Q9HS09 - HALSA - GREMLIN Contacts

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Q9HS09 - Phosphate regulatory protein homolog

UniProt:	Q9HS09	Sequences: MERRKVQVTGGSTFTVSIPKDWARDHSVEAGDEVGFHPDSGSLLLTPIDDTDTDKGTLTITDMHGEELMRAVMTMYVSGFDVLALEAESIDPDQRRVIRDATQGLVGLEVLEETSQRVVIQDLLDSSELSIHNAVRRMHLIAVSMLEDAVTALATRDPDIARDVTNRDDDVDRLWYVVSRIFRGALRSPTVAQEIGITREVAFDYHSSARQLERVADHATKIATATHDLNDDIPEDVVDALETLQADATDIIETAMDALFADTADEATALATQARAQVRDIDDQARDVDDRLHGLTAHHAQHLGLVVDSLSRSADYGGNIAETALQKAAPTPNP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	334 (321)
Sequences:	392 (313)
Seq/√Len:	17.5

HALSA - Q9HS09 Q9HRB9
SULSO - Q980F5 Q7LXS0 Q97VK4 Q97ZI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
213_E	217_D	4.854	1.00
214_R	218_H	4.499	1.00
13_T	17_S	4.091	1.00
148_D	167_R	4.024	1.00
6_V	28_V	3.991	1.00
145_M	168_D	3.902	1.00
168_D	213_E	3.866	1.00
34_V	45_L	3.861	1.00
172_D	217_D	3.576	1.00
168_D	217_D	3.546	1.00
172_D	213_E	3.153	0.99
149_A	219_A	3.102	0.99
171_V	216_A	2.956	0.99
146_L	313_S	2.862	0.98
208_S	259_L	2.766	0.98
316_Y	322_E	2.388	0.95
23_A	28_V	2.384	0.95
8_V	11_G	2.332	0.94
138_M	171_V	2.302	0.94
258_A	267_A	2.179	0.91
19_P	22_W	2.166	0.91
85_L	110_V	2.121	0.90
310_L	314_A	2.038	0.88
11_G	14_F	2.036	0.88
85_L	131_I	2.027	0.88
217_D	322_E	2.022	0.88
168_D	172_D	1.947	0.86
7_Q	13_T	1.946	0.86
29_E	32_D	1.914	0.85
145_M	217_D	1.888	0.84
145_M	213_E	1.886	0.84
107_G	180_R	1.864	0.83
10_G	70_R	1.824	0.82
9_T	12_S	1.823	0.82
36_F	43_L	1.818	0.82
9_T	14_F	1.776	0.80
152_A	161_A	1.766	0.80
9_T	15_T	1.763	0.80
126_S	177_V	1.752	0.79
7_Q	17_S	1.748	0.79
203_F	206_H	1.736	0.79
15_T	214_R	1.729	0.78
13_T	23_A	1.726	0.78
192_A	195_I	1.725	0.78
9_T	214_R	1.696	0.77
150_V	159_D	1.664	0.76
76_Y	107_G	1.657	0.75
5_K	14_F	1.653	0.75
177_V	181_I	1.629	0.74
4_R	19_P	1.621	0.74
102_T	120_I	1.580	0.72
14_F	21_D	1.575	0.71
268_T	325_L	1.567	0.71
138_M	216_A	1.558	0.70
163_D	167_R	1.557	0.70
138_M	213_E	1.555	0.70
312_R	319_N	1.545	0.70
214_R	312_R	1.539	0.70
161_A	164_V	1.531	0.69
29_E	34_V	1.527	0.69
145_M	322_E	1.526	0.69
138_M	217_D	1.523	0.69
213_E	218_H	1.518	0.68
74_T	172_D	1.500	0.67
185_A	195_I	1.453	0.65
142_A	219_A	1.439	0.64
231_D	236_D	1.434	0.64
4_R	22_W	1.430	0.64
5_K	12_S	1.416	0.63
309_S	316_Y	1.400	0.62
10_G	20_K	1.398	0.62
149_A	226_T	1.386	0.61
113_E	167_R	1.370	0.60
149_A	161_A	1.368	0.60
170_D	173_R	1.357	0.59
9_T	20_K	1.351	0.59
