GREMLIN Database
DAPAL - Uncharacterized DapA-like lyase VNG_0444G
UniProt: Q9HS19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (285)
Sequences: 10351 (6825)
Seq/√Len: 404.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_D241_R3.8331.00
43_R80_E3.3041.00
28_D32_S3.1401.00
130_V164_A3.1121.00
271_L295_E3.0131.00
39_A80_E2.8101.00
35_A72_R2.7291.00
35_A76_A2.6261.00
39_A76_A2.5901.00
107_A141_D2.5791.00
71_D105_H2.5281.00
91_V103_A2.4841.00
233_A241_R2.4541.00
207_G212_C2.4411.00
103_A114_V2.2451.00
241_R244_A2.1391.00
43_R84_E2.0681.00
233_A238_D2.0251.00
134_R168_I2.0231.00
232_E236_E2.0151.00
126_G158_S2.0011.00
20_V52_G1.9991.00
208_L234_Y1.9771.00
228_V232_E1.9761.00
138_A168_I1.9631.00
126_G161_T1.9591.00
44_M48_A1.9521.00
295_E299_A1.9101.00
96_T132_H1.9071.00
134_R138_A1.8891.00
51_H232_E1.8891.00
34_D37_T1.8811.00
156_E183_W1.8591.00
267_A291_R1.8561.00
72_R75_T1.8561.00
67_P98_Q1.8381.00
43_R47_D1.8311.00
226_L248_T1.8181.00
127_T131_E1.8011.00
39_A79_D1.7841.00
127_T164_A1.7691.00
48_A225_E1.7451.00
130_V134_R1.7211.00
42_A77_V1.7071.00
163_A190_A1.6961.00
72_R76_A1.6781.00
145_Y173_G1.6631.00
38_T77_V1.6581.00
75_T79_D1.6471.00
78_V87_V1.6471.00
270_G277_G1.6371.00
131_E134_R1.6271.00
137_A168_I1.6171.00
21_P220_A1.6001.00
116_V136_V1.5861.00
37_T40_D1.5831.00
292_A295_E1.5731.00
69_E280_R1.5541.00
55_P77_V1.5481.00
158_S161_T1.5321.00
76_A80_E1.5231.00
244_A248_T1.5191.00
103_A140_V1.5141.00
74_V89_A1.5021.00
162_L174_V1.4921.00
46_V85_V1.4671.00
26_A38_T1.4651.00
38_T73_V1.4411.00
164_A167_E1.4281.00
99_T136_V1.3931.00
107_A140_V1.3811.00
288_D292_A1.3591.00
51_H228_V1.3511.00
24_V269_L1.3501.00
229_G241_R1.3491.00
107_A142_C1.3481.00
131_E135_R1.3461.00
105_H108_S1.3441.00
288_D291_R1.3421.00
229_G233_A1.3381.00
20_V54_F1.3371.00
292_A296_A1.3361.00
267_A271_L1.3351.00
67_P101_A1.3121.00
258_R293_A1.3081.00
134_R167_E1.3011.00
76_A79_D1.2991.00
17_H235_D1.2871.00
287_D290_D1.2751.00
114_V140_V1.2641.00
71_D101_A1.2641.00
225_E229_G1.2621.00
93_A99_T1.2531.00
95_S98_Q1.2521.00
100_V135_R1.2521.00
234_Y239_R1.2351.00
296_A300_D1.2341.00
71_D75_T1.2341.00
88_I113_G1.2291.00
19_V50_V1.2231.00
67_P105_H1.2201.00
145_Y216_V1.2151.00
68_S72_R1.2091.00
205_A242_A1.1911.00
270_G275_D1.1831.00
74_V106_A1.1821.00
188_V196_F1.1811.00
61_E266_K1.1721.00
56_L73_V1.1631.00
75_T105_H1.1621.00
239_R243_R1.1601.00
135_R281_S1.1581.00
42_A81_V1.1581.00
32_S97_R1.1561.00
137_A170_T1.1471.00
160_E190_A1.1361.00
195_T213_A1.1341.00
231_Y235_D1.1301.00
104_E108_S1.1201.00
46_V84_E1.1191.00
28_D34_D1.1101.00
135_R138_A1.1091.00
78_V112_D1.1051.00
229_G232_E1.0901.00
135_R139_A1.0871.00
71_D108_S1.0821.00
81_V87_V1.0811.00
186_Q190_A1.0801.00
36_D39_A1.0721.00
240_E243_R1.0711.00
27_F65_L1.0681.00
267_A270_G1.0631.00
35_A39_A1.0621.00
267_A295_E1.0611.00
268_A298_L1.0601.00
296_A299_A1.0591.00
88_I145_Y1.0541.00
75_T109_V1.0521.00
104_E139_A1.0471.00
114_V142_C1.0321.00
127_T287_D1.0271.00
127_T130_V1.0251.00
42_A80_E1.0251.00
21_P45_V1.0241.00
