GREMLIN Database
PYREL - PyrE-like protein
UniProt: Q9HS16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (197)
Sequences: 114 (78)
Seq/√Len: 5.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_V176_G5.5300.99
96_V118_A2.8340.70
168_I181_C2.8030.69
150_D177_T2.7780.69
76_A168_I2.6860.66
159_T189_G2.5240.61
71_G84_A2.3950.56
124_K166_E2.3400.55
76_A202_L2.2720.52
81_L192_D2.1810.49
67_I77_I2.1150.47
23_E176_G2.0990.46
120_Y160_S2.0980.46
36_S39_V2.0220.44
16_D154_V2.0220.44
81_L198_I1.9830.43
73_R83_D1.9380.41
33_E63_D1.9260.41
124_K189_G1.8860.39
11_A200_A1.8750.39
110_A118_A1.8720.39
172_R178_P1.8540.38
98_I192_D1.8230.37
74_L105_L1.8100.37
23_E107_T1.7920.36
66_T203_Q1.7920.36
186_D198_I1.7720.36
158_V198_I1.7590.35
81_L146_V1.7470.35
108_A200_A1.7470.35
152_F157_T1.7200.34
168_I203_Q1.7090.34
23_E35_A1.6290.31
85_L154_V1.6250.31
11_A176_G1.5870.30
114_G179_V1.5780.30
9_D82_A1.5640.29
60_V207_V1.5520.29
81_L167_T1.5500.29
185_A195_G1.5490.29
16_D146_V1.5160.28
44_T171_V1.5040.28
10_D152_F1.5020.28
63_D166_E1.4930.27
164_I181_C1.4830.27
74_L179_V1.4610.27
124_K159_T1.4510.26
5_D108_A1.4500.26
95_V169_Q1.4440.26
13_A192_D1.4390.26
10_D118_A1.4370.26
95_V115_T1.4290.26
135_L191_G1.4000.25
139_F176_G1.3940.25
88_H199_E1.3920.25
13_A177_T1.3830.25
91_D95_V1.3760.24
77_I194_D1.3570.24
103_V130_G1.3470.24
8_I186_D1.3300.23
108_A178_P1.2880.22
94_L99_E1.2630.22
3_N20_S1.2600.22
12_A98_I1.2590.22
126_Q141_R1.2350.21
4_V136_G1.2310.21
117_L130_G1.2240.21
78_G108_A1.2190.21
56_S206_R1.2150.21
149_R204_V1.2150.21
125_H159_T1.2140.21
168_I198_I1.2140.21
8_I118_A1.2040.20
150_D205_I1.2030.20
32_R151_C1.2020.20
22_G186_D1.1980.20
122_P166_E1.1960.20
91_D193_V1.1920.20
92_V116_D1.1910.20
19_L136_G1.1900.20
179_V192_D1.1880.20
22_G142_N1.1730.20
139_F142_N1.1720.20
109_T152_F1.1700.20
100_K181_C1.1700.20
4_V131_D1.1620.19
33_E109_T1.1600.19
87_D146_V1.1570.19
22_G124_K1.1400.19
167_T176_G1.1400.19
19_L83_D1.1310.19
148_D173_E1.1290.19
37_W57_P1.1220.19
177_T193_V1.1060.18
17_R23_E1.0980.18
106_A184_L1.0900.18
108_A117_L1.0820.18
85_L116_D1.0810.18
77_I87_D1.0600.17
158_V164_I1.0430.17
125_H129_E1.0390.17
19_L73_R1.0360.17
92_V201_L1.0220.17
42_A77_I1.0140.16
23_E171_V1.0030.16
24_I98_I1.0030.16
159_T186_D0.9980.16
148_D177_T0.9950.16
88_H91_D0.9920.16
83_D113_L0.9910.16
115_T136_G0.9890.16
79_I153_V0.9820.16
20_S122_P0.9820.16
180_A198_I0.9820.16
144_A169_Q0.9730.16
137_G195_G0.9730.16
129_E194_D0.9680.16
53_T174_A0.9620.16
67_I153_V0.9610.15
72_A182_G0.9460.15
88_H174_A0.9450.15
29_N35_A0.9350.15
64_W156_D0.9280.15
26_D159_T0.9280.15
94_L115_T0.9090.15
170_A176_G0.9020.14
101_A162_T0.8990.14
87_D199_E0.8930.14
62_V141_R0.8850.14
54_D98_I0.8810.14
55_D168_I0.8770.14
8_I159_T0.8750.14
8_I180_A0.8710.14
8_I62_V0.8680.14
73_R113_L0.8680.14
82_A202_L0.8670.14
3_N29_N0.8610.14
166_E189_G0.8600.14
99_E139_F0.8590.14
122_P125_H0.8580.14
105_L189_G0.8580.14
108_A195_G0.8560.14
135_L154_V0.8530.14
150_D193_V0.8480.14
29_N142_N0.8440.14
42_A114_G0.8350.13
66_T151_C0.8310.13
107_T178_P0.8270.13
67_I202_L0.8250.13
202_L207_V0.8220.13
101_A121_T0.8190.13
63_D180_A0.8140.13
111_N203_Q0.8120.13
29_N73_R0.8050.13
71_G177_T0.8010.13
