Q9HRZ1 - HALSA - GREMLIN Contacts

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Q9HRZ1 - Methylmalonyl-CoA mutase, subunit alpha

UniProt:	Q9HRZ1	Sequences: MLVGRPPTRRFAADPPGRDRDGYREDVYDAVAEQVARYNSDAPVVLGLDWGHTNPVAPLPLGREVTVDPGAQRVVVREERTRIKTASAVRRGMYDEDDLAAIRDGREDWEEETLGPTLDRFGERKESFETDTGGQSVDRLYTPDDVADRDYDADIGFPGEEPYTRGVYPTMYRGRLWTMRQYAGMGTAAETNERFNYLLDEGQTGLSMAFDLPTQMGYDSDATMAQGEVGKSGVAIDTLADMETVFDGIPLDEVSTSMTINAPASVLLAMYIAVGDQQGVDREELRGTIQNDILKEYIARNTYIFPPEPSMRVITDIFEFCAAETPKFNTISISGYHIREAGATAAQEIAFTLGDGIEYVQTALDAGLDVDEFAPQLSFFFNAHNNILEEVAKFRAARRMWATIMEERFDAQNPKSKQLKFHTQTAGSTLTAQQIDNNIVRVAYQALAAVLGGTQSLHTNGKDEALSIPTEESVRTALRTQQILAHESGAADTIDPLAGSYYVEGLTDDIEAEAQAILDEVDSRGGMRRAVEDQWVQRQIQDVAFDRQQEIEEKERVIVGVNEFEVDDEEPEADIEEVTADDERRQIEHLNDVKGDRDSEAVEAALADLRAAAAGDENVMPYIVAAVKAYASVGEICNTLRDVFGEHQPGAAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	653 (541)
Sequences:	2274 (879)
Seq/√Len:	37.8

ECOLI - SCPA
HALSA - Q9HRZ1 Q9HRK7
SULSO - Q97W21

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
360_V	405_M	4.679	1.00
369_D	372_E	3.969	1.00
238_T	593_V	3.888	1.00
513_E	516_A	3.799	1.00
610_R	642_D	3.676	1.00
276_D	628_K	3.630	1.00
364_L	370_V	3.449	1.00
220_S	235_A	3.280	1.00
220_S	237_D	3.269	1.00
243_E	277_Q	3.216	1.00
550_E	556_R	3.209	1.00
403_T	515_Q	3.046	1.00
333_I	377_L	3.046	1.00
486_H	564_F	3.007	1.00
344_T	543_V	2.967	1.00
191_T	195_F	2.950	1.00
436_D	462_K	2.933	1.00
138_D	145_D	2.882	1.00
255_S	286_R	2.875	1.00
361_Q	522_D	2.833	1.00
388_L	502_Y	2.800	1.00
281_D	284_E	2.792	1.00
598_D	601_A	2.754	1.00
592_D	596_D	2.732	1.00
399_R	508_D	2.672	1.00
439_I	476_T	2.661	1.00
613_A	640_L	2.585	1.00
599_S	603_E	2.579	1.00
387_I	391_V	2.554	1.00
399_R	511_E	2.549	1.00
509_D	513_E	2.546	1.00
388_L	503_V	2.537	1.00
252_D	284_E	2.528	1.00
273_A	628_K	2.462	1.00
371_D	416_S	2.461	1.00
189_A	585_R	2.421	1.00
270_M	627_V	2.405	1.00
369_D	412_Q	2.404	1.00
412_Q	416_S	2.343	1.00
527_M	536_V	2.321	1.00
381_F	397_A	2.315	1.00
505_G	509_D	2.303	1.00
319_E	366_A	2.274	0.99
542_D	546_D	2.267	0.99
546_D	550_E	2.250	0.99
406_E	417_K	2.245	0.99
361_Q	365_D	2.244	0.99
222_A	638_N	2.236	0.99
361_Q	409_F	2.225	0.99
588_E	592_D	2.217	0.99
164_T	399_R	2.214	0.99
515_Q	519_D	2.196	0.99
444_Y	484_L	2.194	0.99
584_R	588_E	2.181	0.99
374_A	416_S	2.179	0.99
508_D	512_A	2.115	0.99
520_E	539_Q	2.113	0.99
439_I	462_K	2.075	0.99
547_R	556_R	2.058	0.99
640_L	644_F	2.057	0.99
436_D	472_E	2.042	0.99
437_N	483_I	2.040	0.99
371_D	412_Q	2.034	0.99
386_N	492_D	2.030	0.99
321_C	330_T	1.998	0.99
