GREMLIN Database
GRPE - Protein GrpE
UniProt: Q9HRY0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (180)
Sequences: 4554 (3723)
Seq/√Len: 277.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_V81_L3.4011.00
70_E75_E3.0291.00
163_E198_P2.8411.00
162_T201_E2.5521.00
117_R159_E2.5321.00
165_R170_D2.5101.00
71_L74_A2.4891.00
83_E87_T2.2751.00
124_N127_R2.2181.00
154_R157_E2.1841.00
157_E162_T2.1071.00
124_N151_E2.1051.00
74_A78_V2.0631.00
178_E211_Q2.0581.00
77_E82_T2.0231.00
197_R211_Q2.0181.00
95_Y99_A1.9671.00
194_D213_T1.9271.00
181_M213_T1.8521.00
115_V161_V1.8441.00
117_R158_T1.8381.00
73_D77_E1.8021.00
75_E79_A1.8001.00
183_V193_V1.7961.00
92_F95_Y1.7821.00
176_R201_E1.7331.00
126_D198_P1.7271.00
72_A75_E1.7081.00
82_T86_Q1.7021.00
93_K96_K1.6971.00
166_P195_V1.6611.00
154_R158_T1.6561.00
97_E101_R1.6431.00
76_D80_D1.6201.00
146_E150_D1.6121.00
101_R105_E1.5731.00
115_V207_V1.5531.00
188_P191_T1.5531.00
193_V215_S1.5031.00
127_R130_D1.4881.00
70_E73_D1.4861.00
173_D176_R1.4671.00
126_D149_R1.4611.00
93_K97_E1.4541.00
111_T114_L1.4451.00
67_L71_L1.4441.00
112_E205_R1.4361.00
128_A145_V1.3901.00
187_Q215_S1.3831.00
184_D216_E1.3531.00
136_S139_D1.3471.00
171_S191_T1.3341.00
201_E204_G1.3231.00
64_V67_L1.2961.00
90_A94_N1.2871.00
80_D84_R1.2841.00
71_L75_E1.2801.00
164_I206_V1.2791.00
85_V88_K1.2781.00
187_Q193_V1.2741.00
162_T204_G1.2721.00
69_D73_D1.2711.00
140_G143_E1.2601.00
183_V213_T1.2381.00
100_K104_E1.2381.00
88_K92_F1.2371.00
143_E146_E1.2341.00
103_Q107_R1.2261.00
104_E108_E1.2121.00
150_D154_R1.2061.00
187_Q191_T1.1671.00
79_A83_E1.1651.00
183_V194_D1.1561.00
166_P170_D1.1561.00
168_P195_V1.1521.00
63_R68_T1.1361.00
165_R168_P1.1311.00
196_Y213_T1.1161.00
114_L159_E1.1111.00
156_L161_V1.1081.00
123_D208_R1.1061.00
180_M211_Q1.1021.00
85_V89_Q1.1011.00
69_D72_A1.0971.00
182_R190_G1.0971.00
65_E69_D1.0921.00
68_T72_A1.0911.00
78_V82_T1.0841.00
166_P210_A1.0491.00
168_P194_D1.0431.00
139_D143_E1.0411.00
122_R156_L1.0401.00
125_L149_R1.0351.00
149_R153_D1.0301.00
84_R89_Q1.0261.00
125_L148_T1.0261.00
182_R216_E1.0261.00
103_Q106_I1.0181.00
99_A103_Q1.0081.00
77_E80_D1.0041.00
89_Q93_K1.0031.00
109_R205_R1.0031.00
87_T90_A0.9971.00
195_V210_A0.9911.00
57_V60_L0.9891.00
191_T215_S0.9851.00
81_L85_V0.9831.00
108_E203_S0.9751.00
109_R203_S0.9641.00
121_V155_V0.9631.00
189_A215_S0.9611.00
83_E91_D0.9551.00
63_R66_T0.9441.00
163_E195_V0.9321.00
39_S42_V0.9251.00
153_D163_E0.9201.00
161_V202_M0.9201.00
65_E68_T0.9121.00
77_E81_L0.9031.00
41_R44_A0.8991.00
64_V68_T0.8951.00
126_D130_D0.8881.00
122_R200_Y0.8841.00
87_T94_N0.8741.00
181_M196_Y0.8711.00
178_E197_R0.8701.00
88_K95_Y0.8691.00
76_D79_A0.8681.00
92_F99_A0.8661.00
81_L84_R0.8611.00
44_A47_A0.8581.00
132_E142_R0.8401.00
166_P192_I0.8381.00
72_A76_D0.8291.00
135_E138_E0.8281.00
51_D54_A0.8281.00
172_V179_V0.8271.00
127_R197_R0.8200.99
206_V209_A0.8140.99
106_I110_A0.8120.99
60_L64_V0.8050.99
67_L70_E0.8050.99
153_D157_E0.8000.99
