Q9HS04 - HALSA - GREMLIN Contacts

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Q9HS04 - Copper transport ATP-binding protein

UniProt:	Q9HS04	Sequences: MGPNGTGKTVLLSCLAGGTEPSEGSVSVFGTPVSEDGGRSLSLLLQGGASVDTLSGRETAAFYSRLHPEFTDRWRTYVDDLGIDGDLDKRIKYYSEGMKRKLELSLALSVDAPLYLLDEPTAGVDLSMVQSFHRVIRDRVADGGTVVATSHRPVDADLADRVAFVNGGGVLAVDTPEALLDGVPTVVRVVGQATAGDALAPHVVGDPFYHGDERRGFLREHATLADIREHAGDATVETVEPSYTDAFNYYVHAAADNE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (201)
Sequences:	71962 (40621)
Seq/√Len:	2865.2

ECOLI - YADG METN PROV CYSA FBPC UGPC MALK POTA YCJV POTG MACB MODC YDCT DPPF YEHX RBSA SAPD ARAG OPPF OPPD DPPD DDPD DDPF LSRA GSIA MLAF UUP FEPC MDLB CYDC YHES FECE NIKE YOJI MDLA SAPF MSBA TAUB HISP YECC FHUC SSUB YTFR GLNQ CYDD YPHE YHDZ PHNC ZNUC LPTB GLTL THIQ BTUD LIVG LIVF ARTP PHNK NIKD LOLD SUFC XYLG ALSA FTSE MODF ETTA PSTB FETA MGLA YBBA YDDA CCMA YBHF YEJF PHNL YNJD YBIT YHIH
BACSU - YVRA YHAQ YVFR YHCH TAGH YFIL OPUBA YDBJ METN OPUCA YCBN OPUAA MSMX YXLF YURJ YTRB OPPD YKFD APPD APPF YFMM DPPD RBSA ECFA1 YKPA OPPF YFMR YFMF ECFA2 YFIB YUSV FHUC SUNT YFIC CYDC YHEH TCYN YKNV YXDL YHEI YKNU YLMA YVCR YCLP BCEA YGAD BMRA YKOD YWJA CYDD ECSA YDIF SKFE YXEO SUFC SSUB YJKB ALBC YTLC NATA GLNQ MNTB TCYC FTSE ARTM YVRO YKNY YTHP PSTB1 YHCG PSTB2 YCLH YYBJ EXPZ YTRE ZNUC YUFO YYDI
HALSA - Q9HS04 Q9HRJ6 Q9HHQ5 Q9HMU8 BTUDA Q9HMX3 Q9HNZ9 Q9HMW0 Q9HR06 Q9HMT3 Q9HMX2 Q9HRH8 Q9HMG1 Q9HSQ7 PHNC PSTB2 Q9HHM2 Q9HMG6 Q9HNY3 Y1631 Q9HRZ9 Y2317 Q9HRV7 PSTB1 Q9HR96 Q9HHR7 Q9HQA8 Q9HT03 Q9HMC1 Q9HR21 Q9HMW1
SULSO - Q97UF2 Q7LX64 Q97YY4 Q97UY8 Q97YQ7 Q97VH6 Q97YK2 Q97X18 Q97ZC0 Q97VK9 Q97VF5 Q97VC1 Q97VF4 Q97UH3 Q97VK8 Q97UD4 Q97YP7 Q97YP3 Q97UJ9 Q97YP8 Q97U54 Q980W0 Q97Z03 Q97VY4 Y2030 Q7LY07 Q97UH4 Y1893 Q97VM2 Q7LX80 Q97W42 Q97V00 Q97V01 Q7LXM4 PSTB Q97UG5 Q97Z56 Q97Z96 Q97ZU0 Q980K5 Q97UC2 Q97YP4 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_S	113_P	3.427	1.00
161_R	173_V	3.403	1.00
86_D	89_K	3.070	1.00
25_S	32_P	2.855	1.00
163_A	170_V	2.774	1.00
175_T	178_A	2.679	1.00
174_D	178_A	2.620	1.00
163_A	173_V	2.583	1.00
29_F	113_P	2.254	1.00
76_T	80_D	2.206	1.00
57_R	87_L	2.184	1.00
12_L	149_T	2.091	1.00
56_G	94_Y	2.063	1.00
12_L	116_L	2.043	1.00
75_R	87_L	2.034	1.00
89_K	93_Y	2.025	1.00
57_R	61_A	1.999	1.00
