Q9HRY4 - HALSA - GREMLIN Contacts

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Q9HRY4 - Uncharacterized protein

UniProt:	Q9HRY4	Sequences: METVADVVATLDDPAQPVLRHARPMDARTTRNRVYKTGNALRHRGVRVDAGVAILDAPTPEAVQTFLGASLLGATVAFGPEPVVDARVLAGPTADLGAYDLPAGGQRVGWGEPPADPSWMYFERDVWSENPAFPEPEIDADTTLLAAGGATHREVVAAAERVASERYDSHDAVAVRAPLSDPGTVVAGVVAPLLAGATVVLPPEGGEGTVAVAAADADAVPEADVVSPGSAAPN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	234 (220)
Sequences:	70190 (55230)
Seq/√Len:	3723.6

ECOLI - ENTF AAS ACSA PRPE FADK ENTE CAIC LCFA MENE
BACSU - PPSE SRFAC PPSC PPSB YDAB ACSA LCFB MENE YNGI DHBE YTCI LCFA YHFT DLTA DHBF
HALSA - Q9HRY4 Q9HRY8 Q9HQU8 Q9HNK0 Q9HSM3 Q9HQ43 Q9HQN8
SULSO - Q97WQ9 Q97WU4 Q97U22 Q97UX8 Q97VU7 Q97YI1 Q97UW7 Q97WQ0 Q97YK9 Q97XW4 Q97VT6 Q97WK0 Q97WS5 Q97V27 Q97UF6 Q97X52 Q980E4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_Y	71_L	3.618	1.00
53_A	95_D	3.277	1.00
31_R	71_L	3.255	1.00
92_P	145_L	2.891	1.00
50_A	96_L	2.826	1.00
33_R	64_Q	2.785	1.00
172_A	198_T	2.749	1.00
46_V	74_A	2.705	1.00
31_R	35_Y	2.651	1.00
40_A	44_R	2.626	1.00
13_D	16_Q	2.599	1.00
17_P	24_P	2.533	1.00
69_A	74_A	2.359	1.00
9_A	31_R	2.161	1.00
47_R	50_A	2.133	1.00
65_T	99_Y	2.056	1.00
51_G	76_V	2.017	1.00
163_A	195_A	2.011	1.00
26_D	29_T	2.010	1.00
136_P	139_D	1.964	1.00
171_D	223_A	1.886	1.00
87_R	91_G	1.865	1.00
28_R	32_N	1.846	1.00
42_R	72_L	1.837	1.00
151_T	154_E	1.816	1.00
14_P	28_R	1.747	1.00
20_R	60_P	1.745	1.00
53_A	78_F	1.743	1.00
48_V	139_D	1.741	1.00
37_T	64_Q	1.732	1.00
216_D	220_V	1.731	1.00
49_D	139_D	1.729	1.00
172_A	200_V	1.718	1.00
15_A	28_R	1.704	1.00
25_M	64_Q	1.681	1.00
70_S	141_D	1.674	1.00
34_V	71_L	1.670	1.00
63_V	189_V	1.658	1.00
52_V	69_A	1.640	1.00
79_G	180_S	1.622	1.00
215_A	219_A	1.620	1.00
88_V	92_P	1.602	1.00
23_R	60_P	1.599	1.00
51_G	143_T	1.595	1.00
76_V	93_T	1.578	1.00
168_D	171_D	1.577	1.00
150_A	154_E	1.573	1.00
200_V	222_E	1.550	1.00
57_A	101_L	1.531	1.00
137_E	153_R	1.517	1.00
67_L	193_L	1.504	1.00
174_A	222_E	1.500	1.00
93_T	145_L	1.496	1.00
25_M	60_P	1.491	1.00
202_P	216_D	1.471	1.00
17_P	198_T	1.454	1.00
90_A	95_D	1.445	1.00
192_P	197_A	1.443	1.00
177_A	183_G	1.443	1.00
18_V	27_A	1.441	1.00
212_V	215_A	1.435	1.00
206_G	212_V	1.416	1.00
84_V	87_R	1.362	1.00
9_A	71_L	1.351	1.00
118_S	121_Y	1.348	1.00
138_I	153_R	1.345	1.00
135_E	139_D	1.340	1.00
20_R	23_R	1.336	1.00
35_Y	39_N	1.326	1.00
87_R	114_P	1.312	1.00
227_S	230_S	1.309	1.00
200_V	220_V	1.296	1.00
21_H	203_P	1.290	1.00
171_D	224_D	1.286	1.00
33_R	36_K	1.282	1.00
18_V	30_T	1.269	1.00
84_V	110_W	1.261	1.00
183_G	226_V	1.255	1.00
138_I	151_T	1.243	1.00
16_Q	170_H	1.243	1.00
38_G	71_L	1.234	1.00
53_A	90_A	1.234	1.00
25_M	33_R	1.208	1.00
43_H	126_V	1.195	1.00
66_F	75_T	1.186	1.00
174_A	202_P	1.181	1.00
46_V	97_G	1.167	1.00
46_V	50_A	1.159	1.00
40_A	43_H	1.155	1.00
84_V	107_R	1.148	1.00
38_G	72_L	1.143	1.00
30_T	64_Q	1.136	1.00
