GREMLIN Database
Q9HRZ6 - Pyruvate ferredoxin oxidoreductase, subunit beta
UniProt: Q9HRZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (254)
Sequences: 2794 (1473)
Seq/√Len: 92.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_D192_D5.0161.00
118_T195_S4.4671.00
188_A197_V3.6631.00
173_S181_H3.6261.00
47_F81_V3.2891.00
121_V196_L3.1801.00
173_S184_I3.0731.00
120_V199_T2.5821.00
110_A117_I2.4331.00
186_Q190_E2.4301.00
138_S142_F2.3171.00
94_G119_Y2.2861.00
213_D216_R2.2081.00
123_D198_N2.1381.00
85_N88_L2.1311.00
119_Y194_F2.1091.00
111_V162_A2.1051.00
74_A92_V2.0791.00
168_S191_H2.0781.00
45_D87_D2.0771.00
92_V117_I2.0731.00
157_N160_A2.0631.00
187_E250_V2.0611.00
91_M189_I2.0491.00
172_Q198_N2.0121.00
233_Y236_A1.9761.00
78_G92_V1.9491.00
107_F162_A1.9431.00
49_V81_V1.9381.00
25_D122_M1.9171.00
180_R184_I1.9071.00
192_D262_E1.8971.00
111_V194_F1.8081.00
249_G269_N1.8061.00
32_M185_V1.7931.00
269_N273_L1.7691.00
94_G99_G1.7641.00
56_G59_G1.7481.00
120_V185_V1.7481.00
180_R248_L1.7431.00
30_N34_K1.7321.00
32_M93_A1.7191.00
185_V197_V1.6701.00
187_E253_Q1.6681.00
250_V253_Q1.6391.00
99_G119_Y1.6311.00
121_V158_P1.6201.00
169_F250_V1.6151.00
224_E246_E1.5751.00
28_T201_S1.5391.00
29_M93_A1.5391.00
29_M58_I1.4931.00
46_T89_E1.4931.00
266_V269_N1.4861.00
69_G77_V1.4781.00
118_T189_I1.4721.00
78_G90_V1.4691.00
217_D254_D1.4471.00
100_Y121_V1.4430.99
49_V78_G1.4320.99
99_G121_V1.4140.99
91_M118_T1.3950.99
208_D256_D1.3950.99
270_M273_L1.3870.99
183_E186_Q1.3780.99
232_D236_A1.3760.99
162_A196_L1.3700.99
181_H199_T1.3520.99
182_Q186_Q1.3390.99
267_T270_M1.3250.99
191_H195_S1.3240.99
152_K267_T1.3210.99
49_V92_V1.3210.99
181_H185_V1.3190.99
47_F88_L1.3150.99
173_S180_R1.3130.99
140_S154_P1.2950.99
171_A184_I1.2920.99
75_L119_Y1.2890.99
234_D238_D1.2770.99
67_L77_V1.2740.99
270_M274_P1.2710.99
239_A242_D1.2530.99
169_F187_E1.2480.99
187_E190_E1.2390.98
47_F90_V1.2340.98
268_E272_E1.2310.98
34_K182_Q1.2270.98
32_M120_V1.2250.98
108_I161_L1.2240.98
139_R142_F1.2210.98
263_A266_V1.2190.98
29_M122_M1.2170.98
214_Y218_S1.2020.98
125_R155_P1.1950.98
223_S226_D1.1930.98
159_L170_I1.1880.98
260_Y263_A1.1690.98
45_D89_E1.1660.98
79_T115_V1.1510.97
124_N128_G1.1510.97
89_E189_I1.1490.97
32_M58_I1.1430.97
108_I156_V1.1390.97
123_D155_P1.1350.97
264_H267_T1.1270.97
75_L110_A1.1260.97
167_G170_I1.1080.97
160_A163_M1.1070.97
57_K60_T1.1020.97
100_Y158_P1.1000.97
244_G247_Y1.0990.97
161_L164_A1.0960.97
82_K115_V1.0840.96
36_L46_T1.0760.96
202_P214_Y1.0650.96
36_L189_I1.0650.96
269_N272_E1.0630.96
233_Y237_K1.0560.96
93_A122_M1.0530.96
28_T199_T1.0520.96
29_M33_M1.0490.96
50_A66_A1.0460.96
159_L196_L1.0440.96
144_T147_S1.0400.95
105_G108_I1.0370.95
184_I250_V1.0340.95
