Q9HRY9 - HALSA - GREMLIN Contacts

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Q9HRY9 - Uncharacterized protein

UniProt:	Q9HRY9	Sequences: MFEGRLWTRLLVGGLVAVAVLAGGAVIGMTVLGGTQSGAGSPRIGANASGAYAGIDGVNATREKVVHRGSETYRSVARVSLRPGTDQRRITIRETTSRRHETIVENDSVMTMYDRDTGVVRRFEPAGTTDPRTFGDRVERLFERVNVTDRTASATADGVSPLPVVPVDTARRATGASHTATLRLTYDGTTTVSGRSVYVLRLSATGDVGAAFEQTLWVDTERFFPVQRQTSWVANGEPVTARTTYSDITFDPGVTDDTFTFSAPPNTTVKTYDTPNRTVYPSAQRLAAATEASVPEPATPGSLRLVAATETTGRIHGVGLRYANDTASVTVAKYDRTYPVTGDREIRVAGRNAAVAVGPTTSISWNCATYRYTVRGSGVSLETLREVAASTACG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (328)
Sequences:	252 (224)
Seq/√Len:	12.4

BACSU - YDCC
HALSA - Q9HRY9 Q9HQM2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
331_V	374_V	3.757	0.99
297_P	390_S	3.706	0.99
29_M	34_G	3.217	0.97
387_V	390_S	3.199	0.97
226_V	248_I	3.106	0.97
82_R	256_D	3.105	0.97
219_D	222_R	3.028	0.96
118_G	267_T	2.995	0.96
217_W	227_Q	2.817	0.94
185_T	201_R	2.797	0.94
113_Y	264_P	2.767	0.94
61_T	78_R	2.623	0.92
57_G	252_P	2.521	0.90
331_V	391_T	2.398	0.88
300_P	390_S	2.375	0.87
215_T	231_S	2.276	0.85
24_G	28_G	2.260	0.84
305_L	308_A	2.241	0.84
65_V	242_R	2.240	0.84
113_Y	265_P	2.230	0.83
244_T	386_E	2.217	0.83
232_W	315_I	2.215	0.83
57_G	253_G	2.146	0.81
31_V	34_G	2.144	0.81
305_L	320_L	2.137	0.81
120_V	269_V	2.115	0.80
333_K	372_Y	2.112	0.80
60_A	245_Y	2.084	0.79
251_D	259_F	2.036	0.77
297_P	320_L	1.958	0.74
297_P	388_A	1.955	0.74
82_R	86_D	1.948	0.74
90_I	93_R	1.938	0.73
28_G	32_L	1.918	0.73
226_V	372_Y	1.893	0.72
111_T	269_V	1.892	0.72
84_G	91_T	1.882	0.71
120_V	267_T	1.756	0.66
205_T	223_F	1.747	0.65
225_P	297_P	1.691	0.63
282_S	290_T	1.670	0.62
45_G	80_S	1.664	0.61
322_Y	372_Y	1.646	0.60
29_M	33_G	1.639	0.60
82_R	297_P	1.637	0.60
297_P	300_P	1.630	0.60
89_R	93_R	1.622	0.59
292_A	318_V	1.611	0.59
217_W	365_W	1.597	0.58
219_D	322_Y	1.591	0.58
60_A	257_D	1.588	0.58
176_A	346_I	1.580	0.57
79_V	251_D	1.559	0.56
121_R	304_R	1.544	0.55
21_L	269_V	1.536	0.55
20_V	30_T	1.513	0.54
221_E	380_S	1.506	0.53
91_T	355_V	1.504	0.53
42_P	238_P	1.492	0.53
232_W	373_T	1.492	0.53
285_R	381_L	1.491	0.53
20_V	27_I	1.479	0.52
376_G	384_L	1.475	0.52
44_I	62_R	1.471	0.52
188_G	217_W	1.462	0.51
65_V	298_A	1.462	0.51
25_A	32_L	1.459	0.51
85_T	322_Y	1.458	0.51
106_N	389_A	1.451	0.51
33_G	355_V	1.445	0.50
40_G	363_I	1.428	0.49
249_T	252_P	1.415	0.49
204_A	350_G	1.404	0.48
186_Y	238_P	1.394	0.48
87_Q	348_V	1.391	0.48
104_V	225_P	1.389	0.47
178_H	282_S	1.367	0.46
319_G	322_Y	1.360	0.46
