GREMLIN Database
Q9HRZ2 - Probable oxidoreductase
UniProt: Q9HRZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (242)
Sequences: 65980 (44744)
Seq/√Len: 2876.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_E127_L3.2021.00
119_E123_G2.5561.00
184_L188_L2.5561.00
148_R205_T2.5361.00
20_V99_V2.5171.00
79_A82_S2.5081.00
84_A135_G2.4981.00
91_T139_V2.4231.00
141_R202_A2.3691.00
99_V257_A2.2861.00
151_T190_A2.2821.00
133_T193_L2.2231.00
47_A75_L2.1741.00
123_G127_L2.1401.00
80_L115_A2.1341.00
31_F57_A2.0811.00
43_H69_S2.0691.00
210_H266_E2.0671.00
137_L197_L2.0451.00
31_F60_D2.0191.00
265_G268_I2.0191.00
54_G72_V2.0151.00
36_A251_W2.0111.00
31_F35_R1.9831.00
51_T55_E1.9811.00
71_T93_E1.9481.00
87_A136_L1.9091.00
102_N151_T1.9041.00
26_N48_C1.8761.00
153_S187_L1.8611.00
47_A86_F1.8231.00
45_V90_F1.8221.00
215_A245_S1.8161.00
251_W260_P1.8091.00
19_R43_H1.8001.00
252_P267_Y1.7831.00
58_R62_V1.7431.00
190_A208_A1.7131.00
33_A253_L1.6761.00
89_W93_E1.6531.00
73_H89_W1.6511.00
36_A254_L1.6471.00
51_T74_E1.6441.00
75_L82_S1.6291.00
36_A40_A1.5951.00
50_S53_R1.5841.00
45_V94_F1.5831.00
35_R60_D1.5761.00
58_R72_V1.5491.00
37_F257_A1.5291.00
85_A89_W1.5211.00
115_A131_A1.5201.00
14_D260_P1.5021.00
36_A39_R1.4811.00
125_N182_S1.4621.00
100_L132_L1.4471.00
25_A46_M1.4401.00
19_R96_S1.4151.00
88_D92_A1.4121.00
101_A152_Q1.4031.00
244_Q263_D1.4031.00
126_H185_A1.4021.00
100_L136_L1.3991.00
129_H186_N1.3981.00
75_L86_F1.3851.00
14_D40_A1.3821.00
40_A254_L1.3791.00
158_R268_I1.3671.00
83_V132_L1.3531.00
20_V37_F1.3521.00
59_D63_A1.3451.00
122_F126_H1.3321.00
127_L131_A1.3291.00
108_A120_T1.3211.00
215_A220_L1.3171.00
48_C54_G1.3091.00
82_S85_A1.3071.00
43_H68_A1.3021.00
114_T117_G1.2971.00
89_W92_A1.2811.00
80_L131_A1.2581.00
27_S53_R1.2491.00
55_E59_D1.2491.00
118_F127_L1.2481.00
19_R45_V1.2351.00
80_L84_A1.2301.00
252_P269_G1.2201.00
32_E35_R1.2171.00
71_T94_F1.1961.00
84_A88_D1.1941.00
59_D62_V1.1891.00
153_S208_A1.1891.00
110_P117_G1.1781.00
97_L136_L1.1721.00
55_E58_R1.1661.00
29_L214_A1.1621.00
36_A250_A1.1601.00
45_V71_T1.1601.00
43_H71_T1.1591.00
27_S217_N1.1541.00
102_N133_T1.1531.00
34_T46_M1.1471.00
115_A127_L1.1451.00
193_L206_S1.1441.00
15_Q42_A1.1421.00
187_L266_E1.1381.00
37_F42_A1.1311.00
56_D60_D1.1241.00
42_A99_V1.1231.00
58_R70_L1.1181.00
20_V42_A1.1181.00
209_C253_L1.1171.00
106_V124_V1.1141.00
73_H93_E1.1131.00
33_A101_A1.1091.00
73_H86_F1.1061.00
39_R66_P1.1031.00
78_A120_T1.0961.00
113_E178_A1.0921.00
133_T149_V1.0881.00
190_A206_S1.0631.00
17_G42_A1.0621.00
38_A68_A1.0531.00
139_V142_R1.0441.00
