GREMLIN Database
Q9HRY9 - Uncharacterized protein
UniProt: Q9HRY9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (328)
Sequences: 252 (224)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_V374_V3.7570.99
297_P390_S3.7060.99
29_M34_G3.2170.97
387_V390_S3.1990.97
226_V248_I3.1060.97
82_R256_D3.1050.97
219_D222_R3.0280.96
118_G267_T2.9950.96
217_W227_Q2.8170.94
185_T201_R2.7970.94
113_Y264_P2.7670.94
61_T78_R2.6230.92
57_G252_P2.5210.90
331_V391_T2.3980.88
300_P390_S2.3750.87
215_T231_S2.2760.85
24_G28_G2.2600.84
305_L308_A2.2410.84
65_V242_R2.2400.84
113_Y265_P2.2300.83
244_T386_E2.2170.83
232_W315_I2.2150.83
57_G253_G2.1460.81
31_V34_G2.1440.81
305_L320_L2.1370.81
120_V269_V2.1150.80
333_K372_Y2.1120.80
60_A245_Y2.0840.79
251_D259_F2.0360.77
297_P320_L1.9580.74
297_P388_A1.9550.74
82_R86_D1.9480.74
90_I93_R1.9380.73
28_G32_L1.9180.73
226_V372_Y1.8930.72
111_T269_V1.8920.72
84_G91_T1.8820.71
120_V267_T1.7560.66
205_T223_F1.7470.65
225_P297_P1.6910.63
282_S290_T1.6700.62
45_G80_S1.6640.61
322_Y372_Y1.6460.60
29_M33_G1.6390.60
82_R297_P1.6370.60
297_P300_P1.6300.60
89_R93_R1.6220.59
292_A318_V1.6110.59
217_W365_W1.5970.58
219_D322_Y1.5910.58
60_A257_D1.5880.58
176_A346_I1.5800.57
79_V251_D1.5590.56
121_R304_R1.5440.55
21_L269_V1.5360.55
20_V30_T1.5130.54
221_E380_S1.5060.53
91_T355_V1.5040.53
42_P238_P1.4920.53
232_W373_T1.4920.53
285_R381_L1.4910.53
20_V27_I1.4790.52
376_G384_L1.4750.52
44_I62_R1.4710.52
188_G217_W1.4620.51
65_V298_A1.4620.51
25_A32_L1.4590.51
85_T322_Y1.4580.51
106_N389_A1.4510.51
33_G355_V1.4450.50
40_G363_I1.4280.49
249_T252_P1.4150.49
204_A350_G1.4040.48
186_Y238_P1.3940.48
87_Q348_V1.3910.48
104_V225_P1.3890.47
178_H282_S1.3670.46
319_G322_Y1.3600.46
320_L333_K1.3590.46
187_D322_Y1.3450.45
104_V243_T1.3420.45
266_N325_D1.3410.45
37_S369_T1.3340.45
255_T285_R1.3320.45
70_S380_S1.3320.45
166_P214_Q1.3240.44
107_D217_W1.3210.44
82_R251_D1.3190.44
225_P369_T1.3060.43
168_D364_S1.3030.43
118_G346_I1.2960.43
54_G61_T1.2950.43
61_T247_D1.2950.43
282_S285_R1.2910.42
21_L26_V1.2860.42
348_V369_T1.2850.42
56_D342_G1.2740.42
175_G199_V1.2720.42
334_Y343_D1.2630.41
263_A267_T1.2550.41
308_A322_Y1.2500.40
61_T246_S1.2480.40
24_G183_R1.2410.40
273_D307_A1.2400.40
87_Q127_G1.2380.40
80_S88_R1.2350.40
100_H104_V1.2320.40
44_I291_E1.2270.39
66_V248_I1.2190.39
50_G251_D1.2140.39
218_V227_Q1.2080.38
102_T176_A1.2050.38
33_G200_L1.2040.38
53_A368_A1.2040.38
266_N324_N1.2010.38
48_A266_N1.1830.37
303_L344_R1.1810.37
51_A292_A1.1760.37
269_V358_G1.1710.37
105_E322_Y1.1700.37
72_T342_G1.1690.37
124_E128_T1.1610.36
122_R346_I1.1430.35