320_L	333_K	1.359	0.46
187_D	322_Y	1.345	0.45
104_V	243_T	1.342	0.45
266_N	325_D	1.341	0.45
37_S	369_T	1.334	0.45
255_T	285_R	1.332	0.45
70_S	380_S	1.332	0.45
166_P	214_Q	1.324	0.44
107_D	217_W	1.321	0.44
82_R	251_D	1.319	0.44
225_P	369_T	1.306	0.43
168_D	364_S	1.303	0.43
118_G	346_I	1.296	0.43
54_G	61_T	1.295	0.43
61_T	247_D	1.295	0.43
282_S	285_R	1.291	0.42
21_L	26_V	1.286	0.42
348_V	369_T	1.285	0.42
56_D	342_G	1.274	0.42
175_G	199_V	1.272	0.42
334_Y	343_D	1.263	0.41
263_A	267_T	1.255	0.41
308_A	322_Y	1.250	0.40
61_T	246_S	1.248	0.40
24_G	183_R	1.241	0.40
273_D	307_A	1.240	0.40
87_Q	127_G	1.238	0.40
80_S	88_R	1.235	0.40
100_H	104_V	1.232	0.40
44_I	291_E	1.227	0.39
66_V	248_I	1.219	0.39
50_G	251_D	1.214	0.39
218_V	227_Q	1.208	0.38
102_T	176_A	1.205	0.38
33_G	200_L	1.204	0.38
53_A	368_A	1.204	0.38
266_N	324_N	1.201	0.38
48_A	266_N	1.183	0.37
303_L	344_R	1.181	0.37
51_A	292_A	1.176	0.37
269_V	358_G	1.171	0.37
105_E	322_Y	1.170	0.37
72_T	342_G	1.169	0.37
124_E	128_T	1.161	0.36
122_R	346_I	1.143	0.35
43_R	346_I	1.140	0.35
288_A	298_A	1.140	0.35
225_P	292_A	1.132	0.35
205_T	355_V	1.122	0.34
167_V	181_T	1.121	0.34
85_T	337_T	1.119	0.34
207_D	348_V	1.118	0.34
61_T	300_P	1.110	0.34
124_E	322_Y	1.109	0.34
219_D	364_S	1.105	0.34
295_P	333_K	1.104	0.34
23_G	28_G	1.104	0.34
111_T	261_F	1.102	0.33
114_D	123_F	1.101	0.33
100_H	249_T	1.098	0.33
32_L	288_A	1.098	0.33
65_V	244_T	1.094	0.33
23_G	288_A	1.091	0.33
55_I	384_L	1.089	0.33
73_Y	184_L	1.088	0.33
197_V	227_Q	1.087	0.33
110_M	124_E	1.084	0.33
62_R	66_V	1.082	0.33
254_V	258_T	1.078	0.32
107_D	184_L	1.077	0.32
45_G	374_V	1.076	0.32
112_M	230_T	1.074	0.32
237_E	348_V	1.074	0.32
41_S	348_V	1.071	0.32
288_A	368_A	1.069	0.32
26_V	209_G	1.067	0.32
180_A	300_P	1.067	0.32
110_M	125_P	1.063	0.32
23_G	284_Q	1.061	0.32
256_D	379_V	1.059	0.32
101_E	117_T	1.056	0.31
346_I	358_G	1.056	0.31
221_E	257_D	1.053	0.31
120_V	265_P	1.046	0.31
80_S	222_R	1.043	0.31
189_T	243_T	1.041	0.31
57_G	380_S	1.039	0.31
76_V	258_T	1.037	0.31
251_D	305_L	1.036	0.31
348_V	391_T	1.034	0.30
362_S	372_Y	1.032	0.30
25_A	246_S	1.020	0.30
56_D	361_T	1.017	0.30
106_N	123_F	1.016	0.30
188_G	264_P	1.008	0.29
104_V	120_V	1.004	0.29
114_D	329_V	1.002	0.29
202_L	206_G	1.002	0.29
80_S	353_A	1.001	0.29
27_I	54_G	1.001	0.29
108_S	178_H	0.998	0.29
171_R	248_I	0.996	0.29
200_L	216_L	0.996	0.29
56_D	363_I	0.985	0.28
330_T	379_V	0.984	0.28
65_V	68_R	0.983	0.28
363_I	369_T	0.980	0.28
50_G	248_I	0.979	0.28
219_D	224_F	0.978	0.28