103_N152_Q1.0421.00
214_A244_Q1.0401.00
32_E247_E1.0261.00
90_F94_F1.0251.00
51_T72_V1.0241.00
45_V73_H1.0121.00
111_R141_R1.0121.00
19_R94_F1.0071.00
101_A253_L1.0061.00
106_V120_T1.0051.00
18_R259_N0.9991.00
148_R207_V0.9891.00
122_F127_L0.9861.00
81_D85_A0.9851.00
21_V86_F0.9851.00
56_D59_D0.9841.00
80_L134_A0.9751.00
18_R98_H0.9721.00
152_Q253_L0.9701.00
108_A117_G0.9701.00
62_V69_S0.9691.00
242_V248_Q0.9671.00
148_R262_I0.9621.00
35_R39_R0.9611.00
157_H187_L0.9561.00
194_D264_G0.9411.00
96_S144_S0.9401.00
36_A247_E0.9391.00
129_H151_T0.9341.00
57_A60_D0.9321.00
116_D120_T0.9321.00
46_M70_L0.9291.00
259_N262_I0.9261.00
208_A266_E0.9241.00
29_L33_A0.9231.00
32_E246_A0.9181.00
27_S50_S0.9071.00
85_A88_D0.9051.00
179_Y183_K0.8991.00
133_T189_F0.8991.00
139_V144_S0.8961.00
150_V257_A0.8941.00
38_A61_I0.8921.00
21_V97_L0.8821.00
126_H186_N0.8801.00
43_H94_F0.8781.00
61_I68_A0.8751.00
78_A123_G0.8741.00
77_L128_G0.8731.00
232_L236_R0.8711.00
21_V47_A0.8701.00
35_R66_P0.8691.00
53_R56_D0.8641.00
192_E196_R0.8591.00
25_A47_A0.8581.00
71_T89_W0.8561.00
74_E82_S0.8501.00
33_A250_A0.8491.00
115_A119_E0.8471.00
247_E251_W0.8441.00
135_G138_G0.8421.00
149_V206_S0.8321.00
52_E55_E0.8311.00
81_D84_A0.8311.00
217_N220_L0.8251.00
32_E250_A0.8191.00
130_V189_F0.8191.00
255_Y261_S0.8181.00
151_T206_S0.8171.00
180_S188_L0.8161.00
75_L83_V0.8131.00
258_T261_S0.8071.00
87_A135_G0.7991.00
133_T151_T0.7971.00
61_I70_L0.7971.00
111_R197_L0.7961.00
80_L135_G0.7921.00
91_T142_R0.7891.00
158_R210_H0.7891.00
31_F56_D0.7871.00
252_P255_Y0.7781.00
88_D135_G0.7721.00
86_F132_L0.7671.00
60_D63_A0.7561.00
214_A249_G0.7561.00
158_R187_L0.7541.00
187_L191_Y0.7491.00
231_R235_M0.7481.00
106_V218_L0.7441.00
48_C72_V0.7391.00
137_L141_R0.7381.00
177_E196_R0.7381.00
197_L202_A0.7371.00
37_F254_L0.7321.00
22_V34_T0.7281.00
117_G120_T0.7251.00
177_E189_F0.7211.00
35_R61_I0.7141.00
122_F181_Q0.7131.00
156_A180_S0.7131.00
118_F130_V0.7101.00
32_E36_A0.7061.00
105_G125_N0.7041.00
83_V131_A0.7021.00
62_V67_G0.7021.00
102_N132_L0.7011.00
115_A134_A0.6991.00
30_G103_N0.6991.00
154_S179_Y0.6961.00
224_Q227_G0.6911.00
248_Q262_I0.6901.00
40_A260_P0.6901.00
37_F253_L0.6891.00
232_L235_M0.6891.00
19_R90_F0.6891.00
141_R197_L0.6871.00
52_E56_D0.6831.00
198_R240_A0.6811.00
137_L202_A0.6811.00
102_N129_H0.6801.00
136_L140_L0.6801.00
100_L149_V0.6791.00
160_G188_L0.6751.00
23_T132_L0.6731.00
88_D139_V0.6681.00
125_N183_K0.6671.00
96_S139_V0.6661.00
38_A70_L0.6651.00
242_V262_I0.6651.00
187_L208_A0.6631.00
131_A135_G0.6621.00
184_L191_Y0.6611.00