612_A	622_Y	1.998	0.99
423_T	454_T	1.982	0.99
277_Q	630_Y	1.974	0.99
305_F	637_C	1.972	0.99
349_I	510_I	1.949	0.98
347_Q	539_Q	1.934	0.98
252_D	280_V	1.930	0.98
446_A	484_L	1.920	0.98
243_E	630_Y	1.911	0.98
600_E	604_A	1.902	0.98
405_M	411_A	1.900	0.98
603_E	607_A	1.894	0.98
319_E	323_A	1.878	0.98
587_I	591_N	1.877	0.98
154_D	508_D	1.862	0.98
161_E	402_A	1.857	0.98
611_A	614_A	1.856	0.98
627_V	636_I	1.854	0.98
621_P	625_A	1.854	0.98
566_V	569_E	1.844	0.98
602_V	631_A	1.830	0.98
351_F	535_W	1.829	0.98
239_L	630_Y	1.823	0.97
107_E	111_E	1.804	0.97
282_R	324_E	1.804	0.97
133_G	389_E	1.801	0.97
110_E	115_G	1.787	0.97
349_I	514_A	1.769	0.97
355_D	527_M	1.759	0.97
240_A	243_E	1.738	0.97
357_I	404_I	1.721	0.96
353_L	356_G	1.721	0.96
196_N	248_G	1.718	0.96
529_R	532_E	1.708	0.96
444_Y	448_A	1.700	0.96
608_D	625_A	1.693	0.96
308_E	532_E	1.672	0.96
381_F	394_F	1.668	0.96
161_E	407_E	1.660	0.96
440_V	443_A	1.648	0.95
385_N	445_Q	1.637	0.95
605_A	629_A	1.614	0.95
557_V	563_E	1.613	0.95
137_V	502_Y	1.598	0.95
357_I	409_F	1.589	0.94
514_A	518_L	1.580	0.94
197_Y	471_E	1.572	0.94
138_D	141_Y	1.568	0.94
554_K	563_E	1.565	0.94
271_Y	275_G	1.561	0.94
519_D	523_S	1.560	0.94
612_A	615_G	1.558	0.94
374_A	405_M	1.555	0.94
442_V	445_Q	1.539	0.93
358_E	362_T	1.539	0.93
443_A	488_S	1.531	0.93
335_G	352_T	1.528	0.93
370_V	411_A	1.509	0.93
470_T	473_S	1.509	0.93
348_E	393_K	1.509	0.93
400_M	514_A	1.501	0.92
120_R	123_E	1.500	0.92
641_R	646_E	1.496	0.92
276_D	282_R	1.467	0.92
461_G	474_V	1.461	0.91
429_T	445_Q	1.455	0.91
357_I	518_L	1.448	0.91
402_A	406_E	1.447	0.91
318_F	363_A	1.440	0.91
529_R	533_D	1.437	0.91
594_K	602_V	1.432	0.91
106_R	144_D	1.431	0.91
475_R	566_V	1.429	0.91
601_A	625_A	1.424	0.90
238_T	632_S	1.420	0.90
638_N	642_D	1.415	0.90
270_M	633_V	1.415	0.90
282_R	320_F	1.412	0.90
240_A	596_D	1.409	0.90
371_D	413_N	1.397	0.89
179_M	478_L	1.397	0.89
240_A	630_Y	1.380	0.89
637_C	641_R	1.372	0.89
609_L	622_Y	1.360	0.88
607_A	611_A	1.345	0.88
517_I	535_W	1.343	0.88
128_F	136_S	1.320	0.87
400_M	515_Q	1.319	0.87
272_I	282_R	1.317	0.86
451_L	497_L	1.315	0.86
385_N	429_T	1.299	0.86
239_L	243_E	1.299	0.86
346_A	513_E	1.298	0.86
609_L	626_A	1.285	0.85
312_R	644_F	1.283	0.85
265_S	623_I	1.281	0.85
446_A	457_L	1.277	0.85
612_A	617_E	1.275	0.85
493_T	498_A	1.275	0.85
265_S	640_L	1.274	0.85
179_M	482_Q	1.273	0.85
387_I	447_L	1.270	0.84
318_F	366_A	1.266	0.84
135_Q	513_E	1.257	0.84
250_P	253_E	1.254	0.84
107_E	110_E	1.253	0.84
601_A	605_A	1.251	0.83
383_A	390_E	1.250	0.83
535_W	539_Q	1.250	0.83
143_P	151_Y	1.249	0.83