123_E	126_V	1.129	1.00
52_V	74_A	1.126	1.00
51_G	94_A	1.118	1.00
82_P	89_L	1.106	1.00
173_V	192_P	1.098	1.00
62_A	179_L	1.095	1.00
66_F	185_V	1.087	1.00
85_D	88_V	1.086	1.00
61_E	64_Q	1.083	1.00
32_N	36_K	1.069	1.00
46_V	52_V	1.050	1.00
53_A	76_V	1.047	1.00
53_A	98_A	1.042	1.00
158_A	186_V	1.037	1.00
31_R	130_N	1.023	1.00
66_F	70_S	1.015	1.00
57_A	103_A	1.012	1.00
172_A	222_E	1.008	1.00
200_V	216_D	1.006	1.00
117_P	120_M	1.005	1.00
88_V	91_G	1.001	1.00
33_R	61_E	1.000	1.00
59_T	101_L	0.997	1.00
83_V	86_A	0.996	1.00
175_V	188_G	0.995	1.00
40_A	122_F	0.992	1.00
54_I	65_T	0.989	1.00
37_T	68_G	0.988	1.00
160_E	164_S	0.984	1.00
172_A	223_A	0.982	1.00
30_T	67_L	0.981	1.00
63_V	201_L	0.974	1.00
56_D	59_T	0.973	1.00
37_T	65_T	0.971	1.00
9_A	35_Y	0.964	1.00
105_G	109_G	0.956	1.00
40_A	126_V	0.954	1.00
54_I	75_T	0.953	1.00
33_R	60_P	0.953	1.00
50_A	74_A	0.947	1.00
171_D	197_A	0.947	1.00
158_A	162_V	0.947	1.00
203_P	206_G	0.937	1.00
25_M	30_T	0.936	1.00
19_L	63_V	0.922	1.00
42_R	47_R	0.922	1.00
60_P	64_Q	0.913	1.00
29_T	33_R	0.911	1.00
56_D	62_A	0.911	1.00
29_T	32_N	0.910	1.00
39_N	42_R	0.906	1.00
104_G	107_R	0.902	1.00
226_V	229_G	0.901	1.00
37_T	99_Y	0.898	1.00
75_T	185_V	0.885	1.00
41_L	99_Y	0.885	1.00
66_F	190_V	0.880	1.00
69_A	75_T	0.871	1.00
19_L	60_P	0.868	1.00
159_A	194_L	0.867	1.00
101_L	104_G	0.867	1.00
174_A	216_D	0.858	1.00
163_A	191_A	0.858	1.00
42_R	130_N	0.858	1.00
24_P	198_T	0.851	1.00
142_T	185_V	0.848	1.00
30_T	34_V	0.825	1.00
119_W	122_F	0.820	1.00
192_P	199_V	0.814	1.00
161_R	165_E	0.811	1.00
48_V	135_E	0.809	1.00
112_E	116_D	0.808	1.00
160_E	194_L	0.807	1.00
107_R	110_W	0.807	1.00
67_L	190_V	0.806	1.00
178_P	181_D	0.804	1.00
36_K	40_A	0.801	1.00
217_A	222_E	0.800	1.00
140_A	151_T	0.796	1.00
162_V	186_V	0.792	1.00
76_V	95_D	0.792	1.00
16_Q	169_S	0.788	1.00
41_L	69_A	0.787	1.00
13_D	169_S	0.783	1.00
215_A	218_D	0.782	1.00
16_Q	198_T	0.781	1.00
174_A	217_A	0.780	1.00
175_V	184_T	0.772	1.00
37_T	40_A	0.771	1.00
202_P	205_G	0.755	1.00
53_A	93_T	0.751	1.00
186_V	226_V	0.748	1.00
216_D	219_A	0.746	1.00
100_D	105_G	0.745	1.00
120_M	123_E	0.743	1.00
13_D	196_G	0.741	1.00
34_V	68_G	0.739	1.00
183_G	186_V	0.736	1.00
172_A	221_P	0.731	1.00
55_L	98_A	0.729	1.00
52_V	97_G	0.726	1.00
70_S	75_T	0.726	1.00
8_V	31_R	0.724	1.00
161_R	164_S	0.722	1.00
88_V	145_L	0.721	1.00
175_V	199_V	0.719	1.00
11_L	14_P	0.712	1.00
150_A	182_P	0.712	1.00
167_Y	224_D	0.711	1.00
211_A	215_A	0.709	1.00
44_R	97_G	0.707	1.00
42_R	131_P	0.706	1.00
39_N	128_S	0.704	1.00
173_V	224_D	0.702	1.00
160_E	163_A	0.698	1.00
15_A	26_D	0.696	1.00
32_N	128_S	0.696	1.00
19_L	199_V	0.691	1.00
47_R	74_A	0.691	1.00
214_A	218_D	0.689	1.00
81_E	204_E	0.688	1.00
106_Q	109_G	0.684	1.00
205_G	213_A	0.684	1.00
113_P	116_D	0.680	1.00
198_T	220_V	0.680	1.00
144_L	182_P	0.678	1.00
37_T	41_L	0.673	1.00
39_N	43_H	0.672	1.00
17_P	26_D	0.667	1.00
217_A	225_V	0.666	1.00
7_V	10_T	0.666	1.00