29_A278_P1.0201.00
91_V106_A1.0151.00
100_V104_E1.0081.00
105_H109_V1.0071.00
209_D239_R1.0041.00
286_L290_D1.0001.00
17_H213_A0.9971.00
19_V228_V0.9931.00
241_R245_R0.9861.00
54_F115_V0.9821.00
67_P102_H0.9761.00
286_L294_L0.9701.00
293_A296_A0.9681.00
89_A111_A0.9661.00
270_G291_R0.9661.00
255_A297_D0.9651.00
21_P50_V0.9641.00
165_L171_L0.9601.00
39_A43_R0.9601.00
37_T276_A0.9561.00
92_G117_V0.9561.00
146_V162_L0.9551.00
37_T275_D0.9541.00
291_R295_E0.9511.00
44_M274_F0.9471.00
186_Q254_A0.9471.00
290_D293_A0.9471.00
114_V144_V0.9451.00
137_A144_V0.9431.00
130_V161_T0.9431.00
31_E97_R0.9411.00
184_L207_G0.9401.00
219_V253_R0.9401.00
233_A245_R0.9351.00
148_H156_E0.9301.00
166_A194_L0.9281.00
243_R247_S0.9271.00
41_H269_L0.9271.00
23_V45_V0.9211.00
70_R102_H0.9181.00
131_E284_R0.9171.00
93_A98_Q0.9141.00
118_T155_N0.9131.00
100_V139_A0.9131.00
101_A105_H0.9131.00
126_G164_A0.9071.00
68_S101_A0.9061.00
51_H231_Y0.9011.00
78_V111_A0.8991.00
46_V81_V0.8961.00
271_L299_A0.8941.00
78_V109_V0.8931.00
129_A155_N0.8931.00
209_D243_R0.8871.00
130_V167_E0.8861.00
91_V114_V0.8841.00
251_E300_D0.8801.00
208_L231_Y0.8781.00
87_V111_A0.8781.00
42_A76_A0.8731.00
159_L190_A0.8701.00
277_G291_R0.8701.00
104_E107_A0.8691.00
101_A104_E0.8671.00
289_D292_A0.8631.00
27_F280_R0.8561.00
270_G276_A0.8531.00
31_E281_S0.8501.00
217_S220_A0.8471.00
237_G240_E0.8441.00
223_A252_V0.8431.00
29_A276_A0.8411.00
197_L214_G0.8371.00
204_L215_L0.8361.00
297_D300_D0.8341.00
55_P73_V0.8311.00
137_A171_L0.8291.00
50_V224_P0.8281.00
96_T100_V0.8261.00
209_D234_Y0.8251.00
230_L245_R0.8211.00
19_V215_L0.8101.00
19_V231_Y0.8071.00
289_D293_A0.8031.00
36_D40_D0.8031.00
116_V144_V0.8011.00
159_L186_Q0.8011.00
271_L291_R0.8001.00
56_L89_A0.7981.00
198_A207_G0.7961.00
130_V168_I0.7941.00
168_I171_L0.7941.00
23_V53_V0.7911.00
159_L163_A0.7831.00
74_V111_A0.7831.00
74_V109_V0.7821.00
31_E278_P0.7781.00
19_V220_A0.7771.00
40_D274_F0.7741.00
240_E244_A0.7711.00
68_S71_D0.7661.00
23_V38_T0.7631.00
229_G245_R0.7601.00
65_L73_V0.7581.00
223_A249_V0.7551.00
48_A224_P0.7521.00
58_T121_Y0.7511.00
246_Q250_Y0.7501.00
186_Q189_D0.7471.00
106_A111_A0.7471.00
206_P209_D0.7441.00
223_A226_L0.7421.00
97_R101_A0.7391.00
38_T42_A0.7321.00
250_Y254_A0.7311.00
134_R164_A0.7261.00
81_V84_E0.7251.00
131_E281_S0.7251.00
147_Y175_K0.7211.00
226_L229_G0.7201.00
86_P112_D0.7191.00
99_T116_V0.7191.00
149_I153_T0.7191.00
53_V81_V0.7191.00
110_G142_C0.7171.00
33_L38_T0.7161.00
159_L183_W0.7141.00
277_G285_G0.7121.00
126_G160_E0.7111.00
52_G88_I0.7091.00
191_H194_L0.7081.00
278_P285_G0.7061.00
96_T135_R0.7061.00
28_D278_P0.7041.00
184_L188_V0.7021.00
205_A234_Y0.7021.00
162_L187_A0.6971.00
118_T157_L0.6971.00
28_D36_D0.6971.00
42_A53_V0.6941.00
263_A279_L0.6931.00
46_V80_E0.6911.00
225_E272_R0.6891.00
185_G189_D0.6891.00
81_V85_V0.6881.00
206_P210_V0.6871.00
56_L65_L0.6851.00
258_R290_D0.6841.00
91_V116_V0.6800.99
156_E180_D0.6780.99
157_L162_L0.6780.99
230_L234_Y0.6760.99
182_P202_S0.6730.99
62_F90_G0.6720.99
184_L196_F0.6660.99
