GREMLIN Database
Q9HRY4 - Uncharacterized protein
UniProt: Q9HRY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (220)
Sequences: 70190 (55230)
Seq/√Len: 3723.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y71_L3.6181.00
53_A95_D3.2771.00
31_R71_L3.2551.00
92_P145_L2.8911.00
50_A96_L2.8261.00
33_R64_Q2.7851.00
172_A198_T2.7491.00
46_V74_A2.7051.00
31_R35_Y2.6511.00
40_A44_R2.6261.00
13_D16_Q2.5991.00
17_P24_P2.5331.00
69_A74_A2.3591.00
9_A31_R2.1611.00
47_R50_A2.1331.00
65_T99_Y2.0561.00
51_G76_V2.0171.00
163_A195_A2.0111.00
26_D29_T2.0101.00
136_P139_D1.9641.00
171_D223_A1.8861.00
87_R91_G1.8651.00
28_R32_N1.8461.00
42_R72_L1.8371.00
151_T154_E1.8161.00
14_P28_R1.7471.00
20_R60_P1.7451.00
53_A78_F1.7431.00
48_V139_D1.7411.00
37_T64_Q1.7321.00
216_D220_V1.7311.00
49_D139_D1.7291.00
172_A200_V1.7181.00
15_A28_R1.7041.00
25_M64_Q1.6811.00
70_S141_D1.6741.00
34_V71_L1.6701.00
63_V189_V1.6581.00
52_V69_A1.6401.00
79_G180_S1.6221.00
215_A219_A1.6201.00
88_V92_P1.6021.00
23_R60_P1.5991.00
51_G143_T1.5951.00
76_V93_T1.5781.00
168_D171_D1.5771.00
150_A154_E1.5731.00
200_V222_E1.5501.00
57_A101_L1.5311.00
137_E153_R1.5171.00
67_L193_L1.5041.00
174_A222_E1.5001.00
93_T145_L1.4961.00
25_M60_P1.4911.00
202_P216_D1.4711.00
17_P198_T1.4541.00
90_A95_D1.4451.00
192_P197_A1.4431.00
177_A183_G1.4431.00
18_V27_A1.4411.00
212_V215_A1.4351.00
206_G212_V1.4161.00
84_V87_R1.3621.00
9_A71_L1.3511.00
118_S121_Y1.3481.00
138_I153_R1.3451.00
135_E139_D1.3401.00
20_R23_R1.3361.00
35_Y39_N1.3261.00
87_R114_P1.3121.00
227_S230_S1.3091.00
200_V220_V1.2961.00
21_H203_P1.2901.00
171_D224_D1.2861.00
33_R36_K1.2821.00
18_V30_T1.2691.00
84_V110_W1.2611.00
183_G226_V1.2551.00
138_I151_T1.2431.00
16_Q170_H1.2431.00
38_G71_L1.2341.00
53_A90_A1.2341.00
25_M33_R1.2081.00
43_H126_V1.1951.00
66_F75_T1.1861.00
174_A202_P1.1811.00
46_V97_G1.1671.00
46_V50_A1.1591.00
40_A43_H1.1551.00
84_V107_R1.1481.00
38_G72_L1.1431.00
30_T64_Q1.1361.00
123_E126_V1.1291.00
52_V74_A1.1261.00
51_G94_A1.1181.00
82_P89_L1.1061.00
173_V192_P1.0981.00
62_A179_L1.0951.00
66_F185_V1.0871.00
85_D88_V1.0861.00
61_E64_Q1.0831.00
32_N36_K1.0691.00
46_V52_V1.0501.00
53_A76_V1.0471.00
53_A98_A1.0421.00
158_A186_V1.0371.00
31_R130_N1.0231.00
66_F70_S1.0151.00
57_A103_A1.0121.00
172_A222_E1.0081.00
200_V216_D1.0061.00
117_P120_M1.0051.00
88_V91_G1.0011.00
