GREMLIN Database
Q9HS09 - Phosphate regulatory protein homolog
UniProt: Q9HS09 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (321)
Sequences: 392 (313)
Seq/√Len: 17.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_E217_D4.8541.00
214_R218_H4.4991.00
13_T17_S4.0911.00
148_D167_R4.0241.00
6_V28_V3.9911.00
145_M168_D3.9021.00
168_D213_E3.8661.00
34_V45_L3.8611.00
172_D217_D3.5761.00
168_D217_D3.5461.00
172_D213_E3.1530.99
149_A219_A3.1020.99
171_V216_A2.9560.99
146_L313_S2.8620.98
208_S259_L2.7660.98
316_Y322_E2.3880.95
23_A28_V2.3840.95
8_V11_G2.3320.94
138_M171_V2.3020.94
258_A267_A2.1790.91
19_P22_W2.1660.91
85_L110_V2.1210.90
310_L314_A2.0380.88
11_G14_F2.0360.88
85_L131_I2.0270.88
217_D322_E2.0220.88
168_D172_D1.9470.86
7_Q13_T1.9460.86
29_E32_D1.9140.85
145_M217_D1.8880.84
145_M213_E1.8860.84
107_G180_R1.8640.83
10_G70_R1.8240.82
9_T12_S1.8230.82
36_F43_L1.8180.82
9_T14_F1.7760.80
152_A161_A1.7660.80
9_T15_T1.7630.80
126_S177_V1.7520.79
7_Q17_S1.7480.79
203_F206_H1.7360.79
15_T214_R1.7290.78
13_T23_A1.7260.78
192_A195_I1.7250.78
9_T214_R1.6960.77
150_V159_D1.6640.76
76_Y107_G1.6570.75
5_K14_F1.6530.75
177_V181_I1.6290.74
4_R19_P1.6210.74
102_T120_I1.5800.72
14_F21_D1.5750.71
268_T325_L1.5670.71
138_M216_A1.5580.70
163_D167_R1.5570.70
138_M213_E1.5550.70
312_R319_N1.5450.70
214_R312_R1.5390.70
161_A164_V1.5310.69
29_E34_V1.5270.69
145_M322_E1.5260.69
138_M217_D1.5230.69
213_E218_H1.5180.68
74_T172_D1.5000.67
185_A195_I1.4530.65
142_A219_A1.4390.64
231_D236_D1.4340.64
4_R22_W1.4300.64
5_K12_S1.4160.63
309_S316_Y1.4000.62
10_G20_K1.3980.62
149_A226_T1.3860.61
113_E167_R1.3700.60
149_A161_A1.3680.60
170_D173_R1.3570.59
9_T20_K1.3510.59
101_A105_L1.3440.59
219_A223_A1.3320.58
109_E170_D1.3260.58
218_H319_N1.3220.57
85_L208_S1.3090.57
311_S315_D1.2980.56
123_L168_D1.2960.56
3_R43_L1.2950.56
11_G15_T1.2930.56
213_E216_A1.2920.56
10_G22_W1.2890.55
218_H322_E1.2810.55
27_S118_V1.2780.55
16_V285_A1.2780.55
6_V14_F1.2750.55
44_L85_L1.2620.54
214_R322_E1.2590.54
18_I42_S1.2550.53
308_D315_D1.2380.52
73_M181_I1.2380.52
213_E319_N1.2320.52
303_L306_V1.2300.52
4_R7_Q1.2290.52
233_I287_D1.2100.51
124_L210_R1.2070.50
211_Q319_N1.1980.50
7_Q12_S1.1940.50
112_E167_R1.1930.50
13_T42_S1.1800.49
173_R180_R1.1720.48
252_I317_G1.1670.48
57_T119_V1.1600.48
148_D160_I1.1590.48
169_D172_D1.1580.48
322_E326_Q1.1570.47
133_N137_R1.1460.47
149_A153_L1.1380.46
254_T273_Q1.1340.46
105_L206_H1.1330.46
213_E322_E1.1330.46
45_L265_D1.1320.46
278_V290_D1.1300.46
75_M124_L1.1300.46
