Q9HRX7 - HALSA - GREMLIN Contacts

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Q9HRX7 - Proliferating-cell nucleolar antigen

UniProt:	Q9HRX7	Sequences: MDALSRYEPIIDDFEGFLAACERPLPTTVRVNPLAVTPDRAVEALAAEGVAVDRREWHPGVLEVDTNKPGNTWPYVHGWVHGQEEVSCVPPRVLDPEPGDVVWDACAAPGGKTAQIAAEIDDDGLVVANDDNLGRLSALRGNCDRLGVTSAAVTNTDARRATLDAFPDVAAVDAALVDAPCSCEGTIRKNADALDGAGASASRSLGRLQADILARAVALTRPGGTVVYSTCTFAPEENEAVVDEVLGRTDSRLVEFDVGLASAPGLTEWGDASYDDSLARAQRYYPHHNDTGGFFAAKLEVTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	303 (271)
Sequences:	6868 (4922)
Seq/√Len:	299.0

ECOLI - RSMF RSMB
BACSU - RSMB
HALSA - Q9HRX7
SULSO - Q980N8 Q980Z5 Q980E2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
214_A	248_R	3.684	1.00
210_A	244_E	3.671	1.00
100_D	174_A	3.239	1.00
242_V	299_L	3.212	1.00
225_T	298_K	2.895	1.00
175_A	220_T	2.825	1.00
103_W	172_V	2.783	1.00
225_T	300_E	2.708	1.00
210_A	241_V	2.676	1.00
254_V	300_E	2.626	1.00
217_V	245_V	2.569	1.00
159_R	211_D	2.440	1.00
37_T	40_R	2.335	1.00
173_D	221_R	2.299	1.00
220_T	226_V	2.293	1.00
125_L	152_A	2.287	1.00
281_A	295_F	2.269	1.00
55_R	61_V	2.257	1.00
105_A	216_A	2.183	1.00
127_V	172_V	2.171	1.00
177_V	212_I	2.148	1.00
36_V	41_A	2.090	1.00
143_C	151_A	2.077	1.00
55_R	85_E	2.069	1.00
252_R	300_E	2.063	1.00
122_D	150_S	2.057	1.00
42_V	62_L	2.050	1.00
184_E	232_T	2.037	1.00
214_A	249_T	2.024	1.00
120_I	124_G	2.010	1.00
227_V	298_K	1.982	1.00
113_T	128_A	1.914	1.00
35_A	147_G	1.896	1.00
245_V	249_T	1.844	1.00
41_A	80_V	1.831	1.00
230_T	238_N	1.827	1.00
130_D	136_L	1.825	1.00
44_A	79_W	1.796	1.00
184_E	234_A	1.790	1.00
239_E	283_R	1.770	1.00
206_G	241_V	1.759	1.00
29_V	80_V	1.738	1.00
101_V	125_L	1.723	1.00
97_E	100_D	1.720	1.00
61_V	88_C	1.718	1.00
96_P	100_D	1.677	1.00
91_P	115_Q	1.671	1.00
13_D	287_H	1.667	1.00
116_I	176_L	1.661	1.00
244_E	248_R	1.628	1.00
73_W	77_H	1.626	1.00
14_F	18_L	1.620	1.00
136_L	153_V	1.608	1.00
42_V	52_V	1.587	1.00
53_D	65_D	1.567	1.00
33_P	60_G	1.541	1.00
243_D	247_G	1.515	1.00
117_A	148_V	1.487	1.00
33_P	118_A	1.485	1.00
114_A	146_L	1.472	1.00
86_V	291_T	1.470	1.00
107_A	139_L	1.463	1.00
235_P	240_A	1.459	1.00
213_L	245_V	1.458	1.00
28_T	63_E	1.414	1.00
240_A	243_D	1.402	1.00
38_P	54_R	1.335	1.00
253_L	297_A	1.327	1.00
148_V	151_A	1.315	1.00
254_V	298_K	1.311	1.00
136_L	155_N	1.309	1.00
94_L	174_A	1.293	1.00
101_V	171_A	1.287	1.00
236_E	240_A	1.285	1.00
137_S	140_R	1.283	1.00
93_V	296_A	1.279	1.00
284_Y	291_T	1.269	1.00
19_A	23_R	1.267	1.00
207_R	211_D	1.265	1.00
48_E	74_P	1.263	1.00
101_V	172_V	1.261	1.00
106_C	177_V	1.261	1.00
115_Q	119_E	1.254	1.00
94_L	116_I	1.250	1.00
