Q9HRZ2 - HALSA - GREMLIN Contacts

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Q9HRZ2 - Probable oxidoreductase

UniProt:	Q9HRZ2	Sequences: MSSDDAWTAAALPDQSGRRVVVTGANSGLGFEATRAFARAGAHVVMACRSTERGEDARDDIVAELPGASLTVHELDLAALDSVAAFADWFTAEFDSLHVLANNAGVMAIPRSETADGFETQFGVNHLGHVALTAGLLGVLRRTSGETRVVTQSSGAHRRGRIDFEDLQHEAEYGKWEAYSQSKLANLLFAYELDRRLRAASASVTSVACHPGYAATNLQLRGPQAAGSRLRLLAMRAANALVGQSAEQGAWPLLYAATNPSIDGGEYIGPGGVLNMRGHPERQQPSARSRDEDTARRLWTVSADRTGVDFDLPDPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (242)
Sequences:	65980 (44744)
Seq/√Len:	2876.2

ECOLI - IDNO YGHA HDHA YGCW SRLD YOHF YBBO UCPA FABI KDUD HCAB YGFF YCIK FABG ENTA FOLM YDFG BDCA
BACSU - YXNA YHXD UXUB YHXC DHBA YXBG GS39 YHDF YWFH YXJF DHG2 FADH DHG YJDA YOXD FABG FABL YKVO KDUD FABI YVAG YVRD YUSZ YTKK BACC YQJQ DLTE YMFI BZRD YUXG
HALSA - Q9HRZ2 Q9HQ41 Q9HRV8 Q9HSR4 Q9HNC5 Q9HPP2 Q9HMA5 Q9HS80 Q9HP93
SULSO - Q97UK6 Q97VV6 Q97ZE4 Q97UA4 Q97WF0 Q97WL1 Q97WD7 Q97Y09 Q97VG2 Q97ZA0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
119_E	127_L	3.202	1.00
119_E	123_G	2.556	1.00
184_L	188_L	2.556	1.00
148_R	205_T	2.536	1.00
20_V	99_V	2.517	1.00
79_A	82_S	2.508	1.00
84_A	135_G	2.498	1.00
91_T	139_V	2.423	1.00
141_R	202_A	2.369	1.00
99_V	257_A	2.286	1.00
151_T	190_A	2.282	1.00
133_T	193_L	2.223	1.00
47_A	75_L	2.174	1.00
123_G	127_L	2.140	1.00
80_L	115_A	2.134	1.00
31_F	57_A	2.081	1.00
43_H	69_S	2.069	1.00
210_H	266_E	2.067	1.00
137_L	197_L	2.045	1.00
31_F	60_D	2.019	1.00
265_G	268_I	2.019	1.00
54_G	72_V	2.015	1.00
36_A	251_W	2.011	1.00
31_F	35_R	1.983	1.00
51_T	55_E	1.981	1.00
71_T	93_E	1.948	1.00
87_A	136_L	1.909	1.00
102_N	151_T	1.904	1.00
26_N	48_C	1.876	1.00
153_S	187_L	1.861	1.00
47_A	86_F	1.823	1.00
45_V	90_F	1.822	1.00
215_A	245_S	1.816	1.00
251_W	260_P	1.809	1.00
19_R	43_H	1.800	1.00
252_P	267_Y	1.783	1.00
58_R	62_V	1.743	1.00
190_A	208_A	1.713	1.00
33_A	253_L	1.676	1.00
89_W	93_E	1.653	1.00
73_H	89_W	1.651	1.00
36_A	254_L	1.647	1.00
51_T	74_E	1.644	1.00
75_L	82_S	1.629	1.00
36_A	40_A	1.595	1.00
50_S	53_R	1.584	1.00
45_V	94_F	1.583	1.00
35_R	60_D	1.576	1.00
58_R	72_V	1.549	1.00
37_F	257_A	1.529	1.00
85_A	89_W	1.521	1.00
115_A	131_A	1.520	1.00
14_D	260_P	1.502	1.00
36_A	39_R	1.481	1.00
125_N	182_S	1.462	1.00
100_L	132_L	1.447	1.00
25_A	46_M	1.440	1.00
19_R	96_S	1.415	1.00
88_D	92_A	1.412	1.00
101_A	152_Q	1.403	1.00
244_Q	263_D	1.403	1.00
126_H	185_A	1.402	1.00
