Q9HRZ3 - HALSA - GREMLIN Contacts

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Q9HRZ3 - Uncharacterized protein

UniProt:	Q9HRZ3	Sequences: MSARGPPASMHVDHVGVATEDAADLGELYTALLGAPVAHEEVFDGLHTVFLDLGGDGYVELLEPVDEDTTVGRYLQRTGGGIHHVAFATDDIEAALETARDAGVDRIDEEPRAGAWGHDVAFLHPKDTGGALIEFVEH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	138 (115)
Sequences:	4056 (2361)
Seq/√Len:	220.2

BACSU - YQJC
HALSA - Q9HRZ3
SULSO - Q97W20

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_L	106_R	3.875	1.00
91_D	94_A	3.535	1.00
98_T	102_A	3.224	1.00
27_E	31_A	3.155	1.00
10_M	90_D	2.670	1.00
11_H	88_A	2.440	1.00
21_D	24_D	2.425	1.00
10_M	88_A	2.408	1.00
97_E	101_D	2.344	1.00
52_D	58_Y	2.225	1.00
48_T	51_L	2.197	1.00
20_E	80_G	2.195	1.00
96_L	100_R	2.172	1.00
72_G	76_Q	1.797	1.00
38_A	52_D	1.788	1.00
37_V	49_V	1.743	1.00
93_E	97_E	1.710	1.00
100_R	109_E	1.670	1.00
12_V	85_V	1.618	1.00
64_P	75_L	1.611	1.00
114_G	119_D	1.533	1.00
40_E	47_H	1.530	1.00
94_A	98_T	1.516	1.00
98_T	101_D	1.492	1.00
64_P	72_G	1.482	1.00
64_P	69_T	1.468	1.00
18_A	71_V	1.439	1.00
38_A	58_Y	1.431	1.00
93_E	119_D	1.342	1.00
46_L	51_L	1.339	1.00
73_R	76_Q	1.324	1.00
22_A	26_G	1.278	1.00
35_A	53_L	1.269	1.00
95_A	99_A	1.228	1.00
100_R	106_R	1.212	1.00
48_T	62_L	1.207	1.00
36_P	52_D	1.204	1.00
45_G	66_D	1.191	1.00
99_A	104_V	1.189	1.00
11_H	56_D	1.175	1.00
19_T	61_L	1.174	1.00
30_T	37_V	1.153	1.00
12_V	57_G	1.143	1.00
69_T	72_G	1.135	1.00
95_A	98_T	1.130	1.00
16_G	62_L	1.123	1.00
13_D	88_A	1.111	1.00
93_E	121_A	1.110	1.00
108_D	112_R	1.106	1.00
89_T	95_A	1.104	1.00
111_P	122_F	1.043	1.00
28_L	32_L	1.040	1.00
27_E	30_T	1.036	1.00
94_A	97_E	1.021	1.00
45_G	48_T	1.015	1.00
25_L	28_L	1.010	1.00
30_T	51_L	0.979	1.00
30_T	36_P	0.976	1.00
25_L	29_Y	0.972	1.00
20_E	75_L	0.970	1.00
74_Y	81_G	0.955	1.00
114_G	122_F	0.946	1.00
96_L	121_A	0.942	1.00
93_E	110_E	0.937	1.00
46_L	50_F	0.935	1.00
37_V	40_E	0.921	0.99
47_H	63_E	0.920	0.99
18_A	81_G	0.907	0.99
112_R	119_D	0.904	0.99
48_T	60_E	0.903	0.99
26_G	30_T	0.901	0.99
42_V	47_H	0.896	0.99
108_D	111_P	0.896	0.99
92_I	96_L	0.895	0.99
45_G	51_L	0.889	0.99
49_V	53_L	0.888	0.99
47_H	53_L	0.884	0.99
73_R	77_R	0.884	0.99
48_T	53_L	0.865	0.99
82_I	85_V	0.864	0.99
48_T	52_D	0.850	0.99
46_L	62_L	0.848	0.99
41_E	62_L	0.847	0.99
68_D	72_G	0.846	0.99
112_R	121_A	0.836	0.99
8_A	90_D	0.830	0.99
35_A	57_G	0.830	0.99
