GREMLIN Database
GLCDH - Glucose 1-dehydrogenase
UniProt: Q9HS17 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (295)
Sequences: 52484 (36416)
Seq/√Len: 2120.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_R70_A3.2871.00
33_L68_V3.2031.00
335_A338_D3.0191.00
174_S199_T2.8601.00
29_L70_A2.8221.00
78_S81_Q2.7341.00
82_L137_L2.6991.00
81_Q136_A2.6341.00
28_V134_L2.5741.00
20_R126_Y2.5341.00
143_A330_V2.5221.00
180_N202_C2.4841.00
192_A222_T2.4461.00
5_V16_V2.4121.00
31_R68_V2.3941.00
330_V352_Q2.3811.00
31_R126_Y2.3731.00
175_A191_L2.3671.00
65_A122_F2.3041.00
213_I217_E2.2541.00
24_T27_S2.2371.00
65_A85_P2.2321.00
214_D218_R2.1961.00
76_R131_A2.1921.00
140_S316_A2.1631.00
188_L221_A2.1631.00
29_L128_T2.1411.00
159_E194_R2.1191.00
199_T223_Y2.0991.00
70_A126_Y2.0961.00
313_D317_A2.0621.00
193_A319_P2.0191.00
332_D335_A1.9961.00
151_V186_L1.9331.00
214_D217_E1.9271.00
159_E310_A1.9061.00
176_L203_L1.8821.00
176_L241_V1.8621.00
242_D262_A1.8591.00
266_V296_A1.8541.00
207_S214_D1.7881.00
201_Y241_V1.7851.00
213_I224_I1.7541.00
22_D71_D1.7461.00
338_D341_R1.7401.00
331_H339_A1.7371.00
204_G213_I1.7291.00
266_V298_V1.7261.00
199_T222_T1.7201.00
215_I218_R1.7171.00
68_V82_L1.7141.00
29_L126_Y1.7081.00
71_D79_A1.6651.00
261_L267_A1.6491.00
4_I336_F1.6451.00
77_F81_Q1.6391.00
178_L257_A1.6271.00
143_A352_Q1.5921.00
123_M340_F1.5791.00
23_P128_T1.5741.00
27_S130_P1.5711.00
77_F136_A1.5701.00
29_L71_D1.5671.00
244_V261_L1.5631.00
261_L295_K1.5601.00
337_A341_R1.5561.00
82_L139_D1.5451.00
32_T65_A1.5291.00
261_L265_G1.5281.00
26_G130_P1.5271.00
173_D266_V1.5231.00
27_S128_T1.5121.00
223_Y237_A1.5001.00
25_P74_D1.4971.00
233_D236_A1.4961.00
205_R226_S1.4771.00
137_L145_G1.4581.00
207_S228_T1.4531.00
225_D228_T1.4491.00
244_V257_A1.4481.00
28_V77_F1.4401.00
193_A314_T1.4391.00
34_R143_A1.4231.00
207_S225_D1.4041.00
45_I340_F1.4001.00
23_P29_L1.3991.00
206_R211_P1.3901.00
313_D316_A1.3821.00
174_S201_Y1.3711.00
3_A18_R1.3661.00
34_R352_Q1.3601.00
8_K12_T1.3581.00
187_T245_Y1.3551.00
69_V77_F1.3501.00
178_L203_L1.3411.00
155_E159_E1.3391.00
8_K14_R1.3261.00
25_P73_T1.3081.00
33_L82_L1.2961.00
332_D352_Q1.2931.00
32_T127_F1.2891.00
164_S173_D1.2891.00
188_L202_C1.2881.00
4_I15_L1.2871.00
9_A12_T1.2841.00
20_R29_L1.2751.00
26_G131_A1.2491.00
174_S242_D1.2311.00
77_F134_L1.2221.00
189_A321_W1.2161.00
314_T319_P1.2051.00
217_E224_I1.1981.00
305_A309_R1.1931.00
25_P72_P1.1891.00
173_D242_D1.1771.00
205_R227_R1.1771.00
310_A313_D1.1741.00
156_K307_H1.1591.00
129_S134_L1.1511.00
33_L66_I1.1501.00
336_F351_V1.1411.00
201_Y223_Y1.1231.00
5_V18_R1.1231.00
213_I225_D1.1131.00
215_I346_S1.1021.00
230_P233_D1.0981.00
154_A187_T1.0971.00
70_A79_A1.0961.00
30_V83_V1.0921.00
248_T253_H1.0871.00
159_E307_H1.0861.00
30_V67_G1.0811.00
217_E223_Y1.0811.00
15_L334_A1.0791.00
35_V123_M1.0641.00
23_P27_S1.0641.00
256_D259_D1.0621.00
34_R350_A1.0561.00
207_S213_I1.0481.00
155_E310_A1.0441.00
4_I333_T1.0441.00
37_V339_A1.0411.00
331_H335_A1.0401.00
259_D285_D1.0211.00
157_A270_L1.0171.00
202_C216_I1.0161.00
144_H321_W1.0161.00
309_R313_D1.0151.00
154_A190_I1.0121.00