100_L	136_L	1.399	1.00
129_H	186_N	1.398	1.00
75_L	86_F	1.385	1.00
14_D	40_A	1.382	1.00
40_A	254_L	1.379	1.00
158_R	268_I	1.367	1.00
83_V	132_L	1.353	1.00
20_V	37_F	1.352	1.00
59_D	63_A	1.345	1.00
122_F	126_H	1.332	1.00
127_L	131_A	1.329	1.00
108_A	120_T	1.321	1.00
215_A	220_L	1.317	1.00
48_C	54_G	1.309	1.00
82_S	85_A	1.307	1.00
43_H	68_A	1.302	1.00
114_T	117_G	1.297	1.00
89_W	92_A	1.281	1.00
80_L	131_A	1.258	1.00
27_S	53_R	1.249	1.00
55_E	59_D	1.249	1.00
118_F	127_L	1.248	1.00
19_R	45_V	1.235	1.00
80_L	84_A	1.230	1.00
252_P	269_G	1.220	1.00
32_E	35_R	1.217	1.00
71_T	94_F	1.196	1.00
84_A	88_D	1.194	1.00
59_D	62_V	1.189	1.00
153_S	208_A	1.189	1.00
110_P	117_G	1.178	1.00
97_L	136_L	1.172	1.00
55_E	58_R	1.166	1.00
29_L	214_A	1.162	1.00
36_A	250_A	1.160	1.00
45_V	71_T	1.160	1.00
43_H	71_T	1.159	1.00
27_S	217_N	1.154	1.00
102_N	133_T	1.153	1.00
34_T	46_M	1.147	1.00
115_A	127_L	1.145	1.00
193_L	206_S	1.144	1.00
15_Q	42_A	1.142	1.00
187_L	266_E	1.138	1.00
37_F	42_A	1.131	1.00
56_D	60_D	1.124	1.00
42_A	99_V	1.123	1.00
58_R	70_L	1.118	1.00
20_V	42_A	1.118	1.00
209_C	253_L	1.117	1.00
106_V	124_V	1.114	1.00
73_H	93_E	1.113	1.00
33_A	101_A	1.109	1.00
73_H	86_F	1.106	1.00
39_R	66_P	1.103	1.00
78_A	120_T	1.096	1.00
113_E	178_A	1.092	1.00
133_T	149_V	1.088	1.00
190_A	206_S	1.063	1.00
17_G	42_A	1.062	1.00
38_A	68_A	1.053	1.00
139_V	142_R	1.044	1.00
103_N	152_Q	1.042	1.00
214_A	244_Q	1.040	1.00
32_E	247_E	1.026	1.00
90_F	94_F	1.025	1.00
51_T	72_V	1.024	1.00
45_V	73_H	1.012	1.00
111_R	141_R	1.012	1.00
19_R	94_F	1.007	1.00
101_A	253_L	1.006	1.00
106_V	120_T	1.005	1.00
18_R	259_N	0.999	1.00
148_R	207_V	0.989	1.00
122_F	127_L	0.986	1.00
81_D	85_A	0.985	1.00
21_V	86_F	0.985	1.00
56_D	59_D	0.984	1.00
80_L	134_A	0.975	1.00
18_R	98_H	0.972	1.00
152_Q	253_L	0.970	1.00
108_A	117_G	0.970	1.00
62_V	69_S	0.969	1.00
242_V	248_Q	0.967	1.00
148_R	262_I	0.962	1.00
35_R	39_R	0.961	1.00
157_H	187_L	0.956	1.00
194_D	264_G	0.941	1.00
96_S	144_S	0.940	1.00
36_A	247_E	0.939	1.00
129_H	151_T	0.934	1.00
57_A	60_D	0.932	1.00
116_D	120_T	0.932	1.00
46_M	70_L	0.929	1.00
259_N	262_I	0.926	1.00
208_A	266_E	0.924	1.00
29_L	33_A	0.923	1.00
32_E	246_A	0.918	1.00
27_S	50_S	0.907	1.00
85_A	88_D	0.905	1.00
179_Y	183_K	0.899	1.00
133_T	189_F	0.899	1.00
139_V	144_S	0.896	1.00
150_V	257_A	0.894	1.00
38_A	61_I	0.892	1.00
21_V	97_L	0.882	1.00
126_H	186_N	0.880	1.00
43_H	94_F	0.878	1.00
61_I	68_A	0.875	1.00
