GREMLIN Database
DNAJ - Chaperone protein DnaJ
UniProt: Q9HRY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (349)
Sequences: 5209 (3294)
Seq/√Len: 176.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_T19_E3.8881.00
167_D224_T3.5161.00
17_E58_E3.4361.00
298_Q303_A3.2981.00
361_E368_Q3.1851.00
150_Y335_M3.1651.00
184_Q210_R3.1641.00
174_P220_E3.0661.00
29_S35_V3.0031.00
154_S240_D2.9301.00
180_R219_S2.9111.00
154_S238_T2.8701.00
304_E315_T2.6901.00
174_P223_S2.6511.00
147_S278_H2.6211.00
289_H349_T2.5311.00
288_L346_L2.5261.00
286_D337_R2.4661.00
293_A353_V2.4371.00
363_R367_E2.3931.00
145_T276_E2.3771.00
62_Q66_Q2.3201.00
156_Q236_T2.3021.00
143_T276_E2.2831.00
158_T234_R2.2711.00
3_E47_K2.1921.00
291_R349_T2.1801.00
190_V205_R2.1781.00
324_S354_T2.1681.00
148_E155_K2.1531.00
42_E46_K2.1511.00
183_P210_R2.1341.00
235_A256_E2.1271.00
36_S41_A2.0681.00
361_E364_D2.0011.00
359_S362_Q2.0011.00
365_A368_Q1.9821.00
291_R351_Q1.9801.00
327_T347_Y1.9621.00
304_E317_D1.9311.00
322_T350_V1.9201.00
191_V209_S1.9011.00
163_E233_E1.8941.00
192_T203_Q1.8621.00
143_T274_T1.8611.00
27_Q48_I1.8541.00
39_P42_E1.8151.00
296_F300_V1.8091.00
3_E8_V1.7991.00
364_D368_Q1.7911.00
167_D174_P1.7631.00
306_E313_A1.7411.00
295_S298_Q1.7351.00
141_D274_T1.7341.00
329_R345_D1.7321.00
63_Q72_F1.7321.00
139_R272_D1.7301.00
59_E62_Q1.7181.00
59_E63_Q1.7111.00
136_R258_A1.7081.00
145_T148_E1.6951.00
166_A224_T1.6911.00
247_T274_T1.6811.00
148_E153_V1.6681.00
37_D40_D1.6611.00
184_Q209_S1.6611.00
156_Q238_T1.6601.00
311_D343_N1.6551.00
328_F350_V1.6491.00
166_A233_E1.6171.00
293_A351_Q1.6161.00
70_E73_E1.6101.00
247_T275_V1.6101.00
5_F50_K1.6021.00
5_F54_V1.6011.00
15_A20_I1.5811.00
300_V366_L1.5681.00
31_Y48_I1.5601.00
3_E7_D1.5531.00
306_E315_T1.5371.00
27_Q30_E1.5301.00
179_V216_E1.5141.00
361_E372_A1.5101.00
368_Q371_E1.4981.00
173_Y177_A1.4931.00
106_A109_G1.4831.00
2_S69_H1.4651.00
298_Q370_A1.4581.00
366_L369_F1.4361.00
245_I249_Q1.4341.00
288_L335_M1.4301.00
63_Q67_L1.4251.00
12_S19_E1.4221.00
158_T236_T1.4081.00
58_E61_R1.4071.00
294_V299_A1.3961.00
245_I273_V1.3931.00
150_Y310_L1.3851.00
199_L204_Q1.3711.00
11_V20_I1.3541.00
369_F373_G1.3351.00
319_D328_F1.3341.00
327_T349_T1.3151.00
4_D7_D1.3121.00
146_L288_L1.3101.00
14_D19_E1.3021.00
27_Q31_Y1.2921.00
166_A231_T1.2841.00
142_L273_V1.2811.00
2_S7_D1.2701.00
177_A220_E1.2631.00
184_Q191_V1.2621.00
164_S169_G1.2491.00
18_D22_Q1.2481.00
162_P230_Q1.2471.00
210_R224_T1.2431.00
280_D290_H1.2261.00
296_F354_T1.2251.00
161_R235_A1.2241.00
284_D287_D1.2151.00
250_T270_L1.2131.00
31_Y44_K1.2101.00
246_R286_D1.1981.00
360_D367_E1.1961.00
160_R232_R1.1931.00
249_Q338_L1.1901.00
69_H72_F1.1811.00
39_P43_E1.1781.00
165_C168_C1.1601.00
289_H347_Y1.1591.00
