DNAJ - HALSA - GREMLIN Contacts

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DNAJ - Chaperone protein DnaJ

UniProt:	Q9HRY3	Sequences: MSEDFYDVLGVSRDATEDEIMQAYRDQVSEYHPDVSDDPDAEEKFKKIQKAKDVLTDEETRQQYDQLGHERFEEAEKRGATGNGGGGAGGMGGAGGPFGGGMGGGAGGGMGDIFEQFFGGAGGGGGRGRSGPEQGRDLRTDLTVTLSEAYRGVSKQVTVRRPESCADCGGSGYPEDADVRTCPQCDGQGVVTQVRQTPLGRVQQRQECSRCGGEGELHSETCSTCGGQGQTRERATLTVDIPEGIRTGQTLRMDGEGAPGEPGAPNGDLLVDVTVEEHPDFERDGDDLHHRHAVSFPQAVFGAEIEVPTLDGAATFDLDAGTQSGETFRLKGKGMPRLRRRGNGDLYVTVQVVTPESLSDEQRDALEQFAEAGGEEIDVEQGFFEKLKNSF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	391 (349)
Sequences:	5209 (3294)
Seq/√Len:	176.3

ECOLI - DNAJ CBPA
BACSU - DNAJ
HALSA - DNAJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_T	19_E	3.888	1.00
167_D	224_T	3.516	1.00
17_E	58_E	3.436	1.00
298_Q	303_A	3.298	1.00
361_E	368_Q	3.185	1.00
150_Y	335_M	3.165	1.00
184_Q	210_R	3.164	1.00
174_P	220_E	3.066	1.00
29_S	35_V	3.003	1.00
154_S	240_D	2.930	1.00
180_R	219_S	2.911	1.00
154_S	238_T	2.870	1.00
304_E	315_T	2.690	1.00
174_P	223_S	2.651	1.00
147_S	278_H	2.621	1.00
289_H	349_T	2.531	1.00
288_L	346_L	2.526	1.00
286_D	337_R	2.466	1.00
293_A	353_V	2.437	1.00
363_R	367_E	2.393	1.00
145_T	276_E	2.377	1.00
62_Q	66_Q	2.320	1.00
156_Q	236_T	2.302	1.00
143_T	276_E	2.283	1.00
158_T	234_R	2.271	1.00
3_E	47_K	2.192	1.00
291_R	349_T	2.180	1.00
190_V	205_R	2.178	1.00
324_S	354_T	2.168	1.00
148_E	155_K	2.153	1.00
42_E	46_K	2.151	1.00
183_P	210_R	2.134	1.00
235_A	256_E	2.127	1.00
36_S	41_A	2.068	1.00
361_E	364_D	2.001	1.00
359_S	362_Q	2.001	1.00
365_A	368_Q	1.982	1.00
291_R	351_Q	1.980	1.00
327_T	347_Y	1.962	1.00
304_E	317_D	1.931	1.00
322_T	350_V	1.920	1.00
191_V	209_S	1.901	1.00
163_E	233_E	1.894	1.00
192_T	203_Q	1.862	1.00
143_T	274_T	1.861	1.00
27_Q	48_I	1.854	1.00
39_P	42_E	1.815	1.00
296_F	300_V	1.809	1.00
3_E	8_V	1.799	1.00
364_D	368_Q	1.791	1.00
167_D	174_P	1.763	1.00
306_E	313_A	1.741	1.00
295_S	298_Q	1.735	1.00
141_D	274_T	1.734	1.00
329_R	345_D	1.732	1.00
63_Q	72_F	1.732	1.00
139_R	272_D	1.730	1.00
59_E	62_Q	1.718	1.00
59_E	63_Q	1.711	1.00
136_R	258_A	1.708	1.00
145_T	148_E	1.695	1.00
166_A	224_T	1.691	1.00
247_T	274_T	1.681	1.00
148_E	153_V	1.668	1.00
