Q9HS10 - HALSA - GREMLIN Contacts

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Q9HS10 - Phosphate ABC transporter periplasmic phosphate-binding

UniProt:	Q9HS10	Sequences: MPADDAERTTRTRRQVLAGMGATGAAALAGCQSTSSEDPADDSLSGTVDFAGSSTVFPLATTMSEAFRGGDTGEAHPDVNFNPKSTGTGGGFANHFCTGNADLNNASREVRDAEAQQCTDNDIEPVEFTVATDALTVIVNTDLDIDSITVDELRSIWSAERDTEQWSDVNPDWPDEPLELYGPSSASGTYDYFIESILHGGDTELTHISGGSYTGTEQDRTIIQGVEGSTNAMGYLGYAYYSKSDDRVKALAVDDGDGEPVKPSLETARSGAYTPLSRPLFTYAAKSSLAEPAVAAFLRFWLEHATSEAIVADQVGYVPLSQEAQREQLDALTEAIDAAGSADE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (282)
Sequences:	5922 (4272)
Seq/√Len:	254.4

ECOLI - PSTS
BACSU - PSTS
HALSA - Q9HS10 Q9HML5
SULSO - Q97ZT8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_S	160_E	4.571	1.00
149_T	152_E	3.937	1.00
165_Q	175_D	3.795	1.00
156_I	178_L	3.497	1.00
176_E	231_N	3.432	1.00
167_S	175_D	3.416	1.00
147_S	260_P	3.159	1.00
252_A	262_K	3.018	1.00
148_I	251_L	2.836	1.00
151_D	155_S	2.712	1.00
51_A	101_A	2.612	1.00
137_V	153_L	2.475	1.00
152_E	170_N	2.409	1.00
165_Q	177_P	2.401	1.00
112_D	116_Q	2.372	1.00
138_I	226_V	2.283	1.00
147_S	252_A	2.240	1.00
51_A	95_H	2.234	1.00
146_D	249_K	2.216	1.00
152_E	155_S	2.171	1.00
179_E	229_S	2.165	1.00
66_A	300_F	2.162	1.00
54_S	85_S	2.118	1.00
254_D	260_P	2.115	1.00
53_S	56_V	2.088	1.00
116_Q	120_D	2.078	1.00
108_R	114_E	2.037	1.00
322_Q	326_R	2.022	1.00
86_T	90_G	2.021	1.00
126_V	286_K	2.020	1.00
67_F	296_A	1.951	1.00
264_S	267_T	1.924	1.00
138_I	236_L	1.914	1.00
165_Q	176_E	1.899	1.00
134_A	268_A	1.884	1.00
88_T	106_A	1.827	1.00
139_V	251_L	1.816	1.00
60_A	297_F	1.791	1.00
97_C	118_C	1.773	1.00
137_V	193_F	1.755	1.00
192_Y	278_R	1.746	1.00
57_F	85_S	1.742	1.00
141_T	230_T	1.677	1.00
241_Y	250_A	1.671	1.00
150_V	254_D	1.633	1.00
24_G	27_A	1.623	1.00
117_Q	120_D	1.610	1.00
66_A	74_E	1.597	1.00
157_W	180_L	1.596	1.00
67_F	79_V	1.588	1.00
224_Q	228_G	1.574	1.00
154_R	201_G	1.568	1.00
138_I	248_V	1.563	1.00
164_E	168_D	1.561	1.00
153_L	253_V	1.561	1.00
60_A	301_W	1.560	1.00
149_T	254_D	1.559	1.00
57_F	61_T	1.559	1.00
155_S	163_T	1.537	1.00
148_I	153_L	1.496	1.00
128_F	284_A	1.494	1.00
267_T	270_S	1.485	1.00
27_A	30_G	1.480	1.00
60_A	282_T	1.466	1.00
68_R	80_N	1.453	1.00
282_T	301_W	1.445	1.00
50_F	103_L	1.443	1.00
292_P	296_A	1.436	1.00
95_H	101_A	1.433	1.00
49_D	82_N	1.416	1.00
146_D	252_A	1.400	1.00
149_T	169_V	1.384	1.00
46_G	293_A	1.379	1.00
265_L	313_D	1.374	1.00
295_A	299_R	1.351	1.00
106_A	283_Y	1.349	1.00
226_V	234_G	1.342	1.00
176_E	230_T	1.335	1.00
47_T	82_N	1.334	1.00
253_V	276_L	1.323	1.00
182_G	213_Y	1.311	1.00
28_L	31_C	1.298	1.00
210_G	213_Y	1.298	1.00
63_M	301_W	1.296	1.00
296_A	299_R	1.293	1.00
96_F	104_N	1.287	1.00
105_N	282_T	1.279	1.00
