GREMLIN Database
Q9HS06 - Uncharacterized protein
UniProt: Q9HS06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 94 (89)
Sequences: 911 (631)
Seq/√Len: 66.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_L56_V3.2591.00
45_L69_A3.2311.00
55_E70_V2.9091.00
53_A78_M2.6581.00
11_T36_L2.5391.00
16_F71_L2.2801.00
31_T38_E2.2011.00
26_S29_D2.0691.00
52_D74_D2.0411.00
60_F65_P1.9901.00
22_H25_S1.9111.00
24_E57_R1.8221.00
58_K67_T1.8001.00
36_L40_N1.7831.00
60_F63_K1.7411.00
4_D81_D1.6690.99
46_Q63_K1.6660.99
87_Q91_D1.5960.99
49_E63_K1.5890.99
77_A81_D1.5490.99
59_E68_T1.5270.99
37_T40_N1.4930.99
4_D53_A1.4290.98
18_Y25_S1.3750.98
17_A79_F1.3200.97
6_L51_A1.3110.97
8_H82_H1.3110.97
18_Y33_E1.3100.97
7_V16_F1.2740.96
6_L47_R1.2600.96
9_Q44_H1.2580.96
30_L45_L1.2550.96
24_E68_T1.2460.96
20_Y71_L1.2040.95
16_F53_A1.1480.93
39_G43_S1.1350.93
10_P14_E1.1280.93
4_D74_D1.1210.93
18_Y30_L1.1180.92
82_H85_T1.1160.92
46_Q50_D1.1040.92
61_V66_H1.0940.92
4_D78_M1.0540.90
26_S66_H1.0460.90
64_R68_T1.0080.88
43_S82_H0.9980.87
83_V90_I0.9680.86
18_Y29_D0.9670.86
14_E34_L0.9670.86
5_K47_R0.9470.85
59_E66_H0.9420.84
34_L89_L0.9370.84
13_L79_F0.8960.81
44_H85_T0.8880.81
24_E55_E0.8600.78
85_T88_G0.8570.78
39_G47_R0.8450.77
3_L86_L0.8400.77
79_F83_V0.8330.76
54_V91_D0.8320.76
43_S47_R0.8270.76
20_Y79_F0.8230.75
7_V79_F0.8220.75
61_V64_R0.8060.74
7_V53_A0.8050.74
25_S29_D0.8050.74
73_E81_D0.8040.74
40_N43_S0.8010.73
44_H89_L0.7960.73
3_L82_H0.7890.72
14_E25_S0.7860.72
49_E65_P0.7700.70
40_N47_R0.7610.69
45_L55_E0.7530.69
5_K11_T0.7430.68
28_G31_T0.7360.67
82_H90_I0.7300.66
46_Q86_L0.7290.66
31_T79_F0.7280.66
36_L43_S0.7270.66
27_F38_E0.7260.66
32_D38_E0.7210.65
11_T44_H0.7150.65
16_F48_M0.7080.64
7_V78_M0.7030.63
56_V69_A0.7010.63
11_T34_L0.7010.63
60_F64_R0.6990.63
74_D84_Q0.6940.62
48_M78_M0.6800.61
4_D8_H0.6710.60
24_E70_V0.6620.59
15_L34_L0.6550.58
7_V82_H0.6510.57
5_K10_P0.6460.57
73_E91_D0.6380.56
61_V65_P0.6370.56
82_H86_L0.6330.55
29_D83_V0.6320.55
12_R15_L0.6210.54
7_V44_H0.6190.54
60_F68_T0.6070.52
56_V65_P0.5890.50
10_P33_E0.5730.48
46_Q49_E0.5730.48
79_F90_I0.5710.48
13_L28_G0.5680.48
74_D78_M0.5620.47
21_R47_R0.5610.47
4_D7_V0.5560.46
57_R68_T0.5540.46
37_T47_R0.5490.45
16_F82_H0.5460.45
84_Q88_G0.5450.45
74_D77_A0.5410.44
29_D33_E0.5390.44
17_A90_I0.5380.44
45_L63_K0.5370.44
71_L82_H0.5320.43
50_D77_A0.5320.43
22_H33_E0.5310.43
15_L69_A0.5270.43
21_R54_V0.5270.43
56_V63_K0.5240.42
15_L41_L0.5240.42
45_L54_V0.5200.42
10_P38_E0.5190.42
63_K89_L0.5190.42
23_G76_E0.5170.42
8_H51_A0.5140.41
18_Y80_E0.5120.41
28_G39_G0.5110.41
28_G83_V0.5070.40
5_K73_E0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u1dA 2 1 99.2 0.644 Contact Map
3elkA 3 0.9787 99.2 0.647 Contact Map
2eshA 2 0.9894 99.2 0.652 Contact Map
1xmaA 2 0.9681 99.2 0.652 Contact Map
3hhhA 2 0.9787 99.2 0.653 Contact Map
4ejoA 2 0.9787 99.2 0.656 Contact Map
2zfwA 2 0.9681 99.1 0.663 Contact Map
2e1nA 2 0.9681 99.1 0.665 Contact Map
3f8bA 2 0.9574 99.1 0.668 Contact Map
1ub9A 2 0.9894 99.1 0.67 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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