9_T316_Y1.1270.46
197_I205_Y1.1240.45
183_R204_D1.1210.45
128_E173_R1.1170.45
12_S204_D1.1150.45
13_T121_Q1.1130.45
281_I285_A1.0900.43
77_V179_S1.0850.43
180_R311_S1.0850.43
217_D319_N1.0830.43
218_H312_R1.0810.43
11_G17_S1.0810.43
106_V124_L1.0720.42
4_R10_G1.0710.42
45_L63_M1.0650.42
152_A226_T1.0650.42
4_R13_T1.0600.42
174_L319_N1.0570.41
27_S232_D1.0530.41
148_D214_R1.0470.41
247_D281_I1.0460.41
171_V256_M1.0400.40
308_D316_Y1.0390.40
87_A90_I1.0380.40
95_R148_D1.0370.40
28_V36_F1.0370.40
11_G33_E1.0370.40
212_L272_T1.0310.40
145_M172_D1.0310.40
8_V13_T1.0300.40
41_G53_T1.0270.40
20_K267_A1.0240.40
152_A258_A1.0190.39
164_V216_A1.0120.39
87_A215_V1.0050.38
158_P292_L1.0040.38
26_H41_G1.0040.38
145_M216_A1.0030.38
12_S64_H1.0020.38
32_D141_I0.9990.38
135_V292_L0.9970.38
55_K84_A0.9920.38
159_D255_A0.9910.38
10_G217_D0.9860.37
283_D291_R0.9770.37
6_V26_H0.9760.37
320_I325_L0.9750.37
76_Y80_F0.9690.36
149_A310_L0.9660.36
218_H316_Y0.9620.36
305_L308_D0.9590.36
174_L178_V0.9590.36
4_R16_V0.9590.36
151_T160_I0.9570.36
7_Q11_G0.9560.36
72_V101_A0.9500.35
18_I22_W0.9440.35
182_F209_A0.9380.35
30_A74_T0.9280.34
90_I94_Q0.9270.34
312_R320_I0.9230.34
79_G107_G0.9230.34
13_T33_E0.9220.34
165_T168_D0.9200.34
212_L258_A0.9180.34
185_A259_L0.9160.33
219_A226_T0.9140.33
118_V137_R0.9120.33
212_L269_A0.9090.33
80_F227_H0.9090.33
227_H241_L0.9090.33
210_R256_M0.9060.33
150_V245_Q0.9060.33
215_V252_I0.9050.33
147_E170_D0.8990.33
236_D287_D0.8930.32
80_F286_R0.8920.32
145_M171_V0.8920.32
96_R137_R0.8920.32
181_I184_G0.8910.32
31_G105_L0.8910.32
149_A245_Q0.8880.32
66_E87_A0.8880.32
30_A211_Q0.8840.32
14_F186_L0.8830.32
214_R316_Y0.8820.32
109_E173_R0.8800.32
228_D272_T0.8740.31
8_V25_D0.8730.31
105_L176_Y0.8730.31
76_Y322_E0.8690.31
81_D304_G0.8610.31
89_S163_D0.8590.30
169_D173_R0.8570.30
13_T122_D0.8570.30
131_I135_V0.8540.30
169_D177_V0.8530.30
137_R141_I0.8510.30
18_I111_L0.8450.30
32_D326_Q0.8420.30
172_D319_N0.8380.29
36_F176_Y0.8360.29
76_Y180_R0.8350.29
10_G19_P0.8340.29
5_K310_L0.8330.29
150_V288_V0.8310.29
221_K308_D0.8310.29
47_P134_A0.8290.29
145_M173_R0.8280.29
185_A314_A0.8240.29
68_L174_L0.8210.29
267_A271_A0.8200.29
46_T193_Q0.8150.28
7_Q10_G0.8120.28
72_V315_D0.8110.28
102_T109_E0.8090.28
105_L255_A0.8050.28
42_S251_I0.8010.28
171_V307_V0.8010.28
10_G172_D0.7990.27
235_E315_D0.7980.27
18_I117_R0.7970.27
86_E154_A0.7940.27
309_S325_L0.7920.27
166_N188_S0.7910.27
32_D70_R0.7910.27
172_D312_R0.7890.27
14_F215_V0.7890.27
283_D286_R0.7890.27
10_G213_E0.7880.27