101_A	105_L	1.344	0.59
219_A	223_A	1.332	0.58
109_E	170_D	1.326	0.58
218_H	319_N	1.322	0.57
85_L	208_S	1.309	0.57
311_S	315_D	1.298	0.56
123_L	168_D	1.296	0.56
3_R	43_L	1.295	0.56
11_G	15_T	1.293	0.56
213_E	216_A	1.292	0.56
10_G	22_W	1.289	0.55
218_H	322_E	1.281	0.55
27_S	118_V	1.278	0.55
16_V	285_A	1.278	0.55
6_V	14_F	1.275	0.55
44_L	85_L	1.262	0.54
214_R	322_E	1.259	0.54
18_I	42_S	1.255	0.53
308_D	315_D	1.238	0.52
73_M	181_I	1.238	0.52
213_E	319_N	1.232	0.52
303_L	306_V	1.230	0.52
4_R	7_Q	1.229	0.52
233_I	287_D	1.210	0.51
124_L	210_R	1.207	0.50
211_Q	319_N	1.198	0.50
7_Q	12_S	1.194	0.50
112_E	167_R	1.193	0.50
13_T	42_S	1.180	0.49
173_R	180_R	1.172	0.48
252_I	317_G	1.167	0.48
57_T	119_V	1.160	0.48
148_D	160_I	1.159	0.48
169_D	172_D	1.158	0.48
322_E	326_Q	1.157	0.47
133_N	137_R	1.146	0.47
149_A	153_L	1.138	0.46
254_T	273_Q	1.134	0.46
105_L	206_H	1.133	0.46
213_E	322_E	1.133	0.46
45_L	265_D	1.132	0.46
278_V	290_D	1.130	0.46
75_M	124_L	1.130	0.46
9_T	316_Y	1.127	0.46
197_I	205_Y	1.124	0.45
183_R	204_D	1.121	0.45
128_E	173_R	1.117	0.45
12_S	204_D	1.115	0.45
13_T	121_Q	1.113	0.45
281_I	285_A	1.090	0.43
77_V	179_S	1.085	0.43
180_R	311_S	1.085	0.43
217_D	319_N	1.083	0.43
218_H	312_R	1.081	0.43
11_G	17_S	1.081	0.43
106_V	124_L	1.072	0.42
4_R	10_G	1.071	0.42
45_L	63_M	1.065	0.42
152_A	226_T	1.065	0.42
4_R	13_T	1.060	0.42
174_L	319_N	1.057	0.41
27_S	232_D	1.053	0.41
148_D	214_R	1.047	0.41
247_D	281_I	1.046	0.41
171_V	256_M	1.040	0.40
308_D	316_Y	1.039	0.40
87_A	90_I	1.038	0.40
95_R	148_D	1.037	0.40
28_V	36_F	1.037	0.40
11_G	33_E	1.037	0.40
212_L	272_T	1.031	0.40
145_M	172_D	1.031	0.40
8_V	13_T	1.030	0.40
41_G	53_T	1.027	0.40
20_K	267_A	1.024	0.40
152_A	258_A	1.019	0.39
164_V	216_A	1.012	0.39
87_A	215_V	1.005	0.38
158_P	292_L	1.004	0.38
26_H	41_G	1.004	0.38
145_M	216_A	1.003	0.38
12_S	64_H	1.002	0.38
32_D	141_I	0.999	0.38
135_V	292_L	0.997	0.38
55_K	84_A	0.992	0.38
159_D	255_A	0.991	0.38
10_G	217_D	0.986	0.37
283_D	291_R	0.977	0.37
6_V	26_H	0.976	0.37
320_I	325_L	0.975	0.37
76_Y	80_F	0.969	0.36
149_A	310_L	0.966	0.36
218_H	316_Y	0.962	0.36
305_L	308_D	0.959	0.36
174_L	178_V	0.959	0.36
4_R	16_V	0.959	0.36
151_T	160_I	0.957	0.36
7_Q	11_G	0.956	0.36
72_V	101_A	0.950	0.35
18_I	22_W	0.944	0.35
182_F	209_A	0.938	0.35
30_A	74_T	0.928	0.34
90_I	94_Q	0.927	0.34
312_R	320_I	0.923	0.34
79_G	107_G	0.923	0.34
13_T	33_E	0.922	0.34
165_T	168_D	0.920	0.34
212_L	258_A	0.918	0.34
