19
95_V286_D0.6700.19
188_T310_G0.6700.19
130_C365_E0.6670.19
26_V86_V0.6670.19
127_S340_R0.6660.19
131_L177_H0.6650.19
50_M82_A0.6650.19
173_V198_A0.6610.19
59_G72_P0.6600.19
46_H49_Y0.6590.19
115_D121_V0.6590.19
181_V263_D0.6580.19
83_S99_N0.6580.19
47_T91_R0.6580.19
156_E166_T0.6570.19
13_N189_A0.6550.19
177_H194_L0.6530.19
253_L310_G0.6520.19
173_V348_V0.6520.19
100_L163_A0.6520.19
349_A373_V0.6500.19
50_M85_E0.6500.19
340_R348_V0.6500.19
150_A361_T0.6490.19
271_A343_N0.6480.19
187_A217_I0.6460.19
35_W129_G0.6460.19
334_T337_L0.6430.18
127_S339_P0.6430.18
134_L163_A0.6420.18
144_V282_T0.6400.18
247_T272_G0.6400.18
115_D157_A0.6390.18
316_A342_A0.6390.18
201_R354_E0.6380.18
35_W365_E0.6380.18
33_D47_T0.6300.18
24_L132_S0.6300.18
8_V74_V0.6300.18
121_V309_V0.6300.18
157_A340_R0.6290.18
60_D63_S0.6290.18
277_T281_L0.6280.18
130_C177_H0.6250.18
130_C170_D0.6250.18
16_Q126_P0.6220.18
80_G100_L0.6210.18
131_L174_H0.6170.18
60_D276_D0.6160.18
144_V326_R0.6150.18
178_V284_T0.6140.18
20_E45_R0.6140.18
214_G288_R0.6130.18
195_P198_A0.6120.17
135_L225_G0.6110.17
143_V299_T0.6100.17
246_L291_M0.6080.17
132_S257_G0.6070.17
160_A280_A0.6050.17
237_L339_P0.6050.17
78_A319_L0.6050.17
299_T327_A0.6000.17
97_A100_L0.6000.17
241_W246_L0.6000.17
79_V180_G0.5990.17
21_V80_G0.5980.17
129_G141_A0.5980.17
30_A37_V0.5970.17
286_D305_D0.5970.17
61_A92_A0.5970.17
122_Q261_L0.5950.17
28_D86_V0.5940.17
268_R276_D0.5920.17
234_S322_L0.5920.17
16_Q184_L0.5910.17
137_D313_A0.5900.17
85_E91_R0.5890.17
145_D233_T0.5880.17
102_G109_A0.5870.17
52_V86_V0.5860.17
35_W130_C0.5860.17
169_I356_A0.5840.17
261_L329_F0.5830.17
348_V364_L0.5830.17
287_E327_A0.5820.17
235_E295_V0.5820.17
170_D176_D0.5810.16
128_S340_R0.5800.16
132_S154_Y0.5800.16
39_G358_D0.5800.16
343_N364_L0.5790.16
159_A216_E0.5780.16
204_A250_C0.5770.16
75_V214_G0.5770.16
175_A258_R0.5760.16
172_H258_R0.5760.16
172_H175_A0.5760.16
255_G350_V0.5740.16
160_A327_A0.5740.16
259_P329_F0.5730.16
215_D218_A0.5730.16
36_C320_S0.5730.16
115_D226_V0.5720.16
125_R261_L0.5720.16
47_T61_A0.5710.16
215_D331_D0.5700.16
347_I367_G0.5700.16
347_I369_N0.5700.16
64_V309_V0.5700.16
113_S116_L0.5700.16
227_T283_A0.5650.16
170_D179_S0.5640.16
94_G103_G0.5620.16
214_G306_G0.5620.16
128_S131_L0.5600.16
98_V134_L0.5560.16
135_L204_A0.5560.16
34_A366_R0.5560.16
180_G368_P0.5560.16
113_S242_G0.5530.16
162_D206_D0.5510.16
36_C304_R0.5510.16
146_P276_D0.5510.16
126_P296_T0.5500.16
153_A222_R0.5500.16
85_E88_E0.5490.16
237_L267_A0.5480.16
223_T227_T0.5480.16
134_L158_A0.5480.16
45_R243_D0.5470.15
28_D85_E0.5470.15
52_V81_E0.5460.15
29_G238_V0.5450.15
80_G174_H0.5450.15
176_D329_F0.5450.15
7_S165_I0.5440.15
13_N357_I0.5440.15
240_S284_T0.5410.15
146_P226_V0.5390.15
7_S283_A0.5390.15
317_A359_E0.5380.15
171_S288_R0.5380.15
29_G46_H0.5370.15
8_V164_T0.5370.15
106_A110_F0.5360.15
151_V287_E0.5330.15
5_T29_G0.5310.15
219_V276_D0.5300.15
15_L91_R0.5300.15
11_L247_T0.5290.15
190_A246_L0.5280.15
53_V81_E0.5280.15
259_P270_L0.5270.15
7_S155_V0.5260.15
195_P339_P0.5260.15
162_D328_A0.5260.15
252_F312_L0.5240.15
114_H254_D0.5240.15
149_A342_A0.5240.15
120_V298_S0.5240.15
342_A347_I0.5230.15
343_N348_V0.5230.15
171_S220_G0.5220.15
159_A327_A0.5220.15
252_F294_H0.5210.15
137_D292_P0.5200.15
124_E295_V0.5180.15
32_F169_I0.5170.15
33_D96_D0.5170.15
92_A143_V0.5160.15
224_L254_D0.5150.15
23_V298_S0.5140.15
23_V346_A0.5130.15
7_S210_L0.5130.15
246_L326_R0.5120.14
10_D23_V0.5120.14
255_G336_G0.5110.14
132_S157_A0.5100.14
236_H348_V0.5100.14
7_S33_D0.5080.14
31_E75_V0.5080.14
238_V257_G0.5060.14
84_A276_D0.5060.14
191_A286_D0.5060.14
254_D275_Y0.5060.14
104_M131_L0.5060.14
128_S181_V0.5050.14
289_R360_D0.5040.14
144_V163_A0.5030.14
136_V305_D0.5030.14
174_H194_L0.5030.14
94_G248_G0.5020.14
219_V242_G0.5020.14
149_A181_V0.5000.14
80_G106_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.6915 100 0.69 Contact Map
4efzA 2 0.6649 100 0.71 Contact Map
4yslA 2 0.6702 100 0.715 Contact Map
3r2uA 4 0.6915 100 0.717 Contact Map
4chlA 2 0.609 100 0.74 Contact Map
4ysbA 2 0.5878 100 0.74 Contact Map
2gcuA 3 0.609 100 0.749 Contact Map
1qh5A 1 0.5984 100 0.767 Contact Map
2qedA 1 0.5957 100 0.772 Contact Map
2p18A 1 0.6676 100 0.778 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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