37_D	40_D	1.661	1.00
184_Q	209_S	1.661	1.00
156_Q	238_T	1.660	1.00
311_D	343_N	1.655	1.00
328_F	350_V	1.649	1.00
166_A	233_E	1.617	1.00
293_A	351_Q	1.616	1.00
70_E	73_E	1.610	1.00
247_T	275_V	1.610	1.00
5_F	50_K	1.602	1.00
5_F	54_V	1.601	1.00
15_A	20_I	1.581	1.00
300_V	366_L	1.568	1.00
31_Y	48_I	1.560	1.00
3_E	7_D	1.553	1.00
306_E	315_T	1.537	1.00
27_Q	30_E	1.530	1.00
179_V	216_E	1.514	1.00
361_E	372_A	1.510	1.00
368_Q	371_E	1.498	1.00
173_Y	177_A	1.493	1.00
106_A	109_G	1.483	1.00
2_S	69_H	1.465	1.00
298_Q	370_A	1.458	1.00
366_L	369_F	1.436	1.00
245_I	249_Q	1.434	1.00
288_L	335_M	1.430	1.00
63_Q	67_L	1.425	1.00
12_S	19_E	1.422	1.00
158_T	236_T	1.408	1.00
58_E	61_R	1.407	1.00
294_V	299_A	1.396	1.00
245_I	273_V	1.393	1.00
150_Y	310_L	1.385	1.00
199_L	204_Q	1.371	1.00
11_V	20_I	1.354	1.00
369_F	373_G	1.335	1.00
319_D	328_F	1.334	1.00
327_T	349_T	1.315	1.00
4_D	7_D	1.312	1.00
146_L	288_L	1.310	1.00
14_D	19_E	1.302	1.00
27_Q	31_Y	1.292	1.00
166_A	231_T	1.284	1.00
142_L	273_V	1.281	1.00
2_S	7_D	1.270	1.00
177_A	220_E	1.263	1.00
184_Q	191_V	1.262	1.00
164_S	169_G	1.249	1.00
18_D	22_Q	1.248	1.00
162_P	230_Q	1.247	1.00
210_R	224_T	1.243	1.00
280_D	290_H	1.226	1.00
296_F	354_T	1.225	1.00
161_R	235_A	1.224	1.00
284_D	287_D	1.215	1.00
250_T	270_L	1.213	1.00
31_Y	44_K	1.210	1.00
246_R	286_D	1.198	1.00
360_D	367_E	1.196	1.00
160_R	232_R	1.193	1.00
249_Q	338_L	1.190	1.00
69_H	72_F	1.181	1.00
39_P	43_E	1.178	1.00
165_C	168_C	1.160	1.00
289_H	347_Y	1.159	1.00
222_C	225_C	1.156	1.00
364_D	367_E	1.153	1.00
146_L	335_M	1.153	1.00
336_P	343_N	1.145	1.00
193_Q	206_Q	1.143	1.00
109_G	115_E	1.143	1.00
142_L	241_I	1.137	1.00
292_H	305_I	1.134	1.00
183_P	217_L	1.131	1.00
300_V	354_T	1.121	1.00
332_G	345_D	1.116	1.00
297_P	300_V	1.115	1.00
67_L	71_R	1.113	1.00
50_K	69_H	1.105	1.00
4_D	13_R	1.105	1.00
253_M	271_V	1.105	1.00
310_L	346_L	1.104	1.00
314_A	333_K	1.103	1.00
253_M	256_E	1.087	1.00
2_S	50_K	1.083	1.00
201_R	204_Q	1.078	1.00
287_D	347_Y	1.071	1.00
290_H	346_L	1.070	1.00
210_R	217_L	1.067	1.00
44_K	47_K	1.065	1.00
24_Y	49_Q	1.060	1.00
192_T	205_R	1.055	1.00
108_G	115_E	1.054	1.00
144_V	149_A	1.052	1.00
149_A	275_V	1.051	1.00
26_D	29_S	1.048	1.00