222_C225_C1.1561.00
364_D367_E1.1531.00
146_L335_M1.1531.00
336_P343_N1.1451.00
193_Q206_Q1.1431.00
109_G115_E1.1431.00
142_L241_I1.1371.00
292_H305_I1.1341.00
183_P217_L1.1311.00
300_V354_T1.1211.00
332_G345_D1.1161.00
297_P300_V1.1151.00
67_L71_R1.1131.00
50_K69_H1.1051.00
4_D13_R1.1051.00
253_M271_V1.1051.00
310_L346_L1.1041.00
314_A333_K1.1031.00
253_M256_E1.0871.00
2_S50_K1.0831.00
201_R204_Q1.0781.00
287_D347_Y1.0711.00
290_H346_L1.0701.00
210_R217_L1.0671.00
44_K47_K1.0651.00
24_Y49_Q1.0601.00
192_T205_R1.0551.00
108_G115_E1.0541.00
144_V149_A1.0521.00
149_A275_V1.0511.00
26_D29_S1.0481.00
367_E370_A1.0401.00
361_E365_A1.0390.99
324_S351_Q1.0320.99
151_R335_M1.0290.99
316_F348_V1.0290.99
31_Y36_S1.0280.99
146_L149_A1.0250.99
167_D175_E1.0230.99
316_F328_F1.0200.99
111_G115_E1.0190.99
280_D308_P1.0160.99
165_C225_C1.0130.99
149_A246_R1.0110.99
367_E371_E1.0110.99
160_R234_R1.0110.99
199_L202_V1.0090.99
134_Q137_D1.0090.99
250_T272_D1.0050.99
162_P232_R1.0040.99
298_Q305_I1.0030.99
181_T186_D0.9980.99
362_Q369_F0.9960.99
141_D272_D0.9860.99
63_Q71_R0.9850.99
149_A335_M0.9830.99
277_E282_E0.9830.99
167_D184_Q0.9810.99
365_A369_F0.9770.99
10_G23_A0.9700.99
165_C222_C0.9590.99
181_T216_E0.9510.99
103_G106_A0.9500.99
224_T231_T0.9420.99
8_V47_K0.9320.99
26_D30_E0.9310.99
241_I273_V0.9240.99
287_D345_D0.9190.99
11_V14_D0.9180.99
53_D56_T0.9110.99
198_P201_R0.9080.99
163_E235_A0.9050.99
294_V318_L0.9030.99
110_M115_E0.8990.99
149_A245_I0.8990.99
182_C208_C0.8980.99
322_T328_F0.8980.99
282_E291_R0.8970.99
40_D43_E0.8940.98
49_Q53_D0.8860.98
300_V358_L0.8840.98
3_E69_H0.8840.98
168_C182_C0.8830.98
63_Q70_E0.8790.98
360_D364_D0.8750.98
28_V45_F0.8740.98
105_G109_G0.8720.98
176_D179_V0.8690.98
331_K345_D0.8680.98
171_S175_E0.8640.98
296_F366_L0.8630.98
150_Y343_N0.8630.98
168_C225_C0.8620.98
260_G265_P0.8590.98
252_R270_L0.8530.98
107_G110_M0.8520.98
290_H308_P0.8510.98
173_Y179_V0.8510.98
330_L346_L0.8500.98
139_R250_T0.8480.98
161_R256_E0.8460.98
147_S151_R0.8430.98
151_R311_D0.8390.98
246_R249_Q0.8330.98
325_G351_Q0.8320.98
329_R347_Y0.8300.98
144_V148_E0.8290.98
297_P369_F0.8260.97
214_E262_P0.8210.97
45_F49_Q0.8200.97
337_R340_R0.8200.97
128_G131_G0.8190.97
362_Q366_L0.8150.97
208_C211_C0.8150.97
72_F76_E0.8140.97
223_S226_G0.8140.97
113_I116_Q0.8130.97
180_R217_L0.8100.97
168_C222_C0.8100.97
337_R342_G0.8050.97
133_E261_E0.8040.97
260_G263_G0.8000.97
182_C185_C0.7990.97
358_L362_Q0.7970.97
140_T157_V0.7970.97
37_D42_E0.7930.97
182_C187_G0.7920.97
146_L150_Y0.7900.97
320_A363_R0.7880.97
286_D335_M0.7860.97
108_G112_D0.7830.97
183_P186_D0.7800.96
374_G377_I0.7780.96
168_C227_G0.7780.96
27_Q44_K0.7750.96
318_L350_V0.7730.96
180_R183_P0.7720.96
72_F75_A0.7710.96
38_D42_E0.7700.96
2_S8_V0.7690.96
