GREMLIN Database
Q9HS10 - Phosphate ABC transporter periplasmic phosphate-binding
UniProt: Q9HS10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (282)
Sequences: 5922 (4272)
Seq/√Len: 254.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_S160_E4.5711.00
149_T152_E3.9371.00
165_Q175_D3.7951.00
156_I178_L3.4971.00
176_E231_N3.4321.00
167_S175_D3.4161.00
147_S260_P3.1591.00
252_A262_K3.0181.00
148_I251_L2.8361.00
151_D155_S2.7121.00
51_A101_A2.6121.00
137_V153_L2.4751.00
152_E170_N2.4091.00
165_Q177_P2.4011.00
112_D116_Q2.3721.00
138_I226_V2.2831.00
147_S252_A2.2401.00
51_A95_H2.2341.00
146_D249_K2.2161.00
152_E155_S2.1711.00
179_E229_S2.1651.00
66_A300_F2.1621.00
54_S85_S2.1181.00
254_D260_P2.1151.00
53_S56_V2.0881.00
116_Q120_D2.0781.00
108_R114_E2.0371.00
322_Q326_R2.0221.00
86_T90_G2.0211.00
126_V286_K2.0201.00
67_F296_A1.9511.00
264_S267_T1.9241.00
138_I236_L1.9141.00
165_Q176_E1.8991.00
134_A268_A1.8841.00
88_T106_A1.8271.00
139_V251_L1.8161.00
60_A297_F1.7911.00
97_C118_C1.7731.00
137_V193_F1.7551.00
192_Y278_R1.7461.00
57_F85_S1.7421.00
141_T230_T1.6771.00
241_Y250_A1.6711.00
150_V254_D1.6331.00
24_G27_A1.6231.00
117_Q120_D1.6101.00
66_A74_E1.5971.00
157_W180_L1.5961.00
67_F79_V1.5881.00
224_Q228_G1.5741.00
154_R201_G1.5681.00
138_I248_V1.5631.00
164_E168_D1.5611.00
153_L253_V1.5611.00
60_A301_W1.5601.00
149_T254_D1.5591.00
57_F61_T1.5591.00
155_S163_T1.5371.00
148_I153_L1.4961.00
128_F284_A1.4941.00
267_T270_S1.4851.00
27_A30_G1.4801.00
60_A282_T1.4661.00
68_R80_N1.4531.00
282_T301_W1.4451.00
50_F103_L1.4431.00
292_P296_A1.4361.00
95_H101_A1.4331.00
49_D82_N1.4161.00
146_D252_A1.4001.00
149_T169_V1.3841.00
46_G293_A1.3791.00
265_L313_D1.3741.00
295_A299_R1.3511.00
106_A283_Y1.3491.00
226_V234_G1.3421.00
176_E230_T1.3351.00
47_T82_N1.3341.00
253_V276_L1.3231.00
182_G213_Y1.3111.00
28_L31_C1.2981.00
210_G213_Y1.2981.00
63_M301_W1.2961.00
296_A299_R1.2931.00
96_F104_N1.2871.00
105_N282_T1.2791.00
135_L278_R1.2741.00
119_T124_E1.2451.00
62_T314_Q1.2441.00
99_G285_A1.2441.00
47_T80_N1.2411.00
223_I236_L1.2371.00
156_I169_V1.2361.00
181_Y225_G1.2361.00
27_A31_C1.2311.00
182_G215_G1.2261.00
147_S254_D1.2191.00
313_D319_P1.2191.00
148_I156_I1.2121.00
303_E306_T1.1971.00
131_A280_L1.1961.00
129_T279_P1.1811.00
150_V197_I1.1811.00
219_D240_Y1.1771.00
254_D258_G1.1741.00
95_H100_N1.1661.00
56_V60_A1.1501.00
85_S220_R1.1451.00
92_F106_A1.1451.00
180_L233_M1.1431.00
242_S247_R1.1431.00
111_R114_E1.1401.00
128_F302_L1.1331.00
183_P187_S1.1231.00
265_L269_R1.1221.00
297_F301_W1.1181.00
151_D154_R1.1181.00
266_E270_S1.1181.00
23_T26_A1.1141.00
60_A105_N1.1061.00
136_T241_Y1.1051.00
181_Y232_A1.0941.00
53_S107_S1.0861.00
64_S68_R1.0841.00
116_Q119_T1.0811.00
163_T168_D1.0811.00
64_S83_P1.0781.00
267_T272_A1.0641.00
92_F110_V1.0631.00
219_D236_L1.0511.00
55_T133_D1.0501.00
44_L79_V1.0481.00
132_T279_P1.0481.00
110_V125_P1.0411.00
181_Y229_S1.0341.00
48_V293_A1.0231.00
62_T65_E1.0181.00
93_A98_T1.0151.00
51_A86_T1.0151.00
216_T222_I1.0131.00