367_E	370_A	1.040	1.00
361_E	365_A	1.039	0.99
324_S	351_Q	1.032	0.99
151_R	335_M	1.029	0.99
316_F	348_V	1.029	0.99
31_Y	36_S	1.028	0.99
146_L	149_A	1.025	0.99
167_D	175_E	1.023	0.99
316_F	328_F	1.020	0.99
111_G	115_E	1.019	0.99
280_D	308_P	1.016	0.99
165_C	225_C	1.013	0.99
149_A	246_R	1.011	0.99
367_E	371_E	1.011	0.99
160_R	234_R	1.011	0.99
199_L	202_V	1.009	0.99
134_Q	137_D	1.009	0.99
250_T	272_D	1.005	0.99
162_P	232_R	1.004	0.99
298_Q	305_I	1.003	0.99
181_T	186_D	0.998	0.99
362_Q	369_F	0.996	0.99
141_D	272_D	0.986	0.99
63_Q	71_R	0.985	0.99
149_A	335_M	0.983	0.99
277_E	282_E	0.983	0.99
167_D	184_Q	0.981	0.99
365_A	369_F	0.977	0.99
10_G	23_A	0.970	0.99
165_C	222_C	0.959	0.99
181_T	216_E	0.951	0.99
103_G	106_A	0.950	0.99
224_T	231_T	0.942	0.99
8_V	47_K	0.932	0.99
26_D	30_E	0.931	0.99
241_I	273_V	0.924	0.99
287_D	345_D	0.919	0.99
11_V	14_D	0.918	0.99
53_D	56_T	0.911	0.99
198_P	201_R	0.908	0.99
163_E	235_A	0.905	0.99
294_V	318_L	0.903	0.99
110_M	115_E	0.899	0.99
149_A	245_I	0.899	0.99
182_C	208_C	0.898	0.99
322_T	328_F	0.898	0.99
282_E	291_R	0.897	0.99
40_D	43_E	0.894	0.98
49_Q	53_D	0.886	0.98
300_V	358_L	0.884	0.98
3_E	69_H	0.884	0.98
168_C	182_C	0.883	0.98
63_Q	70_E	0.879	0.98
360_D	364_D	0.875	0.98
28_V	45_F	0.874	0.98
105_G	109_G	0.872	0.98
176_D	179_V	0.869	0.98
331_K	345_D	0.868	0.98
171_S	175_E	0.864	0.98
296_F	366_L	0.863	0.98
150_Y	343_N	0.863	0.98
168_C	225_C	0.862	0.98
260_G	265_P	0.859	0.98
252_R	270_L	0.853	0.98
107_G	110_M	0.852	0.98
290_H	308_P	0.851	0.98
173_Y	179_V	0.851	0.98
330_L	346_L	0.850	0.98
139_R	250_T	0.848	0.98
161_R	256_E	0.846	0.98
147_S	151_R	0.843	0.98
151_R	311_D	0.839	0.98
246_R	249_Q	0.833	0.98
325_G	351_Q	0.832	0.98
329_R	347_Y	0.830	0.98
144_V	148_E	0.829	0.98
297_P	369_F	0.826	0.97
214_E	262_P	0.821	0.97
45_F	49_Q	0.820	0.97
337_R	340_R	0.820	0.97
128_G	131_G	0.819	0.97
362_Q	366_L	0.815	0.97
208_C	211_C	0.815	0.97
72_F	76_E	0.814	0.97
223_S	226_G	0.814	0.97
113_I	116_Q	0.813	0.97
180_R	217_L	0.810	0.97
168_C	222_C	0.810	0.97
337_R	342_G	0.805	0.97
133_E	261_E	0.804	0.97
260_G	263_G	0.800	0.97
182_C	185_C	0.799	0.97
358_L	362_Q	0.797	0.97
140_T	157_V	0.797	0.97
37_D	42_E	0.793	0.97
182_C	187_G	0.792	0.97