43_R346_I1.1400.35
288_A298_A1.1400.35
225_P292_A1.1320.35
205_T355_V1.1220.34
167_V181_T1.1210.34
85_T337_T1.1190.34
207_D348_V1.1180.34
61_T300_P1.1100.34
124_E322_Y1.1090.34
219_D364_S1.1050.34
295_P333_K1.1040.34
23_G28_G1.1040.34
111_T261_F1.1020.33
114_D123_F1.1010.33
100_H249_T1.0980.33
32_L288_A1.0980.33
65_V244_T1.0940.33
23_G288_A1.0910.33
55_I384_L1.0890.33
73_Y184_L1.0880.33
197_V227_Q1.0870.33
110_M124_E1.0840.33
62_R66_V1.0820.33
254_V258_T1.0780.32
107_D184_L1.0770.32
45_G374_V1.0760.32
112_M230_T1.0740.32
237_E348_V1.0740.32
41_S348_V1.0710.32
288_A368_A1.0690.32
26_V209_G1.0670.32
180_A300_P1.0670.32
110_M125_P1.0630.32
23_G284_Q1.0610.32
256_D379_V1.0590.32
101_E117_T1.0560.31
346_I358_G1.0560.31
221_E257_D1.0530.31
120_V265_P1.0460.31
80_S222_R1.0430.31
189_T243_T1.0410.31
57_G380_S1.0390.31
76_V258_T1.0370.31
251_D305_L1.0360.31
348_V391_T1.0340.30
362_S372_Y1.0320.30
25_A246_S1.0200.30
56_D361_T1.0170.30
106_N123_F1.0160.30
188_G264_P1.0080.29
104_V120_V1.0040.29
114_D329_V1.0020.29
202_L206_G1.0020.29
80_S353_A1.0010.29
27_I54_G1.0010.29
108_S178_H0.9980.29
171_R248_I0.9960.29
200_L216_L0.9960.29
56_D363_I0.9850.28
330_T379_V0.9840.28
65_V68_R0.9830.28
363_I369_T0.9800.28
50_G248_I0.9790.28
219_D224_F0.9780.28
25_A363_I0.9770.28
292_A370_Y0.9710.28
23_G256_D0.9690.28
379_V383_T0.9660.28
219_D235_N0.9660.28
202_L291_E0.9630.27
122_R254_V0.9630.27
247_D353_A0.9620.27
288_A365_W0.9610.27
230_T324_N0.9600.27
178_H382_E0.9600.27
42_P350_G0.9600.27
26_V29_M0.9590.27
199_V322_Y0.9590.27
121_R333_K0.9540.27
300_P391_T0.9530.27
22_A389_A0.9500.27
232_W243_T0.9440.27
58_V294_V0.9440.27
297_P305_L0.9430.27
224_F280_Y0.9390.26
84_G102_T0.9360.26
108_S183_R0.9350.26
28_G31_V0.9330.26
24_G29_M0.9320.26
120_V294_V0.9260.26
219_D384_L0.9260.26
47_N256_D0.9110.25
301_G368_A0.9060.25
26_V203_S0.9050.25
29_M384_L0.9030.25
273_D276_N0.9030.25
62_R100_H0.9010.25
120_V309_T0.8930.25
273_D364_S0.8890.25
22_A251_D0.8890.25
237_E255_T0.8870.24
318_V361_T0.8870.24
33_G81_L0.8830.24
77_A116_D0.8820.24
170_A200_L0.8810.24
33_G205_T0.8800.24
319_G332_A0.8800.24
323_A353_A0.8790.24
88_R237_E0.8790.24
38_G288_A0.8780.24
181_T201_R0.8770.24
42_P377_S0.8760.24
55_I200_L0.8740.24
246_S253_G0.8720.24
365_W388_A0.8710.24
126_A218_V0.8700.24
167_V358_G0.8670.24
30_T265_P0.8630.24
68_R335_D0.8610.23
237_E294_V0.8570.23
77_A369_T0.8560.23
59_N305_L0.8560.23
305_L390_S0.8510.23
299_T331_V0.8470.23
61_T318_V0.8420.23
62_R234_A0.8410.23
88_R198_Y0.8410.23
287_A361_T0.8380.23
186_Y200_L0.8380.23
44_I189_T0.8380.23
241_A374_V0.8380.23
