GREMLIN Database
Q9HRY6 - Probable acetyltransferase
UniProt: Q9HRY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (167)
Sequences: 18287 (13947)
Seq/√Len: 1079.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_A151_L2.7811.00
117_R153_A2.6801.00
15_R68_C2.6351.00
15_R21_D2.4511.00
159_V179_D2.3631.00
100_A133_V2.2281.00
33_R108_P2.2241.00
164_E183_R2.2151.00
11_R118_D2.1911.00
69_V83_E2.1611.00
92_A127_V2.1241.00
158_E161_R2.1091.00
140_A148_R2.1081.00
158_E176_V2.0821.00
9_G122_T1.9971.00
140_A151_L1.9691.00
8_E70_D1.9691.00
149_G152_A1.9431.00
9_G118_D1.9321.00
148_R152_A1.8671.00
125_D129_A1.8521.00
102_L120_A1.7491.00
31_D108_P1.7341.00
124_I156_F1.7321.00
23_A46_R1.7251.00
124_I136_V1.7221.00
161_R176_V1.7031.00
134_H164_E1.6801.00
66_V86_P1.6781.00
148_R158_E1.6471.00
46_R50_A1.5831.00
148_R176_V1.5571.00
24_H86_P1.5541.00
142_D174_D1.5411.00
17_V66_V1.5391.00
120_A154_M1.5211.00
167_Y172_Y1.5061.00
107_R110_Y1.4981.00
19_R54_E1.4971.00
22_A50_A1.4901.00
45_S48_Q1.4841.00
152_A158_E1.4821.00
106_L116_G1.4631.00
90_F119_M1.4581.00
122_T125_D1.4541.00
52_G56_W1.4181.00
68_C84_T1.4111.00
13_T70_D1.3511.00
7_T122_T1.3481.00
145_E148_R1.3061.00
135_N179_D1.2981.00
148_R178_Y1.2911.00
90_F123_G1.2861.00
134_H172_Y1.2811.00
117_R150_L1.2761.00
127_V136_V1.2601.00
165_A175_E1.2511.00
24_H85_T1.2391.00
162_R177_W1.2261.00
8_E13_T1.2211.00
67_V119_M1.2151.00
87_I110_Y1.2121.00
69_V87_I1.2111.00
104_Y151_L1.1921.00
143_F173_A1.1781.00
67_V106_L1.1781.00
142_D161_R1.1601.00
126_Y130_Q1.1271.00
116_G150_L1.1131.00
13_T68_C1.1031.00
22_A53_I1.0841.00
69_V115_Y1.0811.00
28_S105_W1.0751.00
140_A178_Y1.0701.00
28_S107_R1.0701.00
111_T146_A1.0701.00
104_Y147_S1.0671.00
85_T110_Y1.0611.00
9_G12_V1.0601.00
101_W139_A1.0581.00
89_S105_W1.0561.00
34_I111_T1.0541.00
147_S151_L1.0531.00
127_V131_Y1.0451.00
85_T109_E1.0341.00
158_E178_Y1.0311.00
33_R36_H1.0221.00
135_N159_V1.0181.00
124_I180_V1.0171.00
161_R174_D1.0101.00
22_A46_R1.0071.00
26_Q46_R1.0061.00
7_T126_Y1.0021.00
126_Y131_Y0.9961.00
134_H182_R0.9951.00
7_T14_L0.9951.00
24_H27_R0.9841.00
99_R137_S0.9811.00
44_R48_Q0.9761.00
19_R50_A0.9741.00
164_E174_D0.9651.00
50_A54_E0.9581.00
65_A123_G0.9511.00
108_P111_T0.9441.00
151_L156_F0.9421.00
6_V13_T0.9381.00
51_D55_H0.9331.00
150_L154_M0.9331.00
138_A156_F0.9311.00
141_Y173_A0.9251.00
65_A126_Y0.9141.00
163_R179_D0.9091.00
43_H49_Q0.9051.00
163_R174_D0.9041.00
92_A123_G0.8931.00
124_I154_M0.8921.00
117_R121_T0.8911.00
156_F180_V0.8911.00
71_D83_E0.8891.00
142_D176_V0.8791.00
121_T125_D0.8761.00
127_V133_V0.8681.00
17_V89_S0.8621.00
69_V85_T0.8541.00
99_R165_A0.8471.00
145_E149_G0.8461.00
118_D122_T0.8401.00
27_R107_R0.8261.00
13_T84_T0.8261.00
112_G146_A0.8251.00
23_A27_R0.8221.00
117_R154_M0.8191.00