185_A	259_L	0.916	0.33
219_A	226_T	0.914	0.33
118_V	137_R	0.912	0.33
212_L	269_A	0.909	0.33
80_F	227_H	0.909	0.33
227_H	241_L	0.909	0.33
210_R	256_M	0.906	0.33
150_V	245_Q	0.906	0.33
215_V	252_I	0.905	0.33
147_E	170_D	0.899	0.33
236_D	287_D	0.893	0.32
80_F	286_R	0.892	0.32
145_M	171_V	0.892	0.32
96_R	137_R	0.892	0.32
181_I	184_G	0.891	0.32
31_G	105_L	0.891	0.32
149_A	245_Q	0.888	0.32
66_E	87_A	0.888	0.32
30_A	211_Q	0.884	0.32
14_F	186_L	0.883	0.32
214_R	316_Y	0.882	0.32
109_E	173_R	0.880	0.32
228_D	272_T	0.874	0.31
8_V	25_D	0.873	0.31
105_L	176_Y	0.873	0.31
76_Y	322_E	0.869	0.31
81_D	304_G	0.861	0.31
89_S	163_D	0.859	0.30
169_D	173_R	0.857	0.30
13_T	122_D	0.857	0.30
131_I	135_V	0.854	0.30
169_D	177_V	0.853	0.30
137_R	141_I	0.851	0.30
18_I	111_L	0.845	0.30
32_D	326_Q	0.842	0.30
172_D	319_N	0.838	0.29
36_F	176_Y	0.836	0.29
76_Y	180_R	0.835	0.29
10_G	19_P	0.834	0.29
5_K	310_L	0.833	0.29
150_V	288_V	0.831	0.29
221_K	308_D	0.831	0.29
47_P	134_A	0.829	0.29
145_M	173_R	0.828	0.29
185_A	314_A	0.824	0.29
68_L	174_L	0.821	0.29
267_A	271_A	0.820	0.29
46_T	193_Q	0.815	0.28
7_Q	10_G	0.812	0.28
72_V	315_D	0.811	0.28
102_T	109_E	0.809	0.28
105_L	255_A	0.805	0.28
42_S	251_I	0.801	0.28
171_V	307_V	0.801	0.28
10_G	172_D	0.799	0.27
235_E	315_D	0.798	0.27
18_I	117_R	0.797	0.27
86_E	154_A	0.794	0.27
309_S	325_L	0.792	0.27
166_N	188_S	0.791	0.27
32_D	70_R	0.791	0.27
172_D	312_R	0.789	0.27
14_F	215_V	0.789	0.27
283_D	286_R	0.789	0.27
10_G	213_E	0.788	0.27
79_G	180_R	0.786	0.27
77_V	176_Y	0.785	0.27
186_L	191_V	0.784	0.27
284_Q	287_D	0.784	0.27
217_D	222_I	0.784	0.27
100_D	212_L	0.784	0.27
34_V	278_V	0.783	0.27
283_D	287_D	0.780	0.27
26_H	124_L	0.778	0.26
119_V	196_G	0.775	0.26
13_T	19_P	0.771	0.26
125_D	128_E	0.770	0.26
172_D	216_A	0.770	0.26
21_D	51_T	0.769	0.26
264_A	325_L	0.769	0.26
12_S	46_T	0.768	0.26
121_Q	259_L	0.767	0.26
7_Q	16_V	0.766	0.26
148_D	163_D	0.763	0.26
241_L	248_A	0.762	0.26
107_G	173_R	0.759	0.26
108_L	271_A	0.758	0.26
6_V	221_K	0.754	0.25
6_V	13_T	0.752	0.25
182_F	221_K	0.752	0.25
247_D	250_D	0.751	0.25
174_L	217_D	0.751	0.25
11_G	120_I	0.746	0.25
98_I	263_T	0.745	0.25
288_V	296_T	0.744	0.25
16_V	29_E	0.744	0.25
32_D	48_I	0.741	0.25
18_I	43_L	0.741	0.25
299_H	306_V	0.740	0.25
184_G	191_V	0.740	0.25
287_D	290_D	0.739	0.25
15_T	226_T	0.736	0.25
77_V	80_F	0.735	0.25
146_L	310_L	0.735	0.25
45_L	85_L	0.734	0.24
138_M	255_A	0.734	0.24
119_V	151_T	0.732	0.24