317_G322_Y0.8330.22
29_M383_T0.8330.22
256_D260_T0.8310.22
331_V367_C0.8310.22
33_G325_D0.8300.22
125_P376_G0.8300.22
167_V317_G0.8280.22
225_P248_I0.8260.22
234_A241_A0.8250.22
199_V250_F0.8220.22
56_D301_G0.8200.22
336_R371_R0.8190.22
249_T280_Y0.8120.22
38_G262_S0.8110.22
264_P267_T0.8080.22
33_G350_G0.8060.22
58_V249_T0.8060.22
71_E122_R0.8030.21
112_M214_Q0.7990.21
185_T368_A0.7990.21
317_G334_Y0.7970.21
105_E111_T0.7960.21
37_S64_K0.7930.21
355_V363_I0.7930.21
256_D309_T0.7910.21
226_V246_S0.7900.21
247_D299_T0.7900.21
200_L221_E0.7880.21
219_D226_V0.7830.21
333_K370_Y0.7830.21
374_V387_V0.7820.21
221_E226_V0.7810.21
125_P128_T0.7810.21
317_G358_G0.7810.21
291_E304_R0.7770.21
106_N214_Q0.7750.20
38_G257_D0.7730.20
218_V264_P0.7730.20
44_I67_H0.7700.20
59_N249_T0.7680.20
312_T331_V0.7630.20
40_G347_R0.7610.20
251_D256_D0.7580.20
20_V282_S0.7580.20
88_R305_L0.7580.20
242_R251_D0.7580.20
169_T174_T0.7580.20
56_D346_I0.7570.20
46_A354_A0.7560.20
282_S286_L0.7550.20
88_R368_A0.7550.20
322_Y339_P0.7540.20
196_S344_R0.7530.20
64_K220_T0.7510.20
243_T315_I0.7500.20
334_Y373_T0.7470.20
167_V254_V0.7450.20
103_I112_M0.7450.20
248_I269_V0.7440.19
190_T242_R0.7440.19
111_T120_V0.7400.19
55_I337_T0.7350.19
26_V208_V0.7330.19
44_I172_R0.7320.19
315_I337_T0.7310.19
203_S211_A0.7250.19
285_R363_I0.7240.19
224_F282_S0.7230.19
44_I290_T0.7190.19
81_L387_V0.7180.19
109_V122_R0.7160.19
20_V25_A0.7130.19
42_P174_T0.7120.18
59_N349_A0.7110.18
80_S368_A0.7110.18
166_P169_T0.7100.18
24_G323_A0.7100.18
121_R167_V0.7050.18
319_G324_N0.7040.18
212_F317_G0.7000.18
43_R203_S0.6990.18
318_V370_Y0.6970.18
266_N295_P0.6960.18
220_T327_A0.6940.18
190_T304_R0.6920.18
48_A200_L0.6900.18
115_R371_R0.6890.18
86_D254_V0.6880.18
104_V328_S0.6870.18
268_T358_G0.6820.18
22_A25_A0.6800.18
113_Y261_F0.6780.17
118_G344_R0.6760.17
244_T337_T0.6760.17
217_W286_L0.6750.17
167_V174_T0.6720.17
216_L374_V0.6720.17
45_G92_I0.6700.17
89_R92_I0.6700.17
189_T349_A0.6660.17
294_V388_A0.6660.17
105_E321_R0.6650.17
302_S380_S0.6640.17
38_G219_D0.6640.17
65_V84_G0.6620.17
71_E174_T0.6590.17
255_T299_T0.6580.17
241_A369_T0.6530.17
230_T376_G0.6510.17
47_N200_L0.6480.17
383_T386_E0.6470.17
285_R389_A0.6460.17
302_S326_T0.6440.16
66_V118_G0.6410.16
81_L333_K0.6410.16
227_Q231_S0.6400.16
216_L376_G0.6400.16
50_G271_T0.6380.16
85_T365_W0.6370.16
120_V365_W0.6350.16
105_E261_F0.6340.16
58_V214_Q0.6310.16
40_G376_G0.6250.16
70_S78_R0.6250.16
82_R259_F0.6250.16
305_L359_P0.6240.16
208_V262_S0.6240.16
352_N389_A0.6180.16
21_L31_V0.6180.16
104_V261_F0.6180.16
113_Y188_G0.6170.16
50_G291_E0.6160.16