33_R61_E1.0001.00
59_T101_L0.9971.00
83_V86_A0.9961.00
175_V188_G0.9951.00
40_A122_F0.9921.00
54_I65_T0.9891.00
37_T68_G0.9881.00
160_E164_S0.9841.00
172_A223_A0.9821.00
30_T67_L0.9811.00
63_V201_L0.9741.00
56_D59_T0.9731.00
37_T65_T0.9711.00
9_A35_Y0.9641.00
105_G109_G0.9561.00
40_A126_V0.9541.00
54_I75_T0.9531.00
33_R60_P0.9531.00
50_A74_A0.9471.00
171_D197_A0.9471.00
158_A162_V0.9471.00
203_P206_G0.9371.00
25_M30_T0.9361.00
19_L63_V0.9221.00
42_R47_R0.9221.00
60_P64_Q0.9131.00
29_T33_R0.9111.00
56_D62_A0.9111.00
29_T32_N0.9101.00
39_N42_R0.9061.00
104_G107_R0.9021.00
226_V229_G0.9011.00
37_T99_Y0.8981.00
75_T185_V0.8851.00
41_L99_Y0.8851.00
66_F190_V0.8801.00
69_A75_T0.8711.00
19_L60_P0.8681.00
159_A194_L0.8671.00
101_L104_G0.8671.00
174_A216_D0.8581.00
163_A191_A0.8581.00
42_R130_N0.8581.00
24_P198_T0.8511.00
142_T185_V0.8481.00
30_T34_V0.8251.00
119_W122_F0.8201.00
192_P199_V0.8141.00
161_R165_E0.8111.00
48_V135_E0.8091.00
112_E116_D0.8081.00
160_E194_L0.8071.00
107_R110_W0.8071.00
67_L190_V0.8061.00
178_P181_D0.8041.00
36_K40_A0.8011.00
217_A222_E0.8001.00
140_A151_T0.7961.00
162_V186_V0.7921.00
76_V95_D0.7921.00
16_Q169_S0.7881.00
41_L69_A0.7871.00
13_D169_S0.7831.00
215_A218_D0.7821.00
16_Q198_T0.7811.00
174_A217_A0.7801.00
175_V184_T0.7721.00
37_T40_A0.7711.00
202_P205_G0.7551.00
53_A93_T0.7511.00
186_V226_V0.7481.00
216_D219_A0.7461.00
100_D105_G0.7451.00
120_M123_E0.7431.00
13_D196_G0.7411.00
34_V68_G0.7391.00
183_G186_V0.7361.00
172_A221_P0.7311.00
55_L98_A0.7291.00
52_V97_G0.7261.00
70_S75_T0.7261.00
8_V31_R0.7241.00
161_R164_S0.7221.00
88_V145_L0.7211.00
175_V199_V0.7191.00
11_L14_P0.7121.00
150_A182_P0.7121.00
167_Y224_D0.7111.00
211_A215_A0.7091.00
44_R97_G0.7071.00
42_R131_P0.7061.00
39_N128_S0.7041.00
173_V224_D0.7021.00
160_E163_A0.6981.00
15_A26_D0.6961.00
32_N128_S0.6961.00
19_L199_V0.6911.00
47_R74_A0.6911.00
214_A218_D0.6891.00
81_E204_E0.6881.00
106_Q109_G0.6841.00
205_G213_A0.6841.00
113_P116_D0.6801.00
198_T220_V0.6801.00
144_L182_P0.6781.00
37_T41_L0.6731.00
39_N43_H0.6721.00
17_P26_D0.6671.00
217_A225_V0.6661.00
7_V10_T0.6661.00
142_T150_A0.6591.00
23_R33_R0.6551.00
68_G72_L0.6541.00
176_R227_S0.6541.00
226_V230_S0.6531.00
57_A104_G0.6511.00
119_W123_E0.6501.00
69_A72_L0.6491.00
206_G210_V0.6461.00
212_V216_D0.6421.00
142_T155_V0.6381.00
20_R203_P0.6371.00
