GREMLIN Database
Q9HS14 - Phosphate-specific transport system accessory protein PhoU
UniProt: Q9HS14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (191)
Sequences: 4350 (3325)
Seq/√Len: 240.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_D131_R3.3281.00
14_E18_Q3.0041.00
2_S114_M2.8941.00
115_A119_S2.6291.00
6_T111_T2.6011.00
34_I76_G2.5501.00
11_M26_E2.5081.00
128_I192_S2.3011.00
136_D186_D2.2931.00
35_N77_D2.2371.00
135_I185_G2.2211.00
71_D190_N2.2031.00
13_L103_G2.1761.00
73_E77_D2.1541.00
5_V72_L2.1531.00
11_M30_G2.0811.00
132_D136_D2.0561.00
31_D77_D1.9771.00
105_R134_D1.9601.00
112_D127_A1.9341.00
8_R34_I1.9101.00
10_R107_I1.9021.00
71_D187_H1.8731.00
17_A100_Q1.8001.00
14_E23_A1.7781.00
25_W87_L1.7751.00
112_D124_A1.7601.00
11_M23_A1.7291.00
148_R152_E1.7011.00
31_D73_E1.6791.00
108_E112_D1.6781.00
25_W29_D1.6711.00
68_I191_I1.6641.00
106_T135_I1.6621.00
35_N73_E1.6451.00
131_R134_D1.6451.00
136_D182_E1.6361.00
5_V34_I1.5811.00
64_S198_M1.5551.00
65_S117_Y1.5331.00
115_A124_A1.4611.00
75_I184_V1.4381.00
12_A79_A1.4091.00
3_E6_T1.4061.00
81_N180_D1.3831.00
113_A188_A1.3511.00
9_L184_V1.3461.00
106_T181_L1.3431.00
12_A86_T1.3381.00
75_I110_V1.3381.00
6_T10_R1.3361.00
121_D124_A1.3301.00
132_D182_E1.3271.00
21_D90_D1.3241.00
98_D145_T1.3221.00
36_Q40_D1.3081.00
45_C62_I1.3061.00
82_L177_T1.2951.00
47_D51_L1.2951.00
123_E126_Y1.2791.00
31_D80_A1.2691.00
182_E186_D1.2661.00
110_V188_A1.2661.00
113_A195_T1.2601.00
109_M185_G1.2591.00
28_I31_D1.2541.00
48_L62_I1.2481.00
108_E131_R1.2421.00
127_A131_R1.2351.00
150_L168_M1.2241.00
134_D137_E1.2221.00
124_A127_A1.2221.00
31_D35_N1.2091.00
30_G33_E1.1501.00
122_V199_V1.1371.00
132_D186_D1.1331.00
119_S124_A1.1271.00
7_D11_M1.1171.00
45_C69_I1.1081.00
40_D44_D1.1071.00
88_D173_R1.1051.00
125_C196_V1.0991.00
139_C178_V1.0961.00
98_D141_S1.0841.00
105_R108_E1.0791.00
20_D23_A1.0731.00
61_L120_A1.0711.00
15_A27_V1.0571.00
115_A118_A1.0321.00
145_T149_D1.0321.00
8_R30_G1.0311.00
21_D87_L1.0301.00
106_T188_A1.0271.00
190_N193_A1.0221.00
85_Y173_R1.0201.00
45_C66_F1.0151.00
105_R131_R1.0141.00
133_D136_D1.0091.00
126_Y196_V1.0081.00
46_I197_Y1.0081.00
6_T107_I1.0061.00
109_M135_I1.0031.00
148_R151_I0.9971.00
26_E30_G0.9931.00
122_V196_V0.9901.00
38_Y67_K0.9891.00
15_A86_T0.9861.00
97_V100_Q0.9831.00
74_R183_R0.9781.00
5_V75_I0.9721.00
105_R135_I0.9621.00
8_R27_V0.9601.00
22_D25_W0.9561.00
116_A128_I0.9471.00
102_I139_C0.9441.00
24_A87_L0.9271.00
104_D108_E0.9251.00
21_D25_W0.9231.00
149_D152_E0.9181.00
107_I111_T0.9161.00
15_A24_A0.9121.00
19_K89_A0.9091.00
142_A178_V0.9071.00
10_R111_T0.9041.00
63_A66_F0.9021.00
50_A59_L0.8981.00
28_I87_L0.8981.00
5_V76_G0.8951.00
4_V33_E0.8901.00
27_V83_A0.8891.00
32_D35_N0.8820.99
101_A134_D0.8790.99
92_D95_P0.8780.99
150_L153_T0.8750.99
46_I63_A0.8720.99
149_D153_T0.8700.99
144_Q148_R0.8680.99
111_T115_A0.8580.99
101_A104_D0.8550.99
27_V30_G0.8450.99
23_A26_E0.8450.99
67_K70_T0.8390.99
116_A125_C0.8360.99
152_E155_I0.8310.99
102_I181_L0.8310.99
38_Y69_I0.8270.99
121_D125_C0.8250.99
11_M14_E0.8160.99
101_A138_R0.8080.99
84_E140_R0.8040.99