21_D	27_E	0.828	0.99
23_A	27_E	0.817	0.99
62_L	71_V	0.811	0.99
52_D	56_D	0.800	0.99
18_A	83_H	0.799	0.98
21_D	80_G	0.787	0.98
113_A	119_D	0.776	0.98
70_T	83_H	0.773	0.98
53_L	57_G	0.769	0.98
24_D	27_E	0.762	0.98
75_L	81_G	0.726	0.97
49_V	52_D	0.720	0.97
15_V	85_V	0.718	0.97
26_G	51_L	0.715	0.97
50_F	53_L	0.715	0.97
92_I	95_A	0.714	0.97
20_E	76_Q	0.713	0.97
47_H	50_F	0.703	0.97
46_L	49_V	0.700	0.97
23_A	49_V	0.696	0.96
99_A	106_R	0.695	0.96
115_A	118_H	0.693	0.96
106_R	121_A	0.687	0.96
18_A	62_L	0.686	0.96
53_L	56_D	0.680	0.96
46_L	52_D	0.670	0.96
21_D	63_E	0.663	0.95
10_M	89_T	0.660	0.95
46_L	71_V	0.657	0.95
26_G	49_V	0.654	0.95
19_T	59_V	0.653	0.95
108_D	121_A	0.652	0.95
117_G	120_V	0.645	0.95
14_H	86_A	0.640	0.94
14_H	84_H	0.631	0.94
35_A	87_F	0.624	0.94
119_D	122_F	0.623	0.94
18_A	75_L	0.622	0.93
67_E	72_G	0.620	0.93
45_G	49_V	0.619	0.93
40_E	49_V	0.612	0.93
17_V	59_V	0.611	0.93
63_E	84_H	0.607	0.93
114_G	120_V	0.606	0.93
112_R	115_A	0.602	0.92
110_E	121_A	0.600	0.92
15_V	82_I	0.593	0.92
45_G	50_F	0.592	0.92
22_A	63_E	0.588	0.91
16_G	83_H	0.583	0.91
118_H	121_A	0.581	0.91
74_Y	78_T	0.580	0.91
119_D	123_L	0.574	0.90
99_A	102_A	0.573	0.90
67_E	76_Q	0.571	0.90
24_D	31_A	0.566	0.90
71_V	83_H	0.563	0.90
8_A	94_A	0.562	0.90
99_A	123_L	0.559	0.89
8_A	33_L	0.557	0.89
97_E	100_R	0.556	0.89
66_D	69_T	0.556	0.89
16_G	84_H	0.553	0.89
50_F	58_Y	0.549	0.88
19_T	22_A	0.549	0.88
13_D	86_A	0.549	0.88
96_L	107_I	0.537	0.87
24_D	34_G	0.536	0.87
29_Y	61_L	0.535	0.87
43_F	65_V	0.534	0.87
20_E	24_D	0.533	0.87
45_G	53_L	0.533	0.87
94_A	101_D	0.533	0.87
75_L	83_H	0.523	0.86
26_G	37_V	0.523	0.86
43_F	74_Y	0.522	0.86
13_D	58_Y	0.518	0.85
12_V	78_T	0.510	0.84
81_G	85_V	0.509	0.84
113_A	122_F	0.509	0.84
89_T	92_I	0.508	0.84
113_A	117_G	0.503	0.84
110_E	113_A	0.501	0.83
40_E	44_D	0.501	0.83
111_P	121_A	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3isqA	2	0.9855	99.9	0.4	Contact Map
1sqdA	2	0.9493	99.8	0.428	Contact Map
1sp8A	2	0.971	99.8	0.438	Contact Map
2r5vA	1	0.9203	99.8	0.445	Contact Map
1cjxA	2	0.9058	99.8	0.447	Contact Map
1t47A	2	0.9638	99.8	0.485	Contact Map
3gm5A	2	0.9565	99.7	0.504	Contact Map
1jc4A	2	0.971	99.7	0.508	Contact Map
3hdpA	2	0.9348	99.7	0.513	Contact Map
3zgjA	1	0.9348	99.7	0.528	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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