GREMLIN Database
Q9HRZ4 - Uncharacterized protein
UniProt: Q9HRZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (199)
Sequences: 19172 (13496)
Seq/√Len: 956.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_S131_E3.4421.00
22_T63_T2.8211.00
9_Q24_E2.7731.00
84_D87_D2.6541.00
14_V20_A2.5921.00
11_V19_I2.5521.00
20_A65_E2.5431.00
144_E148_A2.4751.00
124_R128_A2.4721.00
7_T88_E2.4421.00
7_T24_E2.3751.00
22_T65_E2.3101.00
123_E146_R2.2861.00
10_A22_T2.2351.00
8_V83_R2.1851.00
13_D19_I2.1851.00
38_R52_Y2.1011.00
110_A118_A2.0851.00
111_G184_F2.0731.00
6_V91_V2.0311.00
56_S67_T1.9921.00
40_V90_T1.9881.00
107_L179_A1.9681.00
164_F167_A1.8811.00
12_D20_A1.8701.00
37_V66_V1.8471.00
179_A195_L1.8251.00
10_A85_P1.7511.00
110_A136_Y1.6691.00
21_V80_L1.6331.00
133_A158_L1.6191.00
149_A153_A1.6121.00
115_V134_L1.6031.00
9_Q63_T1.5541.00
105_S133_A1.5311.00
23_F66_V1.5291.00
179_A200_F1.5261.00
192_T196_E1.5241.00
138_D141_P1.5121.00
137_Q187_F1.5021.00
181_V191_A1.4781.00
24_E63_T1.4761.00
35_Q96_G1.4721.00
105_S177_Q1.4681.00
109_L187_F1.4621.00
6_V23_F1.4551.00
104_P178_A1.4231.00
111_G187_F1.4191.00
133_A160_V1.4041.00
196_E202_T1.3971.00
141_P144_E1.3731.00
166_D169_A1.3591.00
70_V78_P1.3491.00
141_P163_A1.3491.00
167_A170_T1.3401.00
37_V91_V1.3391.00
8_V23_F1.3101.00
165_E169_A1.2901.00
12_D22_T1.2851.00
70_V81_A1.2831.00
143_H146_R1.2681.00
109_L191_A1.2681.00
108_L118_A1.2631.00
104_P176_D1.2631.00
160_V163_A1.2591.00
11_V21_V1.2581.00
167_A171_L1.2541.00
148_A151_S1.2521.00
164_F168_V1.2491.00
119_V123_E1.2431.00
157_V162_D1.2421.00
181_V188_C1.2181.00
185_A189_G1.2071.00
165_E197_A1.1901.00
193_D197_A1.1861.00
19_I81_A1.1741.00
119_V146_R1.1691.00
181_V205_V1.1621.00
20_A67_T1.1471.00
168_V171_L1.1311.00
8_V21_V1.1211.00
20_A143_H1.1141.00
38_R92_E1.1071.00
37_V55_L1.1061.00
18_A113_P1.1011.00
164_F171_L1.0981.00
186_A190_A1.0961.00
158_L163_A1.0931.00
126_M153_A1.0851.00
67_T142_V1.0801.00
194_A197_A1.0731.00
11_V84_D1.0721.00
11_V85_P1.0651.00
6_V25_T1.0601.00
7_T26_P1.0591.00
110_A134_L1.0581.00
58_P123_E1.0381.00
108_L121_I1.0321.00
157_V163_A1.0311.00
67_T143_H1.0221.00
126_M154_G1.0221.00
146_R149_A1.0171.00
40_V50_G1.0161.00
118_A134_L1.0021.00
178_A204_A1.0001.00
166_D171_L0.9991.00
158_L162_D0.9981.00
17_D140_A0.9911.00
113_P116_G0.9881.00
71_A74_G0.9871.00
43_F79_W0.9781.00
79_W82_G0.9751.00
60_V127_D0.9721.00
83_R87_D0.9701.00
26_P88_E0.9681.00
107_L177_Q0.9671.00
131_E158_L0.9651.00
17_D69_D0.9631.00
125_A132_V0.9611.00
149_A152_D0.9381.00
189_G193_D0.9341.00
122_A132_V0.9341.00
108_L122_A0.9271.00
39_V66_V0.9211.00
192_T205_V0.9161.00
190_A193_D0.9061.00
159_V163_A0.8961.00
74_G77_G0.8941.00
28_G64_F0.8941.00
108_L132_V0.8911.00
190_A194_A0.8911.00
151_S155_A0.8881.00
100_Y121_I0.8741.00
33_P124_R0.8741.00
145_P149_A0.8741.00
32_E99_Y0.8701.00
201_D204_A0.8621.00
151_S154_G0.8591.00
156_D162_D0.8591.00
173_D177_Q0.8551.00
111_G186_A0.8481.00
8_V11_V0.8371.00
145_P148_A0.8291.00
57_S65_E0.8241.00
119_V143_H0.8221.00
80_L83_R0.8201.00
96_G99_Y0.8151.00
53_Y77_G0.8141.00
154_G157_V0.8051.00
156_D163_A0.8041.00
100_Y106_V0.8011.00
9_Q22_T0.8001.00
68_V80_L0.7981.00
49_E75_V0.7971.00
148_A152_D0.7921.00
49_E76_L0.7911.00