157_W193_F1.0101.00
112_D115_A1.0081.00
25_A28_L1.0061.00
127_E283_Y1.0051.00
284_A298_L1.0031.00
97_C117_Q1.0011.00
113_A116_Q0.9871.00
55_T280_L0.9861.00
137_V273_Y0.9781.00
152_E169_V0.9641.00
227_E247_R0.9601.00
164_E177_P0.9571.00
56_V130_V0.9511.00
53_S60_A0.9511.00
324_A327_E0.9441.00
109_E127_E0.9431.00
222_I234_G0.9391.00
165_Q173_W0.9361.00
253_V273_Y0.9341.00
67_F297_F0.9321.00
135_L192_Y0.9281.00
67_F300_F0.9281.00
322_Q325_Q0.9251.00
179_E214_T0.9171.00
103_L284_A0.9171.00
133_D278_R0.9151.00
201_G204_E0.9141.00
181_Y214_T0.9131.00
92_F104_N0.9121.00
133_D237_G0.9111.00
261_V272_A0.9081.00
238_Y263_P0.9071.00
84_K95_H0.9001.00
117_Q121_N0.8971.00
60_A130_V0.8881.00
131_A312_A0.8881.00
124_E286_K0.8871.00
299_R303_E0.8831.00
292_P295_A0.8821.00
115_A125_P0.8811.00
221_T225_G0.8781.00
130_V282_T0.8761.00
136_T238_Y0.8631.00
64_S81_F0.8610.99
239_A317_Y0.8580.99
293_A296_A0.8560.99
75_A305_A0.8560.99
150_V154_R0.8500.99
62_T66_A0.8480.99
157_W233_M0.8370.99
142_D230_T0.8360.99
139_V249_K0.8350.99
300_F303_E0.8340.99
144_D174_P0.8300.99
269_R318_V0.8300.99
115_A119_T0.8270.99
103_L282_T0.8210.99
101_A104_N0.8190.99
19_G22_A0.8170.99
86_T95_H0.8150.99
192_Y196_S0.8120.99
262_K267_T0.8110.99
115_A127_E0.8060.99
299_R302_L0.8060.99
190_Y235_Y0.8030.99
214_T225_G0.8010.99
323_E326_R0.8000.99
108_R191_D0.7930.99
110_V283_Y0.7930.99
305_A308_E0.7910.99
50_F105_N0.7900.99
25_A31_C0.7890.99
22_A25_A0.7890.99
139_V145_I0.7870.99
130_V280_L0.7860.99
107_S280_L0.7850.99
107_S278_R0.7810.99
308_E313_D0.7770.99
187_S219_D0.7750.99
195_E199_H0.7700.99
20_M24_G0.7690.99
59_L312_A0.7680.99
66_A311_V0.7640.99
21_G24_G0.7620.99
51_A84_K0.7620.99
110_V114_E0.7610.99
64_S297_F0.7580.99
167_S170_N0.7570.99
118_C125_P0.7540.99
254_D257_D0.7520.99
52_G91_G0.7510.99
165_Q168_D0.7510.99
110_V127_E0.7480.99
238_Y242_S0.7470.99
218_Q221_T0.7450.99
55_T107_S0.7430.99
59_L131_A0.7430.99
154_R158_S0.7420.98
148_I173_W0.7400.98
181_Y216_T0.7330.98
306_T311_V0.7330.98
137_V157_W0.7320.98
304_H308_E0.7240.98
158_S203_T0.7240.98
119_T122_D0.7240.98
145_I148_I0.7230.98
148_I253_V0.7210.98
62_T315_V0.7210.98
87_G189_T0.7200.98
31_C41_D0.7190.98
24_G28_L0.7160.98
118_C123_I0.7150.98
238_Y265_L0.7150.98
92_F114_E0.7140.98
181_Y222_I0.7120.98
55_T278_R0.7120.98
225_G229_S0.7120.98
87_G91_G0.7110.98
22_A28_L0.7100.98
298_L302_L0.7050.98
308_E314_Q0.7040.98
155_S158_S0.7040.98
154_R197_I0.7040.98
223_I242_S0.7030.98
127_E281_F0.6990.98
29_A32_Q0.6960.98
25_A29_A0.6950.98
129_T324_A0.6880.98
140_N226_V0.6870.98
252_A260_P0.6860.98
180_L212_S0.6860.98
252_A263_P0.6840.97
266_E269_R0.6840.97
26_A29_A0.6840.97
89_G186_A0.6840.97
282_T298_L0.6770.97
23_T27_A0.6760.97
148_I152_E0.6730.97
148_I233_M0.6710.97
144_D249_K0.6700.97
170_N173_W0.6700.97
53_S188_G0.6700.97
194_I198_L0.6670.97
67_F76_H0.6660.97
261_V267_T0.6610.97
136_T263_P0.6610.97
187_S217_E0.6600.97
118_C121_N0.6570.97
300_F311_V0.6570.97
135_L189_T0.6560.97
183_P235_Y0.6550.97
184_S217_E0.6550.97
91_G188_G0.6530.97