79_V390_S0.6130.16
184_L269_V0.6130.16
25_A305_L0.6120.16
202_L263_A0.6110.16
260_T381_L0.6100.16
188_G339_P0.6100.16
48_A255_T0.6070.15
123_F130_D0.6070.15
21_L37_S0.6060.15
107_D347_R0.6050.15
52_Y250_F0.6020.15
206_G373_T0.6010.15
384_L388_A0.6000.15
109_V127_G0.6000.15
175_G349_A0.5980.15
113_Y267_T0.5980.15
89_R262_S0.5970.15
186_Y294_V0.5960.15
44_I187_D0.5950.15
22_A255_T0.5940.15
21_L25_A0.5920.15
64_K119_V0.5870.15
320_L372_Y0.5870.15
73_Y121_R0.5860.15
130_D224_F0.5850.15
278_T283_A0.5820.15
293_S370_Y0.5820.15
102_T308_A0.5800.15
59_N254_V0.5800.15
122_R320_L0.5770.15
234_A271_T0.5760.15
106_N349_A0.5750.15
46_A248_I0.5730.15
47_N110_M0.5730.15
362_S379_V0.5720.15
66_V116_D0.5700.15
294_V373_T0.5690.14
47_N85_T0.5690.14
200_L372_Y0.5690.14
286_L308_A0.5690.14
379_V384_L0.5660.14
80_S258_T0.5650.14
120_V264_P0.5620.14
180_A339_P0.5620.14
261_F264_P0.5590.14
55_I257_D0.5590.14
24_G318_V0.5580.14
294_V318_V0.5570.14
123_F127_G0.5550.14
251_D369_T0.5530.14
92_I271_T0.5510.14
284_Q290_T0.5500.14
63_E244_T0.5500.14
171_R175_G0.5490.14
26_V63_E0.5480.14
52_Y318_V0.5450.14
185_T344_R0.5440.14
107_D291_E0.5440.14
199_V388_A0.5430.14
115_R234_A0.5430.14
168_D295_P0.5410.14
97_S242_R0.5400.14
216_L339_P0.5400.14
218_V224_F0.5390.14
22_A276_N0.5390.14
257_D296_E0.5380.14
115_R123_F0.5380.14
70_S391_T0.5380.14
79_V349_A0.5370.14
84_G252_P0.5360.14
55_I251_D0.5350.14
110_M123_F0.5350.14
34_G119_V0.5340.14
247_D373_T0.5320.14
88_R316_H0.5300.14
22_A82_R0.5290.13
198_Y343_D0.5290.13
295_P351_R0.5290.13
125_P131_P0.5280.13
34_G42_P0.5280.13
299_T365_W0.5280.13
326_T332_A0.5270.13
69_G334_Y0.5260.13
216_L234_A0.5260.13
298_A372_Y0.5240.13
375_R388_A0.5230.13
329_V390_S0.5220.13
85_T116_D0.5210.13
245_Y258_T0.5210.13
252_P260_T0.5200.13
71_E204_A0.5200.13
210_A308_A0.5190.13
29_M386_E0.5180.13
369_T379_V0.5150.13
110_M260_T0.5140.13
23_G366_N0.5140.13
120_V211_A0.5080.13
224_F237_E0.5070.13
25_A29_M0.5060.13
46_A226_V0.5060.13
305_L351_R0.5030.13
248_I365_W0.5020.13
349_A367_C0.5010.13
65_V387_V0.5000.13
322_Y370_Y0.5000.13
326_T331_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m4wA 2 0.7157 100 0.646 Contact Map
2yzyA 1 0.4112 99.9 0.728 Contact Map
4mxtA 2 0.467 99.9 0.731 Contact Map
3buuA 1 0.4873 99.9 0.751 Contact Map
4z48A 1 0.4949 99.9 0.758 Contact Map
2w7qA 1 0.4822 99.9 0.768 Contact Map
3bk5A 1 0.4924 99.9 0.772 Contact Map
1iwlA 1 0.4492 99.8 0.783 Contact Map
4qa8A 1 0.4619 98.6 0.89 Contact Map
3mh9C 1 0.4848 98.4 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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