GREMLIN Database
Q9HRZ3 - Uncharacterized protein
UniProt: Q9HRZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (115)
Sequences: 4056 (2361)
Seq/√Len: 220.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_L106_R3.8751.00
91_D94_A3.5351.00
98_T102_A3.2241.00
27_E31_A3.1551.00
10_M90_D2.6701.00
11_H88_A2.4401.00
21_D24_D2.4251.00
10_M88_A2.4081.00
97_E101_D2.3441.00
52_D58_Y2.2251.00
48_T51_L2.1971.00
20_E80_G2.1951.00
96_L100_R2.1721.00
72_G76_Q1.7971.00
38_A52_D1.7881.00
37_V49_V1.7431.00
93_E97_E1.7101.00
100_R109_E1.6701.00
12_V85_V1.6181.00
64_P75_L1.6111.00
114_G119_D1.5331.00
40_E47_H1.5301.00
94_A98_T1.5161.00
98_T101_D1.4921.00
64_P72_G1.4821.00
64_P69_T1.4681.00
18_A71_V1.4391.00
38_A58_Y1.4311.00
93_E119_D1.3421.00
46_L51_L1.3391.00
73_R76_Q1.3241.00
22_A26_G1.2781.00
35_A53_L1.2691.00
95_A99_A1.2281.00
100_R106_R1.2121.00
48_T62_L1.2071.00
36_P52_D1.2041.00
45_G66_D1.1911.00
99_A104_V1.1891.00
11_H56_D1.1751.00
19_T61_L1.1741.00
30_T37_V1.1531.00
12_V57_G1.1431.00
69_T72_G1.1351.00
95_A98_T1.1301.00
16_G62_L1.1231.00
13_D88_A1.1111.00
93_E121_A1.1101.00
108_D112_R1.1061.00
89_T95_A1.1041.00
111_P122_F1.0431.00
28_L32_L1.0401.00
27_E30_T1.0361.00
94_A97_E1.0211.00
45_G48_T1.0151.00
25_L28_L1.0101.00
30_T51_L0.9791.00
30_T36_P0.9761.00
25_L29_Y0.9721.00
20_E75_L0.9701.00
74_Y81_G0.9551.00
114_G122_F0.9461.00
96_L121_A0.9421.00
93_E110_E0.9371.00
46_L50_F0.9351.00
37_V40_E0.9210.99
47_H63_E0.9200.99
18_A81_G0.9070.99
112_R119_D0.9040.99
48_T60_E0.9030.99
26_G30_T0.9010.99
42_V47_H0.8960.99
108_D111_P0.8960.99
92_I96_L0.8950.99
45_G51_L0.8890.99
49_V53_L0.8880.99
47_H53_L0.8840.99
73_R77_R0.8840.99
48_T53_L0.8650.99
82_I85_V0.8640.99
48_T52_D0.8500.99
46_L62_L0.8480.99
41_E62_L0.8470.99
68_D72_G0.8460.99
112_R121_A0.8360.99
8_A90_D0.8300.99
35_A57_G0.8300.99
21_D27_E0.8280.99
23_A27_E0.8170.99
62_L71_V0.8110.99
52_D56_D0.8000.99
18_A83_H0.7990.98
21_D80_G0.7870.98
113_A119_D0.7760.98
70_T83_H0.7730.98
53_L57_G0.7690.98
24_D27_E0.7620.98
75_L81_G0.7260.97
49_V52_D0.7200.97
15_V85_V0.7180.97
26_G51_L0.7150.97
50_F53_L0.7150.97
92_I95_A0.7140.97
20_E76_Q0.7130.97
47_H50_F0.7030.97
46_L49_V0.7000.97
23_A49_V0.6960.96
99_A106_R0.6950.96
115_A118_H0.6930.96
106_R121_A0.6870.96
18_A62_L0.6860.96
53_L56_D0.6800.96
46_L52_D0.6700.96
21_D63_E0.6630.95
10_M89_T0.6600.95
46_L71_V0.6570.95
26_G49_V0.6540.95
19_T59_V0.6530.95
108_D121_A0.6520.95
117_G120_V0.6450.95
14_H86_A0.6400.94
14_H84_H0.6310.94
35_A87_F0.6240.94
119_D122_F0.6230.94
18_A75_L0.6220.93
67_E72_G0.6200.93
45_G49_V0.6190.93
40_E49_V0.6120.93
17_V59_V0.6110.93
63_E84_H0.6070.93
114_G120_V0.6060.93
112_R115_A0.6020.92
110_E121_A0.6000.92
15_V82_I0.5930.92
45_G50_F0.5920.92
22_A63_E0.5880.91
16_G83_H0.5830.91
118_H121_A0.5810.91
74_Y78_T0.5800.91
119_D123_L0.5740.90
99_A102_A0.5730.90
67_E76_Q0.5710.90
24_D31_A0.5660.90
71_V83_H0.5630.90
8_A94_A0.5620.90
99_A123_L0.5590.89
8_A33_L0.5570.89
97_E100_R0.5560.89
66_D69_T0.5560.89
16_G84_H0.5530.89
50_F58_Y0.5490.88
19_T22_A0.5490.88
13_D86_A0.5490.88
96_L107_I0.5370.87
24_D34_G0.5360.87
29_Y61_L0.5350.87
43_F65_V0.5340.87
20_E24_D0.5330.87
45_G53_L0.5330.87
94_A101_D0.5330.87
75_L83_H0.5230.86
26_G37_V0.5230.86
43_F74_Y0.5220.86
13_D58_Y0.5180.85
12_V78_T0.5100.84
81_G85_V0.5090.84
113_A122_F0.5090.84
89_T92_I0.5080.84
113_A117_G0.5030.84
110_E113_A0.5010.83
40_E44_D0.5010.83
111_P121_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3isqA 2 0.9855 99.9 0.4 Contact Map
1sqdA 2 0.9493 99.8 0.428 Contact Map
1sp8A 2 0.971 99.8 0.438 Contact Map
2r5vA 1 0.9203 99.8 0.445 Contact Map
1cjxA 2 0.9058 99.8 0.447 Contact Map
1t47A 2 0.9638 99.8 0.485 Contact Map
3gm5A 2 0.9565 99.7 0.504 Contact Map
1jc4A 2 0.971 99.7 0.508 Contact Map
3hdpA 2 0.9348 99.7 0.513 Contact Map
3zgjA 1 0.9348 99.7 0.528 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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