217_V	226_V	1.245	1.00
36_V	79_W	1.244	1.00
218_A	249_T	1.243	1.00
203_R	236_E	1.241	1.00
92_R	119_E	1.237	1.00
31_V	41_A	1.226	1.00
58_H	61_V	1.216	1.00
213_L	226_V	1.210	1.00
28_T	85_E	1.197	1.00
101_V	127_V	1.191	1.00
210_A	248_R	1.187	1.00
96_P	120_I	1.179	1.00
127_V	154_T	1.175	1.00
98_P	121_D	1.174	1.00
42_V	54_R	1.172	1.00
53_D	63_E	1.157	1.00
242_V	246_L	1.155	1.00
81_H	114_A	1.154	1.00
107_A	113_T	1.151	1.00
113_T	126_V	1.145	1.00
74_P	79_W	1.144	1.00
281_A	297_A	1.141	1.00
220_T	301_V	1.140	1.00
129_N	154_T	1.130	1.00
174_A	225_T	1.129	1.00
95_D	225_T	1.127	1.00
74_P	80_V	1.125	1.00
113_T	143_C	1.111	1.00
90_P	115_Q	1.110	1.00
162_T	215_R	1.108	1.00
98_P	123_D	1.108	1.00
114_A	142_N	1.107	1.00
15_E	19_A	1.101	1.00
13_D	288_H	1.099	1.00
215_R	218_A	1.098	1.00
16_G	19_A	1.097	1.00
90_P	296_A	1.091	1.00
235_P	239_E	1.091	1.00
51_A	65_D	1.088	1.00
210_A	214_A	1.086	1.00
29_V	64_V	1.081	1.00
114_A	143_C	1.078	1.00
182_S	205_L	1.066	1.00
252_R	255_E	1.063	1.00
202_S	206_G	1.057	1.00
31_V	38_P	1.055	1.00
58_H	85_E	1.054	1.00
55_R	58_H	1.052	1.00
105_A	158_A	1.040	1.00
59_P	92_R	1.039	1.00
217_V	251_S	1.037	1.00
38_P	62_L	1.035	1.00
96_P	116_I	1.032	1.00
255_E	280_R	1.031	1.00
176_L	229_S	1.028	1.00
133_L	155_N	1.017	1.00
84_E	188_R	1.013	1.00
214_A	244_E	1.012	1.00
206_G	210_A	1.011	1.00
35_A	79_W	1.008	1.00
17_F	233_F	0.998	1.00
158_A	212_I	0.997	1.00
95_D	174_A	0.986	1.00
105_A	177_V	0.980	1.00
52_V	62_L	0.980	1.00
94_L	227_V	0.977	1.00
91_P	116_I	0.972	1.00
120_I	123_D	0.971	1.00
81_H	142_N	0.970	1.00
253_L	281_A	0.969	1.00
103_W	129_N	0.960	1.00
107_A	128_A	0.952	1.00
60_G	92_R	0.951	1.00
161_A	219_L	0.950	1.00
217_V	249_T	0.945	1.00
87_S	294_F	0.926	1.00
215_R	219_L	0.924	1.00
198_G	201_A	0.922	1.00
179_A	212_I	0.921	1.00
116_I	174_A	0.920	1.00
204_S	208_L	0.920	1.00
57_W	85_E	0.915	1.00
96_P	119_E	0.912	1.00
48_E	73_W	0.910	1.00
201_A	204_S	0.908	1.00
96_P	102_V	0.907	1.00
177_V	216_A	0.905	1.00
117_A	150_S	0.902	1.00
43_E	47_A	0.901	1.00
13_D	16_G	0.882	1.00
34_L	148_V	0.879	1.00
23_R	290_D	0.877	1.00
246_L	251_S	0.875	1.00
217_V	220_T	0.875	1.00
90_P	229_S	0.873	1.00
116_I	126_V	0.870	1.00
241_V	244_E	0.861	1.00
81_H	118_A	0.859	1.00
38_P	42_V	0.859	1.00
61_V	85_E	0.854	1.00
86_V	284_Y	0.854	1.00
197_A	201_A	0.854	1.00
284_Y	289_N	0.853	1.00
169_V	218_A	0.851	1.00
136_L	139_L	0.851	1.00
117_A	126_V	0.850	1.00
129_N	161_A	0.849	1.00
43_E	46_A	0.847	1.00
105_A	129_N	0.845	1.00
175_A	216_A	0.843	1.00
140_R	144_D	0.842	1.00
186_T	190_N	0.841	1.00
22_E	194_L	0.840	1.00
42_V	46_A	0.831	1.00
95_D	119_E	0.829	1.00