98_D172_Y0.8171.00
132_G182_R0.8101.00
26_Q49_Q0.8071.00
162_R165_A0.8061.00
12_V115_Y0.8051.00
68_C86_P0.7991.00
12_V119_M0.7931.00
19_R22_A0.7901.00
21_D68_C0.7831.00
85_T107_R0.7801.00
98_D167_Y0.7741.00
59_D62_S0.7711.00
27_R85_T0.7701.00
159_V163_R0.7681.00
135_N181_L0.7591.00
35_R38_L0.7561.00
152_A178_Y0.7541.00
163_R181_L0.7511.00
69_V113_S0.7481.00
22_A26_Q0.7471.00
101_W137_S0.7411.00
106_L115_Y0.7411.00
29_C105_W0.7351.00
37_S141_Y0.7351.00
51_D54_E0.7321.00
33_R111_T0.7311.00
54_E58_E0.7301.00
112_G117_R0.7261.00
139_A162_R0.7221.00
140_A176_V0.7181.00
134_H183_R0.7141.00
121_T154_M0.7121.00
99_R135_N0.7101.00
48_Q51_D0.7091.00
11_R114_G0.7081.00
47_E50_A0.7061.00
145_E152_A0.6981.00
140_A147_S0.6931.00
19_R57_V0.6901.00
110_Y113_S0.6891.00
167_Y171_G0.6861.00
31_D107_R0.6851.00
139_A175_E0.6841.00
24_H107_R0.6731.00
120_A150_L0.6731.00
37_S143_F0.6711.00
27_R109_E0.6631.00
164_E172_Y0.6621.00
112_G149_G0.6521.00
138_A147_S0.6501.00
55_H59_D0.6491.00
10_D118_D0.6471.00
143_F171_G0.6431.00
28_S86_P0.6421.00
9_G14_L0.6381.00
67_V90_F0.6371.00
64_V91_S0.6351.00
117_R146_A0.6321.00
69_V110_Y0.6241.00
149_G153_A0.6151.00
90_F120_A0.6151.00
100_A127_V0.6101.00
32_P36_H0.6091.00
151_L178_Y0.6071.00
12_V118_D0.6061.00
157_T163_R0.6061.00
47_E51_D0.6061.00
106_L110_Y0.5971.00
146_A149_G0.5971.00
95_V100_A0.5941.00
87_I115_Y0.5931.00
31_D111_T0.5921.00
44_R49_Q0.5911.00
168_I171_G0.5901.00
26_Q30_T0.5901.00
92_A100_A0.5861.00
15_R18_E0.5861.00
116_G120_A0.5861.00
138_A178_Y0.5821.00
115_Y118_D0.5821.00
27_R30_T0.5791.00
11_R70_D0.5791.00
35_R40_S0.5771.00
104_Y116_G0.5751.00
154_M180_V0.5741.00
15_R66_V0.5721.00
67_V115_Y0.5691.00
120_A156_F0.5681.00
135_N165_A0.5671.00
137_S162_R0.5671.00
142_D148_R0.5621.00
46_R49_Q0.5591.00
56_W64_V0.5571.00
164_E182_R0.5541.00
104_Y150_L0.5521.00
139_A177_W0.5511.00
112_G150_L0.5501.00
166_R175_E0.5481.00
100_A136_V0.5441.00
125_D130_Q0.5441.00
137_S165_A0.5431.00
55_H58_E0.5401.00
34_I105_W0.5331.00
67_V88_G0.5281.00
98_D134_H0.5231.00
164_E181_L0.5211.00
53_I57_V0.5201.00
106_L111_T0.5181.00
53_I56_W0.5181.00
49_Q52_G0.5181.00
38_L105_W0.5171.00
141_Y168_I0.5171.00
167_Y170_G0.5161.00
93_R101_W0.5141.00
94_H100_A0.5121.00
168_I173_A0.5101.00
86_P89_S0.5061.00
38_L41_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pzjA 2 0.9162 100 0.314 Contact Map
1yreA 2 0.8953 100 0.34 Contact Map
2vzyA 3 0.8377 100 0.341 Contact Map
3tcvA 2 0.9424 100 0.356 Contact Map
2z10A 2 0.9267 100 0.361 Contact Map
2fckA 2 0.8796 100 0.364 Contact Map
3r9fA 1 0.8691 100 0.374 Contact Map
2zw5A 2 0.9162 100 0.376 Contact Map
3fbuA 2 0.8691 100 0.383 Contact Map
1nslA 3 0.8901 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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