135_L	278_R	1.274	1.00
119_T	124_E	1.245	1.00
62_T	314_Q	1.244	1.00
99_G	285_A	1.244	1.00
47_T	80_N	1.241	1.00
223_I	236_L	1.237	1.00
156_I	169_V	1.236	1.00
181_Y	225_G	1.236	1.00
27_A	31_C	1.231	1.00
182_G	215_G	1.226	1.00
147_S	254_D	1.219	1.00
313_D	319_P	1.219	1.00
148_I	156_I	1.212	1.00
303_E	306_T	1.197	1.00
131_A	280_L	1.196	1.00
129_T	279_P	1.181	1.00
150_V	197_I	1.181	1.00
219_D	240_Y	1.177	1.00
254_D	258_G	1.174	1.00
95_H	100_N	1.166	1.00
56_V	60_A	1.150	1.00
85_S	220_R	1.145	1.00
92_F	106_A	1.145	1.00
180_L	233_M	1.143	1.00
242_S	247_R	1.143	1.00
111_R	114_E	1.140	1.00
128_F	302_L	1.133	1.00
183_P	187_S	1.123	1.00
265_L	269_R	1.122	1.00
297_F	301_W	1.118	1.00
151_D	154_R	1.118	1.00
266_E	270_S	1.118	1.00
23_T	26_A	1.114	1.00
60_A	105_N	1.106	1.00
136_T	241_Y	1.105	1.00
181_Y	232_A	1.094	1.00
53_S	107_S	1.086	1.00
64_S	68_R	1.084	1.00
116_Q	119_T	1.081	1.00
163_T	168_D	1.081	1.00
64_S	83_P	1.078	1.00
267_T	272_A	1.064	1.00
92_F	110_V	1.063	1.00
219_D	236_L	1.051	1.00
55_T	133_D	1.050	1.00
44_L	79_V	1.048	1.00
132_T	279_P	1.048	1.00
110_V	125_P	1.041	1.00
181_Y	229_S	1.034	1.00
48_V	293_A	1.023	1.00
62_T	65_E	1.018	1.00
93_A	98_T	1.015	1.00
51_A	86_T	1.015	1.00
216_T	222_I	1.013	1.00
157_W	193_F	1.010	1.00
112_D	115_A	1.008	1.00
25_A	28_L	1.006	1.00
127_E	283_Y	1.005	1.00
284_A	298_L	1.003	1.00
97_C	117_Q	1.001	1.00
113_A	116_Q	0.987	1.00
55_T	280_L	0.986	1.00
137_V	273_Y	0.978	1.00
152_E	169_V	0.964	1.00
227_E	247_R	0.960	1.00
164_E	177_P	0.957	1.00
56_V	130_V	0.951	1.00
53_S	60_A	0.951	1.00
324_A	327_E	0.944	1.00
109_E	127_E	0.943	1.00
222_I	234_G	0.939	1.00
165_Q	173_W	0.936	1.00
253_V	273_Y	0.934	1.00
67_F	297_F	0.932	1.00
135_L	192_Y	0.928	1.00
67_F	300_F	0.928	1.00
322_Q	325_Q	0.925	1.00
179_E	214_T	0.917	1.00
103_L	284_A	0.917	1.00
133_D	278_R	0.915	1.00
201_G	204_E	0.914	1.00
181_Y	214_T	0.913	1.00
92_F	104_N	0.912	1.00
133_D	237_G	0.911	1.00
261_V	272_A	0.908	1.00
238_Y	263_P	0.907	1.00
84_K	95_H	0.900	1.00
117_Q	121_N	0.897	1.00
60_A	130_V	0.888	1.00
131_A	312_A	0.888	1.00
124_E	286_K	0.887	1.00
299_R	303_E	0.883	1.00
292_P	295_A	0.882	1.00
115_A	125_P	0.881	1.00
221_T	225_G	0.878	1.00
130_V	282_T	0.876	1.00
136_T	238_Y	0.863	1.00
64_S	81_F	0.861	0.99
239_A	317_Y	0.858	0.99
293_A	296_A	0.856	0.99
75_A	305_A	0.856	0.99
150_V	154_R	0.850	0.99
62_T	66_A	0.848	0.99
157_W	233_M	0.837	0.99
142_D	230_T	0.836	0.99
139_V	249_K	0.835	0.99
300_F	303_E	0.834	0.99
144_D	174_P	0.830	0.99
269_R	318_V	0.830	0.99
115_A	119_T	0.827	0.99
103_L	282_T	0.821	0.99
101_A	104_N	0.819	0.99
19_G	22_A	0.817	0.99
86_T	95_H	0.815	0.99
192_Y	196_S	0.812	0.99
262_K	267_T	0.811	0.99
115_A	127_E	0.806	0.99
299_R	302_L	0.806	0.99
190_Y	235_Y	0.803	0.99