111_G114_P0.6361.00
30_T63_V0.6331.00
202_P213_A0.6221.00
64_Q68_G0.6191.00
76_V89_L0.6191.00
146_A149_G0.6161.00
159_A190_V0.6131.00
76_V145_L0.6051.00
79_G82_P0.6051.00
48_V133_F0.6021.00
174_A213_A0.5991.00
54_I62_A0.5991.00
175_V201_L0.5981.00
17_P20_R0.5961.00
24_P220_V0.5951.00
75_T142_T0.5941.00
33_R37_T0.5931.00
117_P121_Y0.5921.00
184_T188_G0.5891.00
141_D152_H0.5891.00
51_G140_A0.5871.00
38_G68_G0.5861.00
66_F142_T0.5861.00
202_P212_V0.5861.00
135_E152_H0.5841.00
39_N127_W0.5821.00
167_Y171_D0.5801.00
117_P122_F0.5801.00
82_P86_A0.5801.00
172_A175_V0.5791.00
162_V191_A0.5791.00
62_A77_A0.5781.00
57_A204_E0.5781.00
49_D140_A0.5721.00
158_A161_R0.5721.00
56_D65_T0.5721.00
39_N130_N0.5721.00
170_H223_A0.5711.00
130_N133_F0.5701.00
45_G74_A0.5701.00
177_A226_V0.5701.00
34_V38_G0.5701.00
70_S152_H0.5691.00
7_V160_E0.5691.00
28_R31_R0.5691.00
56_D101_L0.5671.00
25_M29_T0.5641.00
213_A225_V0.5631.00
42_R133_F0.5621.00
34_V37_T0.5601.00
176_R228_P0.5581.00
39_N129_E0.5571.00
62_A66_F0.5541.00
63_V193_L0.5531.00
31_R34_V0.5521.00
159_A191_A0.5511.00
157_A161_R0.5511.00
48_V73_G0.5501.00
82_P180_S0.5481.00
188_G192_P0.5471.00
78_F90_A0.5451.00
112_E115_A0.5441.00
66_F189_V0.5391.00
61_E101_L0.5381.00
77_A144_L0.5371.00
188_G226_V0.5361.00
157_A160_E0.5361.00
213_A217_A0.5361.00
153_R157_A0.5341.00
11_L31_R0.5341.00
109_G112_E0.5321.00
141_D155_V0.5311.00
52_V99_Y0.5291.00
150_A155_V0.5291.00
186_V191_A0.5291.00
182_P186_V0.5281.00
27_A193_L0.5271.00
36_K128_S0.5271.00
86_A89_L0.5211.00
13_D27_A0.5201.00
185_V190_V0.5181.00
40_A123_E0.5181.00
39_N126_V0.5181.00
51_G96_L0.5171.00
203_P212_V0.5161.00
65_T69_A0.5111.00
55_L107_R0.5091.00
183_G188_G0.5091.00
43_H125_D0.5081.00
55_L104_G0.5081.00
158_A188_G0.5081.00
167_Y191_A0.5031.00
163_A194_L0.5031.00
98_A108_V0.5021.00
74_A97_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tsyA 2 0.9872 100 0.315 Contact Map
1pg4A 1 1 100 0.318 Contact Map
2d1sA 1 0.9829 100 0.321 Contact Map
3wv4A 1 0.9615 100 0.328 Contact Map
3ni2A 1 0.9872 100 0.33 Contact Map
4dg8A 1 0.9744 100 0.33 Contact Map
3g7sA 2 0.9829 100 0.331 Contact Map
3wvnA 1 0.9701 100 0.333 Contact Map
3kxwA 1 0.9786 100 0.333 Contact Map
2vsqA 1 0.9957 100 0.333 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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