79_G180_R0.7860.27
77_V176_Y0.7850.27
186_L191_V0.7840.27
284_Q287_D0.7840.27
217_D222_I0.7840.27
100_D212_L0.7840.27
34_V278_V0.7830.27
283_D287_D0.7800.27
26_H124_L0.7780.26
119_V196_G0.7750.26
13_T19_P0.7710.26
125_D128_E0.7700.26
172_D216_A0.7700.26
21_D51_T0.7690.26
264_A325_L0.7690.26
12_S46_T0.7680.26
121_Q259_L0.7670.26
7_Q16_V0.7660.26
148_D163_D0.7630.26
241_L248_A0.7620.26
107_G173_R0.7590.26
108_L271_A0.7580.26
6_V221_K0.7540.25
6_V13_T0.7520.25
182_F221_K0.7520.25
247_D250_D0.7510.25
174_L217_D0.7510.25
11_G120_I0.7460.25
98_I263_T0.7450.25
288_V296_T0.7440.25
16_V29_E0.7440.25
32_D48_I0.7410.25
18_I43_L0.7410.25
299_H306_V0.7400.25
184_G191_V0.7400.25
287_D290_D0.7390.25
15_T226_T0.7360.25
77_V80_F0.7350.25
146_L310_L0.7350.25
45_L85_L0.7340.24
138_M255_A0.7340.24
119_V151_T0.7320.24
6_V9_T0.7290.24
212_L252_I0.7260.24
312_R316_Y0.7210.24
142_A216_A0.7200.24
39_D72_V0.7190.24
214_R320_I0.7180.24
225_A292_L0.7180.24
86_E173_R0.7170.24
18_I23_A0.7160.24
229_L258_A0.7140.24
145_M165_T0.7140.24
13_T324_A0.7140.24
117_R147_E0.7130.24
134_A178_V0.7130.24
137_R140_L0.7110.23
145_M309_S0.7100.23
132_H205_Y0.7090.23
177_V192_A0.7070.23
36_F45_L0.7050.23
179_S206_H0.7030.23
115_S121_Q0.7020.23
172_D176_Y0.7000.23
146_L249_T0.7000.23
236_D250_D0.6990.23
95_R210_R0.6990.23
101_A314_A0.6980.23
82_V98_I0.6960.23
99_R170_D0.6930.23
95_R163_D0.6910.23
8_V34_V0.6900.23
90_I204_D0.6900.23
86_E251_I0.6890.23
20_K214_R0.6890.23
60_I64_H0.6870.22
235_E239_D0.6860.22
7_Q19_P0.6850.22
74_T192_A0.6850.22
53_T266_E0.6830.22
10_G13_T0.6810.22
18_I160_I0.6810.22
182_F319_N0.6810.22
221_K311_S0.6800.22
114_T160_I0.6770.22
12_S85_L0.6740.22
308_D317_G0.6730.22
263_T266_E0.6730.22
160_I218_H0.6730.22
322_E325_L0.6720.22
176_Y322_E0.6710.22
19_P180_R0.6710.22
46_T74_T0.6650.22
178_V234_P0.6650.22
203_F216_A0.6630.21
172_D322_E0.6570.21
41_G185_A0.6560.21
203_F260_F0.6540.21
181_I185_A0.6540.21
316_Y326_Q0.6520.21
14_F23_A0.6520.21
38_P182_F0.6500.21
306_V313_S0.6490.21
10_G31_G0.6480.21
149_A154_A0.6480.21
87_A113_E0.6460.21
172_D309_S0.6460.21
269_A294_G0.6410.21
16_V50_D0.6400.21
307_V314_A0.6400.21
123_L177_V0.6390.20
118_V169_D0.6380.20
240_A291_R0.6370.20
83_L241_L0.6350.20
122_D179_S0.6350.20
137_R249_T0.6330.20
41_G256_M0.6320.20
236_D243_T0.6290.20
147_E159_D0.6290.20
109_E214_R0.6270.20
128_E222_I0.6270.20
76_Y79_G0.6230.20
251_I264_A0.6210.20
288_V291_R0.6200.20
21_D30_A0.6190.20
305_L316_Y0.6190.20
123_L129_L0.6190.20
153_L226_T0.6180.20
248_A270_L0.6180.20
178_V271_A0.6160.20