223_P226_A0.6611.00
88_D91_T0.6581.00
87_A132_L0.6541.00
27_S31_F0.6531.00
18_R146_E0.6531.00
69_S93_E0.6531.00
126_H181_Q0.6481.00
122_F182_S0.6471.00
106_V182_S0.6461.00
55_E72_V0.6441.00
97_L139_V0.6381.00
180_S192_E0.6341.00
238_A263_D0.6331.00
180_S184_L0.6331.00
36_A260_P0.6311.00
207_V256_A0.6311.00
25_A34_T0.6301.00
83_V135_G0.6291.00
129_H133_T0.6291.00
158_R266_E0.6291.00
63_A66_P0.6281.00
140_L146_E0.6271.00
48_C74_E0.6251.00
90_F97_L0.6241.00
121_Q182_S0.6241.00
213_Y219_Q0.6181.00
26_N54_G0.6131.00
15_Q99_V0.6121.00
146_E205_T0.6121.00
194_D198_R0.6101.00
220_L224_Q0.6091.00
28_G216_T0.6071.00
140_L147_T0.6071.00
46_M57_A0.6061.00
84_A138_G0.6051.00
49_R76_D0.6041.00
197_L206_S0.6011.00
54_G74_E0.5991.00
78_A124_V0.5991.00
48_C53_R0.5991.00
118_F126_H0.5981.00
175_K196_R0.5961.00
120_T123_G0.5961.00
104_A128_G0.5951.00
245_S248_Q0.5931.00
150_V253_L0.5921.00
268_I274_L0.5881.00
91_T96_S0.5881.00
235_M243_G0.5871.00
81_D115_A0.5871.00
129_H132_L0.5861.00
57_A61_I0.5851.00
233_L236_R0.5781.00
54_G58_R0.5781.00
87_A91_T0.5781.00
37_F99_V0.5771.00
46_M58_R0.5751.00
80_L116_D0.5731.00
47_A77_L0.5721.00
23_T103_N0.5721.00
60_D66_P0.5711.00
62_V66_P0.5711.00
98_H144_S0.5701.00
127_L130_V0.5661.00
62_V70_L0.5641.00
251_W262_I0.5611.00
126_H189_F0.5611.00
15_Q40_A0.5611.00
130_V134_A0.5601.00
135_G139_V0.5581.00
83_V87_A0.5581.00
125_N179_Y0.5551.00
258_T263_D0.5531.00
38_A69_S0.5521.00
77_L104_A0.5521.00
84_A134_A0.5521.00
90_F93_E0.5501.00
121_Q178_A0.5491.00
38_A44_V0.5491.00
124_V128_G0.5491.00
250_A254_L0.5481.00
86_F90_F0.5461.00
46_M72_V0.5451.00
17_G43_H0.5431.00
21_V90_F0.5371.00
140_L144_S0.5341.00
47_A90_F0.5341.00
108_A121_Q0.5311.00
62_V68_A0.5271.00
187_L210_H0.5251.00
153_S210_H0.5241.00
47_A73_H0.5231.00
144_S147_T0.5211.00
20_V257_A0.5201.00
209_C249_G0.5191.00
193_L197_L0.5181.00
219_Q223_P0.5161.00
159_R273_V0.5161.00
79_A115_A0.5101.00
151_T186_N0.5101.00
27_S48_C0.5091.00
33_A36_A0.5081.00
132_L136_L0.5071.00
177_E192_E0.5041.00
55_E62_V0.5031.00
133_T197_L0.5011.00
21_V132_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w6uA 4 0.8861 100 0.307 Contact Map
1yxmA 4 0.9209 100 0.311 Contact Map
3rd5A 1 0.8418 100 0.315 Contact Map
4weoA 4 0.75 100 0.318 Contact Map
3rihA 4 0.807 100 0.32 Contact Map
1vl8A 4 0.7816 100 0.322 Contact Map
3kvoA 2 0.8386 100 0.323 Contact Map
3lf2A 4 0.7943 100 0.324 Contact Map
4is2A 3 0.6646 100 0.324 Contact Map
4trrA 4 0.788 100 0.324 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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