141_Y	505_G	1.249	0.83
344_T	347_Q	1.244	0.83
605_A	608_D	1.233	0.83
497_L	503_V	1.231	0.82
146_V	149_R	1.231	0.82
182_Y	300_R	1.225	0.82
362_T	365_D	1.224	0.82
121_F	126_E	1.218	0.82
346_A	510_I	1.211	0.81
381_F	423_T	1.207	0.81
289_I	330_T	1.207	0.81
623_I	627_V	1.204	0.81
422_H	456_S	1.202	0.81
215_Q	300_R	1.201	0.81
591_N	594_K	1.194	0.80
178_T	205_G	1.192	0.80
195_F	206_L	1.190	0.80
315_T	362_T	1.187	0.80
386_N	556_R	1.185	0.80
347_Q	517_I	1.180	0.80
196_N	200_D	1.175	0.79
475_R	479_R	1.173	0.79
150_D	154_D	1.171	0.79
638_N	641_R	1.171	0.79
272_I	624_V	1.170	0.79
450_V	490_A	1.170	0.79
142_T	145_D	1.168	0.79
626_A	631_A	1.165	0.79
516_A	519_D	1.163	0.79
323_A	372_E	1.160	0.79
524_R	535_W	1.158	0.78
608_D	612_A	1.152	0.78
132_T	550_E	1.146	0.78
140_L	494_I	1.140	0.77
550_E	555_E	1.137	0.77
623_I	636_I	1.133	0.77
411_A	416_S	1.131	0.77
591_N	595_G	1.130	0.77
106_R	110_E	1.127	0.76
189_A	244_T	1.126	0.76
105_G	108_D	1.125	0.76
120_R	124_R	1.116	0.76
141_Y	502_Y	1.115	0.76
182_Y	215_Q	1.109	0.75
414_P	417_K	1.108	0.75
584_R	591_N	1.102	0.75
450_V	457_L	1.096	0.74
594_K	632_S	1.094	0.74
593_V	630_Y	1.094	0.74
517_I	521_V	1.093	0.74
610_R	614_A	1.089	0.74
180_R	205_G	1.088	0.74
352_T	381_F	1.088	0.74
131_D	137_V	1.087	0.74
195_F	208_M	1.086	0.74
208_M	246_F	1.083	0.74
358_E	361_Q	1.075	0.73
266_V	637_C	1.075	0.73
462_K	472_E	1.075	0.73
517_I	539_Q	1.074	0.73
609_L	640_L	1.073	0.73
399_R	402_A	1.063	0.72
270_M	636_I	1.061	0.72
131_D	135_Q	1.060	0.72
118_L	122_G	1.058	0.72
240_A	593_V	1.049	0.71
256_T	271_Y	1.039	0.70
156_G	164_T	1.037	0.70
530_A	536_V	1.037	0.70
318_F	331_I	1.034	0.70
208_M	245_V	1.031	0.70
371_D	374_A	1.031	0.70
157_F	160_E	1.024	0.69
581_D	585_R	1.022	0.69
164_T	511_E	1.018	0.69
447_L	490_A	1.017	0.69
303_Y	649_P	1.015	0.69
402_A	417_K	1.014	0.68
358_E	528_R	1.013	0.68
429_T	442_V	1.009	0.68
607_A	610_R	1.006	0.68
590_L	632_S	1.005	0.68
139_R	170_T	1.004	0.68
524_R	530_A	1.003	0.68
400_M	404_I	0.999	0.67
161_E	406_E	0.996	0.67
350_A	517_I	0.993	0.67
600_E	603_E	0.991	0.67
610_R	643_V	0.989	0.67
286_R	327_K	0.988	0.66
538_R	542_D	0.988	0.66
639_T	643_V	0.987	0.66
282_R	624_V	0.985	0.66
447_L	451_L	0.985	0.66
353_L	404_I	0.982	0.66
375_P	416_S	0.982	0.66
520_E	535_W	0.980	0.66
190_E	193_E	0.979	0.66
391_V	451_L	0.976	0.65
444_Y	488_S	0.976	0.65
339_R	426_A	0.973	0.65
424_Q	460_N	0.971	0.65
294_L	359_Y	0.971	0.65
387_I	484_L	0.969	0.65
269_A	620_M	0.966	0.65
601_A	604_A	0.964	0.64
212_L	215_Q	0.962	0.64
244_T	247_D	0.959	0.64
517_I	520_E	0.957	0.64
371_D	411_A	0.957	0.64