78_A	123_G	0.874	1.00
77_L	128_G	0.873	1.00
232_L	236_R	0.871	1.00
21_V	47_A	0.870	1.00
35_R	66_P	0.869	1.00
53_R	56_D	0.864	1.00
192_E	196_R	0.859	1.00
25_A	47_A	0.858	1.00
71_T	89_W	0.856	1.00
74_E	82_S	0.850	1.00
33_A	250_A	0.849	1.00
115_A	119_E	0.847	1.00
247_E	251_W	0.844	1.00
135_G	138_G	0.842	1.00
149_V	206_S	0.832	1.00
52_E	55_E	0.831	1.00
81_D	84_A	0.831	1.00
217_N	220_L	0.825	1.00
32_E	250_A	0.819	1.00
130_V	189_F	0.819	1.00
255_Y	261_S	0.818	1.00
151_T	206_S	0.817	1.00
180_S	188_L	0.816	1.00
75_L	83_V	0.813	1.00
258_T	261_S	0.807	1.00
87_A	135_G	0.799	1.00
133_T	151_T	0.797	1.00
61_I	70_L	0.797	1.00
111_R	197_L	0.796	1.00
80_L	135_G	0.792	1.00
91_T	142_R	0.789	1.00
158_R	210_H	0.789	1.00
31_F	56_D	0.787	1.00
252_P	255_Y	0.778	1.00
88_D	135_G	0.772	1.00
86_F	132_L	0.767	1.00
60_D	63_A	0.756	1.00
214_A	249_G	0.756	1.00
158_R	187_L	0.754	1.00
187_L	191_Y	0.749	1.00
231_R	235_M	0.748	1.00
106_V	218_L	0.744	1.00
48_C	72_V	0.739	1.00
137_L	141_R	0.738	1.00
177_E	196_R	0.738	1.00
197_L	202_A	0.737	1.00
37_F	254_L	0.732	1.00
22_V	34_T	0.728	1.00
117_G	120_T	0.725	1.00
177_E	189_F	0.721	1.00
35_R	61_I	0.714	1.00
122_F	181_Q	0.713	1.00
156_A	180_S	0.713	1.00
118_F	130_V	0.710	1.00
32_E	36_A	0.706	1.00
105_G	125_N	0.704	1.00
83_V	131_A	0.702	1.00
62_V	67_G	0.702	1.00
102_N	132_L	0.701	1.00
115_A	134_A	0.699	1.00
30_G	103_N	0.699	1.00
154_S	179_Y	0.696	1.00
224_Q	227_G	0.691	1.00
248_Q	262_I	0.690	1.00
40_A	260_P	0.690	1.00
37_F	253_L	0.689	1.00
232_L	235_M	0.689	1.00
19_R	90_F	0.689	1.00
141_R	197_L	0.687	1.00
52_E	56_D	0.683	1.00
198_R	240_A	0.681	1.00
137_L	202_A	0.681	1.00
102_N	129_H	0.680	1.00
136_L	140_L	0.680	1.00
100_L	149_V	0.679	1.00
160_G	188_L	0.675	1.00
23_T	132_L	0.673	1.00
88_D	139_V	0.668	1.00
125_N	183_K	0.667	1.00
96_S	139_V	0.666	1.00
38_A	70_L	0.665	1.00
242_V	262_I	0.665	1.00
187_L	208_A	0.663	1.00
131_A	135_G	0.662	1.00
184_L	191_Y	0.661	1.00
223_P	226_A	0.661	1.00
88_D	91_T	0.658	1.00
87_A	132_L	0.654	1.00
27_S	31_F	0.653	1.00
18_R	146_E	0.653	1.00
69_S	93_E	0.653	1.00
126_H	181_Q	0.648	1.00
122_F	182_S	0.647	1.00
106_V	182_S	0.646	1.00
55_E	72_V	0.644	1.00
97_L	139_V	0.638	1.00
180_S	192_E	0.634	1.00
238_A	263_D	0.633	1.00
180_S	184_L	0.633	1.00
36_A	260_P	0.631	1.00
207_V	256_A	0.631	1.00
25_A	34_T	0.630	1.00
83_V	135_G	0.629	1.00
129_H	133_T	0.629	1.00
158_R	266_E	0.629	1.00
63_A	66_P	0.628	1.00
140_L	146_E	0.627	1.00
