GREMLIN Database
Q9HS02 - Aldehyde reductase
UniProt: Q9HS02 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (253)
Sequences: 32402 (20941)
Seq/√Len: 1316.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T241_A3.1121.00
95_E135_V2.8621.00
65_A102_G2.7221.00
30_P62_D2.6941.00
211_H255_D2.6481.00
252_D255_D2.4661.00
34_A66_A2.4231.00
91_A129_D2.3821.00
94_T130_L2.3671.00
91_A133_D2.2871.00
39_T43_M2.2661.00
210_K258_K2.0931.00
128_A132_A2.0601.00
34_A62_D2.0391.00
96_Q100_K1.9681.00
205_Q209_E1.9671.00
225_R256_V1.9631.00
105_Y137_E1.9631.00
179_Y183_E1.9571.00
129_D133_D1.9311.00
210_K255_D1.8911.00
237_E241_A1.8891.00
70_D73_D1.8621.00
253_D257_A1.8611.00
39_T237_E1.8421.00
180_A187_L1.8411.00
206_A258_K1.8261.00
87_D129_D1.7971.00
21_G47_H1.7731.00
43_M241_A1.7261.00
226_K260_D1.6801.00
110_Y162_A1.6611.00
213_V249_L1.6541.00
150_D154_D1.6441.00
40_A45_Y1.6341.00
129_D132_A1.6301.00
150_D179_Y1.6201.00
87_D91_A1.6161.00
43_M244_W1.6001.00
58_D100_K1.5951.00
34_A38_R1.5931.00
76_L103_V1.5891.00
203_E206_A1.5781.00
80_V109_L1.5741.00
91_A95_E1.5741.00
78_T106_V1.5741.00
214_S242_D1.5711.00
39_T42_E1.5651.00
38_R66_A1.5631.00
245_A248_D1.5581.00
186_E229_T1.5561.00
29_D32_A1.5561.00
257_A261_G1.5561.00
34_A63_G1.5511.00
78_T97_S1.5371.00
221_A249_L1.5261.00
80_V90_V1.5241.00
126_A129_D1.5231.00
30_P34_A1.5011.00
94_T109_L1.4891.00
9_Q16_E1.4881.00
24_T48_I1.4681.00
77_A110_Y1.4611.00
10_R16_E1.4491.00
41_L74_V1.4471.00
92_P96_Q1.4391.00
52_Q93_A1.4131.00
178_E182_G1.4081.00
15_E138_R1.4071.00
181_D227_G1.3991.00
32_A35_D1.3871.00
95_E99_E1.3861.00
145_E148_H1.3701.00
153_E183_E1.3641.00
213_V217_Q1.3551.00
110_Y188_V1.3421.00
37_V63_G1.3401.00
175_E178_E1.3291.00
241_A245_A1.3081.00
221_A225_R1.3041.00
106_V136_T1.3041.00
87_D125_A1.2871.00
165_V187_L1.2791.00
96_Q99_E1.2791.00
15_E75_F1.2761.00
38_R42_E1.2691.00
35_D39_T1.2661.00
258_K261_G1.2531.00
138_R161_F1.2521.00
153_E179_Y1.2491.00
213_V218_V1.2401.00
130_L136_T1.2361.00
234_A239_H1.2251.00
75_F108_L1.2171.00
203_E258_K1.2141.00
146_P179_Y1.2111.00
136_T139_I1.2091.00
91_A126_A1.2061.00
87_D126_A1.2041.00
101_L106_V1.1941.00
132_A157_G1.1931.00
214_S217_Q1.1901.00
234_A240_I1.1901.00
177_R181_D1.1891.00
71_R103_V1.1861.00
62_D102_G1.1821.00
206_A210_K1.1801.00
121_T155_V1.1781.00
61_G102_G1.1591.00
205_Q215_E1.1531.00
57_E97_S1.1321.00
31_S35_D1.1321.00
114_P148_H1.1271.00
167_F226_K1.1261.00
88_G92_P1.1191.00
71_R105_Y1.1151.00
108_L162_A1.1091.00
89_D92_P1.1091.00
30_P59_A1.1071.00
58_D62_D1.1071.00
170_L201_V1.1061.00
238_D241_A1.0921.00
131_Q161_F1.0881.00
150_D183_E1.0861.00
166_E171_L1.0771.00
95_E133_D1.0771.00
94_T106_V1.0731.00
86_G89_D1.0711.00
47_H188_V1.0681.00