129_L171_V0.6150.20
184_G197_I0.6150.20
16_V19_P0.6120.19
78_S321_A0.6100.19
241_L307_V0.6100.19
149_A223_A0.6090.19
85_L256_M0.6080.19
96_R259_L0.6070.19
108_L173_R0.6060.19
118_V126_S0.6040.19
16_V103_Q0.6030.19
105_L180_R0.6010.19
85_L111_L0.6000.19
29_E236_D0.5980.19
303_L307_V0.5970.19
13_T22_W0.5950.19
220_T307_V0.5950.19
72_V142_A0.5950.19
178_V260_F0.5950.19
157_D162_R0.5920.19
111_L206_H0.5910.19
239_D246_A0.5890.19
82_V230_N0.5880.19
101_A176_Y0.5840.18
125_D326_Q0.5820.18
70_R73_M0.5820.18
82_V121_Q0.5820.18
212_L289_D0.5760.18
223_A249_T0.5760.18
76_Y110_V0.5750.18
198_T228_D0.5750.18
71_A207_S0.5740.18
162_R227_H0.5740.18
174_L278_V0.5720.18
72_V127_S0.5700.18
309_S322_E0.5680.18
106_V264_A0.5680.18
164_V168_D0.5670.18
149_A222_I0.5660.18
8_V43_L0.5650.18
148_D218_H0.5610.18
98_I273_Q0.5600.18
120_I131_I0.5590.17
31_G70_R0.5590.17
9_T194_E0.5590.17
138_M163_D0.5580.17
43_L168_D0.5570.17
11_G211_Q0.5570.17
287_D291_R0.5540.17
215_V313_S0.5540.17
126_S191_V0.5520.17
159_D171_V0.5520.17
182_F289_D0.5510.17
142_A248_A0.5510.17
308_D319_N0.5510.17
181_I268_T0.5490.17
19_P107_G0.5490.17
280_D290_D0.5480.17
87_A94_Q0.5480.17
114_T306_V0.5480.17
17_S192_A0.5470.17
36_F90_I0.5470.17
32_D319_N0.5430.17
203_F210_R0.5400.17
188_S223_A0.5390.17
102_T279_R0.5380.17
9_T113_E0.5330.17
43_L318_G0.5320.17
218_H320_I0.5320.17
17_S24_R0.5320.17
81_D92_P0.5300.16
131_I144_S0.5300.16
6_V43_L0.5270.16
18_I48_I0.5250.16
14_F20_K0.5250.16
157_D222_I0.5250.16
155_T286_R0.5240.16
49_D54_D0.5220.16
146_L288_V0.5220.16
100_D231_D0.5220.16
164_V248_A0.5220.16
120_I320_I0.5210.16
105_L130_S0.5200.16
162_R208_S0.5190.16
6_V30_A0.5190.16
17_S22_W0.5190.16
25_D248_A0.5180.16
212_L282_D0.5170.16
160_I164_V0.5120.16
92_P241_L0.5110.16
50_D243_T0.5110.16
72_V263_T0.5110.16
110_V171_V0.5090.16
269_A325_L0.5040.16
168_D322_E0.5040.16
10_G16_V0.5040.16
99_R212_L0.5040.16
168_D220_T0.5030.16
131_I164_V0.5020.16
230_N255_A0.5010.16
118_V171_V0.5000.16
106_V176_Y0.5000.16
75_M186_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sumB 2 0.6287 100 0.68 Contact Map
1xwmA 2 0.6228 100 0.684 Contact Map
2i0mA 2 0.6048 100 0.689 Contact Map
1t72A 5 0.6347 100 0.693 Contact Map
4q25A 2 0.6198 99.9 0.698 Contact Map
2oltA 5 0.5928 99.9 0.752 Contact Map
3l39A 3 0.5958 99.3 0.839 Contact Map
2mrnA 2 0.1497 98.7 0.877 Contact Map
1mvfD 1 0.1317 98.3 0.889 Contact Map
3o27A 2 0.1527 98.2 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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