212_Y216_R1.0280.95
56_G68_H1.0270.95
173_S185_V1.0230.95
234_D237_K1.0180.95
249_G253_Q1.0160.95
52_I68_H1.0150.95
183_E187_E1.0100.95
174_F222_L1.0100.95
237_K241_L1.0060.95
210_D214_Y1.0050.94
122_M201_S0.9950.94
50_A59_G0.9890.94
174_F200_F0.9840.94
52_I57_K0.9800.94
82_K116_D0.9760.94
231_H235_Q0.9700.93
114_N194_F0.9630.93
174_F218_S0.9550.93
57_K61_Y0.9400.92
232_D235_Q0.9370.92
159_L172_Q0.9340.92
233_Y238_D0.9240.92
32_M91_M0.9220.91
259_P263_A0.9210.91
27_G30_N0.9160.91
118_T188_A0.9140.91
238_D241_L0.9140.91
254_D257_S0.9100.91
118_T185_V0.9060.91
100_Y137_T0.8970.90
81_V90_V0.8930.90
210_D213_D0.8930.90
19_W26_F0.8910.90
89_E116_D0.8880.90
177_D221_D0.8860.90
162_A170_I0.8840.90
55_S122_M0.8790.89
158_P196_L0.8770.89
219_L222_L0.8740.89
79_T113_R0.8620.89
107_F196_L0.8610.88
104_A108_I0.8610.88
83_L115_V0.8560.88
58_I122_M0.8540.88
226_D229_D0.8480.88
110_A194_F0.8470.88
217_D220_V0.8470.88
265_G268_E0.8450.88
266_V270_M0.8440.87
125_R139_R0.8420.87
175_S181_H0.8400.87
126_I205_T0.8330.87
18_T60_T0.8320.87
28_T122_M0.8300.87
80_G84_A0.8220.86
219_L223_S0.8220.86
259_P262_E0.8190.86
52_I56_G0.8150.86
56_G60_T0.8140.85
247_Y250_V0.8120.85
173_S199_T0.8100.85
225_D229_D0.8090.85
161_L165_A0.8040.85
232_D237_K0.8030.85
155_P172_Q0.7970.84
225_D245_K0.7960.84
220_V254_D0.7940.84
230_R233_Y0.7890.84
52_I73_R0.7880.84
235_Q238_D0.7820.83
57_K68_H0.7770.83
209_V214_Y0.7730.82
31_G178_A0.7730.82
260_Y268_E0.7690.82
163_M170_I0.7680.82
54_C102_I0.7650.82
175_S215_F0.7650.82
37_A44_D0.7630.82
36_L91_M0.7620.82
52_I66_A0.7600.81
240_I243_A0.7580.81
82_K90_V0.7570.81
120_V197_V0.7490.80
17_P26_F0.7490.80
108_I165_A0.7480.80
126_I142_F0.7480.80
56_G73_R0.7480.80
214_Y217_D0.7440.80
248_L252_Y0.7410.80
32_M48_V0.7410.80
249_G252_Y0.7390.80
118_T197_V0.7370.79
249_G261_S0.7370.79
211_T214_Y0.7330.79
74_A94_G0.7290.79
78_G117_I0.7270.78
107_F111_V0.7270.78
256_D259_P0.7270.78
19_W58_I0.7240.78
111_V196_L0.7240.78
233_Y241_L0.7170.77
211_T215_F0.7160.77
74_A98_D0.7150.77
264_H272_E0.7080.77
207_N210_D0.7060.76
223_S227_D0.7000.76
15_K18_T0.7000.76
57_K101_S0.6960.75
175_S202_P0.6960.75
225_D228_Y0.6950.75
107_F163_M0.6920.75
222_L225_D0.6880.74
223_S245_K0.6880.74
138_S144_T0.6860.74
97_G135_S0.6840.74
261_S265_G0.6810.74
265_G269_N0.6810.74
249_G262_E0.6750.73
159_L251_L0.6750.73
163_M237_K0.6750.73
215_F218_S0.6700.73
67_L81_V0.6660.72
25_D201_S0.6640.72
221_D251_L0.6640.72
125_R142_F0.6610.72
222_L229_D0.6600.71
180_R247_Y0.6590.71
138_S150_G0.6590.71
221_D227_D0.6590.71
184_I197_V0.6550.71
262_E265_G0.6550.71
239_A243_A0.6550.71
230_R235_Q0.6530.71
32_M46_T0.6520.70
134_A147_S0.6510.70
232_D240_I0.6470.70
49_V74_A0.6440.70
221_D248_L0.6410.69
48_V64_S0.6410.69
216_R223_S0.6410.69