6_V	9_T	0.729	0.24
212_L	252_I	0.726	0.24
312_R	316_Y	0.721	0.24
142_A	216_A	0.720	0.24
39_D	72_V	0.719	0.24
214_R	320_I	0.718	0.24
225_A	292_L	0.718	0.24
86_E	173_R	0.717	0.24
18_I	23_A	0.716	0.24
229_L	258_A	0.714	0.24
145_M	165_T	0.714	0.24
13_T	324_A	0.714	0.24
117_R	147_E	0.713	0.24
134_A	178_V	0.713	0.24
137_R	140_L	0.711	0.23
145_M	309_S	0.710	0.23
132_H	205_Y	0.709	0.23
177_V	192_A	0.707	0.23
36_F	45_L	0.705	0.23
179_S	206_H	0.703	0.23
115_S	121_Q	0.702	0.23
172_D	176_Y	0.700	0.23
146_L	249_T	0.700	0.23
236_D	250_D	0.699	0.23
95_R	210_R	0.699	0.23
101_A	314_A	0.698	0.23
82_V	98_I	0.696	0.23
99_R	170_D	0.693	0.23
95_R	163_D	0.691	0.23
8_V	34_V	0.690	0.23
90_I	204_D	0.690	0.23
86_E	251_I	0.689	0.23
20_K	214_R	0.689	0.23
60_I	64_H	0.687	0.22
235_E	239_D	0.686	0.22
7_Q	19_P	0.685	0.22
74_T	192_A	0.685	0.22
53_T	266_E	0.683	0.22
10_G	13_T	0.681	0.22
18_I	160_I	0.681	0.22
182_F	319_N	0.681	0.22
221_K	311_S	0.680	0.22
114_T	160_I	0.677	0.22
12_S	85_L	0.674	0.22
308_D	317_G	0.673	0.22
263_T	266_E	0.673	0.22
160_I	218_H	0.673	0.22
322_E	325_L	0.672	0.22
176_Y	322_E	0.671	0.22
19_P	180_R	0.671	0.22
46_T	74_T	0.665	0.22
178_V	234_P	0.665	0.22
203_F	216_A	0.663	0.21
172_D	322_E	0.657	0.21
41_G	185_A	0.656	0.21
203_F	260_F	0.654	0.21
181_I	185_A	0.654	0.21
316_Y	326_Q	0.652	0.21
14_F	23_A	0.652	0.21
38_P	182_F	0.650	0.21
306_V	313_S	0.649	0.21
10_G	31_G	0.648	0.21
149_A	154_A	0.648	0.21
87_A	113_E	0.646	0.21
172_D	309_S	0.646	0.21
269_A	294_G	0.641	0.21
16_V	50_D	0.640	0.21
307_V	314_A	0.640	0.21
123_L	177_V	0.639	0.20
118_V	169_D	0.638	0.20
240_A	291_R	0.637	0.20
83_L	241_L	0.635	0.20
122_D	179_S	0.635	0.20
137_R	249_T	0.633	0.20
41_G	256_M	0.632	0.20
236_D	243_T	0.629	0.20
147_E	159_D	0.629	0.20
109_E	214_R	0.627	0.20
128_E	222_I	0.627	0.20
76_Y	79_G	0.623	0.20
251_I	264_A	0.621	0.20
288_V	291_R	0.620	0.20
21_D	30_A	0.619	0.20
305_L	316_Y	0.619	0.20
123_L	129_L	0.619	0.20
153_L	226_T	0.618	0.20
248_A	270_L	0.618	0.20
178_V	271_A	0.616	0.20
129_L	171_V	0.615	0.20
184_G	197_I	0.615	0.20
16_V	19_P	0.612	0.19
78_S	321_A	0.610	0.19
241_L	307_V	0.610	0.19
149_A	223_A	0.609	0.19
85_L	256_M	0.608	0.19
96_R	259_L	0.607	0.19
108_L	173_R	0.606	0.19
118_V	126_S	0.604	0.19
16_V	103_Q	0.603	0.19
105_L	180_R	0.601	0.19
85_L	111_L	0.600	0.19
29_E	236_D	0.598	0.19
303_L	307_V	0.597	0.19
13_T	22_W	0.595	0.19
220_T	307_V	0.595	0.19
72_V	142_A	0.595	0.19
178_V	260_F	0.595	0.19