157_D	177_E	1.988	1.00
73_R	111_D	1.959	1.00
139_R	144_G	1.909	1.00
138_D	142_D	1.888	1.00
73_R	76_T	1.839	1.00
111_D	144_G	1.800	1.00
29_F	40_S	1.764	1.00
57_R	88_D	1.755	1.00
174_D	179_L	1.731	1.00
61_A	70_F	1.723	1.00
150_S	156_A	1.701	1.00
32_P	35_E	1.697	1.00
80_D	142_D	1.692	1.00
71_T	75_R	1.692	1.00
60_A	78_V	1.591	1.00
80_D	138_D	1.582	1.00
78_V	87_L	1.559	1.00
54_L	58_E	1.537	1.00
137_R	158_L	1.536	1.00
178_A	182_G	1.531	1.00
61_A	74_W	1.531	1.00
55_S	58_E	1.518	1.00
27_S	32_P	1.494	1.00
79_D	84_D	1.479	1.00
77_Y	109_S	1.450	1.00
137_R	140_V	1.449	1.00
77_Y	81_L	1.449	1.00
166_N	171_L	1.444	1.00
14_C	21_P	1.441	1.00
117_L	146_V	1.439	1.00
65_R	70_F	1.432	1.00
57_R	71_T	1.430	1.00
75_R	79_D	1.394	1.00
172_A	182_G	1.383	1.00
133_H	155_D	1.366	1.00
16_A	43_L	1.359	1.00
140_V	146_V	1.321	1.00
14_C	19_T	1.318	1.00
86_D	94_Y	1.306	1.00
13_S	19_T	1.303	1.00
61_A	71_T	1.293	1.00
77_Y	105_S	1.283	1.00
59_T	106_L	1.283	1.00
72_D	76_T	1.280	1.00
183_V	187_V	1.269	1.00
55_S	88_D	1.260	1.00
17_G	20_E	1.239	1.00
140_V	160_D	1.231	1.00
46_Q	96_E	1.218	1.00
124_V	132_F	1.215	1.00
129_V	155_D	1.210	1.00
75_R	83_I	1.198	1.00
186_V	189_V	1.197	1.00
14_C	22_S	1.191	1.00
58_E	61_A	1.184	1.00
68_P	72_D	1.160	1.00
177_E	181_D	1.159	1.00
130_Q	134_R	1.156	1.00
82_G	131_S	1.138	1.00
178_A	181_D	1.126	1.00
91_I	102_L	1.124	1.00
67_H	110_V	1.121	1.00
187_V	191_G	1.119	1.00
162_V	176_P	1.111	1.00
129_V	152_R	1.109	1.00
70_F	74_W	1.107	1.00
73_R	77_Y	1.106	1.00
13_S	18_G	1.099	1.00
53_T	92_K	1.094	1.00
69_E	72_D	1.091	1.00
115_Y	144_G	1.090	1.00
42_S	112_A	1.089	1.00
54_L	59_T	1.085	1.00
90_R	93_Y	1.083	1.00
135_V	138_D	1.083	1.00
94_Y	102_L	1.080	1.00
186_V	190_V	1.075	1.00
53_T	58_E	1.070	1.00
11_L	165_V	1.069	1.00
166_N	190_V	1.069	1.00
44_L	117_L	1.068	1.00
64_S	109_S	1.066	1.00
31_T	36_D	1.063	1.00
185_T	188_R	1.060	1.00
69_E	73_R	1.060	1.00
36_D	39_R	1.054	1.00
78_V	83_I	1.052	1.00
76_T	79_D	1.052	1.00
61_A	65_R	1.051	1.00
119_E	151_H	1.051	1.00
60_A	109_S	1.049	1.00
42_S	107_A	1.048	1.00
56_G	102_L	1.045	1.00
77_Y	80_D	1.044	1.00
176_P	186_V	1.043	1.00
31_T	40_S	1.039	1.00
81_L	105_S	1.037	1.00
115_Y	146_V	1.034	1.00
71_T	74_W	1.033	1.00
64_S	70_F	1.031	1.00
136_I	146_V	1.027	1.00
57_R	74_W	1.025	1.00
6_T	165_V	1.023	1.00