47_H77_A1.0651.00
127_L139_I1.0621.00
24_T60_V1.0621.00
150_D182_G1.0611.00
48_I60_V1.0561.00
207_V218_V1.0521.00
122_E125_A1.0481.00
202_P206_A1.0371.00
128_A131_Q1.0361.00
206_A209_E1.0361.00
85_L111_V1.0341.00
223_V230_A1.0341.00
111_V127_L1.0311.00
38_R63_G1.0311.00
35_D237_E1.0231.00
13_V138_R1.0221.00
36_S240_I1.0181.00
130_L135_V1.0081.00
172_Q263_D1.0071.00
169_P259_I1.0071.00
46_R75_F1.0071.00
131_Q158_E1.0001.00
224_R246_S0.9991.00
217_Q245_A0.9951.00
12_A161_F0.9921.00
204_I215_E0.9921.00
146_P150_D0.9901.00
202_P205_Q0.9831.00
9_Q14_V0.9811.00
169_P219_S0.9781.00
151_E155_V0.9741.00
57_E100_K0.9731.00
174_E178_E0.9591.00
18_P46_R0.9561.00
62_D66_A0.9511.00
18_P45_Y0.9351.00
84_E89_D0.9331.00
178_E181_D0.9291.00
19_E247_L0.9291.00
107_D137_E0.9271.00
64_I74_V0.9261.00
91_A94_T0.9221.00
188_V229_T0.9211.00
141_V160_P0.9181.00
19_E224_R0.9181.00
52_Q89_D0.9181.00
217_Q242_D0.9171.00
240_I244_W0.9091.00
126_A130_L0.9001.00
162_A188_V0.8961.00
125_A129_D0.8931.00
242_D245_A0.8921.00
92_P95_E0.8871.00
37_V48_I0.8831.00
130_L133_D0.8791.00
35_D38_R0.8781.00
121_T151_E0.8751.00
163_N180_A0.8721.00
225_R250_E0.8691.00
236_G239_H0.8681.00
41_L70_D0.8631.00
238_D242_D0.8621.00
52_Q84_E0.8601.00
58_D99_E0.8601.00
257_A260_D0.8561.00
128_A157_G0.8541.00
13_V161_F0.8541.00
141_V149_L0.8541.00
87_D122_E0.8421.00
179_Y182_G0.8421.00
77_A188_V0.8411.00
139_I160_P0.8401.00
125_A128_A0.8381.00
52_Q100_K0.8371.00
149_L185_I0.8291.00
220_L246_S0.8251.00
254_E258_K0.8211.00
226_K256_V0.8201.00
91_A130_L0.8191.00
254_E257_A0.8151.00
207_V211_H0.8151.00
77_A108_L0.8051.00
128_A139_I0.8051.00
151_E154_D0.8031.00
22_L40_A0.7981.00
43_M245_A0.7901.00
13_V131_Q0.7861.00
210_K252_D0.7841.00
172_Q260_D0.7791.00
66_A70_D0.7781.00
211_H252_D0.7771.00
52_Q96_Q0.7751.00
219_S223_V0.7721.00
177_R187_L0.7691.00
143_N190_Y0.7661.00
167_F177_R0.7581.00
39_T240_I0.7541.00
225_R253_D0.7541.00
31_S34_A0.7511.00
146_P176_L0.7511.00
98_L135_V0.7471.00
221_A246_S0.7441.00
203_E262_I0.7361.00
153_E159_L0.7351.00
78_T109_L0.7331.00
33_C59_A0.7321.00
235_T239_H0.7321.00
189_A192_P0.7261.00
24_T56_N0.7251.00
98_L103_V0.7221.00
173_Q178_E0.7211.00
113_W143_N0.7201.00
50_T60_V0.7091.00
192_P232_P0.7071.00
176_L180_A0.7041.00
38_R70_D0.6991.00
90_V130_L0.6971.00
85_L123_T0.6971.00
45_Y244_W0.6961.00
189_A230_A0.6931.00
124_L152_A0.6911.00
177_R226_K0.6891.00
146_P175_E0.6871.00
10_R13_V0.6861.00
41_L48_I0.6851.00
94_T135_V0.6851.00
93_A96_Q0.6831.00
213_V245_A0.6831.00
124_L160_P0.6811.00
216_A242_D0.6801.00
213_V248_D0.6801.00
36_S237_E0.6791.00
97_S109_L0.6761.00
20_F224_R0.6741.00
22_L27_N0.6701.00
222_W260_D0.6681.00
141_V144_F0.6671.00
124_L139_I0.6661.00