214_T	225_G	0.801	0.99
323_E	326_R	0.800	0.99
108_R	191_D	0.793	0.99
110_V	283_Y	0.793	0.99
305_A	308_E	0.791	0.99
50_F	105_N	0.790	0.99
25_A	31_C	0.789	0.99
22_A	25_A	0.789	0.99
139_V	145_I	0.787	0.99
130_V	280_L	0.786	0.99
107_S	280_L	0.785	0.99
107_S	278_R	0.781	0.99
308_E	313_D	0.777	0.99
187_S	219_D	0.775	0.99
195_E	199_H	0.770	0.99
20_M	24_G	0.769	0.99
59_L	312_A	0.768	0.99
66_A	311_V	0.764	0.99
21_G	24_G	0.762	0.99
51_A	84_K	0.762	0.99
110_V	114_E	0.761	0.99
64_S	297_F	0.758	0.99
167_S	170_N	0.757	0.99
118_C	125_P	0.754	0.99
254_D	257_D	0.752	0.99
52_G	91_G	0.751	0.99
165_Q	168_D	0.751	0.99
110_V	127_E	0.748	0.99
238_Y	242_S	0.747	0.99
218_Q	221_T	0.745	0.99
55_T	107_S	0.743	0.99
59_L	131_A	0.743	0.99
154_R	158_S	0.742	0.98
148_I	173_W	0.740	0.98
181_Y	216_T	0.733	0.98
306_T	311_V	0.733	0.98
137_V	157_W	0.732	0.98
304_H	308_E	0.724	0.98
158_S	203_T	0.724	0.98
119_T	122_D	0.724	0.98
145_I	148_I	0.723	0.98
148_I	253_V	0.721	0.98
62_T	315_V	0.721	0.98
87_G	189_T	0.720	0.98
31_C	41_D	0.719	0.98
24_G	28_L	0.716	0.98
118_C	123_I	0.715	0.98
238_Y	265_L	0.715	0.98
92_F	114_E	0.714	0.98
181_Y	222_I	0.712	0.98
55_T	278_R	0.712	0.98
225_G	229_S	0.712	0.98
87_G	91_G	0.711	0.98
22_A	28_L	0.710	0.98
298_L	302_L	0.705	0.98
308_E	314_Q	0.704	0.98
155_S	158_S	0.704	0.98
154_R	197_I	0.704	0.98
223_I	242_S	0.703	0.98
127_E	281_F	0.699	0.98
29_A	32_Q	0.696	0.98
25_A	29_A	0.695	0.98
129_T	324_A	0.688	0.98
140_N	226_V	0.687	0.98
252_A	260_P	0.686	0.98
180_L	212_S	0.686	0.98
252_A	263_P	0.684	0.97
266_E	269_R	0.684	0.97
26_A	29_A	0.684	0.97
89_G	186_A	0.684	0.97
282_T	298_L	0.677	0.97
23_T	27_A	0.676	0.97
148_I	152_E	0.673	0.97
148_I	233_M	0.671	0.97
144_D	249_K	0.670	0.97
170_N	173_W	0.670	0.97
53_S	188_G	0.670	0.97
194_I	198_L	0.667	0.97
67_F	76_H	0.666	0.97
261_V	267_T	0.661	0.97
136_T	263_P	0.661	0.97
187_S	217_E	0.660	0.97
118_C	121_N	0.657	0.97
300_F	311_V	0.657	0.97
135_L	189_T	0.656	0.97
183_P	235_Y	0.655	0.97
184_S	217_E	0.655	0.97
91_G	188_G	0.653	0.97
46_G	79_V	0.651	0.97
229_S	232_A	0.647	0.96
304_H	325_Q	0.647	0.96
306_T	312_A	0.647	0.96
191_D	195_E	0.646	0.96
204_E	212_S	0.646	0.96
56_V	282_T	0.645	0.96
321_S	324_A	0.642	0.96
133_D	280_L	0.638	0.96
323_E	327_E	0.638	0.96
44_L	293_A	0.638	0.96
303_E	307_S	0.638	0.96
52_G	87_G	0.637	0.96
57_F	86_T	0.636	0.96
107_S	133_D	0.633	0.96
58_P	240_Y	0.633	0.96
189_T	278_R	0.629	0.96
136_T	250_A	0.625	0.96
42_D	46_G	0.623	0.96
31_C	43_S	0.623	0.96
18_A	22_A	0.621	0.96
91_G	104_N	0.620	0.95
102_D	294_V	0.617	0.95
226_V	232_A	0.617	0.95
126_V	129_T	0.614	0.95
150_V	196_S	0.614	0.95
302_L	307_S	0.612	0.95
285_A	288_S	0.610	0.95
238_Y	268_A	0.610	0.95
237_G	240_Y	0.607	0.95
62_T	311_V	0.607	0.95