99_A102_K0.7950.99
74_A77_E0.7940.99
170_D192_I0.7910.99
151_E154_R0.7900.99
45_L48_D0.7880.99
73_D76_D0.7820.99
36_S39_S0.7780.99
139_D142_R0.7770.99
60_L63_R0.7770.99
193_V213_T0.7590.99
37_A40_E0.7590.99
110_A114_L0.7570.99
94_N97_E0.7520.99
164_I201_E0.7510.99
181_M194_D0.7490.99
113_D116_E0.7430.99
196_Y211_Q0.7400.99
46_D49_N0.7370.99
170_D195_V0.7210.99
112_E202_M0.7160.99
38_L41_R0.7150.99
48_D51_D0.7110.99
97_E100_K0.7110.99
35_T38_L0.7100.99
79_A82_T0.7080.98
125_L145_V0.7050.98
171_S190_G0.6950.98
184_D215_S0.6930.98
61_E64_V0.6890.98
62_A65_E0.6840.98
121_V152_F0.6820.98
53_L57_V0.6800.98
136_S140_G0.6800.98
170_D176_R0.6790.98
189_A216_E0.6770.98
180_M196_Y0.6760.98
177_H192_I0.6760.98
111_T159_E0.6720.98
102_K105_E0.6700.98
102_K106_I0.6690.98
91_D95_Y0.6670.98
104_E107_R0.6660.98
152_F156_L0.6650.98
36_S40_E0.6640.98
113_D117_R0.6630.98
122_R149_R0.6590.98
75_E78_V0.6580.98
43_R46_D0.6560.97
42_V45_L0.6560.97
171_S188_P0.6460.97
144_G147_L0.6430.97
108_E112_E0.6410.97
129_L146_E0.6400.97
143_E150_D0.6370.97
105_E108_E0.6320.97
47_A50_A0.6300.97
39_S48_D0.6300.97
172_V192_I0.6290.97
111_T115_V0.6290.97
55_D58_A0.6260.97
109_R112_E0.6250.97
164_I210_A0.6250.97
145_V148_T0.6240.97
165_R192_I0.6240.97
106_I109_R0.6230.97
66_T69_D0.6230.97
183_V215_S0.6220.97
122_R153_D0.6160.96
126_D153_D0.6160.96
160_G203_S0.6130.96
54_A57_V0.6110.96
36_S42_V0.6080.96
111_T202_M0.6080.96
40_E43_R0.6060.96
120_D197_R0.6060.96
52_A55_D0.6050.96
117_R120_D0.6040.96
202_M207_V0.6020.96
86_Q93_K0.6010.96
108_E204_G0.5980.96
100_K103_Q0.5980.96
127_R131_Q0.5900.95
53_L56_D0.5890.95
155_V159_E0.5860.95
147_L150_D0.5830.95
78_V85_V0.5810.95
58_A61_E0.5810.95
112_E207_V0.5800.95
119_L208_R0.5800.95
111_T203_S0.5780.95
83_E86_Q0.5780.95
70_E74_A0.5740.95
92_F96_K0.5640.94
112_E116_E0.5620.94
128_A131_Q0.5600.94
46_D53_L0.5590.94
137_D140_G0.5550.94
63_R67_L0.5540.94
141_I145_V0.5540.94
121_V151_E0.5430.93
84_R88_K0.5420.93
151_E155_V0.5410.93
129_L149_R0.5410.93
49_N57_V0.5400.93
39_S45_L0.5370.93
195_V198_P0.5350.92
149_R163_E0.5320.92
56_D60_L0.5320.92
91_D213_T0.5300.92
129_L142_R0.5300.92
127_R151_E0.5290.92
130_D194_D0.5270.92
85_V92_F0.5260.92
36_S43_R0.5210.91
132_E141_I0.5200.91
115_V202_M0.5170.91
138_E141_I0.5160.91
120_D151_E0.5160.91
107_R111_T0.5100.90
50_A53_L0.5090.90
92_F103_Q0.5080.90
44_A48_D0.5080.90
107_R113_D0.5070.90
126_D163_E0.5060.90
171_S192_I0.5060.90
138_E143_E0.5020.90
170_D201_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aniA 2 0.7143 100 0.137 Contact Map
3a6mA 2 0.765 100 0.171 Contact Map
1dkgA 2 0.7143 100 0.179 Contact Map
4etpB 1 0.6267 55.4 0.928 Contact Map
3swyA 3 0.212 50.2 0.93 Contact Map
4rsiB 1 0.8249 48 0.931 Contact Map
3mkbB 1 0.5991 37.5 0.935 Contact Map
4rsiA 1 0.7373 37.5 0.935 Contact Map
3swfA 3 0.2719 36.4 0.936 Contact Map
2aa1B 1 0.6129 32 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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