151_V311_A1.0031.00
162_L243_M1.0031.00
180_N204_G0.9911.00
202_C221_A0.9871.00
173_D243_M0.9851.00
180_N188_L0.9811.00
188_L200_L0.9751.00
310_A314_T0.9741.00
157_A245_Y0.9691.00
141_L145_G0.9641.00
180_N216_I0.9621.00
212_T346_S0.9561.00
211_P214_D0.9561.00
84_A312_A0.9531.00
232_A236_A0.9471.00
255_F259_D0.9471.00
38_D64_E0.9441.00
35_V122_F0.9411.00
282_P285_D0.9381.00
8_K11_R0.9371.00
123_M336_F0.9341.00
185_L215_I0.9291.00
176_L260_A0.9281.00
306_R310_A0.9121.00
246_E249_G0.9121.00
20_R71_D0.9101.00
5_V60_V0.9101.00
31_R125_D0.9101.00
206_R212_T0.9071.00
331_H349_T0.8961.00
290_L297_V0.8861.00
178_L244_V0.8831.00
152_S307_H0.8821.00
20_R70_A0.8821.00
4_I13_P0.8801.00
206_R225_D0.8771.00
26_G72_P0.8741.00
59_L120_D0.8711.00
75_T131_A0.8691.00
177_V191_L0.8691.00
147_L315_L0.8681.00
177_V187_T0.8591.00
322_L326_I0.8571.00
38_D63_H0.8551.00
205_R213_I0.8551.00
314_T317_A0.8541.00
264_A294_N0.8531.00
3_A60_V0.8511.00
194_R310_A0.8461.00
159_E163_A0.8401.00
72_P79_A0.8391.00
122_F127_F0.8381.00
174_S239_Q0.8371.00
28_V131_A0.8321.00
204_G224_I0.8301.00
191_L200_L0.8301.00
65_A127_F0.8261.00
36_G64_E0.8231.00
203_L226_S0.8221.00
78_S136_A0.8221.00
85_P129_S0.8211.00
174_S241_V0.8201.00
123_M351_V0.8181.00
190_I311_A0.8181.00
135_V309_R0.8181.00
306_R309_R0.8151.00
244_V267_A0.8131.00
22_D29_L0.8131.00
257_A267_A0.8121.00
24_T128_T0.8101.00
18_R120_D0.8081.00
216_I221_A0.8081.00
231_V234_I0.8011.00
178_L253_H0.7991.00
158_I191_L0.7961.00
229_T233_D0.7891.00
247_A270_L0.7891.00
139_D316_A0.7891.00
154_A186_L0.7791.00
83_V134_L0.7771.00
23_P71_D0.7711.00
38_D41_D0.7691.00
207_S211_P0.7651.00
66_I82_L0.7611.00
201_Y237_A0.7591.00
18_R60_V0.7581.00
66_I137_L0.7571.00
40_T63_H0.7551.00
232_A256_D0.7531.00
190_I314_T0.7531.00
331_H351_V0.7531.00
269_L297_V0.7511.00
157_A187_T0.7451.00
345_T349_T0.7431.00
232_A259_D0.7391.00
200_L222_T0.7381.00
230_P256_D0.7381.00
15_L333_T0.7331.00
84_A137_L0.7321.00
312_A316_A0.7281.00
233_D237_A0.7271.00
26_G74_D0.7261.00
156_K294_N0.7251.00
290_L299_G0.7201.00
34_R66_I0.7191.00
243_M268_A0.7181.00
329_G349_T0.7161.00
76_R305_A0.7161.00
155_E311_A0.7151.00
215_I219_L0.7121.00
327_V330_V0.7111.00
163_A173_D0.7111.00
135_V308_F0.7101.00
177_V202_C0.7101.00
285_D293_E0.7091.00
255_F278_T0.7071.00
154_A183_L0.7061.00
314_T318_L0.7051.00
138_P316_A0.7041.00
66_I146_F0.7021.00
141_L315_L0.6971.00
172_P198_E0.6971.00
329_G338_D0.6961.00
4_I337_A0.6931.00
26_G132_D0.6931.00
241_V244_V0.6901.00
84_A148_T0.6901.00
174_S198_E0.6891.00
82_L140_S0.6861.00
8_K16_V0.6861.00
155_E314_T0.6851.00
21_P128_T0.6841.00
232_A235_P0.6841.00
290_L295_K0.6811.00
81_Q139_D0.6801.00
32_T35_V0.6771.00
329_G346_S0.6751.00
255_F285_D0.6751.00
10_D341_R0.6741.00
195_D198_E0.6741.00
246_E267_A0.6741.00
204_G216_I0.6731.00
189_A219_L0.6721.00
161_A243_M0.6691.00
185_L326_I0.6691.00
294_N304_N0.6681.00
72_P75_T0.6671.00
234_I241_V0.6641.00
28_V69_V0.6621.00
38_D150_P0.6621.00
153_V183_L0.6551.00
33_L352_Q0.6551.00
254_A267_A0.6541.00
215_I326_I0.6521.00
188_L219_L0.6501.00
263_P293_E0.6491.00
154_A158_I0.6491.00
204_G226_S0.6491.00
213_I216_I0.6491.00