161_R258_A0.7670.96
308_P313_A0.7640.96
110_M113_I0.7630.96
297_P370_A0.7620.96
131_G262_P0.7610.96
309_T314_A0.7580.96
198_P204_Q0.7560.96
175_E220_E0.7540.96
8_V48_I0.7530.96
368_Q372_A0.7520.96
175_E178_D0.7520.96
43_E47_K0.7510.96
292_H350_V0.7510.96
316_F330_L0.7500.96
105_G111_G0.7490.96
284_D289_H0.7460.95
198_P202_V0.7450.95
187_G215_G0.7420.95
52_K56_T0.7420.95
214_E217_L0.7410.95
57_D60_T0.7400.95
58_E62_Q0.7400.95
132_P265_P0.7380.95
359_S372_A0.7380.95
243_E336_P0.7360.95
239_V271_V0.7320.95
207_E212_G0.7320.95
362_Q372_A0.7310.95
173_Y218_H0.7280.95
333_K343_N0.7270.95
237_L256_E0.7270.95
365_A372_A0.7260.95
110_M116_Q0.7220.95
30_E44_K0.7220.95
360_D363_R0.7190.94
303_A318_L0.7190.94
11_V61_R0.7180.94
36_S39_P0.7180.94
146_L275_V0.7180.94
370_A374_G0.7170.94
120_G123_G0.7160.94
299_A302_G0.7140.94
112_D116_Q0.7140.94
24_Y53_D0.7130.94
130_S262_P0.7110.94
109_G113_I0.7100.94
313_A333_K0.7090.94
182_C211_C0.7070.94
261_E264_A0.7070.94
109_G118_F0.7060.94
228_Q261_E0.7050.94
31_Y41_A0.7030.94
165_C170_G0.7020.94
63_Q66_Q0.7010.94
5_F69_H0.6970.93
167_D223_S0.6960.93
171_S176_D0.6950.93
239_V253_M0.6940.93
146_L151_R0.6930.93
146_L278_H0.6910.93
242_P245_I0.6900.93
297_P366_L0.6890.93
370_A377_I0.6870.93
144_V245_I0.6870.93
161_R233_E0.6870.93
290_H348_V0.6820.93
142_L271_V0.6820.93
307_V346_L0.6810.93
36_S40_D0.6800.93
22_Q26_D0.6790.93
142_L155_K0.6780.92
323_Q354_T0.6750.92
237_L253_M0.6740.92
2_S47_K0.6740.92
353_V356_E0.6710.92
188_Q192_T0.6690.92
168_C208_C0.6640.92
129_R132_P0.6640.92
106_A111_G0.6630.92
78_R81_T0.6620.92
172_G227_G0.6610.92
73_E76_E0.6590.91
370_A375_E0.6580.91
137_D270_L0.6570.91
323_Q356_E0.6570.91
185_C211_C0.6560.91
362_Q373_G0.6560.91
182_C189_G0.6550.91
77_K80_A0.6540.91
289_H327_T0.6530.91
230_Q259_P0.6530.91
28_V35_V0.6520.91
182_C215_G0.6510.91
247_T277_E0.6480.91
187_G211_C0.6460.91
144_V275_V0.6460.91
112_D115_E0.6460.91
111_G116_Q0.6430.90
174_P177_A0.6430.90
208_C213_G0.6430.90
108_G113_I0.6410.90
150_Y309_T0.6410.90
134_Q265_P0.6380.90
171_S179_V0.6370.90
230_Q261_E0.6360.90
104_G107_G0.6330.90
178_D216_E0.6320.90
190_V207_E0.6290.89
151_R343_N0.6290.89
7_D12_S0.6280.89
209_S212_G0.6280.89
144_V153_V0.6260.89
7_D13_R0.6220.89
41_A44_K0.6220.89
179_V220_E0.6200.89
251_L273_V0.6190.89
306_E314_A0.6180.89
107_G111_G0.6150.88
44_K48_I0.6140.88
308_P314_A0.6120.88
69_H73_E0.6110.88
187_G208_C0.6100.88
113_I117_F0.6080.88
290_H293_A0.6060.88
115_E118_F0.6060.88
70_E74_E0.6050.88
117_F121_A0.6050.88
11_V19_E0.6040.87
322_T326_E0.6030.87
112_D118_F0.6020.87
43_E46_K0.6020.87
282_E289_H0.6010.87
50_K53_D0.5980.87
192_T198_P0.5980.87
71_R75_A0.5960.87
295_S303_A0.5950.87
2_S73_E0.5950.87
311_D333_K0.5950.87
165_C227_G0.5950.87
358_L366_L0.5920.86