246_L	299_L	0.826	1.00
102_V	174_A	0.824	1.00
36_V	44_A	0.817	1.00
225_T	254_V	0.815	1.00
17_F	287_H	0.815	1.00
129_N	156_T	0.814	1.00
156_T	161_A	0.812	1.00
159_R	212_I	0.810	1.00
32_N	35_A	0.808	1.00
94_L	176_L	0.803	1.00
187_I	193_A	0.803	1.00
140_R	153_V	0.799	1.00
227_V	296_A	0.796	1.00
208_L	211_D	0.794	1.00
253_L	256_F	0.787	0.99
127_V	152_A	0.787	0.99
203_R	206_G	0.785	0.99
105_A	212_I	0.783	0.99
162_T	219_L	0.782	0.99
255_E	258_V	0.781	0.99
102_V	124_G	0.780	0.99
58_H	92_R	0.778	0.99
134_G	138_A	0.774	0.99
156_T	160_R	0.768	0.99
210_A	245_V	0.764	0.99
30_R	118_A	0.762	0.99
246_L	253_L	0.761	0.99
73_W	76_V	0.759	0.99
118_A	148_V	0.756	0.99
90_P	227_V	0.755	0.99
286_P	293_G	0.754	0.99
33_P	38_P	0.749	0.99
84_E	292_G	0.744	0.99
105_A	175_A	0.741	0.99
28_T	55_R	0.735	0.99
34_L	122_D	0.734	0.99
30_R	114_A	0.732	0.99
50_V	72_T	0.732	0.99
244_E	247_G	0.730	0.99
84_E	189_K	0.726	0.99
103_W	175_A	0.725	0.99
245_V	251_S	0.723	0.99
21_C	233_F	0.722	0.99
184_E	187_I	0.721	0.99
41_A	45_L	0.720	0.99
206_G	236_E	0.716	0.99
175_A	226_V	0.716	0.99
199_A	203_R	0.715	0.99
122_D	149_T	0.714	0.99
89_V	284_Y	0.712	0.99
226_V	245_V	0.712	0.99
100_D	225_T	0.709	0.99
138_A	141_G	0.709	0.99
220_T	224_G	0.709	0.99
102_V	120_I	0.708	0.99
239_E	243_D	0.707	0.99
141_G	145_R	0.707	0.99
192_D	196_G	0.706	0.99
46_A	52_V	0.705	0.99
46_A	51_A	0.701	0.99
182_S	202_S	0.699	0.99
93_V	256_F	0.698	0.99
30_R	83_Q	0.698	0.99
100_D	173_D	0.695	0.99
39_D	43_E	0.693	0.99
109_P	135_R	0.692	0.99
55_R	63_E	0.691	0.99
60_G	115_Q	0.689	0.99
134_G	137_S	0.688	0.99
93_V	96_P	0.684	0.99
205_L	208_L	0.683	0.98
177_V	213_L	0.680	0.98
17_F	21_C	0.679	0.98
101_V	221_R	0.677	0.98
44_A	74_P	0.676	0.98
113_T	151_A	0.674	0.98
161_A	215_R	0.674	0.98
130_D	139_L	0.671	0.98
168_D	171_A	0.670	0.98
246_L	250_D	0.669	0.98
85_E	291_T	0.668	0.98
246_L	249_T	0.667	0.98
86_V	90_P	0.666	0.98
20_A	23_R	0.663	0.98
102_V	116_I	0.663	0.98
278_L	281_A	0.661	0.98
203_R	207_R	0.661	0.98
48_E	72_T	0.661	0.98
137_S	141_G	0.659	0.98
97_E	174_A	0.656	0.98
40_R	44_A	0.652	0.98
99_G	123_D	0.652	0.98
240_A	244_E	0.651	0.98
26_P	63_E	0.649	0.98
244_E	249_T	0.648	0.98
31_V	62_L	0.648	0.98
81_H	146_L	0.646	0.98
200_S	204_S	0.646	0.98
96_P	115_Q	0.645	0.98
130_D	193_A	0.644	0.98
41_A	74_P	0.644	0.98
78_G	145_R	0.644	0.98
13_D	17_F	0.642	0.98
133_L	137_S	0.640	0.98
41_A	44_A	0.637	0.98
29_V	62_L	0.637	0.98
276_D	281_A	0.636	0.98
14_F	17_F	0.636	0.98
36_V	40_R	0.634	0.98
213_L	244_E	0.627	0.97
75_Y	78_G	0.626	0.97
103_W	219_L	0.624	0.97
204_S	207_R	0.622	0.97
238_N	283_R	0.621	0.97
201_A	205_L	0.615	0.97
