GREMLIN Database
Q9HS04 - Copper transport ATP-binding protein
UniProt: Q9HS04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (201)
Sequences: 71962 (40621)
Seq/√Len: 2865.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_S113_P3.4271.00
161_R173_V3.4031.00
86_D89_K3.0701.00
25_S32_P2.8551.00
163_A170_V2.7741.00
175_T178_A2.6791.00
174_D178_A2.6201.00
163_A173_V2.5831.00
29_F113_P2.2541.00
76_T80_D2.2061.00
57_R87_L2.1841.00
12_L149_T2.0911.00
56_G94_Y2.0631.00
12_L116_L2.0431.00
75_R87_L2.0341.00
89_K93_Y2.0251.00
57_R61_A1.9991.00
157_D177_E1.9881.00
73_R111_D1.9591.00
139_R144_G1.9091.00
138_D142_D1.8881.00
73_R76_T1.8391.00
111_D144_G1.8001.00
29_F40_S1.7641.00
57_R88_D1.7551.00
174_D179_L1.7311.00
61_A70_F1.7231.00
150_S156_A1.7011.00
32_P35_E1.6971.00
80_D142_D1.6921.00
71_T75_R1.6921.00
60_A78_V1.5911.00
80_D138_D1.5821.00
78_V87_L1.5591.00
54_L58_E1.5371.00
137_R158_L1.5361.00
178_A182_G1.5311.00
61_A74_W1.5311.00
55_S58_E1.5181.00
27_S32_P1.4941.00
79_D84_D1.4791.00
77_Y109_S1.4501.00
137_R140_V1.4491.00
77_Y81_L1.4491.00
166_N171_L1.4441.00
14_C21_P1.4411.00
117_L146_V1.4391.00
65_R70_F1.4321.00
57_R71_T1.4301.00
75_R79_D1.3941.00
172_A182_G1.3831.00
133_H155_D1.3661.00
16_A43_L1.3591.00
140_V146_V1.3211.00
14_C19_T1.3181.00
86_D94_Y1.3061.00
13_S19_T1.3031.00
61_A71_T1.2931.00
77_Y105_S1.2831.00
59_T106_L1.2831.00
72_D76_T1.2801.00
183_V187_V1.2691.00
55_S88_D1.2601.00
17_G20_E1.2391.00
140_V160_D1.2311.00
46_Q96_E1.2181.00
124_V132_F1.2151.00
129_V155_D1.2101.00
75_R83_I1.1981.00
186_V189_V1.1971.00
14_C22_S1.1911.00
58_E61_A1.1841.00
68_P72_D1.1601.00
177_E181_D1.1591.00
130_Q134_R1.1561.00
82_G131_S1.1381.00
178_A181_D1.1261.00
91_I102_L1.1241.00
67_H110_V1.1211.00
187_V191_G1.1191.00
162_V176_P1.1111.00
129_V152_R1.1091.00
70_F74_W1.1071.00
73_R77_Y1.1061.00
13_S18_G1.0991.00
53_T92_K1.0941.00
69_E72_D1.0911.00
115_Y144_G1.0901.00
42_S112_A1.0891.00
54_L59_T1.0851.00
90_R93_Y1.0831.00
135_V138_D1.0831.00
94_Y102_L1.0801.00
186_V190_V1.0751.00
53_T58_E1.0701.00
11_L165_V1.0691.00
166_N190_V1.0691.00
44_L117_L1.0681.00
64_S109_S1.0661.00
31_T36_D1.0631.00
185_T188_R1.0601.00
69_E73_R1.0601.00
36_D39_R1.0541.00
78_V83_I1.0521.00
76_T79_D1.0521.00
61_A65_R1.0511.00
119_E151_H1.0511.00
60_A109_S1.0491.00
42_S107_A1.0481.00
56_G102_L1.0451.00
77_Y80_D1.0441.00
176_P186_V1.0431.00
31_T40_S1.0391.00
81_L105_S1.0371.00
115_Y146_V1.0341.00
71_T74_W1.0331.00
64_S70_F1.0311.00
136_I146_V1.0271.00
57_R74_W1.0251.00
6_T165_V1.0231.00
84_D87_L1.0151.00
57_R75_R0.9961.00
74_W77_Y0.9921.00
44_L107_A0.9861.00
59_T91_I0.9861.00
189_V193_A0.9831.00
71_T87_L0.9761.00
54_L62_F0.9711.00
172_A179_L0.9711.00
70_F73_R0.9571.00
83_I86_D0.9541.00
3_P166_N0.9461.00
44_L104_L0.9421.00
171_L185_T0.9411.00
137_R141_A0.9391.00
16_A116_L0.9371.00
148_A159_A0.9351.00
55_S90_R0.9321.00
86_D98_M0.9321.00
114_L145_T0.9311.00
134_R137_R0.9311.00
63_Y106_L0.9181.00
117_L136_I0.9121.00
85_G89_K0.9061.00
176_P180_L0.9061.00
94_Y98_M0.9031.00
170_V173_V0.8951.00
82_G138_D0.8931.00
36_D40_S0.8891.00
157_D180_L0.8871.00
159_A162_V0.8861.00
21_P34_S0.8801.00
116_L147_V0.8691.00
113_P144_G0.8551.00
172_A183_V0.8521.00
188_R191_G0.8491.00
37_G41_L0.8481.00
72_D75_R0.8461.00