166_D170_T0.7911.00
115_V147_L0.7841.00
194_A198_E0.7841.00
24_E62_D0.7761.00
31_A120_A0.7761.00
122_A147_L0.7731.00
57_S123_E0.7691.00
16_P140_A0.7691.00
152_D155_A0.7681.00
148_A161_T0.7631.00
141_P161_T0.7611.00
61_A123_E0.7601.00
151_S159_V0.7551.00
104_P130_A0.7551.00
67_T116_G0.7541.00
23_F89_V0.7511.00
14_V67_T0.7511.00
15_G140_A0.7501.00
106_V130_A0.7491.00
136_Y142_V0.7491.00
35_Q99_Y0.7481.00
25_T28_G0.7461.00
58_P127_D0.7441.00
174_A177_Q0.7391.00
111_G190_A0.7371.00
131_E156_D0.7371.00
17_D72_P0.7361.00
157_V161_T0.7331.00
106_V132_V0.7321.00
169_A198_E0.7201.00
92_E95_F0.7171.00
6_V26_P0.7171.00
43_F46_G0.7131.00
32_E35_Q0.7121.00
191_A194_A0.7111.00
137_Q162_D0.7091.00
18_A142_V0.7071.00
72_P78_P0.7061.00
109_L135_V0.7041.00
122_A134_L0.7021.00
42_E48_T0.7011.00
56_S65_E0.7001.00
50_G92_E0.6981.00
108_L180_F0.6981.00
106_V125_A0.6961.00
13_D16_P0.6961.00
57_S61_A0.6941.00
158_L161_T0.6901.00
176_D204_A0.6891.00
38_R50_G0.6891.00
165_E168_V0.6891.00
60_V124_R0.6881.00
6_V64_F0.6871.00
102_G130_A0.6821.00
147_L159_V0.6791.00
126_M150_L0.6781.00
41_R76_L0.6771.00
173_D176_D0.6761.00
189_G192_T0.6741.00
156_D161_T0.6721.00
138_D161_T0.6721.00
31_A57_S0.6691.00
103_E106_V0.6681.00
39_V80_L0.6651.00
100_Y125_A0.6611.00
134_L157_V0.6601.00
33_P59_T0.6581.00
59_T124_R0.6581.00
124_R127_D0.6551.00
36_F52_Y0.6541.00
115_V136_Y0.6521.00
31_A55_L0.6511.00
181_V195_L0.6481.00
18_A67_T0.6481.00
105_S130_A0.6451.00
151_S157_V0.6451.00
6_V28_G0.6411.00
64_F91_V0.6401.00
61_A127_D0.6381.00
76_L80_L0.6271.00
146_R150_L0.6271.00
126_M132_V0.6251.00
104_P204_A0.6251.00
47_E75_V0.6201.00
58_P61_A0.6201.00
31_A58_P0.6191.00
121_I180_F0.6151.00
144_E159_V0.6121.00
193_D196_E0.6101.00
109_L179_A0.6081.00
31_A59_T0.6061.00
55_L64_F0.6061.00
159_V162_D0.6051.00
156_D160_V0.6041.00
77_G81_A0.6031.00
106_V178_A0.6031.00
73_D78_P0.6011.00
51_R74_G0.5871.00
17_D139_E0.5851.00
51_R76_L0.5821.00
54_T118_A0.5711.00
102_G178_A0.5701.00
164_F169_A0.5691.00
165_E170_T0.5661.00
37_V64_F0.5651.00
107_L133_A0.5651.00
125_A128_A0.5631.00
79_W83_R0.5621.00
181_V192_T0.5621.00
200_F205_V0.5601.00
40_V92_E0.5591.00
119_V147_L0.5571.00
29_F93_G0.5561.00
43_F47_E0.5561.00
40_V48_T0.5531.00
25_T29_F0.5521.00
21_V81_A0.5501.00
6_V89_V0.5441.00
42_E46_G0.5381.00
68_V77_G0.5361.00
143_H147_L0.5331.00
147_L150_L0.5321.00
144_E161_T0.5301.00
173_D200_F0.5301.00
141_P148_A0.5291.00
150_L153_A0.5281.00
125_A129_G0.5261.00
133_A177_Q0.5251.00
126_M157_V0.5241.00
43_F48_T0.5231.00
164_F170_T0.5201.00
157_V160_V0.5201.00
179_A205_V0.5161.00
38_R95_F0.5161.00
148_A159_V0.5151.00
115_V143_H0.5131.00
122_A150_L0.5101.00
34_G96_G0.5081.00
195_L205_V0.5071.00
25_T64_F0.5051.00
83_R89_V0.5021.00
186_A189_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gvhA 3 0.9953 100 0.192 Contact Map
1cqxA 2 0.9953 100 0.204 Contact Map
4g1vA 3 0.9953 100 0.221 Contact Map
1krhA 1 0.9813 100 0.227 Contact Map
4p6vF 1 0.9907 100 0.228 Contact Map
1tvcA 1 0.986 100 0.23 Contact Map
2r6hA 1 0.986 100 0.233 Contact Map
1qfjA 1 0.9439 100 0.236 Contact Map
4u9uA 1 0.9907 100 0.241 Contact Map
3jqqA 2 0.9673 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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