146_L	150_Y	0.790	0.97
320_A	363_R	0.788	0.97
286_D	335_M	0.786	0.97
108_G	112_D	0.783	0.97
183_P	186_D	0.780	0.96
374_G	377_I	0.778	0.96
168_C	227_G	0.778	0.96
27_Q	44_K	0.775	0.96
318_L	350_V	0.773	0.96
180_R	183_P	0.772	0.96
72_F	75_A	0.771	0.96
38_D	42_E	0.770	0.96
2_S	8_V	0.769	0.96
161_R	258_A	0.767	0.96
308_P	313_A	0.764	0.96
110_M	113_I	0.763	0.96
297_P	370_A	0.762	0.96
131_G	262_P	0.761	0.96
309_T	314_A	0.758	0.96
198_P	204_Q	0.756	0.96
175_E	220_E	0.754	0.96
8_V	48_I	0.753	0.96
368_Q	372_A	0.752	0.96
175_E	178_D	0.752	0.96
43_E	47_K	0.751	0.96
292_H	350_V	0.751	0.96
316_F	330_L	0.750	0.96
105_G	111_G	0.749	0.96
284_D	289_H	0.746	0.95
198_P	202_V	0.745	0.95
187_G	215_G	0.742	0.95
52_K	56_T	0.742	0.95
214_E	217_L	0.741	0.95
57_D	60_T	0.740	0.95
58_E	62_Q	0.740	0.95
132_P	265_P	0.738	0.95
359_S	372_A	0.738	0.95
243_E	336_P	0.736	0.95
239_V	271_V	0.732	0.95
207_E	212_G	0.732	0.95
362_Q	372_A	0.731	0.95
173_Y	218_H	0.728	0.95
333_K	343_N	0.727	0.95
237_L	256_E	0.727	0.95
365_A	372_A	0.726	0.95
110_M	116_Q	0.722	0.95
30_E	44_K	0.722	0.95
360_D	363_R	0.719	0.94
303_A	318_L	0.719	0.94
11_V	61_R	0.718	0.94
36_S	39_P	0.718	0.94
146_L	275_V	0.718	0.94
370_A	374_G	0.717	0.94
120_G	123_G	0.716	0.94
299_A	302_G	0.714	0.94
112_D	116_Q	0.714	0.94
24_Y	53_D	0.713	0.94
130_S	262_P	0.711	0.94
109_G	113_I	0.710	0.94
313_A	333_K	0.709	0.94
182_C	211_C	0.707	0.94
261_E	264_A	0.707	0.94
109_G	118_F	0.706	0.94
228_Q	261_E	0.705	0.94
31_Y	41_A	0.703	0.94
165_C	170_G	0.702	0.94
63_Q	66_Q	0.701	0.94
5_F	69_H	0.697	0.93
167_D	223_S	0.696	0.93
171_S	176_D	0.695	0.93
239_V	253_M	0.694	0.93
146_L	151_R	0.693	0.93
146_L	278_H	0.691	0.93
242_P	245_I	0.690	0.93
297_P	366_L	0.689	0.93
370_A	377_I	0.687	0.93
144_V	245_I	0.687	0.93
161_R	233_E	0.687	0.93
290_H	348_V	0.682	0.93
142_L	271_V	0.682	0.93
307_V	346_L	0.681	0.93
36_S	40_D	0.680	0.93
22_Q	26_D	0.679	0.93
142_L	155_K	0.678	0.92
323_Q	354_T	0.675	0.92
237_L	253_M	0.674	0.92
2_S	47_K	0.674	0.92
353_V	356_E	0.671	0.92
188_Q	192_T	0.669	0.92
168_C	208_C	0.664	0.92
129_R	132_P	0.664	0.92
106_A	111_G	0.663	0.92
78_R	81_T	0.662	0.92
172_G	227_G	0.661	0.92
73_E	76_E	0.659	0.91
370_A	375_E	0.658	0.91
137_D	270_L	0.657	0.91