15_L147_V0.8461.00
50_S99_K0.8441.00
121_T132_F0.8421.00
157_D176_P0.8341.00
55_S59_T0.8291.00
60_A74_W0.8211.00
164_F179_L0.8201.00
164_F183_V0.8171.00
51_V54_L0.8121.00
20_E34_S0.7981.00
188_R192_Q0.7961.00
64_S67_H0.7931.00
131_S134_R0.7921.00
25_S34_S0.7801.00
171_L186_V0.7801.00
197_D200_A0.7781.00
14_C26_V0.7741.00
64_S73_R0.7641.00
133_H158_L0.7601.00
194_T197_D0.7581.00
9_T13_S0.7531.00
121_T155_D0.7521.00
30_G33_V0.7511.00
18_G45_L0.7471.00
185_T189_V0.7471.00
77_Y108_L0.7451.00
190_V194_T0.7411.00
41_L114_L0.7401.00
150_S155_D0.7361.00
134_R138_D0.7351.00
29_F33_V0.7271.00
172_A184_P0.7261.00
190_V193_A0.7251.00
153_P180_L0.7231.00
159_A176_P0.7201.00
148_A158_L0.7191.00
166_N169_G0.7031.00
27_S30_G0.7031.00
180_L183_V0.6951.00
95_S98_M0.6921.00
96_E101_K0.6911.00
114_L147_V0.6881.00
88_D91_I0.6841.00
48_G99_K0.6831.00
13_S16_A0.6761.00
52_D92_K0.6741.00
29_F114_L0.6731.00
4_N128_M0.6691.00
44_L103_E0.6681.00
13_S43_L0.6671.00
51_V59_T0.6651.00
25_S35_E0.6631.00
179_L188_R0.6631.00
31_T35_E0.6621.00
16_A41_L0.6581.00
172_A178_A0.6541.00
68_P71_T0.6541.00
128_M131_S0.6461.00
156_A159_A0.6461.00
63_Y110_V0.6441.00
17_G34_S0.6441.00
133_H137_R0.6401.00
31_T37_G0.6371.00
50_S59_T0.6361.00
83_I87_L0.6331.00
62_F66_L0.6301.00
194_T198_A0.6291.00
189_V192_Q0.6271.00
15_L26_V0.6251.00
156_A176_P0.6231.00
4_N119_E0.6221.00
167_G190_V0.6211.00
48_G103_E0.6211.00
161_R175_T0.6101.00
15_L116_L0.6091.00
155_D158_L0.6081.00
74_W87_L0.6031.00
71_T88_D0.6021.00
182_G185_T0.5991.00
184_P188_R0.5931.00
100_R123_G0.5921.00
73_R80_D0.5891.00
108_L144_G0.5891.00
76_T111_D0.5891.00
152_R155_D0.5891.00
91_I99_K0.5871.00
61_A64_S0.5871.00
166_N185_T0.5871.00
4_N124_V0.5841.00
28_V40_S0.5841.00
11_L14_C0.5831.00
75_R78_V0.5821.00
42_S110_V0.5801.00
111_D142_D0.5781.00
28_V114_L0.5741.00
69_E76_T0.5741.00
1_M153_P0.5741.00
183_V186_V0.5731.00
186_V191_G0.5731.00
83_I98_M0.5701.00
156_A162_V0.5701.00
3_P6_T0.5691.00
52_D99_K0.5671.00
64_S110_V0.5641.00
37_G40_S0.5621.00
74_W78_V0.5611.00
107_A115_Y0.5591.00
138_D141_A0.5561.00
133_H148_A0.5511.00
1_M164_F0.5511.00
21_P26_V0.5511.00
104_L132_F0.5511.00
191_G194_T0.5491.00
12_L16_A0.5491.00
72_D79_D0.5481.00
187_V190_V0.5471.00
44_L100_R0.5441.00
127_S130_Q0.5421.00
63_Y66_L0.5421.00
101_K128_M0.5411.00
4_N151_H0.5351.00
165_V170_V0.5351.00
89_K98_M0.5341.00
177_E180_L0.5341.00
28_V37_G0.5321.00
136_I148_A0.5321.00
50_S91_I0.5291.00
81_L135_V0.5281.00
89_K94_Y0.5281.00
26_V33_V0.5261.00
14_C20_E0.5231.00
57_R60_A0.5221.00
4_N101_K0.5221.00
179_L183_V0.5211.00
129_V133_H0.5161.00
191_G195_A0.5141.00
36_D41_L0.5121.00
70_F75_R0.5121.00
28_V39_R0.5111.00
125_D128_M0.5051.00
116_L149_T0.5041.00
56_G60_A0.5011.00
184_P187_V0.5011.00
183_V191_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9109 100 0.151 Contact Map
3tuiC 2 1 100 0.185 Contact Map
4u00A 1 0.7636 100 0.203 Contact Map
2onkA 2 0.7946 100 0.204 Contact Map
4ymuJ 2 0.7597 100 0.205 Contact Map
2oljA 2 0.7597 100 0.205 Contact Map
4huqB 1 0.8876 100 0.205 Contact Map
4rvcA 4 0.7713 100 0.206 Contact Map
4f4cA 1 0.7016 100 0.209 Contact Map
1b0uA 2 0.7791 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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