46_G79_V0.6510.97
229_S232_A0.6470.96
304_H325_Q0.6470.96
306_T312_A0.6470.96
191_D195_E0.6460.96
204_E212_S0.6460.96
56_V282_T0.6450.96
321_S324_A0.6420.96
133_D280_L0.6380.96
323_E327_E0.6380.96
44_L293_A0.6380.96
303_E307_S0.6380.96
52_G87_G0.6370.96
57_F86_T0.6360.96
107_S133_D0.6330.96
58_P240_Y0.6330.96
189_T278_R0.6290.96
136_T250_A0.6250.96
42_D46_G0.6230.96
31_C43_S0.6230.96
18_A22_A0.6210.96
91_G104_N0.6200.95
102_D294_V0.6170.95
226_V232_A0.6170.95
126_V129_T0.6140.95
150_V196_S0.6140.95
302_L307_S0.6120.95
285_A288_S0.6100.95
238_Y268_A0.6100.95
237_G240_Y0.6070.95
62_T311_V0.6070.95
21_G25_A0.6060.95
150_V275_P0.6030.95
22_A26_A0.6030.95
157_W182_G0.6020.95
113_A117_Q0.6000.95
54_S218_Q0.5990.95
160_E203_T0.5980.95
96_F125_P0.5950.94
190_Y194_I0.5930.94
67_F293_A0.5920.94
18_A21_G0.5910.94
311_V314_Q0.5880.94
304_H307_S0.5850.94
216_T225_G0.5850.94
109_E281_F0.5850.94
124_E285_A0.5850.94
87_G90_G0.5850.94
45_S78_D0.5830.94
68_R76_H0.5830.94
178_L231_N0.5810.94
103_L298_L0.5810.94
31_C44_L0.5760.93
141_T231_N0.5760.93
24_G29_A0.5750.93
189_T219_D0.5720.93
167_S171_P0.5720.93
56_V280_L0.5710.93
216_T221_T0.5710.93
48_V294_V0.5700.93
137_V276_L0.5690.93
183_P188_G0.5690.93
268_A277_S0.5680.93
179_E231_N0.5680.93
53_S282_T0.5670.93
148_I169_V0.5660.93
90_G95_H0.5640.93
88_T188_G0.5640.93
138_I234_G0.5630.93
153_L157_W0.5600.92
49_D102_D0.5590.92
79_V293_A0.5590.92
223_I248_V0.5590.92
183_P219_D0.5580.92
55_T317_Y0.5580.92
18_A24_G0.5570.92
66_A304_H0.5560.92
19_G24_G0.5550.92
66_A75_A0.5530.92
129_T132_T0.5530.92
49_D84_K0.5510.92
88_T104_N0.5510.92
236_L240_Y0.5470.92
154_R199_H0.5460.91
18_A25_A0.5460.91
143_L174_P0.5460.91
110_V115_A0.5460.91
129_T320_L0.5460.91
55_T189_T0.5420.91
111_R115_A0.5410.91
60_A83_P0.5400.91
44_L67_F0.5370.91
225_G228_G0.5370.91
286_K292_P0.5370.91
93_A117_Q0.5360.91
194_I203_T0.5350.91
184_S218_Q0.5350.91
54_S235_Y0.5340.91
219_D223_I0.5330.90
54_S87_G0.5320.90
61_T65_E0.5320.90
158_S198_L0.5310.90
268_A271_G0.5300.90
59_L317_Y0.5270.90
149_T260_P0.5260.90
254_D275_P0.5240.90
182_G235_Y0.5210.89
301_W306_T0.5200.89
51_A90_G0.5200.89
118_C122_D0.5180.89
95_H98_T0.5170.89
79_V296_A0.5160.89
237_G278_R0.5160.89
54_S58_P0.5130.89
242_S316_G0.5120.89
197_I276_L0.5100.88
156_I163_T0.5100.88
137_V253_V0.5100.88
54_S183_P0.5070.88
302_L306_T0.5070.88
19_G27_A0.5060.88
153_L197_I0.5060.88
185_S194_I0.5050.88
224_Q227_E0.5050.88
133_D317_Y0.5040.88
193_F197_I0.5040.88
76_H296_A0.5030.88
256_G260_P0.5000.87
21_G27_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f1vA 1 0.8227 100 0.329 Contact Map
4n13A 1 0.718 100 0.463 Contact Map
1ixhA 1 0.811 100 0.534 Contact Map
1pc3A 1 0.8285 100 0.538 Contact Map
4jwoA 1 0.814 100 0.574 Contact Map
4ombA 1 0.811 100 0.577 Contact Map
4lvqA 1 0.7965 100 0.596 Contact Map
4ecfA 1 0.7529 100 0.61 Contact Map
4exlA 1 0.7645 100 0.619 Contact Map
4q8rA 1 0.7006 100 0.62 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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