GREMLIN Database
Q9HRZ8 - Uncharacterized protein
UniProt: Q9HRZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 66 (60)
Sequences: 1869 (1220)
Seq/√Len: 157.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_A21_A2.7191.00
46_F62_P2.5271.00
4_H7_E2.4341.00
22_A51_F2.3931.00
9_R34_E2.0521.00
55_R58_D1.8971.00
14_L51_F1.8141.00
46_F56_I1.7771.00
8_R59_L1.5461.00
8_R54_C1.5251.00
7_E10_G1.5221.00
6_R10_G1.5101.00
54_C58_D1.5011.00
15_S18_D1.4331.00
18_D22_A1.4291.00
7_E13_D1.4061.00
23_V51_F1.3331.00
48_L59_L1.2921.00
25_V30_I1.2761.00
7_E11_E1.2631.00
49_A56_I1.2531.00
31_N35_R1.2281.00
43_E47_K1.2201.00
45_A56_I1.1901.00
12_A53_D1.1821.00
4_H61_D1.1691.00
19_L30_I1.1641.00
29_T38_Y1.1631.00
33_I38_Y1.1271.00
50_D62_P1.1041.00
39_D42_I1.1000.99
43_E62_P1.0290.99
8_R11_E1.0090.99
54_C59_L0.9700.99
10_G13_D0.9580.99
23_V52_F0.9510.99
4_H8_R0.9450.98
14_L18_D0.9290.98
28_Q32_A0.9240.98
14_L22_A0.9190.98
12_A22_A0.9160.98
23_V30_I0.8870.98
6_R13_D0.8790.98
39_D43_E0.8640.97
39_D62_P0.8560.97
27_R60_F0.8510.97
37_R42_I0.8500.97
18_D21_A0.8470.97
38_Y44_L0.8220.96
16_Q30_I0.8150.96
19_L52_F0.8110.96
16_Q27_R0.8000.96
47_K62_P0.7940.96
17_A27_R0.7820.95
25_V29_T0.7800.95
4_H11_E0.7500.94
26_T32_A0.7480.94
41_S44_L0.7420.94
48_L54_C0.7300.93
25_V33_I0.7270.93
8_R12_A0.7120.92
3_N45_A0.6900.91
15_S31_N0.6880.91
11_E54_C0.6840.91
33_I42_I0.6770.90
47_K50_D0.6530.88
5_V61_D0.6520.88
23_V44_L0.6500.88
4_H22_A0.6450.88
4_H55_R0.6040.84
33_I44_L0.5990.84
55_R61_D0.5780.82
44_L47_K0.5750.81
46_F50_D0.5720.81
5_V48_L0.5680.80
40_P44_L0.5670.80
19_L51_F0.5660.80
3_N28_Q0.5610.80
5_V10_G0.5600.79
3_N60_F0.5600.79
45_A60_F0.5500.78
5_V62_P0.5400.77
5_V19_L0.5350.76
41_S52_F0.5220.75
38_Y60_F0.5180.74
6_R35_R0.5140.73
12_A52_F0.5100.73
6_R32_A0.5100.73
6_R15_S0.5080.73
19_L23_V0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y9qA 1 1 99.5 0.255 Contact Map
3u3wA 2 0.9848 99.5 0.259 Contact Map
4yarA 2 1 99.5 0.26 Contact Map
2p5tA 2 0.0606 99.5 0.261 Contact Map
3tysA 2 0.9697 99.5 0.273 Contact Map
4o8bA 2 1 99.5 0.274 Contact Map
4ichA 2 0 99.5 0.274 Contact Map
4ndwA 2 1 99.4 0.276 Contact Map
3mlfA 2 1 99.4 0.279 Contact Map
3ivpA 2 1 99.4 0.281 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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