293_A297_D0.6660.99
148_H176_D0.6640.99
128_A284_R0.6640.99
71_D102_H0.6620.99
16_L113_G0.6620.99
45_V50_V0.6600.99
236_E241_R0.6550.99
67_P71_D0.6520.99
263_A286_L0.6510.99
146_V157_L0.6510.99
34_D275_D0.6510.99
71_D109_V0.6470.99
125_D263_A0.6450.99
44_M272_R0.6450.99
71_D106_A0.6450.99
41_H45_V0.6420.99
233_A236_E0.6420.99
20_V88_I0.6380.99
269_L272_R0.6370.99
204_L230_L0.6340.99
74_V78_V0.6340.99
292_A299_A0.6320.99
286_L291_R0.6320.99
141_D170_T0.6320.99
33_L73_V0.6320.99
66_T97_R0.6320.99
145_Y172_A0.6320.99
17_H51_H0.6310.99
271_L298_L0.6310.99
205_A239_R0.6250.99
23_V77_V0.6230.99
259_G290_D0.6220.99
75_T108_S0.6220.99
28_D31_E0.6210.99
279_L283_L0.6210.99
55_P87_V0.6180.99
63_P122_Y0.6180.99
125_D128_A0.6150.99
189_D247_S0.6140.99
98_Q101_A0.6120.99
172_A195_T0.6090.99
206_P246_Q0.6040.99
45_V48_A0.6030.99
232_E235_D0.5980.99
185_G246_Q0.5910.99
267_A279_L0.5910.99
43_R46_V0.5900.99
188_V213_A0.5900.99
180_D183_W0.5890.99
56_L70_R0.5880.99
163_A191_H0.5870.99
185_G210_V0.5870.99
83_G112_D0.5870.99
160_E186_Q0.5860.99
185_G206_P0.5860.99
160_E163_A0.5830.98
35_A80_E0.5800.98
244_A247_S0.5790.98
58_T147_Y0.5750.98
125_D259_G0.5740.98
205_A246_Q0.5730.98
288_D295_E0.5720.98
279_L284_R0.5710.98
33_L76_A0.5700.98
183_W187_A0.5680.98
161_T164_A0.5680.98
268_A271_L0.5670.98
208_L235_D0.5620.98
222_V268_A0.5610.98
189_D251_E0.5590.98
181_V203_L0.5580.98
157_L161_T0.5580.98
49_G228_V0.5580.98
123_P151_S0.5570.98
79_D82_G0.5560.98
27_F69_E0.5560.98
222_V269_L0.5550.98
24_V265_V0.5530.98
173_G195_T0.5520.98
111_A142_C0.5460.98
54_F88_I0.5440.98
218_A265_V0.5440.98
204_L227_V0.5430.98
118_T133_Y0.5420.98
89_A106_A0.5410.98
200_S203_L0.5400.97
127_T284_R0.5400.97
138_A170_T0.5380.97
133_Y171_L0.5360.97
50_V228_V0.5350.97
165_L168_I0.5340.97
132_H135_R0.5340.97
48_A228_V0.5330.97
222_V265_V0.5320.97
176_D184_L0.5300.97
176_D179_K0.5290.97
88_I115_V0.5290.97
145_Y195_T0.5280.97
255_A293_A0.5280.97
252_V256_L0.5270.97
205_A209_D0.5270.97
245_R248_T0.5250.97
68_S105_H0.5240.97
116_V133_Y0.5240.97
56_L74_V0.5220.97
32_S72_R0.5210.97
234_Y242_A0.5210.97
219_V227_V0.5200.97
260_P264_G0.5180.97
22_P218_A0.5180.97
78_V82_G0.5170.97
23_V42_A0.5160.97
41_H44_M0.5150.97
113_G172_A0.5130.97
22_P217_S0.5130.97
107_A139_A0.5130.97
233_A242_A0.5120.97
261_Y264_G0.5110.96
37_T274_F0.5110.96
187_A196_F0.5100.96
267_A286_L0.5080.96
256_L265_V0.5080.96
29_A275_D0.5060.96
99_T103_A0.5050.96
259_G287_D0.5040.96
100_V136_V0.5040.96
53_V85_V0.5020.96
264_G286_L0.5000.96
196_F207_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cprA 3 0.9868 100 0.062 Contact Map
3l21A 5 0.9704 100 0.066 Contact Map
4oe7A 3 0.9572 100 0.066 Contact Map
4i7wA 3 0.9507 100 0.068 Contact Map
3si9A 3 0.9572 100 0.071 Contact Map
3na8A 3 0.9507 100 0.072 Contact Map
3a5fA 3 0.9507 100 0.072 Contact Map
3s5oA 3 0.9572 100 0.072 Contact Map
2ojpA 2 0.9474 100 0.072 Contact Map
3eb2A 3 0.9539 100 0.073 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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