157_D	162_R	0.592	0.19
111_L	206_H	0.591	0.19
239_D	246_A	0.589	0.19
82_V	230_N	0.588	0.19
101_A	176_Y	0.584	0.18
125_D	326_Q	0.582	0.18
70_R	73_M	0.582	0.18
82_V	121_Q	0.582	0.18
212_L	289_D	0.576	0.18
223_A	249_T	0.576	0.18
76_Y	110_V	0.575	0.18
198_T	228_D	0.575	0.18
71_A	207_S	0.574	0.18
162_R	227_H	0.574	0.18
174_L	278_V	0.572	0.18
72_V	127_S	0.570	0.18
309_S	322_E	0.568	0.18
106_V	264_A	0.568	0.18
164_V	168_D	0.567	0.18
149_A	222_I	0.566	0.18
8_V	43_L	0.565	0.18
148_D	218_H	0.561	0.18
98_I	273_Q	0.560	0.18
120_I	131_I	0.559	0.17
31_G	70_R	0.559	0.17
9_T	194_E	0.559	0.17
138_M	163_D	0.558	0.17
43_L	168_D	0.557	0.17
11_G	211_Q	0.557	0.17
287_D	291_R	0.554	0.17
215_V	313_S	0.554	0.17
126_S	191_V	0.552	0.17
159_D	171_V	0.552	0.17
182_F	289_D	0.551	0.17
142_A	248_A	0.551	0.17
308_D	319_N	0.551	0.17
181_I	268_T	0.549	0.17
19_P	107_G	0.549	0.17
280_D	290_D	0.548	0.17
87_A	94_Q	0.548	0.17
114_T	306_V	0.548	0.17
17_S	192_A	0.547	0.17
36_F	90_I	0.547	0.17
32_D	319_N	0.543	0.17
203_F	210_R	0.540	0.17
188_S	223_A	0.539	0.17
102_T	279_R	0.538	0.17
9_T	113_E	0.533	0.17
43_L	318_G	0.532	0.17
218_H	320_I	0.532	0.17
17_S	24_R	0.532	0.17
81_D	92_P	0.530	0.16
131_I	144_S	0.530	0.16
6_V	43_L	0.527	0.16
18_I	48_I	0.525	0.16
14_F	20_K	0.525	0.16
157_D	222_I	0.525	0.16
155_T	286_R	0.524	0.16
49_D	54_D	0.522	0.16
146_L	288_V	0.522	0.16
100_D	231_D	0.522	0.16
164_V	248_A	0.522	0.16
120_I	320_I	0.521	0.16
105_L	130_S	0.520	0.16
162_R	208_S	0.519	0.16
6_V	30_A	0.519	0.16
17_S	22_W	0.519	0.16
25_D	248_A	0.518	0.16
212_L	282_D	0.517	0.16
160_I	164_V	0.512	0.16
92_P	241_L	0.511	0.16
50_D	243_T	0.511	0.16
72_V	263_T	0.511	0.16
110_V	171_V	0.509	0.16
269_A	325_L	0.504	0.16
168_D	322_E	0.504	0.16
10_G	16_V	0.504	0.16
99_R	212_L	0.504	0.16
168_D	220_T	0.503	0.16
131_I	164_V	0.502	0.16
230_N	255_A	0.501	0.16
118_V	171_V	0.500	0.16
106_V	176_Y	0.500	0.16
75_M	186_L	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sumB	2	0.6287	100	0.68	Contact Map
1xwmA	2	0.6228	100	0.684	Contact Map
2i0mA	2	0.6048	100	0.689	Contact Map
1t72A	5	0.6347	100	0.693	Contact Map
4q25A	2	0.6198	99.9	0.698	Contact Map
2oltA	5	0.5928	99.9	0.752	Contact Map
3l39A	3	0.5958	99.3	0.839	Contact Map
2mrnA	2	0.1497	98.7	0.877	Contact Map
1mvfD	1	0.1317	98.3	0.889	Contact Map
3o27A	2	0.1527	98.2	0.893	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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