25_A	363_I	0.977	0.28
292_A	370_Y	0.971	0.28
23_G	256_D	0.969	0.28
379_V	383_T	0.966	0.28
219_D	235_N	0.966	0.28
202_L	291_E	0.963	0.27
122_R	254_V	0.963	0.27
247_D	353_A	0.962	0.27
288_A	365_W	0.961	0.27
230_T	324_N	0.960	0.27
178_H	382_E	0.960	0.27
42_P	350_G	0.960	0.27
26_V	29_M	0.959	0.27
199_V	322_Y	0.959	0.27
121_R	333_K	0.954	0.27
300_P	391_T	0.953	0.27
22_A	389_A	0.950	0.27
232_W	243_T	0.944	0.27
58_V	294_V	0.944	0.27
297_P	305_L	0.943	0.27
224_F	280_Y	0.939	0.26
84_G	102_T	0.936	0.26
108_S	183_R	0.935	0.26
28_G	31_V	0.933	0.26
24_G	29_M	0.932	0.26
120_V	294_V	0.926	0.26
219_D	384_L	0.926	0.26
47_N	256_D	0.911	0.25
301_G	368_A	0.906	0.25
26_V	203_S	0.905	0.25
29_M	384_L	0.903	0.25
273_D	276_N	0.903	0.25
62_R	100_H	0.901	0.25
120_V	309_T	0.893	0.25
273_D	364_S	0.889	0.25
22_A	251_D	0.889	0.25
237_E	255_T	0.887	0.24
318_V	361_T	0.887	0.24
33_G	81_L	0.883	0.24
77_A	116_D	0.882	0.24
170_A	200_L	0.881	0.24
33_G	205_T	0.880	0.24
319_G	332_A	0.880	0.24
323_A	353_A	0.879	0.24
88_R	237_E	0.879	0.24
38_G	288_A	0.878	0.24
181_T	201_R	0.877	0.24
42_P	377_S	0.876	0.24
55_I	200_L	0.874	0.24
246_S	253_G	0.872	0.24
365_W	388_A	0.871	0.24
126_A	218_V	0.870	0.24
167_V	358_G	0.867	0.24
30_T	265_P	0.863	0.24
68_R	335_D	0.861	0.23
237_E	294_V	0.857	0.23
77_A	369_T	0.856	0.23
59_N	305_L	0.856	0.23
305_L	390_S	0.851	0.23
299_T	331_V	0.847	0.23
61_T	318_V	0.842	0.23
62_R	234_A	0.841	0.23
88_R	198_Y	0.841	0.23
287_A	361_T	0.838	0.23
186_Y	200_L	0.838	0.23
44_I	189_T	0.838	0.23
241_A	374_V	0.838	0.23
317_G	322_Y	0.833	0.22
29_M	383_T	0.833	0.22
256_D	260_T	0.831	0.22
331_V	367_C	0.831	0.22
33_G	325_D	0.830	0.22
125_P	376_G	0.830	0.22
167_V	317_G	0.828	0.22
225_P	248_I	0.826	0.22
234_A	241_A	0.825	0.22
199_V	250_F	0.822	0.22
56_D	301_G	0.820	0.22
336_R	371_R	0.819	0.22
249_T	280_Y	0.812	0.22
38_G	262_S	0.811	0.22
264_P	267_T	0.808	0.22
33_G	350_G	0.806	0.22
58_V	249_T	0.806	0.22
71_E	122_R	0.803	0.21
112_M	214_Q	0.799	0.21
185_T	368_A	0.799	0.21
317_G	334_Y	0.797	0.21
105_E	111_T	0.796	0.21
37_S	64_K	0.793	0.21
355_V	363_I	0.793	0.21
256_D	309_T	0.791	0.21
226_V	246_S	0.790	0.21
247_D	299_T	0.790	0.21
200_L	221_E	0.788	0.21
219_D	226_V	0.783	0.21
333_K	370_Y	0.783	0.21
374_V	387_V	0.782	0.21
221_E	226_V	0.781	0.21
125_P	128_T	0.781	0.21
317_G	358_G	0.781	0.21
291_E	304_R	0.777	0.21
106_N	214_Q	0.775	0.20
38_G	257_D	0.773	0.20
218_V	264_P	0.773	0.20
44_I	67_H	0.770	0.20
59_N	249_T	0.768	0.20
312_T	331_V	0.763	0.20
40_G	347_R	0.761	0.20