100_Y198_N0.6400.69
107_F119_Y0.6400.69
20_C23_C0.6380.69
166_G170_I0.6370.69
70_V73_R0.6360.69
230_R236_A0.6320.68
220_V245_K0.6310.68
59_G68_H0.6270.68
100_Y196_L0.6270.68
200_F246_E0.6270.68
48_V62_M0.6250.67
236_A240_I0.6240.67
75_L99_G0.6220.67
132_G143_E0.6220.67
75_L106_H0.6210.67
125_R138_S0.6200.67
50_A60_T0.6180.66
27_G31_G0.6170.66
17_P68_H0.6110.66
267_T271_A0.6110.66
49_V90_V0.6100.65
216_R222_L0.6090.65
69_G73_R0.6090.65
262_E266_V0.6060.65
265_G273_L0.6060.65
253_Q261_S0.6060.65
55_S201_S0.6040.65
226_D248_L0.5940.63
263_A270_M0.5910.63
71_H102_I0.5900.63
83_L166_G0.5890.63
246_E250_V0.5890.63
243_A246_E0.5870.62
217_D255_E0.5860.62
169_F191_H0.5850.62
81_V85_N0.5810.62
160_A164_A0.5800.62
97_G127_Y0.5790.61
224_E247_Y0.5790.61
177_D180_R0.5770.61
48_V81_V0.5750.61
262_E271_A0.5730.61
265_G272_E0.5730.61
79_T110_A0.5710.60
169_F251_L0.5710.60
53_G73_R0.5690.60
102_I105_G0.5690.60
70_V101_S0.5670.60
230_R238_D0.5670.60
206_F210_D0.5670.60
51_G98_D0.5650.60
149_D152_K0.5610.59
54_C203_C0.5600.59
49_V77_V0.5590.59
264_H268_E0.5560.58
114_N167_G0.5560.58
94_G98_D0.5550.58
74_A137_T0.5540.58
18_T68_H0.5530.58
153_Q167_G0.5520.58
36_L64_S0.5520.58
247_Y251_L0.5510.58
237_K242_D0.5500.57
89_E92_V0.5500.57
253_Q256_D0.5500.57
31_G34_K0.5460.57
58_I93_A0.5450.57
25_D102_I0.5450.57
149_D267_T0.5450.57
35_A183_E0.5420.56
254_D258_T0.5420.56
52_I71_H0.5410.56
70_V77_V0.5400.56
50_A53_G0.5390.56
264_H271_A0.5390.56
98_D109_H0.5370.56
216_R220_V0.5370.56
50_A56_G0.5350.55
101_S136_P0.5340.55
179_L182_Q0.5340.55
114_N153_Q0.5330.55
252_Y258_T0.5330.55
158_P170_I0.5330.55
17_P30_N0.5310.55
156_V165_A0.5300.55
211_T218_S0.5290.55
92_V119_Y0.5290.55
18_T57_K0.5280.54
221_D224_E0.5280.54
134_A137_T0.5280.54
104_A109_H0.5280.54
112_R134_A0.5270.54
200_F226_D0.5260.54
120_V188_A0.5230.54
238_D242_D0.5230.54
113_R167_G0.5230.54
170_I196_L0.5200.53
75_L121_V0.5180.53
123_D172_Q0.5170.53
50_A55_S0.5170.53
89_E118_T0.5150.53
24_G27_G0.5150.53
231_H240_I0.5130.52
62_M82_K0.5110.52
150_G155_P0.5110.52
220_V246_E0.5080.52
27_G175_S0.5050.51
261_S264_H0.5030.51
31_G182_Q0.5030.51
182_Q190_E0.5030.51
176_S202_P0.5010.51
231_H234_D0.5000.51
231_H236_A0.5000.51
140_S143_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.9792 100 0.439 Contact Map
5c4iC 2 0.9654 100 0.537 Contact Map
4kgdA 4 0.8131 99.9 0.744 Contact Map
1v5eA 4 0.8166 99.9 0.755 Contact Map
2panA 3 0.8062 99.9 0.759 Contact Map
1ybhA 4 0.7509 99.9 0.761 Contact Map
4rjjA 5 0.7163 99.9 0.772 Contact Map
2pgnA 4 0.7751 99.9 0.772 Contact Map
1ozhA 4 0.699 99.9 0.775 Contact Map
1t9bA 2 0.782 99.9 0.775 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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