9_Q19_E0.6611.00
26_E195_R0.6581.00
110_Y140_G0.6581.00
207_V255_D0.6571.00
28_E56_N0.6561.00
186_E228_V0.6551.00
128_A158_E0.6551.00
106_V109_L0.6521.00
211_H218_V0.6511.00
223_V228_V0.6491.00
17_M229_T0.6451.00
90_V123_T0.6451.00
72_E105_Y0.6441.00
218_V251_L0.6441.00
192_P223_V0.6421.00
204_I259_I0.6401.00
209_E212_G0.6401.00
251_L256_V0.6401.00
208_A218_V0.6391.00
180_A185_I0.6391.00
21_G232_P0.6381.00
46_R73_D0.6381.00
141_V163_N0.6381.00
239_H242_D0.6311.00
15_E137_E0.6311.00
148_H151_E0.6291.00
167_F223_V0.6281.00
119_D151_E0.6261.00
43_M240_I0.6251.00
90_V126_A0.6201.00
27_N33_C0.6121.00
37_V41_L0.6111.00
21_G229_T0.6091.00
42_E237_E0.6091.00
123_T126_A0.6071.00
119_D122_E0.6061.00
41_L46_R0.6051.00
25_W191_S0.6031.00
213_V221_A0.6021.00
120_A155_V0.6001.00
131_Q136_T0.5981.00
127_L131_Q0.5981.00
70_D74_V0.5971.00
167_F187_L0.5971.00
218_V249_L0.5961.00
131_Q138_R0.5901.00
12_A184_D0.5901.00
204_I219_S0.5881.00
120_A123_T0.5871.00
128_A156_L0.5861.00
9_Q186_E0.5851.00
255_D258_K0.5841.00
41_L73_D0.5821.00
32_A237_E0.5811.00
198_V202_P0.5811.00
150_D153_E0.5801.00
98_L105_Y0.5781.00
69_V74_V0.5761.00
115_A118_Y0.5751.00
86_G123_T0.5741.00
234_A243_N0.5731.00
82_T85_L0.5721.00
199_F202_P0.5711.00
207_V258_K0.5691.00
36_S234_A0.5681.00
98_L106_V0.5671.00
191_S195_R0.5621.00
94_T98_L0.5611.00
208_A215_E0.5601.00
167_F228_V0.5601.00
49_D164_Q0.5591.00
251_L255_D0.5571.00
80_V85_L0.5571.00
91_A135_V0.5551.00
218_V255_D0.5531.00
27_N36_S0.5531.00
217_Q249_L0.5521.00
12_A159_L0.5511.00
218_V259_I0.5471.00
109_L136_T0.5471.00
80_V93_A0.5461.00
50_T56_N0.5431.00
120_A148_H0.5421.00
201_V205_Q0.5411.00
10_R186_E0.5381.00
53_I81_W0.5381.00
109_L127_L0.5371.00
224_R230_A0.5371.00
154_D158_E0.5371.00
48_I64_I0.5301.00
98_L104_D0.5301.00
20_F247_L0.5301.00
22_L36_S0.5301.00
37_V60_V0.5291.00
199_F203_E0.5281.00
167_F172_Q0.5281.00
208_A211_H0.5271.00
17_M47_H0.5271.00
147_R150_D0.5261.00
153_E185_I0.5261.00
121_T125_A0.5251.00
62_D65_A0.5251.00
111_V123_T0.5241.00
64_I70_D0.5231.00
198_V201_V0.5211.00
60_V63_G0.5191.00
41_L63_G0.5131.00
221_A250_E0.5131.00
87_D90_V0.5101.00
141_V152_A0.5081.00
21_G231_I0.5051.00
40_A48_I0.5041.00
50_T101_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vbjA 1 0.9892 100 0.115 Contact Map
1afsA 2 0.9928 100 0.116 Contact Map
1mi3A 3 0.9747 100 0.116 Contact Map
3up8A 1 0.9892 100 0.118 Contact Map
1hw6A 1 0.917 100 0.121 Contact Map
2wzmA 1 0.9783 100 0.121 Contact Map
4mhbA 4 0.9711 100 0.122 Contact Map
3f7jA 1 0.9892 100 0.122 Contact Map
3ln3A 2 0.8989 100 0.122 Contact Map
3b3dA 1 0.9892 100 0.124 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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