404_I	515_Q	0.956	0.64
428_S	551_I	0.954	0.64
381_F	421_F	0.951	0.63
272_I	325_T	0.951	0.63
343_A	540_I	0.951	0.63
601_A	629_A	0.950	0.63
451_L	490_A	0.949	0.63
232_S	301_N	0.949	0.63
215_Q	301_N	0.945	0.63
554_K	557_V	0.945	0.63
117_T	120_R	0.940	0.63
518_L	522_D	0.939	0.62
263_P	637_C	0.937	0.62
448_A	451_L	0.935	0.62
356_G	401_W	0.934	0.62
467_S	575_I	0.931	0.62
614_A	643_V	0.928	0.62
383_A	394_F	0.925	0.61
599_S	602_V	0.925	0.61
182_Y	209_A	0.925	0.61
346_A	350_A	0.921	0.61
129_E	137_V	0.913	0.60
135_Q	509_D	0.913	0.60
597_R	601_A	0.912	0.60
329_N	376_Q	0.904	0.59
516_A	558_I	0.903	0.59
301_N	649_P	0.902	0.59
527_M	649_P	0.901	0.59
608_D	622_Y	0.900	0.59
168_Y	494_I	0.900	0.59
490_A	594_K	0.899	0.59
407_E	410_D	0.898	0.59
585_R	588_E	0.895	0.59
140_L	157_F	0.893	0.59
338_I	355_D	0.892	0.58
308_E	529_R	0.891	0.58
215_Q	232_S	0.890	0.58
450_V	484_L	0.889	0.58
467_S	470_T	0.887	0.58
388_L	500_S	0.884	0.58
318_F	330_T	0.881	0.57
370_V	409_F	0.877	0.57
610_R	639_T	0.871	0.57
383_A	423_T	0.869	0.56
537_Q	541_Q	0.867	0.56
512_A	516_A	0.865	0.56
434_Q	479_R	0.864	0.56
442_V	460_N	0.864	0.56
371_D	375_P	0.863	0.56
275_G	285_L	0.862	0.56
520_E	524_R	0.861	0.56
127_S	139_R	0.858	0.55
163_Y	412_Q	0.857	0.55
244_T	589_H	0.855	0.55
505_G	508_D	0.854	0.55
388_L	497_L	0.850	0.55
436_D	476_T	0.849	0.55
422_H	458_H	0.849	0.55
320_F	325_T	0.848	0.55
212_L	300_R	0.847	0.54
509_D	512_A	0.845	0.54
274_V	278_Q	0.845	0.54
135_Q	388_L	0.845	0.54
343_A	382_N	0.839	0.54
587_I	594_K	0.838	0.54
565_E	569_E	0.838	0.54
239_L	593_V	0.837	0.54
144_D	147_A	0.835	0.53
411_A	417_K	0.834	0.53
382_N	428_S	0.834	0.53
604_A	608_D	0.831	0.53
137_V	493_T	0.830	0.53
583_E	587_I	0.827	0.53
360_V	370_V	0.827	0.53
443_A	453_G	0.826	0.53
161_E	403_T	0.826	0.53
530_A	535_W	0.826	0.53
232_S	302_T	0.825	0.53
384_H	426_A	0.824	0.52
272_I	320_F	0.823	0.52
156_G	399_R	0.822	0.52
189_A	193_E	0.822	0.52
479_R	482_Q	0.821	0.52
180_R	257_S	0.817	0.52
192_N	248_G	0.817	0.52
403_T	511_E	0.815	0.52
448_A	498_A	0.814	0.52
165_R	498_A	0.814	0.52
475_R	569_E	0.813	0.51
263_P	266_V	0.810	0.51
595_G	614_A	0.807	0.51
246_F	249_I	0.807	0.51
388_L	506_L	0.806	0.51
238_T	594_K	0.805	0.51
157_F	494_I	0.805	0.51
493_T	502_Y	0.801	0.50
294_L	528_R	0.801	0.50
141_Y	145_D	0.800	0.50
565_E	568_D	0.798	0.50
130_T	136_S	0.797	0.50
132_T	556_R	0.796	0.50
212_L	303_Y	0.795	0.50
333_I	360_V	0.793	0.50
601_A	611_A	0.788	0.49
196_N	247_D	0.788	0.49
454_T	457_L	0.787	0.49
193_E	197_Y	0.787	0.49
330_T	333_I	0.786	0.49
314_I	318_F	0.785	0.49
314_I	317_I	0.785	0.49