4_V62_V0.7960.13
16_D72_A0.7940.13
168_I171_V0.7860.13
70_A81_L0.7800.13
67_I158_V0.7720.12
52_D91_D0.7680.12
6_D52_D0.7680.12
30_V80_A0.7640.12
99_E126_Q0.7630.12
159_T190_L0.7570.12
159_T166_E0.7550.12
67_I165_T0.7530.12
109_T158_V0.7500.12
20_S61_H0.7500.12
41_R171_V0.7480.12
55_D145_S0.7480.12
42_A173_E0.7480.12
35_A39_V0.7430.12
26_D189_G0.7410.12
23_E122_P0.7370.12
67_I206_R0.7370.12
35_A111_N0.7350.12
71_G143_F0.7330.12
36_S58_R0.7310.12
85_L109_T0.7300.12
16_D206_R0.7180.12
101_A181_C0.7060.11
113_L191_G0.7050.11
108_A165_T0.7040.11
70_A152_F0.7030.11
78_G100_K0.7010.11
88_H146_V0.6980.11
185_A204_V0.6970.11
72_A177_T0.6940.11
9_D114_G0.6930.11
103_V144_A0.6930.11
23_E128_D0.6890.11
23_E36_S0.6890.11
93_D149_R0.6880.11
44_T89_S0.6870.11
160_S180_A0.6820.11
23_E100_K0.6820.11
16_D167_T0.6790.11
9_D113_L0.6780.11
22_G29_N0.6760.11
70_A95_V0.6610.11
58_R206_R0.6600.11
166_E186_D0.6570.11
4_V123_R0.6560.11
129_E192_D0.6550.11
33_E105_L0.6530.11
152_F173_E0.6510.11
85_L121_T0.6500.11
33_E166_E0.6460.11
37_W41_R0.6450.11
162_T170_A0.6450.11
164_I177_T0.6440.11
12_A203_Q0.6430.11
53_T177_T0.6420.11
39_V58_R0.6410.11
37_W92_V0.6400.11
105_L179_V0.6390.11
55_D193_V0.6370.11
168_I180_A0.6320.10
83_D116_D0.6310.10
9_D184_L0.6250.10
66_T95_V0.6220.10
9_D148_D0.6210.10
99_E200_A0.6140.10
61_H120_Y0.6130.10
2_K80_A0.6120.10
43_D121_T0.6110.10
57_P206_R0.6110.10
62_V74_L0.6110.10
77_I80_A0.6100.10
33_E151_C0.6090.10
2_K207_V0.6000.10
19_L67_I0.5990.10
30_V35_A0.5950.10
39_V43_D0.5940.10
11_A37_W0.5940.10
21_R121_T0.5910.10
63_D159_T0.5910.10
114_G167_T0.5890.10
89_S153_V0.5880.10
26_D124_K0.5860.10
1_M11_A0.5850.10
23_E142_N0.5810.10
3_N41_R0.5800.10
77_I88_H0.5790.10
10_D78_G0.5760.10
121_T180_A0.5750.10
185_A191_G0.5740.10
110_A184_L0.5740.10
52_D129_E0.5730.10
5_D205_I0.5680.10
66_T128_D0.5630.10
148_D158_V0.5610.10
55_D136_G0.5600.10
54_D145_S0.5580.10
13_A56_S0.5560.10
73_R80_A0.5560.10
17_R174_A0.5540.10
70_A149_R0.5530.10
77_I118_A0.5530.10
4_V202_L0.5510.09
108_A193_V0.5500.09
1_M40_E0.5490.09
11_A191_G0.5450.09
22_G166_E0.5430.09
22_G140_S0.5430.09
107_T122_P0.5410.09
41_R65_S0.5380.09
103_V199_E0.5370.09
7_L122_P0.5360.09
9_D167_T0.5340.09
36_S63_D0.5330.09
172_R194_D0.5330.09
101_A157_T0.5330.09
14_L120_Y0.5300.09
62_V105_L0.5300.09
13_A76_A0.5290.09
11_A184_L0.5260.09
9_D190_L0.5260.09
78_G173_E0.5230.09
13_A92_V0.5220.09
162_T167_T0.5210.09
53_T91_D0.5180.09
9_D118_A0.5160.09
63_D105_L0.5160.09
147_E152_F0.5160.09
184_L203_Q0.5150.09
128_D191_G0.5150.09
117_L158_V0.5140.09
37_W200_A0.5110.09
9_D128_D0.5100.09
15_A170_A0.5080.09
73_R142_N0.5050.09
179_V195_G0.5030.09
62_V126_Q0.5000.09
89_S146_V0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fymA 4 0.9245 99.9 0.741 Contact Map
2wnsA 2 0.8113 99.9 0.759 Contact Map
2p1zA 2 0.7783 99.9 0.761 Contact Map
3qw4B 4 0.8679 99.9 0.761 Contact Map
4pawA 2 0.7877 99.9 0.763 Contact Map
3n2lA 4 0.783 99.9 0.769 Contact Map
3mjdA 2 0.7877 99.9 0.77 Contact Map
2ps1A 2 0.8208 99.9 0.77 Contact Map
3dezA 2 0.8113 99.8 0.775 Contact Map
4ohcA 5 0.8443 99.8 0.776 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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