21_G	25_A	0.606	0.95
150_V	275_P	0.603	0.95
22_A	26_A	0.603	0.95
157_W	182_G	0.602	0.95
113_A	117_Q	0.600	0.95
54_S	218_Q	0.599	0.95
160_E	203_T	0.598	0.95
96_F	125_P	0.595	0.94
190_Y	194_I	0.593	0.94
67_F	293_A	0.592	0.94
18_A	21_G	0.591	0.94
311_V	314_Q	0.588	0.94
304_H	307_S	0.585	0.94
216_T	225_G	0.585	0.94
109_E	281_F	0.585	0.94
124_E	285_A	0.585	0.94
87_G	90_G	0.585	0.94
45_S	78_D	0.583	0.94
68_R	76_H	0.583	0.94
178_L	231_N	0.581	0.94
103_L	298_L	0.581	0.94
31_C	44_L	0.576	0.93
141_T	231_N	0.576	0.93
24_G	29_A	0.575	0.93
189_T	219_D	0.572	0.93
167_S	171_P	0.572	0.93
56_V	280_L	0.571	0.93
216_T	221_T	0.571	0.93
48_V	294_V	0.570	0.93
137_V	276_L	0.569	0.93
183_P	188_G	0.569	0.93
268_A	277_S	0.568	0.93
179_E	231_N	0.568	0.93
53_S	282_T	0.567	0.93
148_I	169_V	0.566	0.93
90_G	95_H	0.564	0.93
88_T	188_G	0.564	0.93
138_I	234_G	0.563	0.93
153_L	157_W	0.560	0.92
49_D	102_D	0.559	0.92
79_V	293_A	0.559	0.92
223_I	248_V	0.559	0.92
183_P	219_D	0.558	0.92
55_T	317_Y	0.558	0.92
18_A	24_G	0.557	0.92
66_A	304_H	0.556	0.92
19_G	24_G	0.555	0.92
66_A	75_A	0.553	0.92
129_T	132_T	0.553	0.92
49_D	84_K	0.551	0.92
88_T	104_N	0.551	0.92
236_L	240_Y	0.547	0.92
154_R	199_H	0.546	0.91
18_A	25_A	0.546	0.91
143_L	174_P	0.546	0.91
110_V	115_A	0.546	0.91
129_T	320_L	0.546	0.91
55_T	189_T	0.542	0.91
111_R	115_A	0.541	0.91
60_A	83_P	0.540	0.91
44_L	67_F	0.537	0.91
225_G	228_G	0.537	0.91
286_K	292_P	0.537	0.91
93_A	117_Q	0.536	0.91
194_I	203_T	0.535	0.91
184_S	218_Q	0.535	0.91
54_S	235_Y	0.534	0.91
219_D	223_I	0.533	0.90
54_S	87_G	0.532	0.90
61_T	65_E	0.532	0.90
158_S	198_L	0.531	0.90
268_A	271_G	0.530	0.90
59_L	317_Y	0.527	0.90
149_T	260_P	0.526	0.90
254_D	275_P	0.524	0.90
182_G	235_Y	0.521	0.89
301_W	306_T	0.520	0.89
51_A	90_G	0.520	0.89
118_C	122_D	0.518	0.89
95_H	98_T	0.517	0.89
79_V	296_A	0.516	0.89
237_G	278_R	0.516	0.89
54_S	58_P	0.513	0.89
242_S	316_G	0.512	0.89
197_I	276_L	0.510	0.88
156_I	163_T	0.510	0.88
137_V	253_V	0.510	0.88
54_S	183_P	0.507	0.88
302_L	306_T	0.507	0.88
19_G	27_A	0.506	0.88
153_L	197_I	0.506	0.88
185_S	194_I	0.505	0.88
224_Q	227_E	0.505	0.88
133_D	317_Y	0.504	0.88
193_F	197_I	0.504	0.88
76_H	296_A	0.503	0.88
256_G	260_P	0.500	0.87
21_G	27_A	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f1vA	1	0.8227	100	0.329	Contact Map
4n13A	1	0.718	100	0.463	Contact Map
1ixhA	1	0.811	100	0.534	Contact Map
1pc3A	1	0.8285	100	0.538	Contact Map
4jwoA	1	0.814	100	0.574	Contact Map
4ombA	1	0.811	100	0.577	Contact Map
4lvqA	1	0.7965	100	0.596	Contact Map
4ecfA	1	0.7529	100	0.61	Contact Map
4exlA	1	0.7645	100	0.619	Contact Map
4q8rA	1	0.7006	100	0.62	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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