GREMLIN Database
Q9HS15 - Uncharacterized protein
UniProt: Q9HS15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 125 (101)
Sequences: 1957 (923)
Seq/√Len: 91.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_E80_D3.5181.00
11_D15_E3.4061.00
21_L77_A3.1631.00
53_D56_Q2.9771.00
13_A22_F2.9661.00
27_P51_T2.8601.00
37_R91_A2.6331.00
65_L74_T2.5181.00
38_A90_L2.4831.00
43_S49_V2.4081.00
11_D68_H2.3251.00
63_A67_R2.2451.00
59_D63_A2.0531.00
12_A16_N1.9511.00
5_A8_D1.9231.00
38_A87_S1.9161.00
20_V50_H1.8751.00
69_S78_F1.8111.00
45_Y94_A1.6521.00
26_T53_D1.6291.00
9_I57_S1.5721.00
31_Q53_D1.5361.00
54_V74_T1.4701.00
9_I13_A1.4220.99
7_D11_D1.4130.99
20_V52_V1.3830.99
17_N50_H1.3590.99
79_V102_E1.3580.99
74_T83_F1.2990.99
100_A104_N1.2470.98
77_A90_L1.2430.98
41_L90_L1.2290.98
44_D94_A1.2260.98
93_L102_E1.2260.98
101_D105_A1.2250.98
87_S91_A1.2230.98
6_V9_I1.2150.98
21_L38_A1.1660.98
54_V65_L1.1630.98
7_D67_R1.1300.97
13_A50_H1.1200.97
8_D12_A1.1110.97
37_R87_S1.1060.97
69_S83_F1.0880.96
23_M35_S1.0620.96
19_V47_P1.0130.95
84_V102_E1.0020.94
6_V10_V0.9940.94
94_A100_A0.9830.94
68_H78_F0.9790.94
23_M38_A0.9770.93
17_N52_V0.9570.93
38_A77_A0.9540.93
91_A95_D0.9510.93
41_L91_A0.9420.92
7_D64_A0.9370.92
45_Y100_A0.9300.92
13_A52_V0.9190.91
27_P49_V0.9090.91
36_E40_R0.9020.90
40_R44_D0.8960.90
92_E96_R0.8750.89
41_L87_S0.8740.89
8_D11_D0.8600.88
10_V14_I0.8580.88
47_P103_L0.8190.86
94_A99_L0.8090.85
42_I77_A0.7960.84
7_D14_I0.7880.83
69_S76_Q0.7830.83
62_R71_W0.7640.81
79_V103_L0.7640.81
13_A20_V0.7590.81
63_A92_E0.7540.81
6_V64_A0.7380.79
16_N50_H0.7360.79
24_K62_R0.7280.78
26_T29_A0.7200.77
14_I68_H0.7100.76
64_A67_R0.7070.76
11_D14_I0.7030.76
26_T51_T0.6910.75
14_I81_G0.6880.74
98_D102_E0.6840.74
31_Q59_D0.6750.73
56_Q60_E0.6750.73
24_K32_C0.6710.72
57_S60_E0.6630.71
84_V93_L0.6610.71
37_R94_A0.6540.70
52_V61_F0.6530.70
72_E89_I0.6520.70
26_T56_Q0.6510.70
67_R70_G0.6500.70
41_L94_A0.6350.68
66_E78_F0.6340.68
79_V84_V0.6250.67
19_V103_L0.6210.66
93_L98_D0.6180.66
73_T88_D0.6170.66
102_E106_D0.6150.66
68_H76_Q0.6140.66
80_D106_D0.6140.66
41_L45_Y0.6140.66
80_D105_A0.6130.66
27_P43_S0.6020.64
87_S90_L0.5980.64
57_S78_F0.5940.63
23_M62_R0.5920.63
44_D95_D0.5910.63
36_E87_S0.5910.63
36_E52_V0.5910.63
36_E45_Y0.5900.63
102_E105_A0.5900.63
36_E91_A0.5870.62
47_P104_N0.5850.62
76_Q86_G0.5790.61
28_A43_S0.5750.61
34_F71_W0.5740.60
32_C73_T0.5710.60
9_I22_F0.5690.60
27_P50_H0.5680.60
60_E64_A0.5670.60
40_R43_S0.5630.59
63_A74_T0.5600.59
29_A36_E0.5540.58
37_R41_L0.5520.57
101_D104_N0.5440.56
84_V105_A0.5430.56
24_K35_S0.5430.56
34_F88_D0.5420.56
9_I50_H0.5390.56
100_A105_A0.5360.55
39_I43_S0.5340.55
101_D106_D0.5330.55
15_E81_G0.5320.55
93_L99_L0.5310.55
13_A61_F0.5270.54
6_V60_E0.5220.53
55_L62_R0.5220.53
65_L83_F0.5200.53
64_A78_F0.5180.53
37_R40_R0.5140.52
42_I49_V0.5140.52
79_V106_D0.5120.52
10_V46_R0.5120.52
5_A44_D0.5110.52
34_F72_E0.5100.52
10_V26_T0.5090.52
63_A66_E0.5060.51
9_I60_E0.5000.50
7_D22_F0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wciA 3 0.904 99.9 0.494 Contact Map
2jadA 1 0.808 99.9 0.513 Contact Map
2wulA 3 0.856 99.8 0.536 Contact Map
3gx8A 1 0.864 99.8 0.541 Contact Map
1wikA 1 0.872 99.8 0.549 Contact Map
2yanA 1 0.832 99.8 0.561 Contact Map
3ipzA 3 0.856 99.8 0.561 Contact Map
3zywA 1 0.888 99.8 0.568 Contact Map
1u6tA 1 0.84 99.7 0.596 Contact Map
2ltkA 1 0.88 99.7 0.598 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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