151_Y	155_I	0.784	0.49
318_F	376_Q	0.783	0.49
293_I	305_F	0.780	0.49
222_A	634_G	0.780	0.49
551_I	558_I	0.778	0.48
539_Q	542_D	0.777	0.48
288_T	378_S	0.774	0.48
436_D	440_V	0.773	0.48
335_G	381_F	0.773	0.48
316_D	319_E	0.772	0.48
484_L	569_E	0.771	0.48
182_Y	302_T	0.771	0.48
182_Y	212_L	0.771	0.48
391_V	503_V	0.771	0.48
338_I	540_I	0.770	0.48
283_E	324_E	0.770	0.48
497_L	502_Y	0.769	0.48
163_Y	570_E	0.769	0.48
323_A	614_A	0.768	0.47
345_A	384_H	0.768	0.47
357_I	410_D	0.768	0.47
314_I	331_I	0.767	0.47
590_L	594_K	0.767	0.47
146_V	501_Y	0.767	0.47
215_Q	302_T	0.767	0.47
197_Y	200_D	0.764	0.47
239_L	277_Q	0.764	0.47
357_I	411_A	0.763	0.47
133_G	345_A	0.756	0.46
380_F	424_Q	0.756	0.46
251_L	256_T	0.755	0.46
158_P	387_I	0.754	0.46
240_A	592_D	0.754	0.46
198_L	474_V	0.754	0.46
318_F	373_F	0.753	0.46
251_L	278_Q	0.749	0.46
252_D	281_D	0.747	0.46
333_I	373_F	0.745	0.45
339_R	345_A	0.745	0.45
334_S	352_T	0.745	0.45
510_I	514_A	0.744	0.45
141_Y	388_L	0.744	0.45
204_T	253_E	0.744	0.45
336_Y	340_E	0.740	0.45
533_D	536_V	0.737	0.45
590_L	593_V	0.736	0.45
189_A	589_H	0.736	0.45
295_K	337_H	0.736	0.45
298_I	301_N	0.735	0.45
347_Q	543_V	0.729	0.44
611_A	617_E	0.728	0.44
161_E	417_K	0.726	0.44
505_G	512_A	0.725	0.44
191_T	245_V	0.724	0.44
404_I	647_H	0.723	0.43
147_A	154_D	0.719	0.43
358_E	527_M	0.719	0.43
622_Y	626_A	0.716	0.43
625_A	629_A	0.714	0.43
370_V	405_M	0.713	0.43
357_I	361_Q	0.713	0.43
124_R	491_A	0.713	0.43
149_R	155_I	0.712	0.43
382_N	393_K	0.712	0.43
189_A	223_T	0.711	0.42
257_S	288_T	0.710	0.42
230_G	233_G	0.709	0.42
334_S	460_N	0.709	0.42
239_L	270_M	0.706	0.42
179_M	402_A	0.706	0.42
397_A	419_L	0.705	0.42
372_E	416_S	0.705	0.42
502_Y	506_L	0.704	0.42
340_E	427_G	0.703	0.42
434_Q	569_E	0.700	0.41
574_D	578_V	0.700	0.41
360_V	373_F	0.697	0.41
242_M	274_V	0.697	0.41
159_G	165_R	0.696	0.41
424_Q	458_H	0.696	0.41
520_E	523_S	0.695	0.41
186_G	191_T	0.693	0.41
269_A	624_V	0.691	0.41
538_R	558_I	0.690	0.41
625_A	628_K	0.690	0.41
163_Y	414_P	0.688	0.40
233_G	336_Y	0.687	0.40
461_G	640_L	0.686	0.40
192_N	196_N	0.682	0.40
295_K	300_R	0.681	0.40
434_Q	475_R	0.680	0.40
605_A	610_R	0.679	0.40
280_V	284_E	0.678	0.40
612_A	644_F	0.677	0.40
352_T	459_T	0.677	0.40
315_T	366_A	0.676	0.39
352_T	540_I	0.674	0.39
121_F	124_R	0.673	0.39
581_D	584_R	0.673	0.39
193_E	200_D	0.671	0.39
189_A	624_V	0.671	0.39
142_T	157_F	0.671	0.39
357_I	522_D	0.669	0.39
566_V	570_E	0.668	0.39
407_E	411_A	0.668	0.39
318_F	528_R	0.668	0.39
608_D	617_E	0.666	0.39
533_D	538_R	0.664	0.38
294_L	527_M	0.664	0.38
305_F	640_L	0.662	0.38