323_Q	356_E	0.657	0.91
185_C	211_C	0.656	0.91
362_Q	373_G	0.656	0.91
182_C	189_G	0.655	0.91
77_K	80_A	0.654	0.91
289_H	327_T	0.653	0.91
230_Q	259_P	0.653	0.91
28_V	35_V	0.652	0.91
182_C	215_G	0.651	0.91
247_T	277_E	0.648	0.91
187_G	211_C	0.646	0.91
144_V	275_V	0.646	0.91
112_D	115_E	0.646	0.91
111_G	116_Q	0.643	0.90
174_P	177_A	0.643	0.90
208_C	213_G	0.643	0.90
108_G	113_I	0.641	0.90
150_Y	309_T	0.641	0.90
134_Q	265_P	0.638	0.90
171_S	179_V	0.637	0.90
230_Q	261_E	0.636	0.90
104_G	107_G	0.633	0.90
178_D	216_E	0.632	0.90
190_V	207_E	0.629	0.89
151_R	343_N	0.629	0.89
7_D	12_S	0.628	0.89
209_S	212_G	0.628	0.89
144_V	153_V	0.626	0.89
7_D	13_R	0.622	0.89
41_A	44_K	0.622	0.89
179_V	220_E	0.620	0.89
251_L	273_V	0.619	0.89
306_E	314_A	0.618	0.89
107_G	111_G	0.615	0.88
44_K	48_I	0.614	0.88
308_P	314_A	0.612	0.88
69_H	73_E	0.611	0.88
187_G	208_C	0.610	0.88
113_I	117_F	0.608	0.88
290_H	293_A	0.606	0.88
115_E	118_F	0.606	0.88
70_E	74_E	0.605	0.88
117_F	121_A	0.605	0.88
11_V	19_E	0.604	0.87
322_T	326_E	0.603	0.87
112_D	118_F	0.602	0.87
43_E	46_K	0.602	0.87
282_E	289_H	0.601	0.87
50_K	53_D	0.598	0.87
192_T	198_P	0.598	0.87
71_R	75_A	0.596	0.87
295_S	303_A	0.595	0.87
2_S	73_E	0.595	0.87
311_D	333_K	0.595	0.87
165_C	227_G	0.595	0.87
358_L	366_L	0.592	0.86
165_C	182_C	0.592	0.86
280_D	293_A	0.592	0.86
138_L	258_A	0.590	0.86
292_H	348_V	0.588	0.86
185_C	189_G	0.586	0.86
63_Q	73_E	0.586	0.86
117_F	120_G	0.586	0.86
105_G	108_G	0.585	0.86
111_G	117_F	0.585	0.86
222_C	227_G	0.583	0.86
76_E	80_A	0.583	0.86
199_L	203_Q	0.583	0.86
185_C	215_G	0.583	0.86
134_Q	268_D	0.583	0.86
109_G	117_F	0.581	0.85
59_E	66_Q	0.580	0.85
165_C	211_C	0.580	0.85
104_G	108_G	0.579	0.85
162_P	228_Q	0.579	0.85
166_A	169_G	0.578	0.85
171_S	178_D	0.577	0.85
165_C	187_G	0.576	0.85
189_G	215_G	0.574	0.85
211_C	215_G	0.572	0.84
182_C	213_G	0.572	0.84
185_C	208_C	0.571	0.84
76_E	79_G	0.571	0.84
220_E	223_S	0.570	0.84
18_D	25_R	0.569	0.84
308_P	346_L	0.568	0.84
187_G	213_G	0.567	0.84
193_Q	204_Q	0.566	0.84
17_E	56_T	0.565	0.84
255_G	268_D	0.563	0.84
161_R	266_N	0.562	0.83
72_F	77_K	0.561	0.83
169_G	175_E	0.560	0.83
118_F	123_G	0.559	0.83
109_G	112_D	0.559	0.83
54_V	72_F	0.559	0.83