251_D	256_D	0.758	0.20
20_V	282_S	0.758	0.20
88_R	305_L	0.758	0.20
242_R	251_D	0.758	0.20
169_T	174_T	0.758	0.20
56_D	346_I	0.757	0.20
46_A	354_A	0.756	0.20
282_S	286_L	0.755	0.20
88_R	368_A	0.755	0.20
322_Y	339_P	0.754	0.20
196_S	344_R	0.753	0.20
64_K	220_T	0.751	0.20
243_T	315_I	0.750	0.20
334_Y	373_T	0.747	0.20
167_V	254_V	0.745	0.20
103_I	112_M	0.745	0.20
248_I	269_V	0.744	0.19
190_T	242_R	0.744	0.19
111_T	120_V	0.740	0.19
55_I	337_T	0.735	0.19
26_V	208_V	0.733	0.19
44_I	172_R	0.732	0.19
315_I	337_T	0.731	0.19
203_S	211_A	0.725	0.19
285_R	363_I	0.724	0.19
224_F	282_S	0.723	0.19
44_I	290_T	0.719	0.19
81_L	387_V	0.718	0.19
109_V	122_R	0.716	0.19
20_V	25_A	0.713	0.19
42_P	174_T	0.712	0.18
59_N	349_A	0.711	0.18
80_S	368_A	0.711	0.18
166_P	169_T	0.710	0.18
24_G	323_A	0.710	0.18
121_R	167_V	0.705	0.18
319_G	324_N	0.704	0.18
212_F	317_G	0.700	0.18
43_R	203_S	0.699	0.18
318_V	370_Y	0.697	0.18
266_N	295_P	0.696	0.18
220_T	327_A	0.694	0.18
190_T	304_R	0.692	0.18
48_A	200_L	0.690	0.18
115_R	371_R	0.689	0.18
86_D	254_V	0.688	0.18
104_V	328_S	0.687	0.18
268_T	358_G	0.682	0.18
22_A	25_A	0.680	0.18
113_Y	261_F	0.678	0.17
118_G	344_R	0.676	0.17
244_T	337_T	0.676	0.17
217_W	286_L	0.675	0.17
167_V	174_T	0.672	0.17
216_L	374_V	0.672	0.17
45_G	92_I	0.670	0.17
89_R	92_I	0.670	0.17
189_T	349_A	0.666	0.17
294_V	388_A	0.666	0.17
105_E	321_R	0.665	0.17
302_S	380_S	0.664	0.17
38_G	219_D	0.664	0.17
65_V	84_G	0.662	0.17
71_E	174_T	0.659	0.17
255_T	299_T	0.658	0.17
241_A	369_T	0.653	0.17
230_T	376_G	0.651	0.17
47_N	200_L	0.648	0.17
383_T	386_E	0.647	0.17
285_R	389_A	0.646	0.17
302_S	326_T	0.644	0.16
66_V	118_G	0.641	0.16
81_L	333_K	0.641	0.16
227_Q	231_S	0.640	0.16
216_L	376_G	0.640	0.16
50_G	271_T	0.638	0.16
85_T	365_W	0.637	0.16
120_V	365_W	0.635	0.16
105_E	261_F	0.634	0.16
58_V	214_Q	0.631	0.16
40_G	376_G	0.625	0.16
70_S	78_R	0.625	0.16
82_R	259_F	0.625	0.16
305_L	359_P	0.624	0.16
208_V	262_S	0.624	0.16
352_N	389_A	0.618	0.16
21_L	31_V	0.618	0.16
104_V	261_F	0.618	0.16
113_Y	188_G	0.617	0.16
50_G	291_E	0.616	0.16
79_V	390_S	0.613	0.16
184_L	269_V	0.613	0.16
25_A	305_L	0.612	0.16
202_L	263_A	0.611	0.16
260_T	381_L	0.610	0.16
188_G	339_P	0.610	0.16
48_A	255_T	0.607	0.15
123_F	130_D	0.607	0.15
21_L	37_S	0.606	0.15
107_D	347_R	0.605	0.15
52_Y	250_F	0.602	0.15
206_G	373_T	0.601	0.15
384_L	388_A	0.600	0.15
109_V	127_G	0.600	0.15
175_G	349_A	0.598	0.15
113_Y	267_T	0.598	0.15
89_R	262_S	0.597	0.15
186_Y	294_V	0.596	0.15
44_I	187_D	0.595	0.15