9_L79_A0.8030.99
20_D24_A0.8010.99
142_A145_T0.8000.99
4_V34_I0.8000.99
28_I83_A0.7990.99
24_A83_A0.7990.99
3_E118_A0.7970.99
65_S68_I0.7960.99
74_R190_N0.7930.99
3_E115_A0.7930.99
86_T177_T0.7890.99
150_L154_E0.7850.99
13_L181_L0.7840.99
44_D47_D0.7820.99
4_V37_L0.7810.99
33_E36_Q0.7750.99
136_D185_G0.7740.99
138_R141_S0.7690.99
42_E67_K0.7680.99
105_R138_R0.7670.99
67_K194_R0.7660.99
41_L70_T0.7640.99
42_E194_R0.7560.98
73_E190_N0.7560.98
172_S175_L0.7530.98
147_I151_I0.7450.98
85_Y177_T0.7430.98
97_V101_A0.7410.98
182_E185_G0.7410.98
126_Y200_D0.7350.98
168_M171_V0.7310.98
69_I194_R0.7250.98
15_A23_A0.7230.98
126_Y130_E0.7200.98
188_A195_T0.7160.98
48_L52_Q0.7120.98
78_L184_V0.7090.98
19_K90_D0.7050.97
26_E29_D0.7010.97
71_D194_R0.6990.97
102_I138_R0.6990.97
89_A170_D0.6980.97
56_A59_L0.6960.97
137_E141_S0.6920.97
179_R187_H0.6910.97
75_I188_A0.6910.97
78_L180_D0.6830.97
133_D189_V0.6830.97
146_V171_V0.6820.97
189_V193_A0.6790.97
98_D101_A0.6760.97
103_G181_L0.6720.97
128_I131_R0.6710.97
24_A31_D0.6660.96
112_D115_A0.6660.96
18_Q23_A0.6650.96
8_R12_A0.6620.96
32_D36_Q0.6610.96
61_L198_M0.6590.96
52_Q55_V0.6530.96
143_S147_I0.6510.96
151_I168_M0.6500.96
79_A184_V0.6470.96
6_T118_A0.6460.96
106_T184_V0.6450.96
71_D78_L0.6400.96
45_C49_L0.6380.95
109_M132_D0.6380.95
104_D107_I0.6370.95
23_A27_V0.6360.95
42_E45_C0.6350.95
1_M38_Y0.6340.95
109_M188_A0.6320.95
28_I80_A0.6300.95
81_N84_E0.6270.95
13_L17_A0.6250.95
78_L139_C0.6230.95
93_M96_E0.6220.95
39_L42_E0.6220.95
101_A105_R0.6200.95
94_F97_V0.6200.95
77_D190_N0.6090.94
10_R14_E0.6070.94
98_D149_D0.6020.94
132_D185_G0.5980.94
66_F69_I0.5980.94
139_C179_R0.5880.93
16_M177_T0.5870.93
176_L179_R0.5840.93
95_P146_V0.5840.93
78_L187_H0.5800.93
45_C194_R0.5800.93
122_V126_Y0.5780.93
95_P174_L0.5750.92
78_L179_R0.5720.92
24_A28_I0.5720.92
7_D10_R0.5710.92
15_A83_A0.5710.92
8_R79_A0.5710.92
68_I194_R0.5690.92
15_A19_K0.5670.92
41_L69_I0.5640.92
153_T156_D0.5630.92
120_A199_V0.5540.91
113_A192_S0.5530.91
15_A20_D0.5520.91
8_R76_G0.5500.91
85_Y180_D0.5470.90
148_R156_D0.5450.90
17_A96_E0.5440.90
95_P149_D0.5430.90
100_Q104_D0.5430.90
73_E76_G0.5410.90
185_G193_A0.5370.90
148_R153_T0.5360.89
103_G106_T0.5350.89
5_V79_A0.5340.89
81_N189_V0.5330.89
110_V113_A0.5280.89
148_R154_E0.5280.89
113_A191_I0.5240.88
38_Y42_E0.5240.88
54_P59_L0.5230.88
152_E156_D0.5230.88
109_M131_R0.5210.88
81_N85_Y0.5200.88
41_L72_L0.5120.87
37_L40_D0.5100.87
19_K91_R0.5070.87
149_D155_I0.5060.87
108_E134_D0.5060.87
72_L110_V0.5030.86
120_A198_M0.5020.86
85_Y88_D0.5020.86
145_T148_R0.5020.86
194_R198_M0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sumB 2 0.9469 100 0.157 Contact Map
2i0mA 2 0.9179 100 0.168 Contact Map
1xwmA 2 0.942 100 0.17 Contact Map
4q25A 2 0.9227 100 0.181 Contact Map
1t72A 5 0.9227 100 0.205 Contact Map
2oltA 5 0.8792 100 0.421 Contact Map
3l39A 3 0.8744 99.6 0.637 Contact Map
1vctA 3 0.8599 97.2 0.836 Contact Map
3ci9A 5 0.2029 11.9 0.941 Contact Map
3oq3A 1 0.5411 9.8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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