84_D	87_L	1.015	1.00
57_R	75_R	0.996	1.00
74_W	77_Y	0.992	1.00
44_L	107_A	0.986	1.00
59_T	91_I	0.986	1.00
189_V	193_A	0.983	1.00
71_T	87_L	0.976	1.00
54_L	62_F	0.971	1.00
172_A	179_L	0.971	1.00
70_F	73_R	0.957	1.00
83_I	86_D	0.954	1.00
3_P	166_N	0.946	1.00
44_L	104_L	0.942	1.00
171_L	185_T	0.941	1.00
137_R	141_A	0.939	1.00
16_A	116_L	0.937	1.00
148_A	159_A	0.935	1.00
55_S	90_R	0.932	1.00
86_D	98_M	0.932	1.00
114_L	145_T	0.931	1.00
134_R	137_R	0.931	1.00
63_Y	106_L	0.918	1.00
117_L	136_I	0.912	1.00
85_G	89_K	0.906	1.00
176_P	180_L	0.906	1.00
94_Y	98_M	0.903	1.00
170_V	173_V	0.895	1.00
82_G	138_D	0.893	1.00
36_D	40_S	0.889	1.00
157_D	180_L	0.887	1.00
159_A	162_V	0.886	1.00
21_P	34_S	0.880	1.00
116_L	147_V	0.869	1.00
113_P	144_G	0.855	1.00
172_A	183_V	0.852	1.00
188_R	191_G	0.849	1.00
37_G	41_L	0.848	1.00
72_D	75_R	0.846	1.00
15_L	147_V	0.846	1.00
50_S	99_K	0.844	1.00
121_T	132_F	0.842	1.00
157_D	176_P	0.834	1.00
55_S	59_T	0.829	1.00
60_A	74_W	0.821	1.00
164_F	179_L	0.820	1.00
164_F	183_V	0.817	1.00
51_V	54_L	0.812	1.00
20_E	34_S	0.798	1.00
188_R	192_Q	0.796	1.00
64_S	67_H	0.793	1.00
131_S	134_R	0.792	1.00
25_S	34_S	0.780	1.00
171_L	186_V	0.780	1.00
197_D	200_A	0.778	1.00
14_C	26_V	0.774	1.00
64_S	73_R	0.764	1.00
133_H	158_L	0.760	1.00
194_T	197_D	0.758	1.00
9_T	13_S	0.753	1.00
121_T	155_D	0.752	1.00
30_G	33_V	0.751	1.00
18_G	45_L	0.747	1.00
185_T	189_V	0.747	1.00
77_Y	108_L	0.745	1.00
190_V	194_T	0.741	1.00
41_L	114_L	0.740	1.00
150_S	155_D	0.736	1.00
134_R	138_D	0.735	1.00
29_F	33_V	0.727	1.00
172_A	184_P	0.726	1.00
190_V	193_A	0.725	1.00
153_P	180_L	0.723	1.00
159_A	176_P	0.720	1.00
148_A	158_L	0.719	1.00
166_N	169_G	0.703	1.00
27_S	30_G	0.703	1.00
180_L	183_V	0.695	1.00
95_S	98_M	0.692	1.00
96_E	101_K	0.691	1.00
114_L	147_V	0.688	1.00
88_D	91_I	0.684	1.00
48_G	99_K	0.683	1.00
13_S	16_A	0.676	1.00
52_D	92_K	0.674	1.00
29_F	114_L	0.673	1.00
4_N	128_M	0.669	1.00
44_L	103_E	0.668	1.00
13_S	43_L	0.667	1.00
51_V	59_T	0.665	1.00
25_S	35_E	0.663	1.00
179_L	188_R	0.663	1.00
31_T	35_E	0.662	1.00
16_A	41_L	0.658	1.00
172_A	178_A	0.654	1.00
68_P	71_T	0.654	1.00
128_M	131_S	0.646	1.00
156_A	159_A	0.646	1.00
63_Y	110_V	0.644	1.00
17_G	34_S	0.644	1.00
133_H	137_R	0.640	1.00
31_T	37_G	0.637	1.00
50_S	59_T	0.636	1.00