208_C	215_G	0.558	0.83
218_H	221_T	0.556	0.83
7_D	69_H	0.555	0.83
161_R	259_P	0.554	0.83
38_D	41_A	0.554	0.83
135_G	257_G	0.553	0.82
71_R	74_E	0.553	0.82
127_R	130_S	0.552	0.82
278_H	281_F	0.552	0.82
179_V	218_H	0.551	0.82
126_G	129_R	0.551	0.82
144_V	241_I	0.551	0.82
278_H	290_H	0.551	0.82
170_G	227_G	0.548	0.82
299_A	352_V	0.547	0.82
38_D	44_K	0.547	0.82
282_E	349_T	0.545	0.82
108_G	118_F	0.545	0.82
168_C	187_G	0.544	0.81
299_A	323_Q	0.543	0.81
297_P	373_G	0.542	0.81
137_D	252_R	0.541	0.81
309_T	335_M	0.541	0.81
67_L	70_E	0.541	0.81
330_L	333_K	0.540	0.81
293_A	297_P	0.540	0.81
168_C	211_C	0.537	0.81
259_P	262_P	0.537	0.81
373_G	377_I	0.537	0.81
192_T	201_R	0.535	0.80
281_F	310_L	0.534	0.80
151_R	243_E	0.533	0.80
75_A	78_R	0.533	0.80
123_G	128_G	0.532	0.80
175_E	179_V	0.532	0.80
12_S	16_T	0.531	0.80
257_G	264_A	0.530	0.80
310_L	335_M	0.530	0.80
229_G	242_P	0.530	0.80
323_Q	326_E	0.529	0.80
159_V	269_L	0.529	0.80
25_R	29_S	0.528	0.79
228_Q	231_T	0.525	0.79
300_V	321_G	0.525	0.79
138_L	161_R	0.525	0.79
140_T	271_V	0.523	0.79
294_V	298_Q	0.519	0.78
106_A	113_I	0.518	0.78
189_G	213_G	0.517	0.78
324_S	352_V	0.516	0.78
174_P	179_V	0.515	0.78
185_C	222_C	0.514	0.78
173_Y	221_T	0.513	0.78
105_G	110_M	0.511	0.77
180_R	218_H	0.510	0.77
159_V	235_A	0.509	0.77
165_C	189_G	0.508	0.77
174_P	180_R	0.508	0.77
162_P	258_A	0.507	0.77
294_V	350_V	0.506	0.77
302_G	321_G	0.506	0.77
169_G	212_G	0.505	0.76
106_A	110_M	0.504	0.76
19_E	22_Q	0.504	0.76
170_G	182_C	0.504	0.76
189_G	208_C	0.504	0.76
259_P	266_N	0.503	0.76
323_Q	352_V	0.503	0.76
314_A	330_L	0.503	0.76
292_H	303_A	0.503	0.76
164_S	259_P	0.503	0.76
67_L	73_E	0.501	0.76
354_T	366_L	0.500	0.76
278_H	310_L	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lz8A	2	0.4834	100	0.338	Contact Map
4j80A	2	0.688	100	0.365	Contact Map
1nltA	1	0.5703	100	0.454	Contact Map
2q2gA	3	0.445	100	0.605	Contact Map
3agxA	2	0.445	100	0.606	Contact Map
1c3gA	2	0.4297	100	0.623	Contact Map
4j7zA	1	0.2685	100	0.742	Contact Map
1bq0A	1	0.1944	100	0.76	Contact Map
3i38A	5	0.266	99.9	0.77	Contact Map
4wb7A	1	0.8568	99.9	0.771	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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