287_G	328_F	0.660	0.38
515_Q	518_L	0.658	0.38
364_L	409_F	0.658	0.38
313_V	317_I	0.657	0.38
169_P	358_E	0.656	0.38
620_M	623_I	0.656	0.38
312_R	316_D	0.655	0.38
135_Q	389_E	0.654	0.38
271_Y	281_D	0.652	0.37
119_D	122_G	0.650	0.37
593_V	607_A	0.649	0.37
198_L	478_L	0.649	0.37
462_K	492_D	0.649	0.37
117_T	121_F	0.649	0.37
489_G	492_D	0.649	0.37
634_G	638_N	0.648	0.37
214_T	267_L	0.645	0.37
113_T	139_R	0.645	0.37
236_I	242_M	0.644	0.37
413_N	639_T	0.642	0.37
628_K	631_A	0.642	0.37
444_Y	447_L	0.640	0.36
351_F	533_D	0.640	0.36
259_T	337_H	0.639	0.36
151_Y	157_F	0.639	0.36
329_N	420_K	0.638	0.36
450_V	559_V	0.638	0.36
406_E	410_D	0.637	0.36
133_G	434_Q	0.637	0.36
363_A	366_A	0.637	0.36
272_I	558_I	0.636	0.36
210_F	424_Q	0.636	0.36
332_S	380_F	0.635	0.36
412_Q	648_Q	0.635	0.36
593_V	596_D	0.634	0.36
585_R	638_N	0.633	0.36
351_F	498_A	0.632	0.36
516_A	520_E	0.632	0.36
351_F	517_I	0.632	0.36
591_N	642_D	0.631	0.36
266_V	636_I	0.631	0.36
108_D	112_E	0.629	0.35
336_Y	427_G	0.629	0.35
158_P	164_T	0.627	0.35
132_T	386_N	0.626	0.35
425_T	457_L	0.624	0.35
435_I	490_A	0.623	0.35
435_I	466_L	0.623	0.35
138_D	505_G	0.622	0.35
187_T	190_E	0.621	0.35
511_E	515_Q	0.620	0.35
128_F	555_E	0.619	0.35
444_Y	490_A	0.618	0.35
268_L	289_I	0.618	0.35
177_W	393_K	0.617	0.35
176_L	179_M	0.616	0.34
610_R	647_H	0.616	0.34
477_A	540_I	0.615	0.34
427_G	464_E	0.615	0.34
353_L	400_M	0.614	0.34
394_F	423_T	0.614	0.34
193_E	471_E	0.614	0.34
399_R	403_T	0.612	0.34
346_A	443_A	0.612	0.34
447_L	555_E	0.612	0.34
348_E	390_E	0.612	0.34
142_T	648_Q	0.612	0.34
453_G	496_P	0.612	0.34
364_L	369_D	0.611	0.34
209_A	337_H	0.611	0.34
460_N	464_E	0.611	0.34
115_G	119_D	0.611	0.34
240_A	647_H	0.611	0.34
289_I	318_F	0.611	0.34
388_L	536_V	0.610	0.34
118_L	123_E	0.610	0.34
223_T	592_D	0.610	0.34
412_Q	567_D	0.610	0.34
104_D	108_D	0.607	0.34
383_A	421_F	0.606	0.34
547_R	551_I	0.606	0.34
199_L	250_P	0.605	0.34
109_W	139_R	0.605	0.34
218_Y	224_M	0.605	0.34
512_A	642_D	0.605	0.34
353_L	518_L	0.604	0.33
605_A	626_A	0.604	0.33
370_V	416_S	0.602	0.33
443_A	556_R	0.602	0.33
334_S	380_F	0.602	0.33
293_I	304_I	0.601	0.33
183_A	191_T	0.600	0.33
118_L	124_R	0.599	0.33
356_G	456_S	0.598	0.33
346_A	453_G	0.597	0.33
504_E	507_T	0.596	0.33
549_Q	553_E	0.596	0.33
259_T	295_K	0.595	0.33
413_N	416_S	0.594	0.33
557_V	562_N	0.593	0.33
269_A	273_A	0.593	0.33
368_L	644_F	0.593	0.33
283_E	327_K	0.592	0.33
198_L	203_Q	0.591	0.32
138_D	147_A	0.590	0.32
595_G	607_A	0.588	0.32
188_A	310_S	0.586	0.32
139_R	569_E	0.586	0.32
303_Y	307_P	0.586	0.32
