GREMLIN Database
Q9HRX7 - Proliferating-cell nucleolar antigen
UniProt: Q9HRX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (271)
Sequences: 6868 (4922)
Seq/√Len: 299.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_A248_R3.6841.00
210_A244_E3.6711.00
100_D174_A3.2391.00
242_V299_L3.2121.00
225_T298_K2.8951.00
175_A220_T2.8251.00
103_W172_V2.7831.00
225_T300_E2.7081.00
210_A241_V2.6761.00
254_V300_E2.6261.00
217_V245_V2.5691.00
159_R211_D2.4401.00
37_T40_R2.3351.00
173_D221_R2.2991.00
220_T226_V2.2931.00
125_L152_A2.2871.00
281_A295_F2.2691.00
55_R61_V2.2571.00
105_A216_A2.1831.00
127_V172_V2.1711.00
177_V212_I2.1481.00
36_V41_A2.0901.00
143_C151_A2.0771.00
55_R85_E2.0691.00
252_R300_E2.0631.00
122_D150_S2.0571.00
42_V62_L2.0501.00
184_E232_T2.0371.00
214_A249_T2.0241.00
120_I124_G2.0101.00
227_V298_K1.9821.00
113_T128_A1.9141.00
35_A147_G1.8961.00
245_V249_T1.8441.00
41_A80_V1.8311.00
230_T238_N1.8271.00
130_D136_L1.8251.00
44_A79_W1.7961.00
184_E234_A1.7901.00
239_E283_R1.7701.00
206_G241_V1.7591.00
29_V80_V1.7381.00
101_V125_L1.7231.00
97_E100_D1.7201.00
61_V88_C1.7181.00
96_P100_D1.6771.00
91_P115_Q1.6711.00
13_D287_H1.6671.00
116_I176_L1.6611.00
244_E248_R1.6281.00
73_W77_H1.6261.00
14_F18_L1.6201.00
136_L153_V1.6081.00
42_V52_V1.5871.00
53_D65_D1.5671.00
33_P60_G1.5411.00
243_D247_G1.5151.00
117_A148_V1.4871.00
33_P118_A1.4851.00
114_A146_L1.4721.00
86_V291_T1.4701.00
107_A139_L1.4631.00
235_P240_A1.4591.00
213_L245_V1.4581.00
28_T63_E1.4141.00
240_A243_D1.4021.00
38_P54_R1.3351.00
253_L297_A1.3271.00
148_V151_A1.3151.00
254_V298_K1.3111.00
136_L155_N1.3091.00
94_L174_A1.2931.00
101_V171_A1.2871.00
236_E240_A1.2851.00
137_S140_R1.2831.00
93_V296_A1.2791.00
284_Y291_T1.2691.00
19_A23_R1.2671.00
207_R211_D1.2651.00
48_E74_P1.2631.00
101_V172_V1.2611.00
106_C177_V1.2611.00
115_Q119_E1.2541.00
94_L116_I1.2501.00
217_V226_V1.2451.00
36_V79_W1.2441.00
218_A249_T1.2431.00
203_R236_E1.2411.00
92_R119_E1.2371.00
31_V41_A1.2261.00
58_H61_V1.2161.00
213_L226_V1.2101.00
28_T85_E1.1971.00
101_V127_V1.1911.00
210_A248_R1.1871.00
96_P120_I1.1791.00
127_V154_T1.1751.00
98_P121_D1.1741.00
42_V54_R1.1721.00
53_D63_E1.1571.00
242_V246_L1.1551.00
81_H114_A1.1541.00
107_A113_T1.1511.00
113_T126_V1.1451.00
74_P79_W1.1441.00
281_A297_A1.1411.00
220_T301_V1.1401.00
129_N154_T1.1301.00
174_A225_T1.1291.00
95_D225_T1.1271.00
74_P80_V1.1251.00
113_T143_C1.1111.00
90_P115_Q1.1101.00
162_T215_R1.1081.00
98_P123_D1.1081.00
114_A142_N1.1071.00
15_E19_A1.1011.00
13_D288_H1.0991.00
215_R218_A1.0981.00
16_G19_A1.0971.00
90_P296_A1.0911.00
235_P239_E1.0911.00
51_A65_D1.0881.00
210_A214_A1.0861.00
29_V64_V1.0811.00
114_A143_C1.0781.00
182_S205_L1.0661.00
252_R255_E1.0631.00
202_S206_G1.0571.00
31_V38_P1.0551.00
58_H85_E1.0541.00
55_R58_H1.0521.00
105_A158_A1.0401.00
59_P92_R1.0391.00
217_V251_S1.0371.00
38_P62_L1.0351.00
96_P116_I1.0321.00