22_A	255_T	0.594	0.15
21_L	25_A	0.592	0.15
64_K	119_V	0.587	0.15
320_L	372_Y	0.587	0.15
73_Y	121_R	0.586	0.15
130_D	224_F	0.585	0.15
278_T	283_A	0.582	0.15
293_S	370_Y	0.582	0.15
102_T	308_A	0.580	0.15
59_N	254_V	0.580	0.15
122_R	320_L	0.577	0.15
234_A	271_T	0.576	0.15
106_N	349_A	0.575	0.15
46_A	248_I	0.573	0.15
47_N	110_M	0.573	0.15
362_S	379_V	0.572	0.15
66_V	116_D	0.570	0.15
294_V	373_T	0.569	0.14
47_N	85_T	0.569	0.14
200_L	372_Y	0.569	0.14
286_L	308_A	0.569	0.14
379_V	384_L	0.566	0.14
80_S	258_T	0.565	0.14
120_V	264_P	0.562	0.14
180_A	339_P	0.562	0.14
261_F	264_P	0.559	0.14
55_I	257_D	0.559	0.14
24_G	318_V	0.558	0.14
294_V	318_V	0.557	0.14
123_F	127_G	0.555	0.14
251_D	369_T	0.553	0.14
92_I	271_T	0.551	0.14
284_Q	290_T	0.550	0.14
63_E	244_T	0.550	0.14
171_R	175_G	0.549	0.14
26_V	63_E	0.548	0.14
52_Y	318_V	0.545	0.14
185_T	344_R	0.544	0.14
107_D	291_E	0.544	0.14
199_V	388_A	0.543	0.14
115_R	234_A	0.543	0.14
168_D	295_P	0.541	0.14
97_S	242_R	0.540	0.14
216_L	339_P	0.540	0.14
218_V	224_F	0.539	0.14
22_A	276_N	0.539	0.14
257_D	296_E	0.538	0.14
115_R	123_F	0.538	0.14
70_S	391_T	0.538	0.14
79_V	349_A	0.537	0.14
84_G	252_P	0.536	0.14
55_I	251_D	0.535	0.14
110_M	123_F	0.535	0.14
34_G	119_V	0.534	0.14
247_D	373_T	0.532	0.14
88_R	316_H	0.530	0.14
22_A	82_R	0.529	0.13
198_Y	343_D	0.529	0.13
295_P	351_R	0.529	0.13
125_P	131_P	0.528	0.13
34_G	42_P	0.528	0.13
299_T	365_W	0.528	0.13
326_T	332_A	0.527	0.13
69_G	334_Y	0.526	0.13
216_L	234_A	0.526	0.13
298_A	372_Y	0.524	0.13
375_R	388_A	0.523	0.13
329_V	390_S	0.522	0.13
85_T	116_D	0.521	0.13
245_Y	258_T	0.521	0.13
252_P	260_T	0.520	0.13
71_E	204_A	0.520	0.13
210_A	308_A	0.519	0.13
29_M	386_E	0.518	0.13
369_T	379_V	0.515	0.13
110_M	260_T	0.514	0.13
23_G	366_N	0.514	0.13
120_V	211_A	0.508	0.13
224_F	237_E	0.507	0.13
25_A	29_M	0.506	0.13
46_A	226_V	0.506	0.13
305_L	351_R	0.503	0.13
248_I	365_W	0.502	0.13
349_A	367_C	0.501	0.13
65_V	387_V	0.500	0.13
322_Y	370_Y	0.500	0.13
326_T	331_V	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3m4wA	2	0.7157	100	0.646	Contact Map
2yzyA	1	0.4112	99.9	0.728	Contact Map
4mxtA	2	0.467	99.9	0.731	Contact Map
3buuA	1	0.4873	99.9	0.751	Contact Map
4z48A	1	0.4949	99.9	0.758	Contact Map
2w7qA	1	0.4822	99.9	0.768	Contact Map
3bk5A	1	0.4924	99.9	0.772	Contact Map
1iwlA	1	0.4492	99.8	0.783	Contact Map
4qa8A	1	0.4619	98.6	0.89	Contact Map
3mh9C	1	0.4848	98.4	0.895	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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