165_C182_C0.5920.86
280_D293_A0.5920.86
138_L258_A0.5900.86
292_H348_V0.5880.86
185_C189_G0.5860.86
63_Q73_E0.5860.86
117_F120_G0.5860.86
105_G108_G0.5850.86
111_G117_F0.5850.86
222_C227_G0.5830.86
76_E80_A0.5830.86
199_L203_Q0.5830.86
185_C215_G0.5830.86
134_Q268_D0.5830.86
109_G117_F0.5810.85
59_E66_Q0.5800.85
165_C211_C0.5800.85
104_G108_G0.5790.85
162_P228_Q0.5790.85
166_A169_G0.5780.85
171_S178_D0.5770.85
165_C187_G0.5760.85
189_G215_G0.5740.85
211_C215_G0.5720.84
182_C213_G0.5720.84
185_C208_C0.5710.84
76_E79_G0.5710.84
220_E223_S0.5700.84
18_D25_R0.5690.84
308_P346_L0.5680.84
187_G213_G0.5670.84
193_Q204_Q0.5660.84
17_E56_T0.5650.84
255_G268_D0.5630.84
161_R266_N0.5620.83
72_F77_K0.5610.83
169_G175_E0.5600.83
118_F123_G0.5590.83
109_G112_D0.5590.83
54_V72_F0.5590.83
208_C215_G0.5580.83
218_H221_T0.5560.83
7_D69_H0.5550.83
161_R259_P0.5540.83
38_D41_A0.5540.83
135_G257_G0.5530.82
71_R74_E0.5530.82
127_R130_S0.5520.82
278_H281_F0.5520.82
179_V218_H0.5510.82
126_G129_R0.5510.82
144_V241_I0.5510.82
278_H290_H0.5510.82
170_G227_G0.5480.82
299_A352_V0.5470.82
38_D44_K0.5470.82
282_E349_T0.5450.82
108_G118_F0.5450.82
168_C187_G0.5440.81
299_A323_Q0.5430.81
297_P373_G0.5420.81
137_D252_R0.5410.81
309_T335_M0.5410.81
67_L70_E0.5410.81
330_L333_K0.5400.81
293_A297_P0.5400.81
168_C211_C0.5370.81
259_P262_P0.5370.81
373_G377_I0.5370.81
192_T201_R0.5350.80
281_F310_L0.5340.80
151_R243_E0.5330.80
75_A78_R0.5330.80
123_G128_G0.5320.80
175_E179_V0.5320.80
12_S16_T0.5310.80
257_G264_A0.5300.80
310_L335_M0.5300.80
229_G242_P0.5300.80
323_Q326_E0.5290.80
159_V269_L0.5290.80
25_R29_S0.5280.79
228_Q231_T0.5250.79
300_V321_G0.5250.79
138_L161_R0.5250.79
140_T271_V0.5230.79
294_V298_Q0.5190.78
106_A113_I0.5180.78
189_G213_G0.5170.78
324_S352_V0.5160.78
174_P179_V0.5150.78
185_C222_C0.5140.78
173_Y221_T0.5130.78
105_G110_M0.5110.77
180_R218_H0.5100.77
159_V235_A0.5090.77
165_C189_G0.5080.77
174_P180_R0.5080.77
162_P258_A0.5070.77
294_V350_V0.5060.77
302_G321_G0.5060.77
169_G212_G0.5050.76
106_A110_M0.5040.76
19_E22_Q0.5040.76
170_G182_C0.5040.76
189_G208_C0.5040.76
259_P266_N0.5030.76
323_Q352_V0.5030.76
314_A330_L0.5030.76
292_H303_A0.5030.76
164_S259_P0.5030.76
67_L73_E0.5010.76
354_T366_L0.5000.76
278_H310_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lz8A 2 0.4834 100 0.338 Contact Map
4j80A 2 0.688 100 0.365 Contact Map
1nltA 1 0.5703 100 0.454 Contact Map
2q2gA 3 0.445 100 0.605 Contact Map
3agxA 2 0.445 100 0.606 Contact Map
1c3gA 2 0.4297 100 0.623 Contact Map
4j7zA 1 0.2685 100 0.742 Contact Map
1bq0A 1 0.1944 100 0.76 Contact Map
3i38A 5 0.266 99.9 0.77 Contact Map
4wb7A 1 0.8568 99.9 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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