141_G	144_D	0.612	0.97
282_Q	296_A	0.612	0.97
159_R	208_L	0.611	0.97
131_D	208_L	0.610	0.97
103_W	127_V	0.610	0.97
276_D	279_A	0.606	0.97
60_G	119_E	0.605	0.97
202_S	234_A	0.605	0.97
206_G	234_A	0.604	0.97
217_V	301_V	0.602	0.97
233_F	293_G	0.599	0.97
277_S	280_R	0.598	0.97
116_I	124_G	0.594	0.96
95_D	100_D	0.594	0.96
209_Q	228_Y	0.592	0.96
29_V	82_G	0.591	0.96
185_G	293_G	0.589	0.96
123_D	150_S	0.585	0.96
171_A	221_R	0.585	0.96
120_I	126_V	0.584	0.96
70_G	75_Y	0.583	0.96
129_N	158_A	0.582	0.96
187_I	194_L	0.581	0.96
126_V	148_V	0.577	0.96
34_L	118_A	0.577	0.96
159_R	215_R	0.576	0.96
129_N	155_N	0.576	0.96
287_H	291_T	0.574	0.96
143_C	153_V	0.574	0.96
91_P	119_E	0.573	0.96
39_D	54_R	0.569	0.95
25_L	188_R	0.569	0.95
112_K	178_D	0.568	0.95
189_K	292_G	0.566	0.95
89_V	282_Q	0.564	0.95
93_V	298_K	0.563	0.95
39_D	42_V	0.560	0.95
190_N	193_A	0.557	0.95
130_D	143_C	0.557	0.95
129_N	172_V	0.557	0.95
38_P	41_A	0.556	0.95
128_A	151_A	0.555	0.95
242_V	295_F	0.555	0.95
56_E	85_E	0.554	0.95
173_D	224_G	0.554	0.95
222_P	225_T	0.554	0.95
206_G	244_E	0.553	0.95
242_V	253_L	0.553	0.95
93_V	282_Q	0.552	0.95
54_R	62_L	0.552	0.95
238_N	285_Y	0.551	0.95
130_D	155_N	0.550	0.95
117_A	124_G	0.549	0.94
91_P	94_L	0.548	0.94
44_A	48_E	0.548	0.94
109_P	229_S	0.546	0.94
142_N	145_R	0.544	0.94
12_D	16_G	0.543	0.94
196_G	201_A	0.543	0.94
38_P	61_V	0.541	0.94
207_R	244_E	0.541	0.94
157_D	160_R	0.540	0.94
178_D	231_C	0.538	0.94
53_D	290_D	0.536	0.94
143_C	146_L	0.534	0.94
216_A	226_V	0.533	0.94
143_C	148_V	0.532	0.94
217_V	299_L	0.531	0.93
96_P	99_G	0.531	0.93
18_L	22_E	0.526	0.93
218_A	222_P	0.526	0.93
235_P	243_D	0.525	0.93
25_L	189_K	0.525	0.93
214_A	218_A	0.524	0.93
15_E	18_L	0.524	0.93
109_P	139_L	0.523	0.93
239_E	281_A	0.523	0.93
40_R	43_E	0.522	0.93
254_V	280_R	0.520	0.93
248_R	251_S	0.520	0.93
126_V	143_C	0.519	0.93
44_A	47_A	0.519	0.93
168_D	172_V	0.515	0.92
118_A	146_L	0.514	0.92
139_L	153_V	0.512	0.92
211_D	214_A	0.512	0.92
184_E	197_A	0.510	0.92
135_R	184_E	0.510	0.92
239_E	295_F	0.509	0.92
153_V	156_T	0.505	0.92
208_L	212_I	0.501	0.91
214_A	241_V	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2frxA	1	0.9373	100	0.259	Contact Map
1ixkA	1	0.9439	100	0.283	Contact Map
3m4xA	1	0.9538	100	0.286	Contact Map
3m6wA	2	0.967	100	0.296	Contact Map
2yxlA	1	0.9406	100	0.302	Contact Map
2b9eA	1	0.8383	100	0.315	Contact Map
1sqgA	1	0.9208	100	0.333	Contact Map
3ajdA	1	0.8251	100	0.394	Contact Map
4fzvA	1	0.9637	100	0.45	Contact Map
2vdvE	2	0.6568	99.9	0.74	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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