450_V	485_A	0.586	0.32
212_L	302_T	0.585	0.32
269_A	320_F	0.584	0.32
613_A	619_V	0.584	0.32
180_R	287_G	0.583	0.32
209_A	259_T	0.582	0.32
307_P	310_S	0.582	0.32
412_Q	642_D	0.581	0.32
204_T	254_V	0.580	0.32
216_M	646_E	0.580	0.32
434_Q	476_T	0.580	0.32
203_Q	206_L	0.580	0.32
265_S	498_A	0.580	0.32
298_I	355_D	0.580	0.32
263_P	305_F	0.579	0.32
345_A	389_E	0.579	0.32
365_D	553_E	0.579	0.32
202_G	495_D	0.578	0.31
403_T	406_E	0.577	0.31
620_M	624_V	0.577	0.31
104_D	107_E	0.577	0.31
167_V	418_Q	0.577	0.31
146_V	614_A	0.576	0.31
243_E	270_M	0.576	0.31
206_L	210_F	0.575	0.31
240_A	277_Q	0.575	0.31
598_D	624_V	0.575	0.31
443_A	483_I	0.574	0.31
386_N	547_R	0.574	0.31
509_D	516_A	0.573	0.31
404_I	417_K	0.572	0.31
385_N	483_I	0.571	0.31
234_V	245_V	0.570	0.31
116_P	120_R	0.570	0.31
345_A	510_I	0.569	0.31
222_A	226_Q	0.568	0.31
484_L	488_S	0.568	0.31
389_E	434_Q	0.568	0.31
119_D	127_S	0.568	0.31
276_D	280_V	0.567	0.31
451_L	503_V	0.565	0.30
323_A	601_A	0.565	0.30
301_N	537_Q	0.564	0.30
134_G	149_R	0.564	0.30
544_A	548_Q	0.564	0.30
183_A	195_F	0.563	0.30
180_R	340_E	0.563	0.30
297_Y	368_L	0.562	0.30
206_L	259_T	0.561	0.30
462_K	573_A	0.560	0.30
622_Y	625_A	0.560	0.30
400_M	518_L	0.560	0.30
569_E	648_Q	0.560	0.30
570_E	588_E	0.559	0.30
319_E	322_A	0.559	0.30
346_A	349_I	0.556	0.30
584_R	592_D	0.556	0.30
235_A	241_D	0.556	0.30
605_A	615_G	0.555	0.30
189_A	247_D	0.555	0.30
192_N	393_K	0.555	0.30
364_L	411_A	0.555	0.30
466_L	573_A	0.555	0.30
548_Q	589_H	0.555	0.30
476_T	644_F	0.554	0.30
260_I	264_A	0.554	0.30
567_D	601_A	0.554	0.30
619_V	640_L	0.553	0.30
199_L	252_D	0.553	0.30
617_E	621_P	0.553	0.30
593_V	599_S	0.551	0.29
195_F	246_F	0.551	0.29
513_E	556_R	0.551	0.29
347_Q	428_S	0.550	0.29
401_W	514_A	0.549	0.29
486_H	556_R	0.549	0.29
518_L	633_V	0.548	0.29
588_E	638_N	0.548	0.29
301_N	429_T	0.547	0.29
208_M	236_I	0.546	0.29
111_E	115_G	0.546	0.29
296_E	300_R	0.545	0.29
182_Y	232_S	0.544	0.29
216_M	232_S	0.544	0.29
207_S	481_Q	0.543	0.29
207_S	424_Q	0.543	0.29
573_A	577_E	0.541	0.29
428_S	586_Q	0.541	0.29
167_V	498_A	0.539	0.29
334_S	459_T	0.539	0.29
360_V	364_L	0.539	0.29
261_N	295_K	0.539	0.29
120_R	127_S	0.539	0.29
543_V	547_R	0.538	0.28
238_T	241_D	0.538	0.28
203_Q	446_A	0.537	0.28
194_R	198_L	0.537	0.28
350_A	539_Q	0.537	0.28
369_D	503_V	0.537	0.28
193_E	631_A	0.537	0.28
237_D	586_Q	0.536	0.28
276_D	281_D	0.536	0.28
447_L	556_R	0.536	0.28
595_G	604_A	0.536	0.28
203_Q	498_A	0.534	0.28
410_D	414_P	0.534	0.28
301_N	536_V	0.534	0.28
459_T	481_Q	0.533	0.28
282_R	325_T	0.533	0.28
509_D	617_E	0.532	0.28