255_E280_R1.0311.00
176_L229_S1.0281.00
133_L155_N1.0171.00
84_E188_R1.0131.00
214_A244_E1.0121.00
206_G210_A1.0111.00
35_A79_W1.0081.00
17_F233_F0.9981.00
158_A212_I0.9971.00
95_D174_A0.9861.00
105_A177_V0.9801.00
52_V62_L0.9801.00
94_L227_V0.9771.00
91_P116_I0.9721.00
120_I123_D0.9711.00
81_H142_N0.9701.00
253_L281_A0.9691.00
103_W129_N0.9601.00
107_A128_A0.9521.00
60_G92_R0.9511.00
161_A219_L0.9501.00
217_V249_T0.9451.00
87_S294_F0.9261.00
215_R219_L0.9241.00
198_G201_A0.9221.00
179_A212_I0.9211.00
116_I174_A0.9201.00
204_S208_L0.9201.00
57_W85_E0.9151.00
96_P119_E0.9121.00
48_E73_W0.9101.00
201_A204_S0.9081.00
96_P102_V0.9071.00
177_V216_A0.9051.00
117_A150_S0.9021.00
43_E47_A0.9011.00
13_D16_G0.8821.00
34_L148_V0.8791.00
23_R290_D0.8771.00
246_L251_S0.8751.00
217_V220_T0.8751.00
90_P229_S0.8731.00
116_I126_V0.8701.00
241_V244_E0.8611.00
81_H118_A0.8591.00
38_P42_V0.8591.00
61_V85_E0.8541.00
86_V284_Y0.8541.00
197_A201_A0.8541.00
284_Y289_N0.8531.00
169_V218_A0.8511.00
136_L139_L0.8511.00
117_A126_V0.8501.00
129_N161_A0.8491.00
43_E46_A0.8471.00
105_A129_N0.8451.00
175_A216_A0.8431.00
140_R144_D0.8421.00
186_T190_N0.8411.00
22_E194_L0.8401.00
42_V46_A0.8311.00
95_D119_E0.8291.00
246_L299_L0.8261.00
102_V174_A0.8241.00
36_V44_A0.8171.00
225_T254_V0.8151.00
17_F287_H0.8151.00
129_N156_T0.8141.00
156_T161_A0.8121.00
159_R212_I0.8101.00
32_N35_A0.8081.00
94_L176_L0.8031.00
187_I193_A0.8031.00
140_R153_V0.7991.00
227_V296_A0.7961.00
208_L211_D0.7941.00
253_L256_F0.7870.99
127_V152_A0.7870.99
203_R206_G0.7850.99
105_A212_I0.7830.99
162_T219_L0.7820.99
255_E258_V0.7810.99
102_V124_G0.7800.99
58_H92_R0.7780.99
134_G138_A0.7740.99
156_T160_R0.7680.99
210_A245_V0.7640.99
30_R118_A0.7620.99
246_L253_L0.7610.99
73_W76_V0.7590.99
118_A148_V0.7560.99
90_P227_V0.7550.99
286_P293_G0.7540.99
33_P38_P0.7490.99
84_E292_G0.7440.99
105_A175_A0.7410.99
28_T55_R0.7350.99
34_L122_D0.7340.99
30_R114_A0.7320.99
50_V72_T0.7320.99
244_E247_G0.7300.99
84_E189_K0.7260.99
103_W175_A0.7250.99
245_V251_S0.7230.99
21_C233_F0.7220.99
184_E187_I0.7210.99
41_A45_L0.7200.99
206_G236_E0.7160.99
175_A226_V0.7160.99
199_A203_R0.7150.99
122_D149_T0.7140.99
89_V284_Y0.7120.99
226_V245_V0.7120.99
100_D225_T0.7090.99
138_A141_G0.7090.99
220_T224_G0.7090.99
102_V120_I0.7080.99
239_E243_D0.7070.99
141_G145_R0.7070.99
192_D196_G0.7060.99
46_A52_V0.7050.99
46_A51_A0.7010.99
182_S202_S0.6990.99
93_V256_F0.6980.99
30_R83_Q0.6980.99
100_D173_D0.6950.99
39_D43_E0.6930.99
109_P135_R0.6920.99
55_R63_E0.6910.99
60_G115_Q0.6890.99
134_G137_S0.6880.99
93_V96_P0.6840.99
205_L208_L0.6830.98
177_V213_L0.6800.98
17_F21_C0.6790.98
101_V221_R0.6770.98
44_A74_P0.6760.98
113_T151_A0.6740.98
161_A215_R0.6740.98
130_D139_L0.6710.98
168_D171_A0.6700.98
246_L250_D0.6690.98
85_E291_T0.6680.98
246_L249_T0.6670.98
86_V90_P0.6660.98
20_A23_R0.6630.98
102_V116_I0.6630.98