142_T	150_A	0.659	1.00
23_R	33_R	0.655	1.00
68_G	72_L	0.654	1.00
176_R	227_S	0.654	1.00
226_V	230_S	0.653	1.00
57_A	104_G	0.651	1.00
119_W	123_E	0.650	1.00
69_A	72_L	0.649	1.00
206_G	210_V	0.646	1.00
212_V	216_D	0.642	1.00
142_T	155_V	0.638	1.00
20_R	203_P	0.637	1.00
111_G	114_P	0.636	1.00
30_T	63_V	0.633	1.00
202_P	213_A	0.622	1.00
64_Q	68_G	0.619	1.00
76_V	89_L	0.619	1.00
146_A	149_G	0.616	1.00
159_A	190_V	0.613	1.00
76_V	145_L	0.605	1.00
79_G	82_P	0.605	1.00
48_V	133_F	0.602	1.00
174_A	213_A	0.599	1.00
54_I	62_A	0.599	1.00
175_V	201_L	0.598	1.00
17_P	20_R	0.596	1.00
24_P	220_V	0.595	1.00
75_T	142_T	0.594	1.00
33_R	37_T	0.593	1.00
117_P	121_Y	0.592	1.00
184_T	188_G	0.589	1.00
141_D	152_H	0.589	1.00
51_G	140_A	0.587	1.00
38_G	68_G	0.586	1.00
66_F	142_T	0.586	1.00
202_P	212_V	0.586	1.00
135_E	152_H	0.584	1.00
39_N	127_W	0.582	1.00
167_Y	171_D	0.580	1.00
117_P	122_F	0.580	1.00
82_P	86_A	0.580	1.00
172_A	175_V	0.579	1.00
162_V	191_A	0.579	1.00
62_A	77_A	0.578	1.00
57_A	204_E	0.578	1.00
49_D	140_A	0.572	1.00
158_A	161_R	0.572	1.00
56_D	65_T	0.572	1.00
39_N	130_N	0.572	1.00
170_H	223_A	0.571	1.00
130_N	133_F	0.570	1.00
45_G	74_A	0.570	1.00
177_A	226_V	0.570	1.00
34_V	38_G	0.570	1.00
70_S	152_H	0.569	1.00
7_V	160_E	0.569	1.00
28_R	31_R	0.569	1.00
56_D	101_L	0.567	1.00
25_M	29_T	0.564	1.00
213_A	225_V	0.563	1.00
42_R	133_F	0.562	1.00
34_V	37_T	0.560	1.00
176_R	228_P	0.558	1.00
39_N	129_E	0.557	1.00
62_A	66_F	0.554	1.00
63_V	193_L	0.553	1.00
31_R	34_V	0.552	1.00
159_A	191_A	0.551	1.00
157_A	161_R	0.551	1.00
48_V	73_G	0.550	1.00
82_P	180_S	0.548	1.00
188_G	192_P	0.547	1.00
78_F	90_A	0.545	1.00
112_E	115_A	0.544	1.00
66_F	189_V	0.539	1.00
61_E	101_L	0.538	1.00
77_A	144_L	0.537	1.00
188_G	226_V	0.536	1.00
157_A	160_E	0.536	1.00
213_A	217_A	0.536	1.00
153_R	157_A	0.534	1.00
11_L	31_R	0.534	1.00
109_G	112_E	0.532	1.00
141_D	155_V	0.531	1.00
52_V	99_Y	0.529	1.00
150_A	155_V	0.529	1.00
186_V	191_A	0.529	1.00
182_P	186_V	0.528	1.00
27_A	193_L	0.527	1.00
36_K	128_S	0.527	1.00
86_A	89_L	0.521	1.00
13_D	27_A	0.520	1.00
185_V	190_V	0.518	1.00
40_A	123_E	0.518	1.00
39_N	126_V	0.518	1.00
51_G	96_L	0.517	1.00
203_P	212_V	0.516	1.00
65_T	69_A	0.511	1.00
55_L	107_R	0.509	1.00
183_G	188_G	0.509	1.00
43_H	125_D	0.508	1.00
55_L	104_G	0.508	1.00
158_A	188_G	0.508	1.00
167_Y	191_A	0.503	1.00
163_A	194_L	0.503	1.00
98_A	108_V	0.502	1.00
74_A	97_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tsyA	2	0.9872	100	0.315	Contact Map
1pg4A	1	1	100	0.318	Contact Map
2d1sA	1	0.9829	100	0.321	Contact Map
3wv4A	1	0.9615	100	0.328	Contact Map
3ni2A	1	0.9872	100	0.33	Contact Map
4dg8A	1	0.9744	100	0.33	Contact Map
3g7sA	2	0.9829	100	0.331	Contact Map
3wvnA	1	0.9701	100	0.333	Contact Map
3kxwA	1	0.9786	100	0.333	Contact Map
2vsqA	1	0.9957	100	0.333	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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