243_M266_V0.6481.00
250_H253_H0.6481.00
11_R341_R0.6461.00
234_I237_A0.6461.00
64_E149_E0.6451.00
155_E307_H0.6441.00
159_E190_I0.6411.00
160_L307_H0.6411.00
159_E164_S0.6401.00
63_H149_E0.6391.00
162_L268_A0.6381.00
239_Q262_A0.6371.00
192_A200_L0.6361.00
231_V235_P0.6341.00
38_D149_E0.6331.00
150_P182_S0.6311.00
150_P186_L0.6291.00
43_E48_T0.6271.00
221_A224_I0.6261.00
251_A255_F0.6251.00
218_R321_W0.6241.00
161_A164_S0.6231.00
175_A243_M0.6221.00
34_R330_V0.6211.00
307_H310_A0.6191.00
331_H338_D0.6191.00
30_V85_P0.6181.00
86_T135_V0.6171.00
37_V123_M0.6171.00
142_A145_G0.6171.00
162_L266_V0.6171.00
187_T270_L0.6161.00
157_A268_A0.6101.00
35_V351_V0.6091.00
40_T44_V0.6061.00
6_V12_T0.6041.00
74_D131_A0.6031.00
56_A59_L0.6001.00
30_V134_L0.5991.00
339_A351_V0.5991.00
85_P134_L0.5981.00
176_L244_V0.5961.00
201_Y234_I0.5961.00
156_K160_L0.5921.00
62_G123_M0.5921.00
131_A134_L0.5901.00
38_D348_K0.5901.00
77_F131_A0.5901.00
315_L322_L0.5901.00
149_E153_V0.5891.00
135_V312_A0.5881.00
42_H46_A0.5871.00
23_P26_G0.5871.00
12_T337_A0.5851.00
37_V351_V0.5841.00
33_L137_L0.5831.00
39_G43_E0.5831.00
135_V305_A0.5821.00
76_R79_A0.5791.00
160_L296_A0.5781.00
163_A243_M0.5741.00
278_T282_P0.5741.00
300_S303_S0.5731.00
241_V260_A0.5731.00
190_I194_R0.5721.00
295_K299_G0.5721.00
153_V270_L0.5711.00
21_P126_Y0.5701.00
21_P27_S0.5641.00
75_T78_S0.5631.00
204_G212_T0.5601.00
308_F312_A0.5581.00
130_P133_A0.5571.00
72_P78_S0.5561.00
19_P22_D0.5551.00
66_I145_G0.5541.00
158_I190_I0.5541.00
253_H257_A0.5531.00
85_P122_F0.5501.00
185_L219_L0.5501.00
216_I224_I0.5481.00
255_F280_E0.5481.00
342_D345_T0.5471.00
162_L173_D0.5451.00
40_T43_E0.5451.00
228_T233_D0.5441.00
244_V260_A0.5411.00
255_F282_P0.5401.00
44_V51_G0.5381.00
44_V49_H0.5351.00
174_S223_Y0.5351.00
253_H256_D0.5351.00
177_V188_L0.5341.00
76_R136_A0.5341.00
329_G335_A0.5331.00
246_E271_G0.5321.00
188_L216_I0.5311.00
32_T85_P0.5311.00
192_A221_A0.5261.00
36_G146_F0.5261.00
235_P240_P0.5261.00
39_G181_G0.5261.00
186_L190_I0.5251.00
204_G225_D0.5251.00
171_R194_R0.5241.00
60_V121_G0.5231.00
21_P29_L0.5211.00
150_P348_K0.5211.00
13_P340_F0.5211.00
27_S119_A0.5211.00
292_L301_V0.5201.00
309_R312_A0.5181.00
331_H352_Q0.5181.00
11_R45_I0.5161.00
240_P262_A0.5151.00
141_L316_A0.5131.00
300_S304_N0.5121.00
206_R213_I0.5111.00
186_L320_D0.5101.00
187_T247_A0.5091.00
161_A298_V0.5081.00
20_R128_T0.5081.00
155_E190_I0.5081.00
23_P73_T0.5071.00
136_A139_D0.5061.00
160_L163_A0.5051.00
161_A268_A0.5051.00
217_E222_T0.5051.00
157_A300_S0.5021.00
32_T67_G0.5021.00
27_S131_A0.5021.00
225_D229_T0.5021.00
58_E62_G0.5011.00
268_A300_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cdcA 3 0.9551 100 0.189 Contact Map
2b5wA 2 0.9691 100 0.195 Contact Map
4ilkA 2 0.9129 100 0.221 Contact Map
4ej6A 1 0.9242 100 0.221 Contact Map
1h2bA 4 0.9242 100 0.225 Contact Map
3widA 4 0.9551 100 0.228 Contact Map
2dq4A 4 0.9354 100 0.228 Contact Map
3ip1A 4 0.9382 100 0.229 Contact Map
4cpdA 2 0.9326 100 0.23 Contact Map
1kolA 4 0.9522 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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