48_C	74_E	0.625	1.00
90_F	97_L	0.624	1.00
121_Q	182_S	0.624	1.00
213_Y	219_Q	0.618	1.00
26_N	54_G	0.613	1.00
15_Q	99_V	0.612	1.00
146_E	205_T	0.612	1.00
194_D	198_R	0.610	1.00
220_L	224_Q	0.609	1.00
28_G	216_T	0.607	1.00
140_L	147_T	0.607	1.00
46_M	57_A	0.606	1.00
84_A	138_G	0.605	1.00
49_R	76_D	0.604	1.00
197_L	206_S	0.601	1.00
54_G	74_E	0.599	1.00
78_A	124_V	0.599	1.00
48_C	53_R	0.599	1.00
118_F	126_H	0.598	1.00
175_K	196_R	0.596	1.00
120_T	123_G	0.596	1.00
104_A	128_G	0.595	1.00
245_S	248_Q	0.593	1.00
150_V	253_L	0.592	1.00
268_I	274_L	0.588	1.00
91_T	96_S	0.588	1.00
235_M	243_G	0.587	1.00
81_D	115_A	0.587	1.00
129_H	132_L	0.586	1.00
57_A	61_I	0.585	1.00
233_L	236_R	0.578	1.00
54_G	58_R	0.578	1.00
87_A	91_T	0.578	1.00
37_F	99_V	0.577	1.00
46_M	58_R	0.575	1.00
80_L	116_D	0.573	1.00
47_A	77_L	0.572	1.00
23_T	103_N	0.572	1.00
60_D	66_P	0.571	1.00
62_V	66_P	0.571	1.00
98_H	144_S	0.570	1.00
127_L	130_V	0.566	1.00
62_V	70_L	0.564	1.00
251_W	262_I	0.561	1.00
126_H	189_F	0.561	1.00
15_Q	40_A	0.561	1.00
130_V	134_A	0.560	1.00
135_G	139_V	0.558	1.00
83_V	87_A	0.558	1.00
125_N	179_Y	0.555	1.00
258_T	263_D	0.553	1.00
38_A	69_S	0.552	1.00
77_L	104_A	0.552	1.00
84_A	134_A	0.552	1.00
90_F	93_E	0.550	1.00
121_Q	178_A	0.549	1.00
38_A	44_V	0.549	1.00
124_V	128_G	0.549	1.00
250_A	254_L	0.548	1.00
86_F	90_F	0.546	1.00
46_M	72_V	0.545	1.00
17_G	43_H	0.543	1.00
21_V	90_F	0.537	1.00
140_L	144_S	0.534	1.00
47_A	90_F	0.534	1.00
108_A	121_Q	0.531	1.00
62_V	68_A	0.527	1.00
187_L	210_H	0.525	1.00
153_S	210_H	0.524	1.00
47_A	73_H	0.523	1.00
144_S	147_T	0.521	1.00
20_V	257_A	0.520	1.00
209_C	249_G	0.519	1.00
193_L	197_L	0.518	1.00
219_Q	223_P	0.516	1.00
159_R	273_V	0.516	1.00
79_A	115_A	0.510	1.00
151_T	186_N	0.510	1.00
27_S	48_C	0.509	1.00
33_A	36_A	0.508	1.00
132_L	136_L	0.507	1.00
177_E	192_E	0.504	1.00
55_E	62_V	0.503	1.00
133_T	197_L	0.501	1.00
21_V	132_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w6uA	4	0.8861	100	0.307	Contact Map
1yxmA	4	0.9209	100	0.311	Contact Map
3rd5A	1	0.8418	100	0.315	Contact Map
4weoA	4	0.75	100	0.318	Contact Map
3rihA	4	0.807	100	0.32	Contact Map
1vl8A	4	0.7816	100	0.322	Contact Map
3kvoA	2	0.8386	100	0.323	Contact Map
3lf2A	4	0.7943	100	0.324	Contact Map
4is2A	3	0.6646	100	0.324	Contact Map
4trrA	4	0.788	100	0.324	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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