83_I	87_L	0.633	1.00
62_F	66_L	0.630	1.00
194_T	198_A	0.629	1.00
189_V	192_Q	0.627	1.00
15_L	26_V	0.625	1.00
156_A	176_P	0.623	1.00
4_N	119_E	0.622	1.00
167_G	190_V	0.621	1.00
48_G	103_E	0.621	1.00
161_R	175_T	0.610	1.00
15_L	116_L	0.609	1.00
155_D	158_L	0.608	1.00
74_W	87_L	0.603	1.00
71_T	88_D	0.602	1.00
182_G	185_T	0.599	1.00
184_P	188_R	0.593	1.00
100_R	123_G	0.592	1.00
73_R	80_D	0.589	1.00
108_L	144_G	0.589	1.00
76_T	111_D	0.589	1.00
152_R	155_D	0.589	1.00
91_I	99_K	0.587	1.00
61_A	64_S	0.587	1.00
166_N	185_T	0.587	1.00
4_N	124_V	0.584	1.00
28_V	40_S	0.584	1.00
11_L	14_C	0.583	1.00
75_R	78_V	0.582	1.00
42_S	110_V	0.580	1.00
111_D	142_D	0.578	1.00
28_V	114_L	0.574	1.00
69_E	76_T	0.574	1.00
1_M	153_P	0.574	1.00
183_V	186_V	0.573	1.00
186_V	191_G	0.573	1.00
83_I	98_M	0.570	1.00
156_A	162_V	0.570	1.00
3_P	6_T	0.569	1.00
52_D	99_K	0.567	1.00
64_S	110_V	0.564	1.00
37_G	40_S	0.562	1.00
74_W	78_V	0.561	1.00
107_A	115_Y	0.559	1.00
138_D	141_A	0.556	1.00
133_H	148_A	0.551	1.00
1_M	164_F	0.551	1.00
21_P	26_V	0.551	1.00
104_L	132_F	0.551	1.00
191_G	194_T	0.549	1.00
12_L	16_A	0.549	1.00
72_D	79_D	0.548	1.00
187_V	190_V	0.547	1.00
44_L	100_R	0.544	1.00
127_S	130_Q	0.542	1.00
63_Y	66_L	0.542	1.00
101_K	128_M	0.541	1.00
4_N	151_H	0.535	1.00
165_V	170_V	0.535	1.00
89_K	98_M	0.534	1.00
177_E	180_L	0.534	1.00
28_V	37_G	0.532	1.00
136_I	148_A	0.532	1.00
50_S	91_I	0.529	1.00
81_L	135_V	0.528	1.00
89_K	94_Y	0.528	1.00
26_V	33_V	0.526	1.00
14_C	20_E	0.523	1.00
57_R	60_A	0.522	1.00
4_N	101_K	0.522	1.00
179_L	183_V	0.521	1.00
129_V	133_H	0.516	1.00
191_G	195_A	0.514	1.00
36_D	41_L	0.512	1.00
70_F	75_R	0.512	1.00
28_V	39_R	0.511	1.00
125_D	128_M	0.505	1.00
116_L	149_T	0.504	1.00
56_G	60_A	0.501	1.00
184_P	187_V	0.501	1.00
183_V	191_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yerA	2	0.9109	100	0.151	Contact Map
3tuiC	2	1	100	0.185	Contact Map
4u00A	1	0.7636	100	0.203	Contact Map
2onkA	2	0.7946	100	0.204	Contact Map
4ymuJ	2	0.7597	100	0.205	Contact Map
2oljA	2	0.7597	100	0.205	Contact Map
4huqB	1	0.8876	100	0.205	Contact Map
4rvcA	4	0.7713	100	0.206	Contact Map
4f4cA	1	0.7016	100	0.209	Contact Map
1b0uA	2	0.7791	100	0.209	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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