588_E	595_G	0.532	0.28
250_P	280_V	0.532	0.28
115_G	120_R	0.532	0.28
533_D	570_E	0.532	0.28
386_N	542_D	0.531	0.28
374_A	419_L	0.531	0.28
212_L	304_I	0.531	0.28
434_Q	566_V	0.530	0.28
169_P	199_L	0.530	0.28
339_R	384_H	0.529	0.28
476_T	649_P	0.528	0.28
448_A	483_I	0.528	0.28
305_F	510_I	0.528	0.28
189_A	243_E	0.527	0.28
451_L	502_Y	0.527	0.28
141_Y	493_T	0.527	0.28
106_R	138_D	0.526	0.28
218_Y	317_I	0.526	0.28
188_A	235_A	0.526	0.28
357_I	527_M	0.526	0.28
483_I	557_V	0.526	0.28
193_E	558_I	0.526	0.28
182_Y	301_N	0.525	0.28
133_G	479_R	0.525	0.28
385_N	488_S	0.525	0.28
469_P	483_I	0.525	0.28
245_V	334_S	0.524	0.27
472_E	484_L	0.524	0.27
415_K	418_Q	0.524	0.27
186_G	298_I	0.523	0.27
137_V	147_A	0.523	0.27
512_A	523_S	0.522	0.27
194_R	197_Y	0.521	0.27
168_Y	553_E	0.520	0.27
159_G	166_G	0.519	0.27
461_G	535_W	0.518	0.27
360_V	401_W	0.518	0.27
130_T	512_A	0.518	0.27
239_L	274_V	0.518	0.27
181_Q	203_Q	0.517	0.27
351_F	527_M	0.517	0.27
126_E	512_A	0.517	0.27
516_A	523_S	0.517	0.27
112_E	168_Y	0.516	0.27
333_I	376_Q	0.516	0.27
204_T	503_V	0.516	0.27
105_G	152_D	0.516	0.27
587_I	593_V	0.515	0.27
357_I	400_M	0.514	0.27
345_A	447_L	0.514	0.27
421_F	454_T	0.513	0.27
118_L	643_V	0.513	0.27
475_R	647_H	0.512	0.27
283_E	403_T	0.512	0.27
179_M	485_A	0.512	0.27
220_S	229_V	0.512	0.27
159_G	163_Y	0.511	0.27
290_Q	337_H	0.511	0.27
360_V	505_G	0.510	0.26
205_G	288_T	0.510	0.26
118_L	126_E	0.509	0.26
210_F	335_G	0.509	0.26
380_F	421_F	0.508	0.26
129_E	492_D	0.508	0.26
197_Y	201_E	0.508	0.26
485_A	491_A	0.507	0.26
180_R	424_Q	0.507	0.26
147_A	331_I	0.507	0.26
372_E	412_Q	0.506	0.26
191_T	260_I	0.506	0.26
314_I	366_A	0.506	0.26
516_A	604_A	0.506	0.26
163_Y	418_Q	0.504	0.26
226_Q	587_I	0.504	0.26
356_G	592_D	0.504	0.26
119_D	126_E	0.503	0.26
126_E	157_F	0.502	0.26
151_Y	498_A	0.502	0.26
424_Q	457_L	0.502	0.26
111_E	163_Y	0.502	0.26
131_D	492_D	0.501	0.26
212_L	232_S	0.501	0.26
163_Y	369_D	0.501	0.26
169_P	589_H	0.500	0.26
108_D	111_E	0.500	0.26
158_P	633_V	0.500	0.26
335_G	338_I	0.500	0.26
127_S	134_G	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xc8A	2	0.9387	100	0.185	Contact Map
4r3uA	2	0.8499	100	0.193	Contact Map
2xijA	2	0.8346	100	0.204	Contact Map
1reqA	1	0.8515	100	0.215	Contact Map
1reqB	1	0.7948	100	0.335	Contact Map
3kp1A	2	0.7626	100	0.564	Contact Map
1ccwB	2	0.6968	100	0.824	Contact Map
3fm3A	1	0.1378	36.4	0.985	Contact Map
3ijdA	2	0.3599	29	0.986	Contact Map
1p8aA	1	0.2037	21.6	0.987	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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