278_L281_A0.6610.98
203_R207_R0.6610.98
48_E72_T0.6610.98
137_S141_G0.6590.98
97_E174_A0.6560.98
40_R44_A0.6520.98
99_G123_D0.6520.98
240_A244_E0.6510.98
26_P63_E0.6490.98
244_E249_T0.6480.98
31_V62_L0.6480.98
81_H146_L0.6460.98
200_S204_S0.6460.98
96_P115_Q0.6450.98
130_D193_A0.6440.98
41_A74_P0.6440.98
78_G145_R0.6440.98
13_D17_F0.6420.98
133_L137_S0.6400.98
41_A44_A0.6370.98
29_V62_L0.6370.98
276_D281_A0.6360.98
14_F17_F0.6360.98
36_V40_R0.6340.98
213_L244_E0.6270.97
75_Y78_G0.6260.97
103_W219_L0.6240.97
204_S207_R0.6220.97
238_N283_R0.6210.97
201_A205_L0.6150.97
141_G144_D0.6120.97
282_Q296_A0.6120.97
159_R208_L0.6110.97
131_D208_L0.6100.97
103_W127_V0.6100.97
276_D279_A0.6060.97
60_G119_E0.6050.97
202_S234_A0.6050.97
206_G234_A0.6040.97
217_V301_V0.6020.97
233_F293_G0.5990.97
277_S280_R0.5980.97
116_I124_G0.5940.96
95_D100_D0.5940.96
209_Q228_Y0.5920.96
29_V82_G0.5910.96
185_G293_G0.5890.96
123_D150_S0.5850.96
171_A221_R0.5850.96
120_I126_V0.5840.96
70_G75_Y0.5830.96
129_N158_A0.5820.96
187_I194_L0.5810.96
126_V148_V0.5770.96
34_L118_A0.5770.96
159_R215_R0.5760.96
129_N155_N0.5760.96
287_H291_T0.5740.96
143_C153_V0.5740.96
91_P119_E0.5730.96
39_D54_R0.5690.95
25_L188_R0.5690.95
112_K178_D0.5680.95
189_K292_G0.5660.95
89_V282_Q0.5640.95
93_V298_K0.5630.95
39_D42_V0.5600.95
190_N193_A0.5570.95
130_D143_C0.5570.95
129_N172_V0.5570.95
38_P41_A0.5560.95
128_A151_A0.5550.95
242_V295_F0.5550.95
56_E85_E0.5540.95
173_D224_G0.5540.95
222_P225_T0.5540.95
206_G244_E0.5530.95
242_V253_L0.5530.95
93_V282_Q0.5520.95
54_R62_L0.5520.95
238_N285_Y0.5510.95
130_D155_N0.5500.95
117_A124_G0.5490.94
91_P94_L0.5480.94
44_A48_E0.5480.94
109_P229_S0.5460.94
142_N145_R0.5440.94
12_D16_G0.5430.94
196_G201_A0.5430.94
38_P61_V0.5410.94
207_R244_E0.5410.94
157_D160_R0.5400.94
178_D231_C0.5380.94
53_D290_D0.5360.94
143_C146_L0.5340.94
216_A226_V0.5330.94
143_C148_V0.5320.94
217_V299_L0.5310.93
96_P99_G0.5310.93
18_L22_E0.5260.93
218_A222_P0.5260.93
235_P243_D0.5250.93
25_L189_K0.5250.93
214_A218_A0.5240.93
15_E18_L0.5240.93
109_P139_L0.5230.93
239_E281_A0.5230.93
40_R43_E0.5220.93
254_V280_R0.5200.93
248_R251_S0.5200.93
126_V143_C0.5190.93
44_A47_A0.5190.93
168_D172_V0.5150.92
118_A146_L0.5140.92
139_L153_V0.5120.92
211_D214_A0.5120.92
184_E197_A0.5100.92
135_R184_E0.5100.92
239_E295_F0.5090.92
153_V156_T0.5050.92
208_L212_I0.5010.91
214_A241_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2frxA 1 0.9373 100 0.259 Contact Map
1ixkA 1 0.9439 100 0.283 Contact Map
3m4xA 1 0.9538 100 0.286 Contact Map
3m6wA 2 0.967 100 0.296 Contact Map
2yxlA 1 0.9406 100 0.302 Contact Map
2b9eA 1 0.8383 100 0.315 Contact Map
1sqgA 1 0.9208 100 0.333 Contact Map
3ajdA 1 0.8251 100 0.394 Contact Map
4fzvA 1 0.9637 100 0.45 Contact Map
2vdvE 2 0.6568 99.9 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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